LOCUS       NM_177586               5026 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 5A2 (Eif5a2),
            mRNA.
ACCESSION   NM_177586
VERSION     NM_177586.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5026)
  AUTHORS   Connors,C.T., Villaca,C.B.P., Anderson-Baucum,E.K., Rosario,S.R.,
            Rutan,C.D., Childress,P.J., Padgett,L.R., Robertson,M.A. and
            Mastracci,T.L.
  TITLE     A Translational Regulatory Mechanism Mediated by Hypusinated
            Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and
            Function
  JOURNAL   Diabetes 73 (3), 461-473 (2024)
   PUBMED   38055903
  REMARK    GeneRIF: A Translational Regulatory Mechanism Mediated by
            Hypusinated Eukaryotic Initiation Factor 5A Facilitates beta-Cell
            Identity and Function.
REFERENCE   2  (bases 1 to 5026)
  AUTHORS   Yang,J., Xiang,H., Cheng,M., Jiang,X., Chen,Y., Zheng,L., Yan,S.,
            Zhang,S., Zhang,C., Chen,W. and Chen,D.
  TITLE     microRNA-15a-5p suppresses hypoxia-induced tumor growth and
            chemoresistance in bladder cancer by binding to eIF5A2
  JOURNAL   Neoplasma 71 (1), 60-69 (2024)
   PUBMED   38506035
  REMARK    GeneRIF: microRNA-15a-5p suppresses hypoxia-induced tumor growth
            and chemoresistance in bladder cancer by binding to eIF5A2.
REFERENCE   3  (bases 1 to 5026)
  AUTHORS   Schultz,C.R., Sheldon,R.D., Xie,H., Demireva,E.Y., Uhl,K.L.,
            Agnew,D.W., Geerts,D. and Bachmann,A.S.
  TITLE     New K50R mutant mouse models reveal impaired hypusination of eif5a2
            with alterations in cell metabolite landscape
  JOURNAL   Biol Open 12 (3) (2023)
   PUBMED   36848144
  REMARK    GeneRIF: New K50R mutant mouse models reveal impaired hypusination
            of eif5a2 with alterations in cell metabolite landscape.
REFERENCE   4  (bases 1 to 5026)
  AUTHORS   Xu,G., Chen,H., Wu,S., Chen,J., Zhang,S., Shao,G., Sun,L., Mu,Y.,
            Liu,K., Pan,Q., Li,N., An,X., Lin,S. and Chen,W.
  TITLE     Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy
            and cisplatin resistance
  JOURNAL   Cell Death Dis 13 (8), 683 (2022)
   PUBMED   35931669
  REMARK    GeneRIF: Eukaryotic initiation factor 5A2 mediates hypoxia-induced
            autophagy and cisplatin resistance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5026)
  AUTHORS   Pallmann,N., Braig,M., Sievert,H., Preukschas,M.,
            Hermans-Borgmeyer,I., Schweizer,M., Nagel,C.H., Neumann,M.,
            Wild,P., Haralambieva,E., Hagel,C., Bokemeyer,C., Hauber,J. and
            Balabanov,S.
  TITLE     Biological Relevance and Therapeutic Potential of the Hypusine
            Modification System
  JOURNAL   J Biol Chem 290 (30), 18343-18360 (2015)
   PUBMED   26037925
REFERENCE   6  (bases 1 to 5026)
  AUTHORS   Chen,M., Huang,J.D., Deng,H.K., Dong,S., Deng,W., Tsang,S.L.,
            Huen,M.S., Chen,L., Zan,T., Zhu,G.X. and Guan,X.Y.
  TITLE     Overexpression of eIF-5A2 in mice causes accelerated organismal
            aging by increasing chromosome instability
  JOURNAL   BMC Cancer 11, 199 (2011)
   PUBMED   21612665
  REMARK    GeneRIF: activation of eIF-5A2 repressed p19 level and therefore
            destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells.
