LOCUS       NM_013507               7760 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4, gamma 2
            (Eif4g2), transcript variant 1, mRNA.
ACCESSION   NM_013507
VERSION     NM_013507.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7760)
  AUTHORS   Hacisuleyman,E., Hale,C.R., Noble,N., Luo,J.D., Fak,J.J., Saito,M.,
            Chen,J., Weissman,J.S. and Darnell,R.B.
  TITLE     Neuronal activity rapidly reprograms dendritic translation via
            eIF4G2:uORF binding
  JOURNAL   Nat Neurosci 27 (5), 822-835 (2024)
   PUBMED   38589584
  REMARK    GeneRIF: Neuronal activity rapidly reprograms dendritic translation
            via eIF4G2:uORF binding.
REFERENCE   2  (bases 1 to 7760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7760)
  AUTHORS   Jia,Z., Wang,Y., Gao,J., Zheng,M., Wang,P. and Zu,G.
  TITLE     miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION
            AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY
            TARGETING EIF4G2
  JOURNAL   Shock 60 (4), 594-602 (2023)
   PUBMED   37646610
  REMARK    GeneRIF: miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL
            PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER
            ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
REFERENCE   4  (bases 1 to 7760)
  AUTHORS   Kim,S.H., Choi,J.H., Marsal-Garcia,L., Amiri,M., Yanagiya,A. and
            Sonenberg,N.
  TITLE     The mRNA translation initiation factor eIF4G1 controls
            mitochondrial oxidative phosphorylation, axonal morphogenesis, and
            memory
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2300008120 (2023)
   PUBMED   37307456
REFERENCE   5  (bases 1 to 7760)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7760)
  AUTHORS   Shaughnessy,J.D. Jr., Largaespada,D.A., Tian,E., Fletcher,C.F.,
            Cho,B.C., Vyas,P., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mrvi1, a common MRV integration site in BXH2 myeloid leukemias,
            encodes a protein with homology to a lymphoid-restricted membrane
            protein Jaw1
  JOURNAL   Oncogene 18 (12), 2069-2084 (1999)
   PUBMED   10321731
REFERENCE   7  (bases 1 to 7760)
  AUTHORS   Levy-Strumpf,N. and Kimchi,A.
  TITLE     Death associated proteins (DAPs): from gene identification to the
            analysis of their apoptotic and tumor suppressive functions
  JOURNAL   Oncogene 17 (25), 3331-3340 (1998)
   PUBMED   9916995
  REMARK    Review article
REFERENCE   8  (bases 1 to 7760)
  AUTHORS   Imataka,H., Olsen,H.S. and Sonenberg,N.
  TITLE     A new translational regulator with homology to eukaryotic
            translation initiation factor 4G
  JOURNAL   EMBO J 16 (4), 817-825 (1997)
   PUBMED   9049310
  REMARK    GeneRIF: in vitro and in vivo studies in human show that
            translation starts at a non-AUG (GUG) codon. Suggest the same in
            mouse based on sequence conservation.
REFERENCE   9  (bases 1 to 7760)
  AUTHORS   Yamanaka,S., Poksay,K.S., Arnold,K.S. and Innerarity,T.L.
  TITLE     A novel translational repressor mRNA is edited extensively in
            livers containing tumors caused by the transgene expression of the
            apoB mRNA-editing enzyme
  JOURNAL   Genes Dev 11 (3), 321-333 (1997)
   PUBMED   9030685
REFERENCE   10 (bases 1 to 7760)
  AUTHORS   Shaughnessy,J.D. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     cDNA cloning, expression analysis, and chromosomal localization of
            a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G
  JOURNAL   Genomics 39 (2), 192-197 (1997)
   PUBMED   9027506
  REMARK    GeneRIF: translation starts at a non-AUG translation initiation
            codon (GUG).
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI874618.1, BC043034.1 and
            AC150312.2.
            
            On Jul 24, 2006 this sequence version replaced NM_013507.2.
