LOCUS       NM_007921               1940 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus E74-like factor 3 (Elf3), transcript variant 2, mRNA.
ACCESSION   NM_007921
VERSION     NM_007921.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Fung,K.Y., de Geus,E.D., Ying,L., Cumming,H., Bourke,N.,
            Foster,S.C. and Hertzog,P.J.
  TITLE     Expression of Interferon Epsilon in Mucosal Epithelium is Regulated
            by Elf3
  JOURNAL   Mol Cell Biol 44 (8), 334-343 (2024)
   PUBMED   38975675
  REMARK    GeneRIF: Expression of Interferon Epsilon in Mucosal Epithelium is
            Regulated by Elf3.
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Nakamura,T., Nishikawa,Y., Shiokawa,M., Takeda,H., Yokode,M.,
            Matsumoto,S., Muramoto,Y., Ota,S., Yoshida,H., Okada,H., Kuwada,T.,
            Marui,S., Matsumori,T., Maruno,T., Uza,N., Kodama,Y., Hatano,E. and
            Seno,H.
  TITLE     ELF3 suppresses gallbladder cancer development through
            downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway
  JOURNAL   J Pathol 261 (1), 28-42 (2023)
   PUBMED   37345534
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Yang,L., Wang,H., Guo,M., He,M., Zhang,W., Zhan,M. and Liu,Y.
  TITLE     ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling
            pathway in gallbladder cancer
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1085-1095 (2023)
   PUBMED   36988891
  REMARK    GeneRIF: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1
            signaling pathway in gallbladder cancer.
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Lu,Y., Ding,J., Huang,J. and Zhao,Y.
  TITLE     ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via
            upregulation of HMGB1 expression
  JOURNAL   J Biosci 48 (2023)
   PUBMED   37946371
  REMARK    GeneRIF: ESE-1 mediates lipopolysaccharide-induced BV2 cell
            inflammation via upregulation of HMGB1 expression.
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Kim,J.H., Wilder,P.J., Hou,J., Nowling,T. and Rizzino,A.
  TITLE     Activation of the murine type II transforming growth factor-beta
            receptor gene: up-regulation and function of the transcription
            factor Elf-3/Ert/Esx/Ese-1
  JOURNAL   J Biol Chem 277 (20), 17520-17530 (2002)
   PUBMED   11893733
  REMARK    GeneRIF: Evidence that mElf-3, a member of the Ets family, plays a
            key role in the activation of the mTbetaR-II promoter.
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Ng,A.Y., Waring,P., Ristevski,S., Wang,C., Wilson,T., Pritchard,M.,
            Hertzog,P. and Kola,I.
  TITLE     Inactivation of the transcription factor Elf3 in mice results in
            dysmorphogenesis and altered differentiation of intestinal
            epithelium
  JOURNAL   Gastroenterology 122 (5), 1455-1466 (2002)
   PUBMED   11984530
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Yoshida,N., Yoshida,S., Araie,M., Handa,H. and Nabeshima,Y.
  TITLE     Ets family transcription factor ESE-1 is expressed in corneal
            epithelial cells and is involved in their differentiation
  JOURNAL   Mech Dev 97 (1-2), 27-34 (2000)
   PUBMED   11025204
REFERENCE   9  (bases 1 to 1940)
  AUTHORS   Neve,R., Chang,C.H., Scott,G.K., Wong,A., Friis,R.R., Hynes,N.E.
            and Benz,C.C.
  TITLE     The epithelium-specific ets transcription factor ESX is associated
            with mammary gland development and involution
  JOURNAL   FASEB J 12 (14), 1541-1550 (1998)
   PUBMED   9806763
REFERENCE   10 (bases 1 to 1940)
  AUTHORS   Tymms,M.J., Ng,A.Y., Thomas,R.S., Schutte,B.C., Zhou,J., Eyre,H.J.,
            Sutherland,G.R., Seth,A., Rosenberg,M., Papas,T., Debouck,C. and
            Kola,I.
  TITLE     A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA
            sequences, murine genomic organization, human mapping to 1q32.2 and
            expression in tissues and cancer
  JOURNAL   Oncogene 15 (20), 2449-2462 (1997)
   PUBMED   9395241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130277.6 and BC138692.1.