            This subsequently allowed for the accumulation of chromosomal
            instability.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5026)
  AUTHORS   Parkinson,N., Hardisty-Hughes,R.E., Tateossian,H., Tsai,H.T.,
            Brooker,D., Morse,S., Lalane,Z., MacKenzie,F., Fray,M.,
            Glenister,P., Woodward,A.M., Polley,S., Barbaric,I., Dear,N.,
            Hough,T.A., Hunter,A.J., Cheeseman,M.T. and Brown,S.D.
  TITLE     Mutation at the Evi1 locus in Junbo mice causes susceptibility to
            otitis media
  JOURNAL   PLoS Genet 2 (10), e149 (2006)
   PUBMED   17029558
REFERENCE   8  (bases 1 to 5026)
  AUTHORS   Jenkins,Z.A., Haag,P.G. and Johansson,H.E.
  TITLE     Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved
            vertebrate variant of eukaryotic translation initiation factor 5A
            with tissue-specific expression
  JOURNAL   Genomics 71 (1), 101-109 (2001)
   PUBMED   11161802
  REMARK    GeneRIF: Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A)
            stimulates ribosomal peptidyltransferase activity, transport of
            HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys
            50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and
            eIF5AII.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122490.3.
            
            On Oct 4, 2017 this sequence version replaced NM_177586.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY205265.1, AY205264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC122490.3         47227-47363
            138-338             AC122490.3         47966-48166
            339-443             AC122490.3         48678-48782
            444-575             AC122490.3         59635-59766
            576-5026            AC122490.3         60346-64796
FEATURES             Location/Qualifiers
     source          1..5026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 12.25 cM"
     gene            1..5026
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /note="eukaryotic translation initiation factor 5A2"
                     /db_xref="GeneID:208691"
                     /db_xref="MGI:MGI:1933735"
     exon            1..137
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            138..338
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            339..443
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            444..575
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            576..5026
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3528..3533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /note="hexamer: AATAAA"
     polyA_site      3551
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /note="major polyA site"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
                     /note="hexamer: AATAAA"
     polyA_site      5022
                     /gene="Eif5a2"
                     /gene_synonym="9630038B20; eIF5AII"
ORIGIN      
        1 ggcgggccgg ggcggggagc cgggtgtggg aagcgtggcg gccccgcccc gtctcctgga
       61 ccagccgcgg ccgccagcgc cgccgcagcc gcagggaccg gcggacgcag caaaggcgtg
