LOCUS       NM_001347149            4314 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript
            variant 5, mRNA.
ACCESSION   NM_001347149 XM_017319988
VERSION     NM_001347149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4314)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 4314)
  AUTHORS   Susanto,T.T., Hung,V., Levine,A.G., Chen,Y., Kerr,C.H., Yoo,Y.,
            Oses-Prieto,J.A., Fromm,L., Zhang,Z., Lantz,T.C., Fujii,K.,
            Wernig,M., Burlingame,A.L., Ruggero,D. and Barna,M.
  TITLE     RAPIDASH: Tag-free enrichment of ribosome-associated proteins
            reveals composition dynamics in embryonic tissue, cancer cells, and
            macrophages
  JOURNAL   Mol Cell 84 (18), 3545-3563 (2024)
   PUBMED   39260367
REFERENCE   3  (bases 1 to 4314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4314)
  AUTHORS   Takada,Y., Fierro,L., Sato,K., Sanada,T., Ishii,A., Yamamoto,T. and
            Kotani,T.
  TITLE     Mature mRNA processing that deletes 3' end sequences directs
            translational activation and embryonic development
  JOURNAL   Sci Adv 9 (47), eadg6532 (2023)
   PUBMED   38000026
REFERENCE   5  (bases 1 to 4314)
  AUTHORS   Fidalgo,M.F., Fonseca,C.G., Caldas,P., Raposo,A.A., Balboni,T.,
            Henao-Misikova,L., Grosso,A.R., Vasconcelos,F.F. and Franco,C.A.
  TITLE     Aerocyte specification and lung adaptation to breathing is
            dependent on alternative splicing changes
  JOURNAL   Life Sci Alliance 5 (12), e202201554 (2022)
   PUBMED   36220570
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4314)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   7  (bases 1 to 4314)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   8  (bases 1 to 4314)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (bases 1 to 4314)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (bases 1 to 4314)
  AUTHORS   Saxton,A.M., Eisen,E.J., Johnson,B.H. and Burkhart,J.G.
  TITLE     New mutation causing jaundice in mice
  JOURNAL   J Hered 76 (6), 441-446 (1985)
   PUBMED   4086788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY284852.1, AL837505.21, AL954140.7 and CO038990.1.
            
            On Oct 24, 2017 this sequence version replaced NM_001347149.1.
            
            Transcript Variant: This variant (5) encodes isoform 5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.31080.1,
                                           SRR6116558.112857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               BY284852.1         2-424
            424-561             AL837505.21        107671-107808       c
            562-652             AL837505.21        43308-43398         c
            653-896             AL837505.21        40346-40589         c
            897-1000            AL837505.21        12949-13052         c
            1001-1154           AL954140.7         91814-91967         c
            1155-1380           AL954140.7         88583-88808         c
            1381-1419           AL954140.7         81963-82001         c
            1420-4221           AL954140.7         78588-81389         c
            4222-4294           CO038990.1         21-93               c
            4295-4295           AL954140.7         78514-78514         c
            4296-4314           CO038990.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.36 cM"
     gene            1..4314
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /note="ELAV like RNA binding protein 1"
                     /db_xref="GeneID:15569"
                     /db_xref="MGI:MGI:1100887"
     exon            1..561
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..652
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..1747
