LOCUS       NM_201357               1701 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus EARP complex and GARP complex interacting protein 1
            (Eipr1), transcript variant 1, mRNA.
ACCESSION   NM_201357 XM_354665
VERSION     NM_201357.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1701)
  AUTHORS   Wang,D.C., Wang,H.F. and Yuan,Z.N.
  TITLE     Runx2 induces bone osteolysis by transcriptional suppression of
            TSSC1
  JOURNAL   Biochem Biophys Res Commun 438 (4), 635-639 (2013)
   PUBMED   23933319
  REMARK    GeneRIF: Overexpression of Runx2 induces bone osteolysis in a
            TSSC1-dependent manner.
REFERENCE   4  (bases 1 to 1701)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 1701)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136986.6 and CT010449.10.
            
            On Mar 25, 2020 this sequence version replaced NM_201357.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031458.1, AK150308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC136986.6         137624-137809
            187-270             AC136986.6         145875-145958
            271-403             AC136986.6         152577-152709
            404-560             CT010449.10        130363-130519       c
            561-660             CT010449.10        111571-111670       c
            661-797             CT010449.10        99839-99975         c
            798-965             CT010449.10        96105-96272         c
            966-1130            CT010449.10        94393-94557         c
            1131-1701           CT010449.10        91736-92306         c
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 11.26 cM"
     gene            1..1701
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /note="EARP complex and GARP complex interacting protein
                     1"
                     /db_xref="GeneID:380752"
                     /db_xref="MGI:MGI:1289332"
     exon            1..186
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1305
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /note="isoform a is encoded by transcript variant 1;
                     protein TSSC1; tumor suppressing subtransferable candidate
                     1; EARP-interacting protein; endosome-associated recycling
                     protein-interacting protein; tumor-suppressing STF cDNA 1
                     protein; Golgi-associated retrograde protein-interacting
                     protein; tumor-suppressing subchromosomal transferable
                     fragment candidate gene 1 protein; EARP and GARP
                     complex-interacting protein 1"
                     /codon_start=1
                     /product="EARP and GARP complex-interacting protein 1
                     isoform a"
                     /protein_id="NP_958745.2"
                     /db_xref="CCDS:CCDS25855.1"
                     /db_xref="GeneID:380752"
                     /db_xref="MGI:MGI:1289332"
                     /translation="MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIH
                     IIDFDDENNIINKNVLLHQAGEIWHISASPADKGVLATCYNKTTDSRVQACAAVWRMP
                     KELESGSHESPDDPASTAQTLELLCHLDNSAQGNVACVVWEPMGDGKKVISLADSHIL
                     LWDLQPSSSQAVLASSATLEGRGQLKFTAGRWSPHHNCTQVATASDTTLRGWDTRSMS
                     QIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVW
                     SVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDGDISDPEEHHAEKSKEPL
                     QDNVIATYEEHEDSVYAVDWASADPWLFASLSYDGRLVINRVPRALKYHILL"
     exon            187..270
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..403
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..560
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..660
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..797
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..965
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1130
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1701
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1701
                     /gene="Eipr1"
                     /gene_synonym="D12Ertd604e; Tssc1"
                     /note="major polyA site"
ORIGIN      
        1 gaagaaaaca ggaagtgagc cgtcagggag ccggtctggg tctcgtagtc catttttcag
       61 gcggggaatg aatgggttct gagcgatccc tggtgagggg ggactcgagc tctgaggcgt
      121 gagtagctgg gtaggcagag tatcatggaa gacgacgccc cggtgattta cgggctggaa
      181 ttccaggcac gtgctctaac acctcaaact gcggaaacag atgccattcg cttcttggtt
      241 gggacgcagt ctcttaaata tgataatcag atccacatca tagactttga tgacgaaaat
      301 aacattataa ataaaaatgt cctcctccat caagcgggtg agatctggca catcagtgcc
      361 agcccggcag ataaaggtgt gctggccacc tgctacaaca aaactacaga cagtcgagtc
      421 caggcgtgtg cagctgtgtg gaggatgccc aaggaattag aatccggtag ccacgagtcc
      481 cctgacgacc ctgcaagcac tgctcagacc ctggagctgc tctgtcacct tgacaactcg
      541 gcccaaggca acgtggcctg tgtcgtgtgg gaaccgatgg gggatgggaa gaaggtcatt
      601 tccctggccg atagccacat cctgctgtgg gacctccagc ccagctcgag ccaggctgtg
      661 ctggccagct cagcaacact ggaaggaagg ggacagctga agttcaccgc ggggcggtgg
      721 agcccacacc acaactgtac ccaggtggcc acagcaagtg acacgaccct ccgaggatgg
      781 gacacacgga gcatgagcca gatatactgc atagagaacg ctcatgggca gctggtgcgt
      841 gacctagact tcaaccccaa caagcagtat tacctcgcca gctgtggaga tgactgcaag
      901 gtgaagttct gggacacacg gaatgtcacc gagcctgtga agaccctgga ggagcactcc
      961 cactgggtgt ggagtgtgcg ctacaaccac tctcacgacc agctggtcct cactggcagc
     1021 agcgacagca gagtcatcct gtccaacatg gtatctatct cctcagagcc ctttggtcac
     1081 ctggtggacg acggtgacat cagtgatcca gaagagcacc atgctgaaaa gagcaaggaa
     1141 cccctgcagg acaacgttat tgccacctat gaggagcatg aggacagcgt gtatgcagtg
     1201 gactgggcct cagctgaccc atggctgttt gcttccctaa gttacgacgg gagactggtt
     1261 atcaacagag ttcccagggc actgaagtac cacatactgc tctagtggcc catggcactg
     1321 ctgcttggta cttggcaaat tctcagaaat ctgcagctac gaggtaattc ctttcacaga
     1381 cagattccct ccttgggaga accagcattg cttctacagg agctctgagg gacatggcgc
     1441 ttctgccagc agctcatctg atgctgtcag cacactgctc agcatgggcg ggagctttac
     1501 tggacacagc tgtccatgtg tgaattgatg gctgcccagt ctctgtttgg tttctggttt
     1561 ctgtttaaag ggtgttggaa gtttaacttt tccccagtgt gtttccacct tcctgttgtc
     1621 atgagattgc aaactgaaat aaagtcagtg ggatgcgcac agcctcctcc tttcaggctc
     1681 cctgccccac tgaggaagtc a
//