      121 cggtgcgggg ccggaagttc cctcagaaaa accgcacatc tccccagtcc accatggcag
      181 acgaaattga tttcactact ggagatgcag gggcttccag cacttatcct atgcagtgct
      241 cagccctgcg caaaaacggc ttcgtcgtgc tcaaagggcg accatgcaaa atcgtggaga
      301 tgtcaacttc caagactggg aagcatggtc atgccaaggt acaccttgtt ggaattgaca
      361 ttttcactgg caaaaaatat gaagacattt gtccttctac tcacaacatg gatgttccaa
      421 atattaagag aaacgattat caactcatat gcattcagga tggttacctt tccctgctga
      481 cagaaactgg cgaagtccgt gaagatctta agctgccaga aggtgaactg ggcaaagaaa
      541 tagaagggaa atacaatgca ggtgaagatg tgcaggtgtc tgtcatgtgt gccatgagtg
      601 aagaatacgc tgtagccata aagccctgca aatagacaag ccctgcaaat ggaccatcag
      661 cataaccagg tccattggtc tggatctagt tgtcccaaag ctatggcctt cataagaaac
      721 ctcatgtttg ttgttatgtt tttattgttt taaaaaagtg ctggcttagg tttgcaggca
      781 gttagtaagt ttaaacaaat ataccaaaac gtataatttt ataagtatct gtcctataac
      841 actcctgtgg ttttcatcat gtgaccataa gaaacaaata caacagcttc agtaaatgtc
      901 acttttctga gcaaatcact cctgatctta agtggttaac aaaccagggt tttaaatcag
      961 caatgtagca tgtaggcgaa tggaagtatc atgcatttca gttgaattgc tttgtgctga
     1021 tttcagactt tatatctaga attcatagac tataagatgg tctgtgtggc agacacacat
     1081 cttgaaacga aactctattt atcaaacagt gtcattctct tggtggtcag atgtcccata
     1141 ttatcttcat catgtttatc tgtgctgtgt tgatgacgac agacctacag agtagtttca
     1201 gttgacggag ggaagggaac tgctgcgtac gtctgagcta gtccaccagg cagtggagat
     1261 tcacaggggc agaggcaaag tgctggttaa cgctgtagag ttgactcaag acctttcaac
     1321 cagcacacaa agtgacagag ctctggttgt atttttgctt ttggctatgt ccccagcctc
     1381 tgcctcatta caggagtgac ctttccagag acgctcacta cttccagcca taatgcctaa
     1441 gtgatcatga tgttgccctc cctgcaattt tttttaagta atttgttttt gacgttagac
     1501 taaaaatagg aattttaaag ttgctttgga attctcgact ttaaattgat ttgttaagta
     1561 tatgtacact tttctaaagt gtaataggtg taaccatgga agaaaggtta tcttatttga
     1621 aaattatttt aagtgtgtat atacttttat tgttttgtga cttaattctt ttactgatgt
     1681 aaaatacaac taggattctg tggcctggat tattttactg cattgtaggt aatgcccctc
     1741 catttttgtt tagacttctg gattgtgtgt aaattgtgtc taaaattgta gacatggttg
     1801 tgggcttgag aggaacaaat ggaatcacaa tcatggcctt ggcgtgcagc ttagaacaga
     1861 atccctctca gtcccacctt gactctctga tgccggctct cgggttcctc ttctcatgtc
     1921 tggacccttt gttcccagct aggaaaaatg tgtaacaatg taactcacct aatcagcaac
     1981 ttgaaatagc tttacaaatg gaagacccca agattttagt tccttaattt gtatgcagtt
     2041 ttaaatcttg tcttgttatc aaaaggtatc atctcttttt gataacaaga taaaccaatc
     2101 cagagatgaa gcaagatacc ctaggagacg tgccgggaag ggatgtctaa agcacaagat
     2161 attgacgttg tagccagttg actttagtgt gacccgttag cttctgcccg tgcaaagcac
     2221 aattaggaat taggctcaat ttttcccagg tatctgctct atgctgcttt cgattcctgc
     2281 tgctgggggt tccttgcagg actgattgac atgttagccc caggaattcc aggaagtgat
     2341 ttctttctgc tttgctgtct tctggtcatt gtcttgccaa taagtagcca cactggtgtt
     2401 ttgatttcat atttctttag gagttgcatg ctcttatcct tcctaattta tcaaatttca
     2461 catgcatctc tacttttcat tgtagtatat gcatataaat tagagcagtg tacctctagc
     2521 tccgtacctt gaatggcaaa aactacttag gcctaagtat ttcgatttaa ataatatata