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     ELAV-like protein 2; ELAV-like neuronal protein 1; nervous
                     system-specific RNA-binding protein Mel-N1; HU-antigen B;
                     ELAV (embryonic lethal, abnormal vision, Drosophila)-like
                     2 (Hu antigen B)"
                     /codon_start=1
                     /product="ELAV-like protein 2 isoform 5"
                     /protein_id="NP_001334078.1"
                     /db_xref="CCDS:CCDS84753.1"
                     /db_xref="GeneID:15569"
                     /db_xref="MGI:MGI:1100887"
                     /translation="MAVRLCDVASLLRSGSWAAEPWTGQVIAAMETQLSNGPTCNNTA
                     NGPTTVNNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRD
                     KITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSG
                     LPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQ
                     KPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAY
                     GVKRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNV
                     KVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA"
     exon            653..896
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1000
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1154
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1380
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1419
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..4301
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4204..4209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /note="hexamer: AACAAA"
     polyA_site      4221
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /note="major polyA site"
     regulatory      4282..4287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
                     /note="hexamer: AATAAA"
     polyA_site      4301
                     /gene="Elavl2"
                     /gene_synonym="Hub; mel-N1"
ORIGIN      
        1 atacttccgc gcgtgctgcc cgggatagga ctctggcaga gcagctgcac acacggcagt
       61 gcggaggcag agaaggggtt ggtgatacgg tgctataaat ctgtggtcca gtccacctcc
      121 cttttaagac gtcctccccc cttatttctg ttctcactta gagatgcagc agcttactcc
      181 tgtagcgacc tactaaaaag caacacggag aaagacatcg tctttttgaa aaaacgttct
      241 ttcgtctctt ttctttgttc cttggtttgt ttttcttgca cctttttgtt tagttgaacg
      301 gcaataggag tagtctctcc gtctttttaa actctctttt ttaagtttcc cctccccttt
      361 catatttttt ttcatcattt cttttagcat tggactttgg ggtcgaaagc atttcttttt
      421 atttgcttct tttaagccga gcacagttta ggtttcgtgc tgtcttaaga gaactatcca
      481 gcagcttctt gctcatcctt attgggagaa gtgcaccgtt actttaaaaa tacacataca
      541 caaaaacctt aagggagaaa gacggcaact ccaaactaac atggcagtca gactgtgtga
      601 tgtggcttct ctgcttagaa gcggttcgtg ggcagcagag ccttggaccg ggcaggtaat
      661 tgctgccatg gaaacacaac tgtctaatgg gccaacttgc aataacacag ccaatggtcc
      721 aaccactgta aacaacaact gctcctcacc agttgactcc gggaacacag aggacagcaa
      781 gaccaaccta atagtcaact accttcctca gaacatgaca caggaagaac taaagagtct
      841 ttttgggagc attggcgaga tagagtcctg taagcttgta agagacaaaa taacagggca
      901 gagcttgggt tacggatttg tgaactacat tgaccccaag gatgcagaga aagctatcaa
      961 cactctgaat ggattgagac ttcaaaccaa aacaataaaa gtttcctatg ctcgcccaag
     1021 ctcagcctca atcagagatg caaacttata cgtcagcggg cttccaaaaa ccatgaccca
     1081 gaaggagctg gaacagctgt tttcacagta tgggcgcatc attacttctc ggattcttgt
     1141 cgaccaggtc actggcatat caaggggtgt agggtttatt cgatttgaca agcggattga
     1201 ggcagaagaa gctatcaaag gcctaaatgg ccagaaacct cctggtgcca cagagccaat
     1261 cactgtaaag tttgctaata atccaagcca aaaaaccaat caggccatcc tttcccagct
     1321 gtaccagtct ccaaacagaa ggtacccagg accgctagct cagcaggcac agcgttttag
