LOCUS       NM_033561               2503 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus eukaryotic translation initiation factor 4H (Eif4h),
            transcript variant 1, mRNA.
ACCESSION   NM_033561
VERSION     NM_033561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Godoy-Corchuelo,J.M., Ali,Z., Brito Armas,J.M., Martins-Bach,A.B.,
            Garcia-Toledo,I., Fernandez-Beltran,L.C., Lopez-Carbonero,J.I.,
            Bascunana,P., Spring,S., Jimenez-Coca,I., Munoz de Bustillo
            Alfaro,R.A., Sanchez-Barrena,M.J., Nair,R.R., Nieman,B.J.,
            Lerch,J.P., Miller,K.L., Ozdinler,H.P., Fisher,E.M.C.,
            Cunningham,T.J., Acevedo-Arozena,A. and Corrochano,S.
  TITLE     TDP-43-M323K causes abnormal brain development and progressive
            cognitive and motor deficits associated with mislocalised and
            increased levels of TDP-43
  JOURNAL   Neurobiol Dis 193, 106437 (2024)
   PUBMED   38367882
  REMARK    Erratum:[Neurobiol Dis. 2024 Nov;202:106708. doi:
            10.1016/j.nbd.2024.106708.. PMID: 39462744]
REFERENCE   3  (bases 1 to 2503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2503)
  AUTHORS   Screen,M., Matheson,L.S., Howden,A.J., Strathdee,D., Willis,A.E.,
            Bushell,M., Sansom,O. and Turner,M.
  TITLE     RNA helicase EIF4A1-mediated translation is essential for the GC
            response
  JOURNAL   Life Sci Alliance 7 (2), e202302301 (2023)
   PUBMED   38011999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2503)
  AUTHORS   Fratta,P., Sivakumar,P., Humphrey,J., Lo,K., Ricketts,T.,
            Oliveira,H., Brito-Armas,J.M., Kalmar,B., Ule,A., Yu,Y., Birsa,N.,
            Bodo,C., Collins,T., Conicella,A.E., Mejia Maza,A.,
            Marrero-Gagliardi,A., Stewart,M., Mianne,J., Corrochano,S.,
            Emmett,W., Codner,G., Groves,M., Fukumura,R., Gondo,Y., Lythgoe,M.,
            Pauws,E., Peskett,E., Stanier,P., Teboul,L., Hallegger,M.,
            Calvo,A., Chio,A., Isaacs,A.M., Fawzi,N.L., Wang,E., Housman,D.E.,
            Baralle,F., Greensmith,L., Buratti,E., Plagnol,V., Fisher,E.M. and
            Acevedo-Arozena,A.
  TITLE     Mice with endogenous TDP-43 mutations exhibit gain of splicing
            function and characteristics of amyotrophic lateral sclerosis
  JOURNAL   EMBO J 37 (11) (2018)
   PUBMED   29764981
REFERENCE   6  (bases 1 to 2503)
  AUTHORS   Valero,M.C., de Luis,O., Cruces,J. and Perez Jurado,L.A.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   7  (bases 1 to 2503)
  AUTHORS   Martindale,D.W., Wilson,M.D., Wang,D., Burke,R.D., Chen,X.,
            Duronio,V. and Koop,B.F.
  TITLE     Comparative genomic sequence analysis of the Williams syndrome
            region (LIMK1-RFC2) of human chromosome 7q11.23
  JOURNAL   Mamm Genome 11 (10), 890-898 (2000)
   PUBMED   11003705
REFERENCE   8  (bases 1 to 2503)
  AUTHORS   Doyle,J.L., DeSilva,U., Miller,W. and Green,E.D.
  TITLE     Divergent human and mouse orthologs of a novel gene
            (WBSCR15/Wbscr15) reside within the genomic interval commonly
            deleted in Williams syndrome
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 285-290 (2000)
   PUBMED   11124535
REFERENCE   9  (bases 1 to 2503)
  AUTHORS   Korenberg,J.R., Chen,X.N., Devon,K.L., Noya,D., Oster-Granite,M.L.
            and Birren,B.W.
  TITLE     Mouse molecular cytogenetic resource: 157 BACs link the chromosomal
            and genetic maps
  JOURNAL   Genome Res 9 (5), 514-523 (1999)
   PUBMED   10330132
REFERENCE   10 (bases 1 to 2503)
  AUTHORS   DeSilva,U., Massa,H., Trask,B.J. and Green,E.D.
  TITLE     Comparative mapping of the region of human chromosome 7 deleted in
            williams syndrome
  JOURNAL   Genome Res 9 (5), 428-436 (1999)
   PUBMED   10330122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ158448.1, AC166938.5,
            AK045004.1 and CF750202.1.
            
            On Aug 19, 2015 this sequence version replaced NM_033561.1.
