LOCUS       NM_001381876            6234 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus E74 like ETS transcription factor 4 (Elf4), transcript
            variant 1, mRNA.
ACCESSION   NM_001381876 XM_006541526
VERSION     NM_001381876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6234)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 6234)
  AUTHORS   Wang,Q., Du,J. and Ma,R.
  TITLE     White adipocyte-derived exosomal miR-23b inhibits thermogenesis by
            targeting Elf4 to regulate GLP-1R transcription
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (8), 5847-5860 (2024)
   PUBMED   38334823
  REMARK    GeneRIF: White adipocyte-derived exosomal miR-23b inhibits
            thermogenesis by targeting Elf4 to regulate GLP-1R transcription.
REFERENCE   3  (bases 1 to 6234)
  AUTHORS   Cao,M., Chen,P., Peng,B., Cheng,Y., Xie,J., Hou,Z., Chen,H., Ye,L.,
            Li,H., Wang,H., Ren,L., Xiong,L., Geng,L. and Gong,S.
  TITLE     The transcription factor ELF4 alleviates inflammatory bowel disease
            by activating IL1RN transcription, suppressing inflammatory TH17
            cell activity, and inducing macrophage M2 polarization
  JOURNAL   Front Immunol 14, 1270411 (2023)
   PUBMED   38022496
  REMARK    GeneRIF: The transcription factor ELF4 alleviates inflammatory
            bowel disease by activating IL1RN transcription, suppressing
            inflammatory TH17 cell activity, and inducing macrophage M2
            polarization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6234)
  AUTHORS   Li,L., Wang,S. and Wang,W.
  TITLE     Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion
            mice through promotion of pyroptosis, inflammation, oxidative
            stress, and endoplasmic reticulum stress
  JOURNAL   BMC Mol Cell Biol 24 (1), 22 (2023)
   PUBMED   37474923
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6234)
  AUTHORS   Salinas,S.A., Mace,E.M., Conte,M.I., Park,C.S., Li,Y.,
            Rosario-Sepulveda,J.I., Mahapatra,S., Moore,E.K., Hernandez,E.R.,
            Chinn,I.K., Reed,A.E., Lee,B.J., Frumovitz,A., Gibbs,R.A.,
            Posey,J.E., Forbes Satter,L.R., Thatayatikom,A., Allenspach,E.J.,
            Wensel,T.G., Lupski,J.R., Lacorazza,H.D. and Orange,J.S.
  TITLE     An ELF4 hypomorphic variant results in NK cell deficiency
  JOURNAL   JCI Insight 7 (23), e155481 (2022)
   PUBMED   36477361
  REMARK    GeneRIF: An ELF4 hypomorphic variant results in NK cell deficiency.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6234)
  AUTHORS   Kim,Y.J., Kim,B.G., Lee,S.J., Lee,H.K., Lee,S.H., Ryoo,H.M. and
            Cho,J.Y.
  TITLE     The suppressive effect of myeloid Elf-1-like factor (MEF) in
            osteogenic differentiation
  JOURNAL   J Cell Physiol 211 (1), 253-260 (2007)
   PUBMED   17167770
  REMARK    GeneRIF: These findings suggest that MEF promotes cell
            proliferation and functions as a negative regulator of osteogenic
            differentiation by directly interacting with Runx2 and suppressing
            its transcriptional activity.
REFERENCE   7  (bases 1 to 6234)
  AUTHORS   Lacorazza,H.D., Yamada,T., Liu,Y., Miyata,Y., Sivina,M., Nunes,J.
            and Nimer,S.D.
  TITLE     The transcription factor MEF/ELF4 regulates the quiescence of
            primitive hematopoietic cells
  JOURNAL   Cancer Cell 9 (3), 175-187 (2006)
   PUBMED   16530702
REFERENCE   8  (bases 1 to 6234)
  AUTHORS   Garcia-Barros,M., Lacorazza,D., Petrie,H., Haimovitz-Friedman,A.,
            Cardon-Cardo,C., Nimer,S., Fuks,Z. and Kolesnick,R.