     1381 gttggacaat ctgctcaata tggcttatgg agtgaagagg ttttctccaa tgacgatcga
     1441 tggaatgacc agtctggctg gaattaatat tcctgggcac cctggaacag gctggtgcat
     1501 atttgtgtac aacctggcgc ctgatgcaga tgaaagtatc ctgtggcaaa tgtttgggcc
     1561 ttttggagct gtcaccaacg tgaaggtcat ccgtgacttt aacaccaata agtgcaaagg
     1621 ttttggattt gtgactatga caaactatga tgaggcggcc atggcgatag ctagcctcaa
     1681 tggataccgc ctgggagaca gagtcctgca ggtctccttt aagacaaaca aaacgcacaa
     1741 agcctaatga gctcttgtcc tcagtccatt tatatatgaa aactatacaa caaaagcaag
     1801 ttaagagaaa ctttatacat tagtaaatgt ctttgtaagt cagtgttgag atggggataa
     1861 atgactactt agcatcctaa gaaatatgtg agatttttta ttgctagtat ttgaattaaa
     1921 acttcttaaa tatcttttat gtttgaatat ggacaagagg tacagggttt ttacctgtca
     1981 cattgcattc tattgccttc tttgaagaag gtggaccttt taaagtgttt cagctaaggg
     2041 aagacatttc ttttcttttt acataactgc cttgatcctg tgagtaagta ctgaggcttt
     2101 gtgttgtagc tcttcagttg gttgtctttc cccacctcct tatctttcct tttctttctc
     2161 tttcttttgt ctttgttttt tcctttccat tctttaatta gctttgtgtt tggtttacat
     2221 ttcaagcatt gctgttatgt ctcagaaaag cattttgaag tttacatttt tatttatgaa
     2281 gttacaaaca gtatttattt tgtaattctg atttgggctg gggcaggggg ggcgacatta
     2341 taaacgctta ttgtaagaat actggagaac ttttcgtaaa gcagtacctt gccaaagaga
     2401 taagagcctc tttgatgtgg gtttaaaaaa agcatctatt tttataaaaa agaaaatttg
     2461 gagaaacttt ttactggtcc tggaacaaat attttgactt gaatactttg agaaatctct
     2521 tcatatgaca cctagtgagc ttttaaaatt taccaggaaa tttgcaacgg ttggaaaatt
     2581 tagaaagatt tatgatgtag aaaaatactt ttgagatctt tgtatgagag gaattgagtc
     2641 agtgagggaa cactgctggt ttcattttcg taatcaccag tggggcgtct gatcatcctg
     2701 gttgttatgt gatagatggc tcacattgat ttgtgatttt gaaacaaata aaaaaaattt
     2761 acaaaagaat atataagagc aggcaagaaa tttaaattac caagagatgg gggaaaatct
     2821 gttcttccta aagaaatccc ttcagataga gctcatggtg tttagtgatg tacttgcagt
     2881 atcgtttgaa gaattgtttt gtcttaagga agatgagatg ttgcacacgt ttggatggca
     2941 gcaagtcagc aaaggcgacc tgagttggat atatttggag gtattttgag agttacgttt
     3001 aaggctaaca cctgagcttt gtgtgatgta aataagacct tgtgtttatg aacctttcag
     3061 ctaattttat ttttttccct tacatatcaa gtgatgttca ggttttgaat gttttgtatc
     3121 agttcttttc tttgtaaatg gcattaacat tgttacttga ggtcttgctt attcagttct
     3181 gttgtcctga ggacttgaat ttacagtgca tcagattcgt tggctaattc tgtctgtaga
     3241 tagtctagct tcagctgttt atggtgatgc tacattttcg tttataaata tgtttgtggt
     3301 aaaaaaaaaa gaaaaaaatg agtataacca taggttttga acaaatttcc ttacattttt
     3361 catacaaaaa tcataaatat ctgtatgcta ttgaaattta actttgtatg atgcttaaac
     3421 cactatttgg ggaaataata aaataagtct ttaccatgta tgaaagaaat tttaaaaaat
     3481 acaaaatatt ttctgattag catctagctt ataataaatt ttcaaaaaag ctgaaggcaa
     3541 ctgtggcctt catcaggatg cactgagaac tatatagtta cgtcctgcgt tttgtataaa
     3601 ctgagatgct catgtgcttc cccttagaac aggcaatgtg ctatgcataa catagttgta
     3661 cattatcttt gcagttgctt tgagttttat tttttattat ttaaaactgt agttataaaa
     3721 attttcagta tagtacagta catatactgt gaggcgcgtg ctaaagtgaa caagcgagtt
     3781 ttcatgctga cccactcaat gctattcaga actcaattgg cttagcactt tctcatatcc
     3841 ttaggtgcat ttagattgtc agagttaacc tgcgttaaaa aaaaataaaa taaaatacat
     3901 gtatatattt aaaaaaaaaa ataaggtttc ccttgtgggc aaacagcagc tacacgcttc
     3961 tttcctgtgc tactgtagca aaccacagca ttgatgagaa ggcatgcgga ctgtgcttca
     4021 cttcacagtg tttacccgag cacttaataa aatgtaaggc tggtatttat ttgaagttgt
     4081 acagtatgac ttaattcaca tctgttggaa tagaaaatat attctgttga gtatttaaga
     4141 ggctgtacat gttttctttt gtgtttggat tctttgtgct ttttcatgtt cggtacatca
     4201 ataaacaaag ttgaagggaa agaactgtgt atctttaaat acatctggat tgtggggtac
     4261 ctatgcgcag tctagttcaa aaataaataa ataaataaaa aaaaaaaaaa aaaa
//
