LOCUS       NM_010485               6030 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus ELAV like RNA binding protein 1 (Elavl1), mRNA.
ACCESSION   NM_010485
VERSION     NM_010485.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6030)
  AUTHORS   Kwon,M.S., Chung,H.K., Xiao,L., Yu,T.X., Sharma,S., Cairns,C.M.,
            Chen,T., Chae,S., Turner,D.J. and Wang,J.Y.
  TITLE     Interaction between microRNA-195 and HuR regulates Paneth cell
            function in the intestinal epithelium by altering SOX9 translation
  JOURNAL   Am J Physiol Cell Physiol 327 (3), C817-C829 (2024)
   PUBMED   39099425
REFERENCE   2  (bases 1 to 6030)
  AUTHORS   LYu,P., Pan,H., Hu,K., Xue,Y., Li,Q., Lin,R., Zheng,S., Guo,Z. and
            Guo,K.
  TITLE     The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis
            and accelerates atherosclerosis
  JOURNAL   Atherosclerosis 393, 117554 (2024)
   PUBMED   38663275
  REMARK    GeneRIF: The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol
            homeostasis and accelerates atherosclerosis.
REFERENCE   3  (bases 1 to 6030)
  AUTHORS   Zhong,X., Wang,K., Wang,Y., Wang,L., Wang,S., Huang,W., Jia,Z.,
            Dai,S.S. and Huang,Z.
  TITLE     Angiotension II directly bind P2X7 receptor to induce myocardial
            ferroptosis and remodeling by activating human antigen R
  JOURNAL   Redox Biol 72, 103154 (2024)
   PUBMED   38626575
  REMARK    GeneRIF: Angiotension II directly bind P2X7 receptor to induce
            myocardial ferroptosis and remodeling by activating human antigen
            R.
REFERENCE   4  (bases 1 to 6030)
  AUTHORS   Liu,C., Lin,Y., Wang,Y., Lin,S., Zhou,J., Tang,H., Yi,X., Ma,Z.,
            Xia,T., Jiang,B., Tian,F., Ju,Z., Liu,B., Gu,X., Yang,Z. and
            Wang,W.
  TITLE     HuR promotes triglyceride synthesis and intestinal fat absorption
  JOURNAL   Cell Rep 43 (5), 114238 (2024)
   PUBMED   38748875
  REMARK    GeneRIF: HuR promotes triglyceride synthesis and intestinal fat
            absorption.
REFERENCE   5  (bases 1 to 6030)
  AUTHORS   Lachiondo-Ortega,S., Rejano-Gordillo,C.M., Simon,J.,
            Lopitz-Otsoa,F., C Delgado,T., Mazan-Mamczarz,K.,
            Goikoetxea-Usandizaga,N., Zapata-Pavas,L.E., Garcia-Del Rio,A.,
            Guerra,P., Pena-Sanfelix,P., Herman-Sanchez,N., Al-Abdulla,R.,
            Fernandez-Rodriguez,C., Azkargorta,M., Velazquez-Cruz,A., Guyon,J.,
            Martin,C., Zalamea,J.D., Egia-Mendikute,L., Sanz-Parra,A.,
            Serrano-Macia,M., Gonzalez-Recio,I., Gonzalez-Lopez,M.,
            Martinez-Cruz,L.A., Pontisso,P., Aransay,A.M., Barrio,R.,
            Sutherland,J.D., Abrescia,N.G.A., Elortza,F., Lujambio,A.,
            Banales,J.M., Luque,R.M., Gahete,M.D., Palazon,A., Avila,M.A., G
            Marin,J.J., De,S., Daubon,T., Diaz-Quintana,A., Diaz-Moreno,I.,
            Gorospe,M., Rodriguez,M.S. and Martinez-Chantar,M.L.
  TITLE     SUMOylation controls Hu antigen R posttranscriptional activity in
            liver cancer
  JOURNAL   Cell Rep 43 (3), 113924 (2024)
   PUBMED   38507413
  REMARK    GeneRIF: SUMOylation controls Hu antigen R posttranscriptional
            activity in liver cancer.
REFERENCE   6  (bases 1 to 6030)
  AUTHORS   King,P.H., Fuller,J.J., Nabors,L.B. and Detloff,P.J.
  TITLE     Analysis of the 5' end of the mouse Elavl1 (mHuA) gene reveals a
            transcriptional regulatory element and evidence for conserved
            genomic organization
  JOURNAL   Gene 242 (1-2), 125-131 (2000)
   PUBMED   10721704
REFERENCE   7  (bases 1 to 6030)
  AUTHORS   Atasoy,U., Watson,J., Patel,D. and Keene,J.D.