            
            Summary: This gene encodes eukaryotic translation initiation factor
            4H (eIF4H) that plays a critical role in the process of protein
            synthesis. The encoded protein is an RNA-binding protein that, in
            concert with other translation initiation factors, helps unwind the
            5' cap-proximal region of mRNA to prepare it for ribosomal
            attachment. Mice lacking the encoded protein displayed growth
            retardation with a significant reduction of body weight, a smaller
            brain volume and altered brain morphology. Behaviorally, mice
            lacking the encoded protein exhibit severe impairments of
            fear-related associative learning and memory formation. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132034.1, AK135390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CJ158448.1         2-17
            17-66               CJ158448.1         19-68
            67-67               AC166938.5         69600-69600
            68-80               CJ158448.1         70-82
            81-2487             AK045004.1         2-2408
            2488-2491           AC166938.5         89065-89068
            2492-2503           CF750202.1         234-245
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.71 cM"
     gene            1..2503
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /note="eukaryotic translation initiation factor 4H"
                     /db_xref="GeneID:22384"
                     /db_xref="MGI:MGI:1341822"
     exon            1..169
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..857
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     williams-Beuren syndrome chromosomal region 1 protein
                     homolog"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4H
                     isoform 1"
                     /protein_id="NP_291039.1"
                     /db_xref="CCDS:CCDS19723.1"
                     /db_xref="GeneID:22384"
                     /db_xref="MGI:MGI:1341822"
                     /translation="MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTA
                     YVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYD
                     GALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGGSRESRGGWDSRDDFNSGYRD
                     DFLGGRGGSRPGDRRAGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTV
                     ATPLNQVANPNSAIFGGARPREEVVQKEQE"
     exon            170..357
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..422
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..519
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..579
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..717
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..2494
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /note="hexamer: AATAAA"
     polyA_site      2490
                     /gene="Eif4h"
                     /gene_synonym="D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H;
                     Wbscr1; Wscr1"
                     /note="major polyA site"
ORIGIN      
        1 aggcagcgcg gcggacagcc ccggtagcgg ggcgggcggg gggaggagga gttatattgc
       61 ggggtccttc ctcgctggcc cgctggttcc tcaaggagcg gagacggcaa atggcggact
      121 tcgataccta cgacgatcgg gcctacagca gcttcggcgg cggtagaggg tcccgaggca
      181 gtgctggtgg ccatgggtcc cggagccaga aggagctacc cacagagccc ccctacacag
      241 cttacgtagg aaatctccct tttaacacag ttcagggtga catagatgct atctttaagg
      301 atctcagcat acggagtgtg cggctagtca gagacaaaga cacagacaaa tttaaagggt
      361 tctgctatgt agaatttgat gaggtggatt ccctgaagga ggctctgact tatgacggtg
      421 cactcttggg tgaccggtca cttcgtgtgg acattgcaga aggcagaaaa caagataaag
      481 gtggctttgg attcaggaaa ggtggacctg atgacagagg aatgggtggc tctcgagaat
      541 ctagaggtgg atgggattcc cgggatgact tcaactctgg ctacagggat gacttcttag
      601 ggggtagggg gggcagtcgc cctggggacc ggcgagcagg ccctccaatg gggagtcgct
      661 ttcgagatgg ccctcctctg cgtggctcca acatggactt cagagaaccc acagaagagg
      721 aacgagcaca gagacctcgg ctgcagctta aacctcggac agtggcaacg cccctcaatc
      781 aagtagccaa ccccaactca gccatctttg ggggagccag gcccagagag gaagtggttc
      841 agaaggagca agaatgagct taggttggga gggaatgggg cgtgggggag ctggagcaag
      901 accacggcct ggtggcagcc ggtcgcccta caggccccat tcccgcctgg cactgtcctc
      961 cttacagcgg aaacacagag cttgtgagtg catgtcagct gttaacaagt ggtttctagt
     1021 acattcttgg ctttgctata tctatctagt gcctgttttg tgctttcttt ctgttttctt
     1081 tctctcccct ctcactcctg ccctctcccc gcccttccca cgtggtgtgg atgttggtca
     1141 cgtgtggaag gtgggctgag gtgcttcatc ctttgctttc tttctttcct ttacacgccc
     1201 tggccacact ccgggcgtgc tgtcctctgc tttttctcag agcttctctc caacctgcat
     1261 gtcgagttct gtgttgctgt ggcttctggg aaagagctag agccactagc taggtggctg
     1321 gtggtgactt gttggtgtcc agctgggatg agcatgcaga attgatgcac cttggggtag
     1381 aacaaagaaa ctgcctgctg ctcctgagag gctgctgtgt ttggggtcta tcacccgccc
     1441 cagcagcctg atcagccgta gcaggctcct gtcagacagt gaggccagat gggtgcaggg
     1501 gagtctggac cttctgcact ggtggcgacc tgggtggcag tggccatgtg gctttgctcc
     1561 tgctcgctct taagaccaag tggaagctca ttccctgctc ttcctgggcc atggaggccg
     1621 cttgggggtg caacccgctg cagctcaatc cgcttcctgc agctgaggcc tgtaggaagc
     1681 aggggtggtg ctggagctgc accgggcagc tgtgctttgc actgagtctg cgctctttcc
     1741 cttgtgtctg tctgatccag ggcgcttagc ccaagaggct gctcgccacc acagctcaag
     1801 gcctagagtc tggcactttc tctgatcagt tacccagctg ttgagaccct cagtacctag
     1861 gtgtctagaa acctctaggt gtgctgcttc ctctgtgggg cagacccctg ctcccgcaga
     1921 cagtatggag cactcacttg agagagagca aaggggatca accaggtttg gcttttggct
     1981 tgaacagttg tgtgtgaaca atggaaaagg attggcaccc agtctccgtc tgctccaatt
     2041 ggagcagtag gggtcagcca gccactagag ccttggggaa aggggctgag aggtgtgcag
     2101 cttgcttggt agccagcagc ttcctgccag cctacccctt ggctcgggat tgtctttgtt
     2161 gcaaggtctc ggcaatttac agaactctca ctccttccct cgcctgccat cttctctgct
     2221 tctgagataa gaaccatttg tgtaacacca atacctaact taagacagac atgcattgcg
     2281 tggttgtaat caaagctgat gctttcagat gatgtaatcc atctccaatg cggaaaagac
     2341 aggcccgtcc atccacattg ctgggcaccc agctgactgt aagaatggaa ttccaaacac
     2401 ttaacacatt cagttctatg acagaaagtg agtctatgga tatggtattt tgtgaatgat
     2461 cttttaaata aaagagaacc ttacataaca cttaaaaaaa aaa
//
