LOCUS       NM_010579               1495 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 6 (Eif6),
            mRNA.
ACCESSION   NM_010579
VERSION     NM_010579.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Sjovall,D., Ghosh,S., Fernandez-Fuentes,N., Velasco-Hernandez,T.,
            Hogmalm,A., Menendez,P., Hansson,J., Guibentif,C. and Jaako,P.
  TITLE     Defective ribosome assembly impairs leukemia progression in a
            murine model of acute myeloid leukemia
  JOURNAL   Cell Rep 43 (11), 114864 (2024)
   PUBMED   39412990
REFERENCE   2  (bases 1 to 1495)
  AUTHORS   Chen,Y., Wang,Z., Xian,X., Zhuang,Y., Chang,J., Zhan,X., Han,X.,
            Chen,Q., Yang,Z. and Chen,R.
  TITLE     Eukaryotic initiation factor 6 repression mitigates atherosclerosis
            progression by inhibiting macrophages expressing Fasn
  JOURNAL   IUBMB Life 75 (5), 440-452 (2023)
   PUBMED   36469534
  REMARK    GeneRIF: Eukaryotic initiation factor 6 repression mitigates
            atherosclerosis progression by inhibiting macrophages expressing
            Fasn.
REFERENCE   3  (bases 1 to 1495)
  AUTHORS   Scagliola,A., Miluzio,A., Mori,G., Ricciardi,S., Oliveto,S.,
            Manfrini,N. and Biffo,S.
  TITLE     Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma
            Growth: An In Vivo and In Vitro Study
  JOURNAL   Int J Mol Sci 23 (14), 7720 (2022)
   PUBMED   35887068
  REMARK    GeneRIF: Inhibition of eIF6 Activity Reduces Hepatocellular
            Carcinoma Growth: An In Vivo and In Vitro Study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1495)
  AUTHORS   Jaako,P., Faille,A., Tan,S., Wong,C.C., Escudero-Urquijo,N.,
            Castro-Hartmann,P., Wright,P., Hilcenko,C., Adams,D.J. and
            Warren,A.J.
  TITLE     eIF6 rebinding dynamically couples ribosome maturation and
            translation
  JOURNAL   Nat Commun 13 (1), 1562 (2022)
   PUBMED   35322020
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1495)
  AUTHORS   Keen,A.N., Payne,L.A., Mehta,V., Rice,A., Simpson,L.J., Pang,K.L.,
            Del Rio Hernandez,A., Reader,J.S. and Tzima,E.
  TITLE     Eukaryotic initiation factor 6 regulates mechanical responses in
            endothelial cells
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35024764
  REMARK    GeneRIF: Eukaryotic initiation factor 6 regulates mechanical
            responses in endothelial cells.
REFERENCE   6  (bases 1 to 1495)
  AUTHORS   Gandin,V., Miluzio,A., Barbieri,A.M., Beugnet,A., Kiyokawa,H.,
            Marchisio,P.C. and Biffo,S.
  TITLE     Eukaryotic initiation factor 6 is rate-limiting in translation,
            growth and transformation
  JOURNAL   Nature 455 (7213), 684-688 (2008)
   PUBMED   18784653
  REMARK    GeneRIF: eIF6 is the first eIF associated with the large 60S
            subunit that regulates translation in response to extracellular
            signals
REFERENCE   7  (bases 1 to 1495)
  AUTHORS   Ceci,M., Offenhauser,N., Marchisio,P.C. and Biffo,S.
  TITLE     Formation of nuclear matrix filaments by p27(BBP)/eIF6
  JOURNAL   Biochem Biophys Res Commun 295 (2), 295-299 (2002)
   PUBMED   12150946
  REMARK    GeneRIF: role in forming nuclear matrix filaments
REFERENCE   8  (bases 1 to 1495)
  AUTHORS   Wood,L.C., Ashby,M.N., Grunfeld,C. and Feingold,K.R.
  TITLE     Cloning of murine translation initiation factor 6 and functional
            analysis of the homologous sequence YPR016c in Saccharomyces
            cerevisiae
  JOURNAL   J Biol Chem 274 (17), 11653-11659 (1999)
   PUBMED   10206977
REFERENCE   9  (bases 1 to 1495)
  AUTHORS   Cho,S.H., Cho,J.J., Kim,I.S., Vliagoftis,H., Metcalfe,D.D. and
            Oh,C.K.
  TITLE     Identification and characterization of the inducible murine mast
            cell gene, imc-415
  JOURNAL   Biochem Biophys Res Commun 252 (1), 123-127 (1998)
   PUBMED   9813156
REFERENCE   10 (bases 1 to 1495)
  AUTHORS   Biffo,S., Sanvito,F., Costa,S., Preve,L., Pignatelli,R.,
            Spinardi,L. and Marchisio,P.C.
