LOCUS       NM_173363               3966 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 5 (Eif5),
            transcript variant 1, mRNA.
ACCESSION   NM_173363
VERSION     NM_173363.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3966)
  AUTHORS   Capriati,M., Hao,C., D'Cruz,S.C., Monfort,C., Chevrier,C.,
            Warembourg,C. and Smagulova,F.
  TITLE     Genome-wide analysis of sex-specific differences in the
            mother-child PELAGIE cohort exposed to organophosphate metabolites
  JOURNAL   Sci Rep 13 (1), 8003 (2023)
   PUBMED   37198424
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3966)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   3  (bases 1 to 3966)
  AUTHORS   Kraushar,M.L., Thompson,K., Wijeratne,H.R., Viljetic,B., Sakers,K.,
            Marson,J.W., Kontoyiannis,D.L., Buyske,S., Hart,R.P. and Rasin,M.R.
  TITLE     Temporally defined neocortical translation and polysome assembly
            are determined by the RNA-binding protein Hu antigen R
  JOURNAL   Proc Natl Acad Sci U S A 111 (36), E3815-E3824 (2014)
   PUBMED   25157170
REFERENCE   4  (bases 1 to 3966)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3966)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 3966)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3966)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   8  (bases 1 to 3966)
  AUTHORS   De Sousa,P.A., Watson,A.J. and Schultz,R.M.
  TITLE     Transient expression of a translation initiation factor is
            conservatively associated with embryonic gene activation in murine
            and bovine embryos
  JOURNAL   Biol Reprod 59 (4), 969-977 (1998)
   PUBMED   9746750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI391022.1, AK163368.1, AK160828.1 and AW547465.2.
            
            [WARNING] On Mar 4, 2025 this sequence was replaced by NM_173363.6.
            
            On Dec 17, 2009 this sequence version replaced NM_173363.4.
            