  TITLE     Host acid sphingomyelinase regulates microvascular function not
            tumor immunity
  JOURNAL   Cancer Res 64 (22), 8285-8291 (2004)
   PUBMED   15548696
REFERENCE   9  (bases 1 to 6234)
  AUTHORS   Kurpios,N.A., Sabolic,N.A., Shepherd,T.G., Fidalgo,G.M. and
            Hassell,J.A.
  TITLE     Function of PEA3 Ets transcription factors in mammary gland
            development and oncogenesis
  JOURNAL   J Mammary Gland Biol Neoplasia 8 (2), 177-190 (2003)
   PUBMED   14635793
  REMARK    Review article
REFERENCE   10 (bases 1 to 6234)
  AUTHORS   Lacorazza,H.D., Miyazaki,Y., Di Cristofano,A., Deblasio,A.,
            Hedvat,C., Zhang,J., Cordon-Cardo,C., Mao,S., Pandolfi,P.P. and
            Nimer,S.D.
  TITLE     The ETS protein MEF plays a critical role in perforin gene
            expression and the development of natural killer and NK-T cells
  JOURNAL   Immunity 17 (4), 437-449 (2002)
   PUBMED   12387738
  REMARK    GeneRIF: MEF-/- mice have a profound reduction in the number of
            NK-T and NK cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669901.26 and AL844594.4.
            
            On Apr 17, 2020 this sequence version replaced XM_006541526.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155203.1, SRR13422597.518920.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AL669901.26        25290-25737         c
            449-725             AL844594.4         76268-76544         c
            726-897             AL844594.4         72894-73065         c
            898-990             AL844594.4         72466-72558         c
            991-1182            AL844594.4         71198-71389         c
            1183-1266           AL844594.4         70345-70428         c
            1267-1459           AL844594.4         70061-70253         c
            1460-1837           AL844594.4         68837-69214         c
            1838-6234           AL844594.4         63240-67636         c
FEATURES             Location/Qualifiers
     source          1..6234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 25.67 cM"
     gene            1..6234
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /note="E74 like ETS transcription factor 4"
                     /db_xref="GeneID:56501"
                     /db_xref="MGI:MGI:1928377"
     exon            1..448
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            449..725
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     CDS             654..2621
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /note="myeloid elf-1-like factor; E74-like factor 4;
                     myeloid elf-1-like factor; myeloid elf-1 like factor;
                     E74-like factor 4 (ets domain transcription factor)"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-4"
                     /protein_id="NP_001368805.1"
                     /db_xref="GeneID:56501"
                     /db_xref="MGI:MGI:1928377"
                     /translation="MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPEL
                     VHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVAT
