LOCUS       NM_001362983            3397 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus elaC ribonuclease Z 2 (Elac2), transcript variant 3,
            mRNA.
ACCESSION   NM_001362983
VERSION     NM_001362983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Richman,T.R., Ermer,J.A., Baker,J., Siira,S.J., Kile,B.T.,
            Linden,M.D., Rackham,O. and Filipovska,A.
  TITLE     Mitochondrial gene expression is required for platelet function and
            blood clotting
  JOURNAL   Cell Rep 42 (11), 113312 (2023)
   PUBMED   37889747
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Stentenbach,M., Ermer,J.A., Rudler,D.L., Perks,K.L., Raven,S.A.,
            Lee,R.G., McCubbin,T., Marcellin,E., Siira,S.J., Rackham,O. and
            Filipovska,A.
  TITLE     Multi-omic profiling reveals an RNA processing rheostat that
            predisposes to prostate cancer
  JOURNAL   EMBO Mol Med 15 (6), e17463 (2023)
   PUBMED   37093546
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Liang,J., Liang,J., Tan,Q. and Wang,Z.
  TITLE     ELAC2 Functions as a Key Gene in the Early Development of Placental
            Formation Based on WGCNA
  JOURNAL   Cells 12 (4), 613 (2023)
   PUBMED   36831280
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3397)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Siira,S.J., Rossetti,G., Richman,T.R., Perks,K., Ermer,J.A.,
            Kuznetsova,I., Hughes,L., Shearwood,A.J., Viola,H.M., Hool,L.C.,
            Rackham,O. and Filipovska,A.
  TITLE     Concerted regulation of mitochondrial and nuclear non-coding RNAs
            by a dual-targeted RNase Z
  JOURNAL   EMBO Rep 19 (10) (2018)
   PUBMED   30126926
  REMARK    GeneRIF: We show that ELAC2 is required for processing of tRNAs and
            for the balanced maintenance of C/D box snoRNAs, miRNAs, and a new
            class of tRNA fragments. We identify that correct biogenesis of
            regulatory non-coding RNAs is essential for both cytoplasmic and
            mitochondrial protein synthesis and the assembly of mitochondrial
            ribosomes and cytoplasmic polysomes.
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Bogenhagen,D.F., Martin,D.W. and Koller,A.
  TITLE     Initial steps in RNA processing and ribosome assembly occur at
            mitochondrial DNA nucleoids
  JOURNAL   Cell Metab 19 (4), 618-629 (2014)
   PUBMED   24703694
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Elbarbary,R.A., Takaku,H. and Nashimoto,M.
  TITLE     Functional analyses for tRNase Z variants: an aspartate and a
            histidine in the active site are essential for the catalytic
            activity
  JOURNAL   Biochim Biophys Acta 1784 (12), 2079-2085 (2008)
   PUBMED   18809514
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Tavtigian,S.V., Simard,J., Teng,D.H., Abtin,V., Baumgard,M.,
            Beck,A., Camp,N.J., Carillo,A.R., Chen,Y., Dayananth,P.,
            Desrochers,M., Dumont,M., Farnham,J.M., Frank,D., Frye,C.,
            Ghaffari,S., Gupte,J.S., Hu,R., Iliev,D., Janecki,T., Kort,E.N.,
            Laity,K.E., Leavitt,A., Leblanc,G., McArthur-Morrison,J.,
            Pederson,A., Penn,B., Peterson,K.T., Reid,J.E., Richards,S.,
            Schroeder,M., Smith,R., Snyder,S.C., Swedlund,B., Swensen,J.,
            Thomas,A., Tranchant,M., Woodland,A.M., Labrie,F., Skolnick,M.H.,
            Neuhausen,S., Rommens,J. and Cannon-Albright,L.A.