  TITLE     ELAV protein HuA (HuR) can redistribute between nucleus and
            cytoplasm and is upregulated during serum stimulation and T cell
            activation
  JOURNAL   J Cell Sci 111 (Pt 21), 3145-3156 (1998)
   PUBMED   9763509
REFERENCE   8  (bases 1 to 6030)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (bases 1 to 6030)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   10 (bases 1 to 6030)
  AUTHORS   Good,P.J.
  TITLE     A conserved family of elav-like genes in vertebrates
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4557-4561 (1995)
   PUBMED   7753842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY775007.1, AK080365.1, AK028769.1, AC155164.5 and BB305633.2.
            
            On Mar 23, 2007 this sequence version replaced NM_010485.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034536.1, AK080365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY775007.1         1-43
            44-2468             AK080365.1         2-2426
            2469-4493           AK028769.1         1153-3177
            4494-5569           AC155164.5         181655-182730
            5570-6030           BB305633.2         192-652
FEATURES             Location/Qualifiers
     source          1..6030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 2.0 cM"
     gene            1..6030
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /note="ELAV like RNA binding protein 1"
                     /db_xref="GeneID:15568"
                     /db_xref="MGI:MGI:1100851"
     exon            1..215
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /inference="alignment:Splign:2.1.0"
     exon            216..403
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1212
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /note="melG; hu-antigen R; ELAV (embryonic lethal,
                     abnormal vision, Drosophila)-like 1 (Hu antigen R);
                     elav-like generic protein; HU-antigen A; ELAV (embryonic
                     lethal, abnormal vision)-like 1 (Hu antigen R)"
                     /codon_start=1
                     /product="ELAV-like protein 1"
                     /protein_id="NP_034615.2"
                     /db_xref="CCDS:CCDS22084.1"
                     /db_xref="GeneID:15568"
                     /db_xref="MGI:MGI:1100851"
                     /translation="MSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQEELRSLFSSIG
                     EVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAISTLNGLRLQSKTIKVSYARPSSEV
                     IKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEA
                     EEAITSFNGHKPPGSSEPITVKFAANPNQNKNMALLSQLYHSPARRFGGPVHHQAQRF
                     RFSPMGVDHMSGISGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVI
                     RDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK"
     exon            404..507
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /inference="alignment:Splign:2.1.0"
     exon            508..661
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /inference="alignment:Splign:2.1.0"
     exon            662..887
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /inference="alignment:Splign:2.1.0"
     exon            888..6030
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /note="hexamer: ATTAAA"
     polyA_site      2469
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /note="major polyA site"
     regulatory      5393..5398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /note="hexamer: AATAAA"
     polyA_site      5430
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
     regulatory      5810..5815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
                     /note="hexamer: ATTAAA"
     polyA_site      5827
                     /gene="Elavl1"
