LOCUS       NM_053255               4971 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus elaC ribonuclease Z 1 (Elac1), mRNA.
ACCESSION   NM_053255 NM_028983
VERSION     NM_053255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4971)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4971)
  AUTHORS   Wang,B., Harrison,W., Overbeek,P.A. and Zheng,H.
  TITLE     Transposon mutagenesis with coat color genotyping identifies an
            essential role for Skor2 in sonic hedgehog signaling and cerebellum
            development
  JOURNAL   Development 138 (20), 4487-4497 (2011)
   PUBMED   21937600
REFERENCE   3  (bases 1 to 4971)
  AUTHORS   Tavtigian,S.V., Simard,J., Teng,D.H., Abtin,V., Baumgard,M.,
            Beck,A., Camp,N.J., Carillo,A.R., Chen,Y., Dayananth,P.,
            Desrochers,M., Dumont,M., Farnham,J.M., Frank,D., Frye,C.,
            Ghaffari,S., Gupte,J.S., Hu,R., Iliev,D., Janecki,T., Kort,E.N.,
            Laity,K.E., Leavitt,A., Leblanc,G., McArthur-Morrison,J.,
            Pederson,A., Penn,B., Peterson,K.T., Reid,J.E., Richards,S.,
            Schroeder,M., Smith,R., Snyder,S.C., Swedlund,B., Swensen,J.,
            Thomas,A., Tranchant,M., Woodland,A.M., Labrie,F., Skolnick,M.H.,
            Neuhausen,S., Rommens,J. and Cannon-Albright,L.A.
  TITLE     A candidate prostate cancer susceptibility gene at chromosome 17p
  JOURNAL   Nat Genet 27 (2), 172-180 (2001)
   PUBMED   11175785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY286576.1, AF308697.1, CV556353.1, AK018424.1 and AC132418.3.
            
            On Aug 2, 2006 this sequence version replaced NM_053255.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.913439.1,
                                           SRR9219381.167220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               BY286576.1         2-157
            157-314             AF308697.1         156-313
            315-986             CV556353.1         50-721
            987-2476            AK018424.1         568-2057
            2477-4971           AC132418.3         94799-97293
FEATURES             Location/Qualifiers
     source          1..4971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 49.83 cM"
     gene            1..4971
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /note="elaC ribonuclease Z 1"
                     /db_xref="GeneID:114615"
                     /db_xref="MGI:MGI:1890495"
     exon            1..78
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            79..243
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1175
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /EC_number="3.1.26.11"
                     /note="RNase Z 1; tRNase Z 1; ribonuclease Z 1; tRNA 3
                     endonuclease 1; elaC homolog protein 1; elaC homolog 1"
                     /codon_start=1
                     /product="zinc phosphodiesterase ELAC protein 1"
                     /protein_id="NP_444485.2"
                     /db_xref="CCDS:CCDS37855.1"
                     /db_xref="GeneID:114615"
                     /db_xref="MGI:MGI:1890495"
                     /translation="MSMDVTFLGTGAAYPSPTRGASAVVLRCEGECWLFDCGEGTQTQ
                     LMKSQLKAGRITKIFITHLHGDHFFGLPGLLCTISLQSGSVVARQPIEIYGPVGLRDF
                     IWRTMELSHTELVFPYVVHELVPTADQCPVEELREFAHMDETDSSPKGQGRTILLDAE
                     ENSYCLVDDEQFVVKAFRLFHRIPSFGFSVVEKKRAGKLNAQKLRDLGVPPGPAYGKL