  TITLE     A candidate prostate cancer susceptibility gene at chromosome 17p
  JOURNAL   Nat Genet 27 (2), 172-180 (2001)
   PUBMED   11175785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663045.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.13264.1,
                                           SRR1660821.95201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AL663045.7         2715-3011
            298-348             AL663045.7         3398-3448
            349-419             AL663045.7         3587-3657
            420-484             AL663045.7         4288-4352
            485-542             AL663045.7         5297-5354
            543-611             AL663045.7         6436-6504
            612-743             AL663045.7         7274-7405
            744-802             AL663045.7         9243-9301
            803-861             AL663045.7         10951-11009
            862-934             AL663045.7         11088-11160
            935-1047            AL663045.7         11712-11824
            1048-1143           AL663045.7         13033-13128
            1144-1282           AL663045.7         15901-16039
            1283-1368           AL663045.7         16119-16204
            1369-1487           AL663045.7         17916-18034
            1488-1584           AL663045.7         18986-19082
            1585-1723           AL663045.7         21548-21686
            1724-1762           AL663045.7         22021-22059
            1763-1872           AL663045.7         22188-22297
            1873-1972           AL663045.7         22817-22916
            1973-2093           AL663045.7         22998-23118
            2094-2172           AL663045.7         23366-23444
            2173-2317           AL663045.7         23976-24120
            2318-3397           AL663045.7         24675-25754
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 40.42 cM"
     gene            1..3397
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /note="elaC ribonuclease Z 2"
                     /db_xref="GeneID:68626"
                     /db_xref="MGI:MGI:1890496"
     exon            1..297
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..348
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..419
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..484
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..542
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..611
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..743
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..802
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..861
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..934
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1047
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1143
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1282
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1368
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1487
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1584
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1723
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1762
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1872
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1972
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2093
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2172
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2317
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..3397
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2904..2909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /note="hexamer: AATAAA"
     polyA_site      2923
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /note="major polyA site"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
                     /note="hexamer: AATAAA"
     polyA_site      3393
                     /gene="Elac2"
                     /gene_synonym="1110017O07Rik; D11Wsu80e; Hpc2"
ORIGIN      
        1 gccatgcggt ggaggggcgg tgcttgtggc ggcgtgaggg gtctggctgc cttgtcagcc
       61 tggtgtggtc gggtgcatgt gggcgctccg ctcactgttg cgtccccttg gcctgcgcac
