LOCUS       NP_075991                593 aa            linear   ROD 31-MAY-2024
DEFINITION  ETS-related transcription factor Elf-2 isoform 1 [Mus musculus].
ACCESSION   NP_075991 XP_006502089
VERSION     NP_075991.1
DBSOURCE    REFSEQ: accession NM_023502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 593)
  AUTHORS   Neupane,S., Berardinelli,S.J., Cameron,D.C., Grady,R.C.,
            Komatsu,D.E., Percival,C.J., Takeuchi,M., Ito,A., Liu,T.W.,
            Nairn,A.V., Moremen,K.W., Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats is essential for
            ECM remodeling and signaling during bone development
  JOURNAL   Matrix Biol 107, 77-96 (2022)
   PUBMED   35167946
REFERENCE   2  (residues 1 to 593)
  AUTHORS   Fausther,M., Lavoie,E.G., Goree,J.R. and Dranoff,J.A.
  TITLE     An Elf2-like transcription factor acts as repressor of the mouse
            ecto-5'-nucleotidase gene expression in hepatic myofibroblasts
  JOURNAL   Purinergic Signal 13 (4), 417-428 (2017)
   PUBMED   28667437
REFERENCE   3  (residues 1 to 593)
  AUTHORS   Woods,L., Perez-Garcia,V., Kieckbusch,J., Wang,X., DeMayo,F.,
            Colucci,F. and Hemberger,M.
  TITLE     Decidualisation and placentation defects are a major cause of
            age-related reproductive decline
  JOURNAL   Nat Commun 8 (1), 352 (2017)
   PUBMED   28874785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 593)
  AUTHORS   Guan,F.H., Bailey,C.G., Metierre,C., O'Young,P., Gao,D., Khoo,T.L.,
            Holst,J. and Rasko,J.E.
  TITLE     The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in
            vitro and perturbs early lymphocytic development in vivo
  JOURNAL   J Hematol Oncol 10 (1), 75 (2017)
   PUBMED   28351373
  REMARK    GeneRIF: ELF2 isoforms are important regulators of cellular
            proliferation, cell cycle progression, and apoptosis. In respect to
            this, ELF2B acts in a dominant negative fashion compared to ELF2A
            and as a putative tumour suppressor gene. The regulatory interplay
            between ELF2 isoforms contributes substantially to early B and T
            cell development.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 593)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (residues 1 to 593)
  AUTHORS   Kobberup,S., Nyeng,P., Juhl,K., Hutton,J. and Jensen,J.
  TITLE     ETS-family genes in pancreatic development
  JOURNAL   Dev Dyn 236 (11), 3100-3110 (2007)
   PUBMED   17907201
REFERENCE   7  (residues 1 to 593)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   8  (residues 1 to 593)
  AUTHORS   Hsu,T., Trojanowska,M. and Watson,D.K.
  TITLE     Ets proteins in biological control and cancer
  JOURNAL   J Cell Biochem 91 (5), 896-903 (2004)
   PUBMED   15034925
  REMARK    Review article
REFERENCE   9  (residues 1 to 593)
  AUTHORS   Iljin,K., Dube,A., Kontusaari,S., Korhonen,J., Lahtinen,I.,
            Oettgen,P. and Alitalo,K.
  TITLE     Role of ets factors in the activity and endothelial cell
            specificity of the mouse Tie gene promoter
  JOURNAL   FASEB J 13 (2), 377-386 (1999)
   PUBMED   9973326
REFERENCE   10 (residues 1 to 593)
  AUTHORS   Wilkinson,D.A., Neale,G.A., Mao,S., Naeve,C.W. and Goorha,R.M.
  TITLE     Elf-2, a rhombotin-2 binding ets transcription factor: discovery
            and potential role in T cell leukemia
  JOURNAL   Leukemia 11 (1), 86-96 (1997)
   PUBMED   9001422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161183.10, AF256217.1 and AC118601.17.
            
            On Mar 22, 2014 this sequence version replaced XP_006502089.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3303072.1,
                                           SRR7652917.462785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 22.19 cM"
     Protein         1..593
                     /product="ETS-related transcription factor Elf-2 isoform
                     1"
                     /note="ets family transcription factor ELF2A2; ETS-related
                     transcription factor Elf-2; ets domain transcription
                     factor"
                     /calculated_mol_wt=63072
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Region          3..108
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Region          146..199
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            191
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Region          209..289
                     /region_name="Ets"
                     /note="Ets-domain; pfam00178"
                     /db_xref="CDD:459700"
     Region          362..383
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15723; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            372
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            432
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15723; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            496
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     Site            523
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15723; propagated from
                     UniProtKB/Swiss-Prot (Q9JHC9.1)"
     CDS             1..593
                     /gene="Elf2"
                     /gene_synonym="2610036A20Rik; A230104O07Rik; EU32; NERF;
                     NERF-1A; NERF-1B; NERF-2"
                     /coded_by="NM_023502.2:478..2259"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17337.1"
                     /db_xref="GeneID:69257"
                     /db_xref="MGI:MGI:1916507"
ORIGIN      
        1 masavvdsgg salelpsdgg enqeggdtgp dcpavivepv psarleqgya aqvlvyddet
       61 ymmqdvaeeq evetensetv easvhssnah ctdktieaae allhmesptc lrdsrspvev
      121 fvppcistpe fihaamrpdv itetvvevst eesepmdasp iptspdshep mkkkkvgrkp
      181 ktqqspvsng spelgikkka regkgnttyl weflldllqd kntcpryikw tqrekgifkl
      241 vdskavsklw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk dmpknivvid
      301 ddksetcped laaaaddksl ervslsaesl lkaatavrgg knssplncsr aekgvarvvn
      361 itspthdgss rsptttapvs aaaaprtvrv amqvpvvmts lgqkisavav qsvnagtgsp
      421 litstspasa sspkvviqtv ptvmpasten gdritmqpak iitipatqla qcqlqaksnl
      481 tgsgsinivg tplavraltp vsiahgtpvm rlsvpaqqas gqtpprvisa llkgpegkse
      541 akkqehdvkt lqlveekgad gnktvthvvv vsapsaialp vtmkteglvt cek
//