                     KNGISVVLDNGVTISPQDVLKKPMVGRKVCILGDCSGVVGDGGVKLCFEADLLIHEAT
                     LDDSQMDKAREHGHSTPQMAAAFAKLCRAKRLVLTHFSQRYKPTALAREGEADGIAEL
                     RKQAEAVLELQEVTLAEDFMVIGIPIKK"
     exon            244..708
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..4971
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
     regulatory      4947..4952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4971
                     /gene="Elac1"
                     /gene_synonym="2610018O07Rik; 8430417G19Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccgctc gcacactgct gggcctcgga gccggcctgc gcctccctcc gctccggcgg
       61 gcctcgggga gagagagggg tggaagatgt ctatggatgt gacctttctt gggacaggag
      121 cagcatatcc atcaccgacc cgtggcgcct ctgcggtggt tcttcggtgc gagggcgagt
      181 gctggctctt tgactgtggg gagggaacac agacccagct tatgaaaagc cagcttaaag
      241 cagggagaat taccaagatc ttcatcacac atctccatgg cgaccacttc tttggccttc
      301 caggcctcct ctgtaccatc agcctgcaga gtggctctgt ggtcgccagg cagcctattg
      361 agatctacgg ccccgtcggg cttcgggact ttatctggag aaccatggag ctctctcaca
      421 cggagttggt gtttccttac gtggttcacg agctagttcc tacagctgac cagtgtcctg
      481 tagaagaact gagagaattt gcacacatgg atgaaacaga cagctctccc aaaggacaag
      541 gacgaactat cttgctagat gcagaagaaa actcatactg tctggttgat gacgagcagt
      601 ttgtggtaaa agcatttcgc ctctttcata gaattccatc ctttggcttt tcagttgtgg
      661 aaaagaagcg tgcaggtaaa ctcaacgcac agaagctgag agatctcggt gtgccaccag
      721 gtcctgccta tgggaagctg aaaaacggaa tttctgttgt tttggataat ggagttacaa
      781 tttctcccca agacgtctta aaaaagccta tggttggaag aaaagtttgc atcctgggtg
      841 actgttctgg ggttgtgggt gacgggggcg tgaagctgtg ctttgaggcc gacctgctga
      901 tccacgaggc cactctggat gattcccaga tggacaaagc gagagagcac ggccacagca
      961 cgccgcagat ggcagcggcg tttgcaaagc tgtgccgtgc caagaggcta gttctgaccc
     1021 acttcagtca gaggtacaaa ccaaccgcct tggcgagaga aggggaggca gacggcatcg
     1081 cagagctgag gaagcaagca gaggccgtgt tagagctcca agaagtgact ctagcagaag
     1141 attttatggt gatcggcatt ccgatcaaga aatgaaaccc gagctactga gtgcattaat
     1201 gaggacgtgg tatggatgta ttaccaggcc tgcaccacag attttgtgtt gtgggttgtg
     1261 agtgattttt ttttccttaa aattactttg gccctaacaa tcctaaagat ggagctggat
     1321 tgccgagctg gctcagtagt gagagggaac aagattttga atgatgagtc atttttaaaa
     1381 gatgaaaaat ttaaatgatt taaaatttaa attttaggtg atgaaaaatc cttcttaaag
     1441 tgcaggtgtg acaaaacaat ccatgtgcag ggacttactc tgtggctgct gctacagaga
     1501 gaattccaca ctctgggcag tgttagactt agctttgccg agctcagttg ccattgttgg
     1561 caaagtatat aagactgggt cctcttggct agaaaacggg agcagaattt gcatagagtt
     1621 tgtgttcctg acacagggat aaacgtacgg gcaatactgg tgcagtattg ataacgtggt
     1681 ggtgctttcg ccggaacggt cagtacaggt ttgggctaag ttttatctta gcactttgtt
     1741 caacattctg gtttctttta gcacatggac ctgggtagtc tactgagaat gaattagata
     1801 cattggattg gttttcctgt tgcagtgacg gaggggagat ggtgacagca cagtagatta
     1861 gtcagtgggg gtcaggaatg ccatatatgc tgcacagttt gcgttagtcc tgcgtaataa
     1921 ttacctcaaa gttctaggcc tgttcagaga cacagattcc accttttatt cctaatgtga
     1981 atatgcgctg ccaaagttaa tggtgtaatg gattagtaga tgagccatat cctccaatag
     2041 gaggcaaagg atgggcgtgc tggaattgga tgccacatca ggtagtattt ggagacatga
     2101 gccatcaagt gaatcttaca gatgtggaga gagacagtca ccccctcccc agggagcgtc
     2161 tgcctcaggc ctggtggtcc cggagctggg tagagagctg ctgcctctgc ttccagagac
     2221 caagttagga ggtcagagtg gccttgacgc tgcactgcca agcagcctgg gtgattctca