      121 catgtcgcag ggttcggctc gtcggccgcg gccatccaaa gacccactgc gacacctgcg
      181 tacgcgggag aagcgcggcc cgggtcccgg gggcccgaac accgtgtacc tgcaggtggt
      241 ggcggcgggc ggccgggacg cgggggctgc tctctatgtc ttctcggaat acaacaggta
      301 cctttttaac tgcggagaag gcgtccaacg acttatgcag gaacacaaac tgaaagtcgc
      361 tcgcttggac aacatctttc tgactcggat gcattggtca aatgttgggg ggttgtgtgg
      421 aatgatttta actttaaagg aaaccgggct tcccaaatgt gttctgtctg gaccaccaca
      481 gctggagaaa tatctagaag caatcaaaat attttctggt ccattgaaag gaatagaact
      541 ggccgtgcgg cctcactctg caccagaata caaggatgag accatgactg tttaccaggt
      601 ccctatccac agtgaacgga ggtgtggaaa gcaacagcca tcccagagcc ccagaacatc
      661 tcccaacagg ctcagtccca aacagtcatc ggactctgga tcagctgaaa atgggcagtg
      721 ccctccagag gacagcagtg caggtgccaa caggaaagca tggggcaggg acccctcctt
      781 agtggtagct tttgtctgca agcttcactt gaggaaagga aacttcttgg tgcttaaagc
      841 aaaggagctg ggccttcctg ttgggacggc cgccattgca cccatcattg ctgctgtcaa
      901 ggacgggaag agtatcactt acgaaggaag agagattgct gctgaagagc tttgtacacc
      961 cccagatcct ggtcttgtat tcattgtggt agagtgtcct gatgaaggat tcatcctgcc
     1021 catctgtgag aacgacacct ttaaaaggta ccaggcagag gctgatgcac ctgtggcgct
     1081 ggtggtccac atagccccag aatctgtact catcgacagc agataccagc agtggatgga
     1141 gaggttcggg cctgacacac agcacctgat tctgaatgag aattgcccct cggtccacaa
     1201 cctgcgcagc cacaagattc agacccagct cagcctcatc caccctgaca tcttccccca
     1261 gcttaccagc ttctatagta aggaggaagg gtccaccctc agcgtgccaa cagttcgggg
     1321 tgaatgcctc ctcaagtatc agctccgccc caagagagag tggcagaggg ataccacact
     1381 cgactgcaat actgatgaat tcatagctga ggccttggag ctccccagtt tccaggagag
     1441 tgtggaggag tatcggaaga acgtgcagga aaacccagcc ccagcagaga aaagaagcca
     1501 gtatcctgaa attgtcttcc tgggtacggg gtctgccatc ccaatgaaga tccgaaatgt
     1561 cagttccaca ctcgtcaacc taagccctga caagtcagtg ctcctggatt gtggagaagg
     1621 cacttttggg cagttgtgcc gtcattacgg acagcaaata gaccgagtct tatgcagcct
     1681 cacggctgtg tttgtgtccc acctgcacgc cgaccaccac acgggcttgc tgaatatctt
     1741 gctgcagaga gagcatgcgt tggcatctct ggggaaaccc ttccagccct tgcttgtggt
     1801 ggctcctacc cagctcaggg cctggctgca gcagtatcac aaccactgcc aggagattct
     1861 gcaccacgtc agtatgattc ctgccaaatg ccttcagaaa ggggcagagg tctccaatac
     1921 tacattggaa aggctgataa gcttgctgtt ggaaacatgt gacttagaag aatttcagac
     1981 ctgcctggta cggcactgca agcatgcttt tggctgtgca ctggtacatt catctggctg
     2041 gaaagtcgtc tactcggggg ataccatgcc ctgtgaggct ctggtccaga tggggaaaga
     2101 tgccaccctc ctgatacatg aagccactct ggaggatggc ttggaagagg aagcagtaga
     2161 gaagacacac agcaccacct cccaggctat taatgtgggg atgcggatga atgcggagtt
     2221 catcatgctg aaccacttca gtcagcggta cgccaagatc ccccttttca gccctgactt
     2281 caacgagaaa gttggcatcg cctttgacca catgaaggtc tgctttggag acttcccgac
     2341 agtgcccaag ctgattcccc cactgaaggc cctgtttgca ggtgacattg aagagatggt
     2401 ggaacgcagg gagaagaggg agctacggct ggtgcgagca gccctcctga cccagcaggc
     2461 agacagccca gaggacagag aaccccaaca gaagcgggcc cacacagatg aaccacacag
     2521 cccacagagc aagaaggtca gagcccagtg aagtctaagc catcctggac tgtaggctgt
     2581 tctctgccct gtgtggaagc cacatctgtc accttggtgg gagccagcgc acacaactag
     2641 ccaggaggca gtatggagtc agcctgcagt actccatggt catggctggg agctcccatc
     2701 tgccaggggc ctccgactcc tggaggcgaa cacagtcgaa gacagcaagc cggtctttaa
     2761 agaagttatg gaaattgagg tgtctgcccc ttactcacta gcacaggggt tttctctgca
     2821 tgccagagtc aagccatgtt acaagtgaca ttgggtgtat atgtcccagg ctccaagcat
     2881 agtatttgca aggactcaga ctcaataaag ctcaagtttg gaatcctgct tcagtgtggg
     2941 gtcttctgtg ggctgggtta cccagtgagg ccgcatctcc cgtgcctgtg agcctgttgt
     3001 gctcttggtc catgatgagt gacaatcact atgaaagtat gaagaaatgt caccttgggc
     3061 tagatgcctg ttggaacctg aaagcaggtt agtgactgaa acttggaagg atgttcaaag
     3121 tcgactctaa catgtgcgtg ttctccccac ccaggagagc gtggcaaaca ctttaggagc
     3181 gcgagtgtga cacggcgagg acttggcctg ccttccctgg cgaggacttg gcctgccttc
     3241 cctggcgagg acttggcctg ccttccctgg cctggcggcg ctctgctcac ttcctcatga
     3301 ggcagcacag gatgttgtga ctgccccgca gccttcaccg aaacaagacc atgtgccaag
     3361 ctcagggtta ataaatctat tttaataaca ttactct
//