                     /gene_synonym="2410055N02Rik; Hua; HUR"
ORIGIN      
        1 tgggccgcgg ggccggggag cgggtcgtgc gcgctgagga ggagccgcag ccgtcgccgt
       61 cgccgtcgcc gtcgccgtcg ccgtcgccgc taccgctacc gctaccgctc tgccgccgcc
      121 gccgccgccg ccaccgctgc cgaggccgtg cggagccgtt atcgccgcgc cgcccgcccc
      181 ggagcagagt cccgggcctt cccgcccgtg ttcagatttt taaataatac aatgtctaat
      241 ggttatgaag accacatggc ggaagactgc agggatgaca ttgggagaac gaatttaatt
      301 gtcaactacc tccctcagaa catgacccaa gaggaactac gaagtctgtt cagcagcatt
      361 ggcgaggttg aatctgcaaa gcttattcgg gataaagtag caggacacag cttgggctac
      421 ggttttgtga actatgtgac tgcaaaagat gcagagagag caatcagcac actgaacggc
      481 ttgagactcc agtccaaaac cattaaggtg tcatatgctc gcccaagctc agaggtcatc
      541 aaagatgcca acttatacat cagtgggctc ccaaggacca tgacacagaa ggatgtggaa
      601 gacatgtttt ctcggtttgg gcgaatcatc aactccaggg tccttgtgga tcagaccaca
      661 ggtttgtcca gaggggttgc ctttatccgg tttgacaaac ggtcagaagc agaagaggca
      721 attaccagtt tcaatggtca taaaccccca ggttcctccg agcccatcac agtgaagttt
      781 gcagccaatc ccaaccagaa caaaaacatg gctctcctct cgcagctgta ccactcgcct
      841 gctaggcggt ttggaggccc tgtacaccac caggcacaga gattcaggtt ctcccctatg
      901 ggtgtagatc acatgagtgg gatttctggt gtcaatgtcc ccggcaatgc ttcctcgggc
      961 tggtgcatct tcatctacaa ccttgggcaa gacgccgatg aggggatcct ctggcagatg
     1021 tttggcccct ttggtgcagt taccaatgtg aaagtgattc gtgatttcaa caccaacaag
     1081 tgcaaagggt ttggttttgt gaccatgaca aactatgaag aagctgcaat ggccatagca
     1141 agtctgaacg gctaccgcct gggggacaaa attttacagg tttccttcaa aaccaacaag
     1201 tcccacaaat aactcgctca tgcttttttt ttctttcctt cttttttttt tccttttctt
     1261 ttttcttttt ttgtacggaa tagataatta agagtgaaga agttgaaact tttttgttag
     1321 tgtacaactc attttgcgcc aattttcaca agtgtttgtc ttagtctaaa tgagaagtgc
     1381 aaaggttttt atactctggg atgcaaccga catgttcaaa tgcttgaaat cccacaaatg
     1441 ttagaccaat tttaagtttc ttaagttatt tcctttaaag tatatattaa agtgaaaccg
     1501 aagtagactg cgctgactaa ccagtcactc tggacggtgg tgggactgaa gcatgctttt
     1561 acttctaaga ctgtctaaca cctgtttcat ctgatgtctc cacagactgg atttaaaaca
     1621 aaacaaaaaa aatttttttt taatttcttt gttttagttt ttaacctaaa gatgttagac
     1681 agatggggag tgtgtttttt ctcaactgct tcactatttt aaacaatttc tgctttaggt
     1741 gacaggaaat ttgccctccc cagcagtccc actgctgccc cctgcccact cagtcccagc
     1801 tctatagtgt tgggagcagc agcagggccc atattctggg gctcccacaa ggggagatgg
     1861 gaagaggttc cacatgttgg gctgagccag gccctccaga gacacaaaag gtgttttgta
     1921 agcccaggca ccaatgagaa cggaccaaag agtttcaggg cagctccagt atattccaga
     1981 gtcaaacctg agctccaggc atgcctgaag atgccccact cctctgacat cctgagcgtc
     2041 tgtccacaca ttgcatgcat ggtgcccaca catcagatac tgttgttcat gcaacttccc
     2101 gagtttccaa gaccatttaa cctagcttga atgcacaacg attgctctgt ttttaatgac
     2161 acagaaacat ttgagcattg tattttctcg catcccttct tgtgagcact agactttttc
     2221 caatcttagt cagattttgc tttgaaattt tgcttttgta tggacactca gcagaaaagt
     2281 acttcttgcc agttatctat taacaaaatc ctttgatttg tagttttaag gattaaccct
     2341 caaagttctc ttcataactg ccttgacgtt tggggttctg ttctgttaat tttcttttgc
     2401 ttttttgtgt tttttgtttg tttttacttt tgcatttaag accattaaat ttgattttgt
     2461 tttgctcgag ttttgttttg ttttttgttt taccttttct ttcttttttg gctagggaag
     2521 ggcacagaca gcccagcatt cagggaggag tctgtcagac cttaaacact tgcctcaagt
     2581 ttaaaaaaca tttctggagc tatggtataa gaaatacagc tatggatcaa tggttcttaa
     2641 ctcaggagct ggtaggaaag gtcaaaggga agggaagagc acatgaggcc tgacccctac
     2701 agccctcagg actgttctga tgtttattag tatgtggaga gaatgagaac aggctagtgc
     2761 agttactggc agctcttcac tttgatgtaa gcctggagtg tataacagca ggctagtatt
     2821 tagttcttga tatcatggta tgatagcatt atttacacat atctgtttag ttatatatac
     2881 atatatatat acatatagct attttgtttc atttacttaa gtggaaaact gagcaaaaag
     2941 cacagccatc tctaaagtag gtcagtgtat caagaagccc atgtacaaat tgaggctgcc