            
            On Jul 10, 2009 this sequence version replaced NM_007921.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. The
            resulting isoform (2) is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138692.1, AF016294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC130277.6         55317-55352
            37-1895             BC138692.1         1-1859
            1896-1940           AC130277.6         60171-60215
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.42 cM"
     gene            1..1940
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /note="E74-like factor 3"
                     /db_xref="GeneID:13710"
                     /db_xref="MGI:MGI:1101781"
     exon            1..124
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            125..292
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1248
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ETS-related transcription factor Elf-3;
                     epithelium-specific Ets transcription factor 1;
                     epithelium-restricted Ets protein ESX;
                     epithelial-restricted with serine box"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-3 isoform
                     2"
                     /protein_id="NP_031947.1"
                     /db_xref="CCDS:CCDS78689.1"
                     /db_xref="GeneID:13710"
                     /db_xref="MGI:MGI:1101781"
                     /translation="MAATCEISNVFSNYFNAMYSSEDPTLAPAPPTTFGTEDLVLTLN
                     NQQMTLEGPEKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLC
                     SCALEELRLVFGPLGDQLHAQLRDLTSNSSDELSWIIELLEKDGMSFQESLGDSGPFD
                     QGSPFAQELLDDGRQASPYYCSTYGPGAPSPGSSDVSTARTATPQSSHASDSGGSDVD
                     LDLTESKVFPRDGFPDYKKGEPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLW
                     EFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMR
                     YYYKREILERVDGRRLVYKFGKNSSGWKEEEVGESRN"
     exon            293..514
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            515..610
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            611..730
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            731..820
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            821..937
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1133
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1940
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /note="hexamer: AATAAA"
     polyA_site      1935
                     /gene="Elf3"
                     /gene_synonym="ESE-1; ESX; jen"
                     /note="major polyA site"
ORIGIN      
        1 ggcagcgccc tggccacact catcactgct acctgcggag ccttcgaccg cttagatttc
       61 ttcccttcct gtggcctcag aagcctgctc acccgcctgc cacaccgaac cctgacacac
      121 ctcggggccc tcatggctgc cacctgtgag atcagcaacg tttttagtaa ctacttcaac
      181 gccatgtaca gctcagaaga ccccaccctg gctcctgctc ctccgactac ctttggcact
      241 gaagacttgg tgttgaccct gaacaaccaa cagatgacac tggaaggtcc agagaaggca
      301 agctggacta gcgagcggcc ccagttctgg tcgaagaccc aggttctgga gtggatcagc
      361 taccaagtgg agaagaacaa gtatgacgcc agctccatcg acttctcccg ctgcgacatg
      421 gacggagcca ccctctgcag ctgtgcgctg gaggagctgc ggctagtctt tggacctctg
      481 ggagaccagc tccatgccca gcttcgggac ctcacctcca actcttctga tgaactcagc
      541 tggatcatcg agctgctgga gaaggatggc atgtccttcc aagagagcct aggcgactcg
      601 ggcccctttg atcagggaag tccttttgcc caggaactcc tggatgatgg ccgccaggcc
      661 agtccctact actgcagtac ctatggccct ggagcgccct cccccggcag ctctgatgtc
      721 tccactgcaa ggaccgctac tccccagagt tcccatgctt ctgactccgg tggaagtgat
      781 gtggacctgg acctcaccga gagcaaggtc ttccctagag atggctttcc tgactataag
      841 aagggggaac ccaagcacgg gaagaggaaa cgggggcgtc ccagaaagct gagcaaggaa
      901 tactgggact gtctggaggg caagaagagc aagcacgccc ccagaggtac tcacctgtgg
      961 gagtttatcc gagacatcct aatccacccc gagctcaacg aaggcctcat gaagtgggag
     1021 aaccggcacg agggtgtgtt caagtttctt cgctcagagg ccgtggccca actctggggc
     1081 cagaagaaga agaacagcaa catgacctat gagaagctga gccgagccat gaggtattac
     1141 tacaaacggg agatcctgga acgggtggat ggccgacggc tcgtctacaa gtttggcaag
     1201 aactctagtg gctggaagga agaagaggtt ggagagagtc ggaattaagg atcggggctg
     1261 gacccaggac ctgactcagg catgaactcc agaactgaag ccttcctgga aggacaggca
     1321 ggcctgatgg cccccttaac atggatgtgt tccctgtgtt gctgtagaga ggaagaacct
     1381 gttgggcgtg ccctctgcag tctcctcaag tgcagccttt ggcctctctc ctcgccctct
     1441 tggaattaca agccccaggg tttgaaccaa cttgttcgat aactctccag ctgtgactcc
     1501 agttccctcc cgtcccaaca tggactgcaa atgagaccca cctgcagatg cctggcctca
     1561 gccaaggagg ctggggagac tgtggcagga gactgcaggg acggagggga cagggttgtg
     1621 tcctcggtac ttcctggact gccttccacc tctctgctca gtactcaggc tccacagacg
     1681 ggggtcggat catccctaat ttatgtgcta taaatattcc aggtgtatat agagagctat
     1741 tttttctaaa gcatttcccc tccctgctct tctccactga gtgctggtgg ccagactgat
     1801 ttttttttag gccccctaac tggaccagcg agaagtaggg tgattccagg accccctctt
     1861 cccccagagg ggtctcctgg atcccctttc ctgtgaatgg aggctccaat aaagtgcctt
     1921 ctgggctttt tctaaccttg
//