  TITLE     Isolation of a novel beta4 integrin-binding protein (p27(BBP))
            highly expressed in epithelial cells
  JOURNAL   J Biol Chem 272 (48), 30314-30321 (1997)
   PUBMED   9374518
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL845445.14, BX004872.6 and
            AL929233.9.
            
            On Mar 21, 2007 this sequence version replaced NM_010579.1.
            
            Summary: The protein encoded by this gene is a eukaryotic
            translation initiation factor that regulates both ribosome
            biogenesis and translation, which are rate-limiting factors for
            cell growth. The encoded protein binds 60S ribosomes and prevents
            their association with 40S ribosomes. This gene may play a role in
            oncogenesis as well. [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015274.1, AF047046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AL845445.14        2001-2273           c
            274-599             BX004872.6         3669-3994           c
            600-685             BX004872.6         3467-3552           c
            686-861             AL929233.9         132741-132916       c
            862-1038            AL929233.9         132068-132244       c
            1039-1220           AL929233.9         131713-131894       c
            1221-1495           AL929233.9         128713-128987       c
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..1495
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /note="eukaryotic translation initiation factor 6"
                     /db_xref="GeneID:16418"
                     /db_xref="MGI:MGI:1196288"
     exon            1..599
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..1230
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /EC_number="3.6.5.3"
                     /note="B4 integrin interactor; integrin beta 4 binding
                     protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 6"
                     /protein_id="NP_034709.1"
                     /db_xref="CCDS:CCDS16956.1"
                     /db_xref="GeneID:16418"
                     /db_xref="MGI:MGI:1196288"
                     /translation="MAVRASFENNCEVGCFAKLTNAYCLVAIGGSENFYSVFEGELSD
                     AIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLS
                     ALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGL
                     VHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVV
                     ESVFKLNEAKPSTIATSMRDSLIDSLT"
     exon            600..685
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            686..861
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1038
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1220
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1495
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /note="hexamer: ATTAAA"
     polyA_site      1495
                     /gene="Eif6"
                     /gene_synonym="1110004P11; CAB; eIF-6; imc-415; Itgb4bp;
                     p27(BBP); p27BBP"
                     /note="major polyA site"
ORIGIN      
        1 ctcatctttt catttgccca gcctcaggtt tgattgatta ttccttctaa aaagacccac
       61 taggaggtga agccaaaaac ctaaagcaag aaaacgtgca ggaggcgggg tcgggcggag
      121 tcacctagta accatcgagt cctcccaaag ggtggggcta gagtgaccag cagctccgcc
      181 cggctcctgc gcgctcccgg aagcgggcct gggaggaggc ggaaacggaa agctagttac
      241 gggagaagtt gttgcagcgt gtagacattg gagtcgcttg gtgagctgtt gggactctgg
      301 gcggcaaaag tcagttccgg gtcgcagggc gagaggactt ggggcaggag agccaggagg
      361 gatccgtccg cacgcccggg catctgaggg gcccgagagg gcggggtttg aggaggcgag
      421 gctggttgac ccggctccgg agtggatctg tcggcccaga acccgcagtc gtgctgcccc
      481 ccagcctctc tcatggcggt cagagcgtcg ttcgagaaca actgtgaggt cggttgtttt
      541 gccaaactca caaacgccta ctgcctggtg gccatcggag gctcagagaa cttctatagt
      601 gtgttcgagg gtgagctctc cgatgccatt cccgtggtgc acgcatccat cgccggctgc
      661 cgaatcatcg ggcgcatgtg tgtggggaac aggcatgggc tcctggtacc caacaacacc
      721 accgaccagg agctgcagca catccgcaac agcctgcctg actccgtgca gatacggcgg
      781 gtggaggagc ggctctcggc ccttggcaat gtcaccacct gcaatgacta tgtggccttg
      841 gtccacccag acttggacag ggagacagaa gagatcctgg ctgatgtcct caaggtggaa
      901 gtcttcagac agacagttgc tgaccaggtg ctagtaggaa gctactgtgt cttcagtaat
      961 cagggggggc tggtgcaccc taaaacttct atcgaggacc aggatgagtt gtcctccctt
     1021 cttcaggtcc cccttgtggc aggcactgtg aaccgaggga gtgaggtgat tgctgctggg
     1081 atggtggtga acgattggtg tgctttctgt ggtctggaca cgaccagcac ggagctgtca
     1141 gtggtggaga gcgtcttcaa gctgaatgaa gccaagccaa gtaccattgc caccagcatg
     1201 cgggattccc tcattgacag cctcacatga gtcaccgtcc atgctgccgt gtgggctcct
     1261 gcctctggac tttggctcat tttccatgcc tgagctagtc tgtaccagat gctggcagtg
     1321 gggcatggca gagctcggta gagctgaatt gattgcccaa cccttcacct gtgccatctc
     1381 ttgacaattg ttactggaaa gcctgccctg tcatgctggc tttcagttct tgtggctctt
     1441 ggatgaaagt tctgctatct tgtgccccac cccattaaag gactgcctcc cacca
//