            Transcript Variant: This variant (1) represent the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.134474.1,
                                           SRR1660811.76315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               AI391022.1         1-525
            526-2403            AK163368.1         409-2286
            2404-3801           AK160828.1         1976-3373
            3802-3966           AW547465.2         1-165               c
FEATURES             Location/Qualifiers
     source          1..3966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.03 cM"
     gene            1..3966
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /note="eukaryotic translation initiation factor 5"
                     /db_xref="GeneID:217869"
                     /db_xref="MGI:MGI:95309"
     exon            1..139
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            140..333
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            334..613
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1831
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /note="eIF-5"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 5"
                     /protein_id="NP_775539.1"
                     /db_xref="CCDS:CCDS26180.1"
                     /db_xref="GeneID:217869"
                     /db_xref="MGI:MGI:95309"
                     /translation="MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAK
                     ALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPEC
                     ENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEK
                     KNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEIS
                     DHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKEIVAEAERLDVKAMGPL
                     VLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHI
                     LKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEE
                     EDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI"
     exon            614..695
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            696..868
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            869..980
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1120
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1279
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1441
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1606
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1741
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..3966
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /note="hexamer: ATTAAA"
     regulatory      3799..3804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /note="hexamer: ATTAAA"
     polyA_site      3804
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /note="major polyA site"
     regulatory      3822..3827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
                     /note="hexamer: ATTAAA"
     polyA_site      3829
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
     polyA_site      3878
                     /gene="Eif5"
                     /gene_synonym="2810011H21Rik; D12Ertd549e"
ORIGIN      
        1 gcgagccaat gacaagagaa gttgggaggg cctgcggcca ataagcggtg gctgcccggt
       61 acaaggggcg ggctccgggg ccgagggtag cttgagcgcg gcggcggcgt tgttcagtca
      121 gagcgagaac attccagagg tcgccaggct cggcgctgct ggtgtggacg cggacgtcgc
      181 tgggacagtc cctcccgctg ctcggcggcg gcacctgccc agccgcccct ccgctcgccg
      241 ccggccccgc cgctccggac ccggtttcca gcgcctcttc ctcccagtcc cgggcgagcc
      301 gcgttgggtt tatgtcttta tttgacgaaa acgagctgtt gcgcagccat tggtacctgt
      361 attggggaaa catagcatac aagcaagaag cttacagcct cagtggcgaa aattttttca
      421 tgtcagagac cgagaactct tgcagtcgtt tatgtcatcc cttcttctcc agacagaaga
      481 taccaaaaag ttgcaatcaa agatctcttc atcttattga taaagtcact aataagccaa
      541 aatgtctgtc aacgtcaacc gcagcgtgtc agaccagttc tatcgctaca agatgccccg
      601 tttgattgct aaggttgagg gcaaaggaaa tggaatcaag acagttatag tcaacatggt
      661 tgacgttgca aaggcgctta atcggcctcc aacgtatccc accaaatatt ttggttgtga
      721 gctgggagca cagacccagt ttgatgttaa gaatgaccgt tacattgtca atggatctca
      781 tgaggcgaat aagctgcaag acatgttgga tggattcatt aaaaaatttg ttctctgtcc
      841 tgagtgtgag aatcctgaaa cagatctgca tgtcaatcca aagaagcaaa caataggtaa
      901 ttcttgtaaa gcctgtgggt accgaggcat gcttgacaca catcataaac tctgtacatt
      961 cattctcaaa aacccacctg agaatagtga cattggtaca ggaaagaaag aaaaggaaaa
     1021 gaaaaataga aagggcaagg acaaggaaaa tggctctgta tctaccagtg agacaccacc
     1081 acctccacca ccaaatgaaa ttagtcctcc acatgctgtg gaagaagagg aagatgatga
     1141 ttggggggag gatacaactg aggaagctca aaggcgcaga atggatgaaa tcagtgacca
     1201 tgcaaaaggt ctgacactta gtgatgattt ggaaagaact gtagaagagc gtgttaacat
     1261 cctgtttgat tttgttaaga aaaagaaaga agagggcatt attgattcat ctgataaaga
     1321 aattgtggct gaggcagaaa gactggatgt aaaagccatg ggtcctcttg ttttgacaga
     1381 agttctcttt gatgagaaga taagagagca aatcaagaaa tacaggcgcc attttctaag
     1441 attttgtcat aacaacaaaa aggctcagcg gtaccttctt catggtttgg aatgtgtggt
     1501 agcaatgcat caagctcagc tgatctccaa gatcccacac atcctgaagg agatgtatga
     1561 tgccgacctg ttagaggagg aggtcattat cagctggtca gaaaaggcct ctaagaaata
     1621 tgtctcaaaa gaacttgcca aagagattcg tgtcaaagca gagccattta ttaaatggtt
     1681 gaaggaagca gaggaagaat cttctggtgg tgaggaagaa gatgaagacg aaaatattga
     1741 ggtcgtatat tcgaaaactg ccagtgtacc aaaagttgaa actgtgaagt ctgacaacaa
     1801 ggatgatgac attgatattg acgccattta aaagaatgga tgcaacttag cttaacagtg
     1861 taatgctgca aatttttctc cattatcagc cagaagtgca acatgtatgt gcaagagcta
     1921 aagtggctta acatcatgct acacttgata ctaaaaagct attactgtga gtggtctata
     1981 attaagccca atgagacatc tagggagtcc atacatatca gtgagcagtt gtagtttgct
     2041 tatttatagc atgtttcttt cggaaaaacc tagtggtgga cacatttgga tcacatttat
     2101 acagttataa aaaataaaga tttgattttg gtcattcttc agactttggg ctatgaatgg
     2161 cttatactga agtaattggc tacttttagg atgttacacc atttaattta ggctccttga
     2221 gtttgatggg ttgttaggaa ctgaaaactt gaagaatgca aacaaatata atgaacttac
     2281 tcagccatta agaaatgaag tattttgaaa gttgtatctc cagtcccagt ccattcagat
     2341 tggcaactga caattcttgt cattctaagg aaattggtga ttaaatgaca gtgtgacatc
     2401 ctcgtaagaa gtaaaaatga cctgtgtgtc ctatggttta agagcaaatt ttaaaacttg
     2461 gaagttgtgg ttttccagtt tgtgtacact cacccccaaa ttgtagtctt tcaagtcgtg
     2521 tgcattgcac gttggataag ccagggaaat tgttaacaaa taagtatttt gtgtgtgttt
     2581 agtggttgct ttgtattgag agaaaagctt tgaggtgtga ttaaatcgta agctctgatt
     2641 ctatttggga gaaacaggaa aaaaggtgca cttaatctct agctaaaaca gcgtaatttt
     2701 tcaactttta cccttaaatt ataatttcaa gatgtttaga catactgtat cttgtgtttg
     2761 tgtaccccct ccccaatatt atggtttatt ctttaatgcc ttttaatttg gatataatag
     2821 cttgtacttt agattttggt tgctatcttg ccaaaataag tgttactgtt tttcaagctt
     2881 gacccccttc cccaattgtc ttatttaaag agaaagttaa actcatactt ctgagtcaga
     2941 gcctgtattt tggtgtaaga cttgggatat tttttacttc acattgaata tagctggata
     3001 cctgagagac tgatggccac tgggtgggtg cagctagcta aggcctgacc agcccattca
     3061 gagccttgga cttcagacac aaaagtgagt tcttacacac ttgctggtgt aagctctatc
     3121 tggggtcctg actatatttg aaaacttgtc ttcaatatta aaaacagcac atatttcttt
     3181 ctacaaaagt gcattctggg agttaaaaat ccatgtggtt aatttgtgtg tggcgtgcta
     3241 gctcatacat tatttgaatt tcattctttg tgtcatccat ctcacagatt attagacttt
     3301 aataaacaat gtaaaaaatt gtgcattaaa atcatacaaa tatttagtaa aattagaact
     3361 ttaataagag tttgagtgtg gagcaggagc catacacctg gaatggtaac aagggaatgt
     3421 gctgtgtcac accaaagatg tggtacttgg aaagtcactt gtctcctggg tttcagattc
     3481 tttgttgcat ggtccgccca tctccatttg tcatcatttt ttgagattct caagtacatc
     3541 agcacattcg gcctcaggtt ggcaagattt ttgtcttaga gctgttgctt taaagggaaa
     3601 cggtcaggtc ttagacactt aggaaggtct tgggcttctg ttcattctgg tgccaaacca
     3661 gtgggattca aatttcacac aatctgggtt ttactcatgg aggttaacct gataggaata
     3721 atccttcgtt gctctattga ggtgtcataa agtttcctgt ttcaaacagc tacattactt
     3781 gattaaaaca atgttaaaat taaatttctg tctgctttaa tattaaaaag tatgttttca
     3841 ttttactgta agtaaaaagc actgaatgct gtccaggatt atagctcatg ctttgaattt
     3901 aaatgttggg tactctggag aagtatgtca gccctatgca tgaaaacatg ttggtaattt
     3961 cattgg
//