     3001 tgttccctcc cccgcctcct tttcctgact tccctggagg ctcgttgcag tgttctctac
     3061 cattggtgag gttgtctcat gtactcaggc tttgtcccac cctaagtgag tcaagtgctg
     3121 ctcagtacct cattccatcc cataattccc agcctatagg gcctgaaacc cagaaccaaa
     3181 ggctcatatg cccagatctg accaaaaaag gagaggggtc ctctgctttg agggtgcaga
     3241 gtgcacctcc ccgtgggacc aaaatgttgt gataaaatac gcatttctag tttcttagcc
     3301 agcattcttc tgagtggagg tgggattctc ctcagtcgtg tagcctttgt attccacacc
     3361 tgaaagagac tgtgtcttta aaggacctgg tgctcagagc tagcacctta atcactatac
     3421 catccctacc acccaacacc tgtttactcc atagtaactc tgagaggaac tgggggaaat
     3481 gtcaccagct tctggaggtc acttcaagtt cgacattttc tttctgtgtg gtctccactg
     3541 tctgggtagc actctagata aaagtcccag tgcattcctt gatgagcttt ctttgtcagt
     3601 gtctagaaga aagtagcttt gaaaaggcat tcctgaaagc agttttcatt ctatgaaagg
     3661 actaggtcct ggccctggac gcgttcatga cagctagtca ggctgggcag aaatacagaa
     3721 cccagacgtg tgtgtagctc agagattaaa gcacttgccc agcatgaggg cagccctgag
     3781 ctctgtcccc agcattggag gaaaagtcac aacccaagag aaaggggttt tttttgtttt
     3841 gttttttaag gagaaattca tcctgttttt attgagcaag ttaaggccat ttcttttgtt
     3901 gggaaatctg atggaaaaaa atacagagag taggtaatgt tcattcatca gaaatatggt
     3961 ttgaccaata ccaaagaggc tttgactgag ttctcttgac ctcctctggt agtgggttat
     4021 ttcttgagcc acctccaggt tcttccgcct acttctggtt gggttgcctg tttctttctt
     4081 gagtgattct ctcccccaat tgaaacttct aggtaatgtg ccaagccatc ctggctgtgc
     4141 ctctggtcac agaagtgtga ctatatctcc ctcctcccca tactctgatc agctaccatc
     4201 ttccttgact acctgagaac caaacttccc ttggagggtg ggatgtgatg ccactatatt
     4261 gaatgggttc tgtctccctt gaagttgcct taacctttta gtggcagtaa gtagttaaga
     4321 aactcgtaca caccttcaga ctggacctcc tgctataagg agttaaagct ggagtctccc
     4381 agctgacatt taaggagaac cctgctgggt cagagaaatt aatgagcctc caagacaacg
     4441 gcagttacct atatggggtt gcttccaaat aatagccatt tgtctataaa gttatgtgtt
     4501 gaaaggatgt gacctactcc agtcattaga tttggaaatc gaagttgaaa taactcagct
     4561 cttccagtta gcgtgtttca gcaagatttt atctcttgat ggtttatgtg gccagctttt
     4621 ctatattggg tgagagaata tgagtatgct gaaaggtctt ctgcctcctc tatccccaac
     4681 accttacccc ttcccatctt ttcaggaact gcctcaccta ctgggacccg aggtaactcc
     4741 tggggaggga tccctggggt tcatcatact caaggggtca ggaatcgtgt ttccaaacct
     4801 tcctagagta ccccaatcat catgaatgct tactgttgag tggcattgat gatttgacac
     4861 attcttaggg gagcaacaga acatgcattt ccatcctaaa taaggaccct cccacttcca
     4921 cctttgacct ttaataatga ttgtattaca tttccccata accttttgct gatgtggttc
     4981 aatttatttc tctcagtcat gaaaattatt tatttattta tttattttta tttatttgtt
     5041 tgtttattta tttatttatt acttgtgagt caccagctgc caagtatttg cattagtctg
     5101 gtggagactt tgagaggact gtgcttttct gttcccctcc cccagaaaag aaggctggtt
     5161 ggttggttgg tttgaaccac ctctcttccc acatgctgtt tccctcacca tggcttactt
     5221 tgggggaggg gagggcttct accagctgat tcccttgttg tacactagat ggctagacat
     5281 ttttgtatat tagtgtgttt taagttattg atttgtttta tatgaaataa tttatttttc
     5341 aggtaccatt ttttttttca ttttaacttt gtttttacat gggtttgttt tcaataaagt
     5401 ctgacattgc tgtccaaagt caacaataaa gtgaatccca ttgtgttctt ttgaggatgt
     5461 ttatgtaact agcctttaaa agtaattttc agaaaaagaa aggtggggaa caaaaacctt
     5521 taacctattt tccttttccc attgcctttt tccccactac tttaaatcct tgtgaataaa
     5581 tgttcttcag tgttttagga agaaaaaagc aaacctagat tttgataatc cagaagattt
     5641 cagattaacg aagctttgaa agaaccattt ttcgaaattt cagtgacgtg tgaatatttt
     5701 ttgtcaatgg ctttctcaaa gagaatgaaa cttttgcacc attttcagag tttttataga
     5761 gatgccaaat tgatatattt acatgtaatg gaaacataaa aaaagtttta ttaaacaatt
     5821 gttcatagct gtgtagacat tttaattcag cttccaaagc tcttcaaagt cgtattttgg
     5881 agatgcgggg tgttaactga cgattccaaa ccagtcagtt gtctgaagac tcggttcctt
     5941 ccacaggtgt caggtttgtg ttaaagcatt ctatgttacc actgactgca attctgtgat
     6001 attttggtaa taaatgaagt gggatcattg
//