                     PSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEK
                     VSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALL
                     QDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGI
                     LAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVG
                     TRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLTK
                     TVSSSPAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVS
                     TFKDTFTLQTSFPLNTNLQENQVATQGAPLILSGLPQLLAGANPQSNPAPSQVIGAGS
                     AGPSSQPPGTVIAAFIRTSSGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLR
                     ELLRDQGHLQPLPSQVLSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSGSGPLF
                     VTEPSVTRSPTQAPFSPFNPTSLIKMEPQDI"
     exon            726..897
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            898..990
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1182
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1266
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1459
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1837
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..6234
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6214..6219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /note="hexamer: AATAAA"
     polyA_site      6234
                     /gene="Elf4"
                     /gene_synonym="Gm9907; Mef"
                     /note="major polyA site"
ORIGIN      
        1 agtccctcct cgccctgcct cctgcgcgcc cagcccagcc tccgcccgcg gggacgtgtg
       61 tgagtgtgtc tgtgtgtgag tgtgtctgtg tgtgtgtgtg tgcgtgcgtg cgcgcgtgtg
      121 tgctgtgtgt gtctccagtg cgatttcccc tttctctcgc tagcctcggc gcagctctcc
      181 agcggctcgc gcccccctcc tcatcagcgg gtgccccccg ccgcccttcc ctcggcgcgg
      241 cctcccggga acctcgggac tcccgtcgca ctgccggcac cctggttcct cttcatccgg
      301 ggcgccgccg tctcacctgg ggctcgcatc tcgctcgccc tccaactttg ccattggcgg
      361 cggcggcggc ggcggcggga cgtgtgggag aagcccagcg cctcgcccgg ccgcccgccc
      421 gcccggacca gcctgccccg gcgccgaggt tgctcttgtg gttggcatag cccagcatgc
      481 aatcttgagc ctggcatagt ccacacccac tccaactctg gttatcctcc ccagaggctc
      541 agagaaggca ctagattgat cctaacatac ctgaataact tctgttcgac aacaaaccac
      601 cgcagctcca gggagccggg ggagtctcat tgtcagctct ggcagaagcc agtatggcta
      661 ttgctctgca gcccagtgat ctggtcttcg agtttgcaag caacgggatg gatgatatcc
      721 accagctgga agacccttca gtgttcccag ccgtgatcgt ggaacaggtc ccctatcctg
      781 aattagtgca tctgtgctca ggactggatc tggatgaggt ccacaatggc atcataaggg
      841 acaggacctt gtgcatgaca caggatcaga ttttagaagg cagtattttg ctgacagatg
      901 atgatgtatc cacctcaaat aacgtgtcat ccactgaagt cctattcaat gtggcaactc
      961 ccagtgatgt cctggatgag aagcagatct tcagctcacc ggaagtgctt tcagactcca
     1021 actctgttca ggccatcaat ctacccaact tcctgctctc tacccctgaa cctgatgacc
     1081 tgaagaagac aagtgatgct ggtgaccaga aggagcattc tgaggaggag aaggtctcca
     1141 gagaggaaaa tcttaggaag atggggaagg cacggaagag aaaccgaaag accaagaaca
     1201 accgaagtac ctcacctgtc actgacccta gcatgcctat acggaagaaa tccaaagatg