     2281 aagacatgag tattgaacta gcctagaaga aaaaaattgt cttttttttc tatgtattta
     2341 aattgagggt atatatattt tatagattct tatatatatg tttgtgtatt atatacttta
     2401 tgcatggata tttttacatg aaggctgacc tccctccact attttcctaa agcaaaataa
     2461 agatatttta ttggacaaat aaaagctagg agtttattat cagaaaatcc tctgtaagaa
     2521 attctgaggc attattttgg cacaataaaa ataatgttgg aaggttgaca aaccataaag
     2581 gggcaaagag atgggtgttg agaaacactg attacagtgc ctaccgacaa gtccagaccc
     2641 acgctctcat tagcatcaaa tagtctctca aagtgtgaga cttcatgtaa tttagagttg
     2701 tatcatttaa taatgtcttt tatcgctgag gttgatttct gtgagtagaa ggaaactgac
     2761 aagaagtcaa acttcttgtg ttcaggtctc tatctccaag gagttagttc tttctcattc
     2821 tctctgtgtt acagaacacc ttaggcatgg tggcaaggct aaggcaggaa aataggagcc
     2881 cgggctacat agtaggactt tatcttttaa aaaagacaga aaaaagtaaa tgtgacttgt
     2941 aacatatctc atgtccattc acattcctca ctgtccatgg gagtggcctg cttagtactt
     3001 agtacttagt gcttagtgct tagtactcta ttgaagacag gacttcatca acttaaaacc
     3061 gaagtcctac cctctctttc acctctccct gtttttaaca aggtctcgcc gtgcagccca
     3121 aactggcccc aagctccaag cactcctgct caggagctgg gcttataaac atgcatttgt
     3181 aatctgccat agtgttttga ataattcttt cccaagaaaa gtttatagtt tttaggctgg
     3241 gagtgtagcc tggtgggaga gcactggctt agttttggtc tgtggtataa aaaggaaaga
     3301 taattattgc ctcctagtgc taatatcctt cttatgtctt taagtcaata cagataatct
     3361 aactcttttg tttctctgaa tattctgatg tcagcttgaa attttgctac attttctctt
     3421 tttaatgaaa taagaatcct tcccaagtgt gcacatccca aatgggcgtg gtggtatttc
     3481 acctcacaaa ggtgtatgtt tagcgtgaag tgaacgagat ctgtctttac tgactgattt
     3541 gagggctagg gaattaatag gagtatcgac ttccttcttt ctctttcttc ttttttcctt
     3601 taagattaga atctcatgta gcccaggcta accttgaacc tgctatgtag ccaaggatga
     3661 ccttgaattt gtgatacttc tgtctccacc tccagagtgc tgaggtaacc gtcttatgtc
     3721 accatgctag gtctatgtgg tactgaggac ggagcctagg actctgtacc tgccaaggat
     3781 cccagagccc aagtatgtgg ggctttggtt tggtttggtt ttctagggga tactaagaag
     3841 gaagcactgg ccgcaccttt gaatattctt tcatgacaga gaaaaagaag tctaagggga
     3901 gactgggggg taatagtggg taatgtttct tttcttcagt gtgcaaaaat gaaaaacaac
     3961 tatttaagca cattatgttt caaaaagcaa gagaagtggc tgggaatgta gctcagggat
     4021 aggacactgg ttagcctgag caaggtcgtg ggcttgatcc ccagagtgtc tactcgacaa
     4081 cagaaaagta agggggcaga gagggaacat gaacggttaa gagtgggttc agataaggat
     4141 gcatgaagat gtagcgatga aacgcattcg gtacagttaa aacgtattaa taattctttt
     4201 taagtggaga aagaaggctt gggagaaggg gcaagaagtt tggggagaca agacaggttg
     4261 ctgcttctgt ggtggcttta tgagtcacca gtacgatgga tgttctgacg aagagtgtgt
     4321 atatatcatt tagtatagca gttacgtcat agcacatcca tacagaataa ctcctctaga
     4381 taactggtca tctccacata ggcactccag ggagctgaca gttcaagtct ttgtaatatt
     4441 cctgttcacc atctactgcc gccagagtgg gctttttccc aggatgtaaa tttttgccat
     4501 ctctccctgg cttgaaactt ggtagtgatc tggctttact cacctctcca acctgatctt
     4561 agtccccagg gctccttagg tttgcagccc cagcctcaag atcttctgat gtcacagagc
     4621 cgtccagtct ctgcttcctt cctgcttcct tctcctgaaa tggcatttgc cacactcccc
     4681 aaatcaacct agtgattaac cttacgtctt agctttgctt tcaggcctca tggaagtctg
     4741 cctggccggc tccttcctgc taggaagtgt actttgctca gcccgtcaac ccgtcttttt
     4801 gatacttgtc ggtcacagct tcatttagcc tctgtatgtg atgtttctcc tccacagcag
     4861 ctctgtaagc cacaccgggg cagagctctt gtctgtgtct gttccccttt atgactgact
     4921 cagtgcctgg aacatcagag gcactcaata aagagtgttg actggatcac a
//