     2581 agtgtacata ctccaacatg taactataga ctttaaagat acaggactgt ttattttcac
     2641 ataagtcagt agatgtttct cttaaagcaa aatattgcat ttagtaaagc tttataaatt
     2701 atattaaagg gaagcagggg ttatgtactt tttaacagaa aacagaaatg acttcttttg
     2761 acatcagaaa aatgctacca gttgattcct aatatttgtt gtacttatag cagatctccg
     2821 gcctcacaag gcaccatgtt gagaatggaa ttcgttctga cgtcaccgcc atctgcgtct
     2881 gtacacattt ctttctttct ttgccattta gacagtatta acaggttgaa cgtttttgtt
     2941 ctagaataac agcttaattt ctattgtgaa gattttgcca cactgataac aattgtgtgt
     3001 cctctgacct agatcagacc cttttggctt tgacttgggc tgccagtcac ttgaagtgga
     3061 ccaagcactt gactctgttc ccctccatag tacagatttc tataccagtg cttttatatc
     3121 agtgaccaaa atacttgcag ccagatgtga tatcttcaag agagcacact gcagtgcagt
     3181 gtttagagaa gttggggatg catgcttttc attagcgcac agtgtgagtg tatatacaaa
     3241 tacacacagc tttgttcatt tgtcaagtcc ttccaactac taaatgtact gtagtctggt
     3301 agtgcctcaa atgttagttt gatattcatt gtttttaatt tgtaagtttt tcagaatttg
     3361 tcttgtattt ttaaggctct caattagatt gtttctagtt gagctggact tcaaatgcac
     3421 tgttctcagg gctgcttgtg cagaaactga agtgtcatta ttttaaagat agctgcctac
     3481 aaatatattg caagtttttc ccaagtcgta atactgtaat acatacaaat aaaaatcctt
     3541 agtataacat atttaagcta tctggtaagt gtttggtttt tttttgtttg tttgtttgtt
     3601 tgttttaaag tgggagcatt agtagcagcc gtactggaat cgtgctgtag tttttgcttc
     3661 agagtaaaat cccaggggtc ttactgtgga accctgtcct tggtggtgta tctgagagca
     3721 tgtttttggc acagatgcaa aagaagagtt ttggagctag acattgatac attggttctc
     3781 agacacattc aagaacagac aggaaattct taactctttt gggtatctta caatgtttac
     3841 atgctggatt cacacttgct atgaggaaat atggatgtct ggtataagat caaagctatt
     3901 aaggtgtatt tccataaaca gtatattata ctgataggaa cttgtaaatc ttctaatatt
     3961 taagtatact attacatagt tctcaagact tttttctgtc aagatttcga agaaggcaac
     4021 aaagactttt ttttttttaa atctaagtgg ataaatctta aaattgaatc taataactta
     4081 aatctgtgaa atgtgttctc tgaattggac aaacaacatt attatttgat tgtagagaga
     4141 acattgggac ttagcttacg gagcacagat gttctgtgga aacagggttt aagtcactat
     4201 gtaatttaat ttttccatta atccaaacac caacataact accaagtgag gtcatgcacc
     4261 tgaaaagagc tgtaaatatt taataaatat gttttcttca tgtgaaggac atatcgtagg
     4321 gtagtgcaca caaggtcacc ctctgctgta aacatcctta ctgccaaact tctccatcac
     4381 tactgtccac acttaaaaca ggcctggacc tatattacag taacaaggga gattctttta
     4441 tgtatatgac attcttagaa accatttcta gacgttggtg ggatttggtt catcttagtt
     4501 tgaaactgta gttttaaaaa cactgaatag taaactattc agcaatggct gaagagccta
     4561 tgagacgctg tggctatgct cgtccttaag ccgattcctt attgtggctg atctactaca
     4621 aataatccct catcattatt acaaagacta cttcacatta ctagctctga accatgataa
     4681 aacaatgaca tttccctatt ctcttgtact cgtatccccc tccctagaag aaaacagata
     4741 aatggcattg tctaatccat tggcactttg ttaatattat ttttgtctta aatataggac
     4801 acttcttgaa tttacttgca aatgttttgt taaaacttta aaattgtaag atctgaatat
     4861 tataattgtg cgttttacat tttaaaagta agtaaacttt gaatgttaaa tctctggcta
     4921 tactaaaata tccttgtcaa tgataacatt ttgttacctt aaaatatatg tctgttaact
     4981 tcgtgttata ttaaatgaaa ataaacttaa cagtgcacaa ttctta
//