     1261 gcaaaggcag caccatttat ctgtgggagt tcctcctggc tcttctgcaa gacagaaaca
     1321 cctgccccaa gtacattaag tggacgcaga gagagaaggg catcttcaag ttggtggact
     1381 ccaaggctgt gtccaagctg tggggcaagc agaaaaacaa acctgacatg aactacgaga
     1441 ccatggggcg agccctgaga tattattatc aaagaggaat cctggccaaa gtggaagggc
     1501 agaggctggt ataccagttc aaggagatgc ctaaggactt ggtggtgatt gatgatgaag
     1561 aagagagccc tgagacacca gaagactctt cccaggcctc gacttcctcc acaccctcga
     1621 ccagtaccat ccggagagcc agctccaggg tcggaaccag agcctccccc gaggacaagg
     1681 ataaccctcc ctgggagaag ccaaaagtcc aacacactgg tctccagcca tctgcaagcc
     1741 tggagttagg attgtctgtg gatgaggagg ttcccaccac ctccaccatg cttgccagcc
     1801 cactacagag ccaggccagg ctcaccaaaa ctgtgagttc ttctccagca cccagtaaca
     1861 tccacctagg agtagcccct gtggggcctg gctccactgt caccctgcag accatcccgc
     1921 tgactacggt gctgaccaat gggcctcctg ccagtactac tgctccaact caactcgttc
     1981 ttcagagtgt cccgcaggtg tcaacattca aggacacctt cactttgcag acctccttcc
     2041 ccctgaacac caatttgcaa gagaaccagg tggcaaccca aggggcccca ctgatcctca
     2101 gtggtctccc ccaacttctg gctggggcca accctcagag caacccagct ccatcccagg
     2161 tcataggtgc tgggtcagca gggcctagct ctcagccccc tgggactgtg attgctgcct
     2221 ttatcaggac ttccagtggc acatcagtgc ctgtggtaaa ggaggggccc ttgaggtcct
     2281 cttcatatgt gcagggtgtg gttactgggg cacccgtgga ggggctgttg gttcctgaag
     2341 agaccctgag agagctcctg agagatcagg gtcatcttca gccacttccg agtcaggtgc
     2401 tctcaagggg ttcccataac ctgagccttg tggggaacca gactctctct ccccctagcc
     2461 accccactgt tgggctaacc ccagtggctg agctcgagct ctcgtcaggc tcagggcccc
     2521 tgttcgtaac tgagcctagt gtgaccagat ccccaaccca ggcccctttc tccccattca
     2581 atcccacttc cctcattaag atggaacccc aagatatata aacaaaggga tcaaaagtat
     2641 gacccaccgg gcaaaattgt gaagcatttt catgtggact taagtaagag tacccaccct
     2701 tctatctcgt ggggtgtgag aacatttgat tccaagttcc ccaggcctat ttgacatcgc
     2761 tctgaccaaa gtgtgcccag ttcaagcatc tggcaccaga ccagggcctt caagagcact
     2821 agggagtaga tgtgctcttg gaatgaaaat gagctgactt ggtgatggag ggaaatccac
     2881 aagccaggaa gcagcttgtg gccagatctg gtcagcagct tcacaggacg agttaggcct
     2941 ggtcatactt cgttatctgt attccttaca cagggaattt accatccaat atgtgaatat
     3001 cttcgtatgc atctgtgtgc acttgtgggt ctgtatcttc atttctttgg gaaggatagg
     3061 atgtagatgt caggtcttgt ctgtgtttgt gtgtgtgtcc gtctgtccgt ccgtccctcc
     3121 ctaggtcagc cacagagatg aggcagtttt aagagaaagc actctgtaac tttttcttgt
     3181 tgttgttggc aagcaacaat gcctttctga gactggaagg aactggtgga atgcccctcc
     3241 tcccagtcta tagaggtgtc acagagctgg aaaaggtcta ggtaggagaa cttcaatggg
     3301 tgcatatgct gagaggacac tgctaaggga caagaggcca tgtatgttaa aaccatagtg
     3361 ggagagagaa ggaacacact tagtcctggg agcacttgct tgtcatagtc accttgccac
     3421 caggctggaa cccggagtgc tctactgaag gttgtgaggc aaagcactta tctctaggca
     3481 gccctgatta taaagtccct agccaggcct gagtgcattg aatggttgtg gccagggctt
     3541 ttggctgttt gtataaaatc agccctatgc ttgacaataa cagccctttg tgatccagta
     3601 ctcttccttc cctatcttgg gttccctctt cactctgtct gcgctgagaa attccacctg
     3661 tcctcagttg ctgaggctag tggggtggca aggctagctc cagccataca gtctcactca
     3721 ctctcccacc ctctcgctct cacagtggct ctttgctttt tatttctgcc catcacatct
     3781 aacccgattc tcgcttcact gagatgacag gagcgagcac acatgggttc ctacagctcc
     3841 tgtcagccca tgagtctgct tttctctttt ctgtttctgg aaagagctct cctgatctta
     3901 gtctctcagc agagggtctc catctccctt ttttgaatct gcttgcctct ttcctaccag
     3961 gtttaggaac aatgtgtgga gatgtcacac ccagaaccaa gtctagctag cctctggcga
     4021 ctttggttaa tgtgaatcag tgctccagga ccttctctat gtcctctatg ccaaaaacac
     4081 ccacttgacc taactacctc cctggccggt catcctcctc cctactgttc cctctccttc
     4141 cctggaggaa ggagccatct gtggctctat gcaggtgtgt ttgctacatt cccagcaatt
     4201 ggcgctgaaa tgtctgttct aataaaattg gctgatgatg tcaatctctg gatggatgga
     4261 tggaaggaag gaaggaagga aggaagcatc tagagaaaag gtcaccattg ttggcgttag
     4321 tgtttgctgt tcttgttgtg tttgggtttt agttttttgg ggtttttgaa cttgctctgt
     4381 tggttaagat gaccttgaac ttccggttct cacccccccc cttccttgtt ctcacatgtg
     4441 gatcaccatg tggttctgtg gaccaaagcc aggactctgt gcaggcgtga cgagtactcc
     4501 tagcaactgt gctaccttcc aagctcaatc attttttttt caatcagttt taatgagcac
     4561 aaagggacag tatgagttgc catcagcctg ggacctaatc tctccataca ccattgtgct
     4621 ttctgttttc gtgcgggctc ctcctctctg tgtgtgggtg ttctccaagg gtctccattt
     4681 tgtcatgggc cagttctttc acatgagttc tggaacctac ttctctaagt tcctggctct
     4741 cgctcagccc tagtgatctg cttctgttca tgatgccacc attctgctga ccttctagac
     4801 tggaaatctc agagctgtct ggtgggctct gtgcacttga ccctgcccct ctccctcatc
     4861 tcctgttatc tggcctgtct tcatttccag agcctccagc ctagcccatg cctcttaacg
     4921 tcccacttcc caatgtgact tctcagcact tctctctggc aggctacttg ctctggcctt
     4981 cctctgctaa aaagccttca gcgagtcctg gcctgcagac taggccagtc cttaaactgc
     5041 tgatccccac ccactcagga ttttctagct ggtctaggcc tagctttagt tccccaatcg
     5101 tggcagggcc caagaagttg gggagcactt ggagagtaaa tcttgaaaga tttgaagttt
     5161 gataacaacc caccagggaa aagagctcga agtcggtggc atttcactag tgggtcctct
     5221 ctgatattcc ccactcaccc catgccaagg tactcttcga ggagtccatg gtctttgaac
     5281 ttgttcccac ttaatgcctt ttctttcctg ggttccatct aaccaatatg ctctatcctc
     5341 ttactaacaa tggaaaactg tgtctcaaga tggaattgag tgggaacagc cagttcttac
     5401 ctttaattct taaacttgta actgccactt gatggacagg tgactagaaa cagcctgtga
     5461 catctctgtt gtaatcacaa actgttactt agactgtaag tttagtacct tttatctcct
     5521 gtgtgtgtta ccttctgagg ggtaggcacc accgtgtcac ccacaacact gggcatacta
     5581 taacgcagat gagcatccct gaccagttac tgtttgatct gatgagagct gggaagcaaa
     5641 cttttgaggt agctgaccgc cgtcctcccc tctcgcttag gcagttactc caggtgcttc
     5701 actgcccagt gctgcccccc ccccccacag gaccacctca ccctctatct taacatcaaa
     5761 aatttgtatt actttcaaca tccctctgat cctaaagaca acttcttgtt cagtttcttc
     5821 cttacccaga gtgttaaact agctaaccgg ttaactaacc cttgctgaca agcgttctgc
     5881 aagaggctta caggagaacc tcaggagaca gatttccttg aaccagagtc aggtggcagc
     5941 aatccccctg cttttgtgat ggcctgccta atggagtcag gagtcaagtg atggtcctca
     6001 cgtcccagcg gctgatatgt gactccctcc tcctggctcc cacagcactt tgtatatacc
     6061 tcttattgta gcacattgta tgtagttctt tgattgtgtt catgtacggt ttcccttcaa
     6121 cagactgtga gctcctccag agcaggagct gtgtgctagt cagtgatgta tccccagcac
     6181 ctagccacag tgcctgatac acagtaggtg ctcaataaat gtttattgaa aggc
//