            
            Summary: Translation initiation is mediated by specific recognition
            of the cap structure by eukaryotic translation initiation factor 4F
            (eIF4F), which is a cap binding protein complex that consists of
            three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this
            gene shares similarity with the C-terminal region of eIF4G, that
            contains the binding sites for eIF4A and eIF3; eIF4G in addition,
            contains a binding site for eIF4E at the N-terminus. Unlike eIF4G
            which supports cap-dependent and independent translation, this gene
            product functions as a general repressor of translation by forming
            translationally inactive complexes. Transgene expression of the
            apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive
            editing of this mRNA, which could contribute to the potent
            oncogenesis induced by overexpression of APOBEC-1. In vitro and in
            vivo studies in human indicate that translation of this mRNA
            initiates exclusively at a non-AUG (GUG) codon. This also appears
            to be true for mouse. Two alternatively spliced transcript variants
            that encode different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127064.1, SRR1660811.246826.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 9027506, 9049310
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AI874618.1         1-320
            321-3813            BC043034.1         1-3493
            3814-7760           AC150312.2         99630-103576        c
FEATURES             Location/Qualifiers
     source          1..7760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.0 cM"
     gene            1..7760
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /note="eukaryotic translation initiation factor 4, gamma
                     2"
                     /db_xref="GeneID:13690"
                     /db_xref="MGI:MGI:109207"
     exon            1..246
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            247..373
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..3053
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /exception="alternative start codon"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (GUG) translation initiation codon; translation
                     repressor Nat1; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; novel
                     APOBEC-1 target 1"
                     /codon_start=1
                     /transl_except=(pos:333..335,aa:Met)
                     /product="eukaryotic translation initiation factor 4 gamma
                     2 isoform 1"
                     /protein_id="NP_038535.2"
                     /db_xref="CCDS:CCDS40088.1"
                     /db_xref="GeneID:13690"
                     /db_xref="MGI:MGI:109207"
                     /translation="MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPG
                     QNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLN
                     VGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQS
                     TTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELG
                     KLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQ
                     YFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDL
                     GVFIPAPMAQGRNDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDR
                     FSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQ
                     GQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTP
                     PLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEAVVTDYLNSGNANDAVSG
                     VREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNV
                     LEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAK
                     LQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQI
                     KLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAPSK
                     EQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYD
                     MEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD"
     exon            374..439
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            440..580
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            581..683
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            684..815
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            816..882
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1034
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1145
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1229
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1328
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1467
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1628
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1742
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1868
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1973
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2189
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2448
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2653
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2865
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2987
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..7760
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3793..3798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /note="hexamer: AATAAA"
     polyA_site      3813
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /note="major polyA site"
     regulatory      4997..5002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /note="hexamer: AATAAA"
     polyA_site      5016
                     /gene="Eif4g2"
                     /gene_synonym="DAP-5; E130105L11Rik; Nat1; Natm1; p97"
                     /note="major polyA site"
ORIGIN      
        1 gttgggcttc agacacgcct cagcgccagc agcgagccgg agctctatgg aggtggcggc
       61 gggtaccagg tggcggctgc agcagctact cctctgagct gagactttca agccggccgc
      121 gtctccttcc tcccccttcc ctcccccttt tttgttttcc gttccccttc cccctccctt
      181 ccccgtcccc gacgaccgga tccagaggag gcagctgcgg tggcagctgc tgagttctcg
      241 gtgaaggctt ttcatttcta ccatcccctc ccctccccac cccatccatt aatattattc
      301 ttttgaagat tcttcgttgt caagccgcca aagtggagag tgcgattgca gaagggggtg
      361 cttctcgttt cagtgcttct tcgggcggag gaggaagtag gggtgcacct cagcactatc
      421 ccaagactgc tggcaacagc gagttcctgg ggaaaacccc agggcaaaac gctcagaaat
      481 ggattcctgc acgaagcact agacgagatg acaactccgc agcaaacaac tccgcaaatg
      541 aaaaagaacg acatgatgca atcttcagga aagtaagagg catactaaat aagcttactc
      601 ctgaaaagtt tgacaagcta tgccttgagc tcctcaatgt gggtgtagag tctaaactca
      661 tccttaaagg ggtcatactg ctgattgtgg acaaagcctt agaagagcca aagtatagct
      721 cgctgtatgc tcagctatgt ctgcgattgg cagaagatgc accaaacttt gatggcccag
      781 cagcagaggg tcaaccagga cagaagcaaa gcacaacatt cagacgcctc ttgatttcca
      841 aattgcaaga tgaatttgaa aaccgaacca gaaatgttga tgtctatgat aagcgtgaaa
      901 atcccctcct tcctgaggag gaggaacaga gagccattgc taagatcaag atgttgggga
      961 acatcaaatt cattggagaa cttggcaagc ttgatcttat tcatgaatct atccttcata
     1021 agtgcatcaa aacacttttg gaaaagaaga agagagtcca actcaaagat atgggagagg
     1081 atttggagtg cctctgtcag ataatgagga cagtgggacc tcgattagac catgaacgag
     1141 ccaagtcctt aatggatcag tactttgcca gaatgtgttc cttaatgtta agtaaggaat
     1201 tgccagccag gattcgtttc ctactgcagg atactgtaga gttgcgagag caccattggg
     1261 ttcctcgcaa ggcttttctt gacaatggac caaagacgat caatcaaatc cgtcaagatg
     1321 cagtaaaaga tctaggagtg tttattcctg ctcctatggc tcaagggagg aatgacttct
     1381 tcctggaggg accgttcatg ccgccaagga tgaaaatgga tagggaccca cttgggggac
     1441 ttgctgatat gtttggacaa atgccaggta gtggaattgg tactggtcca ggagttatcc
     1501 aggatagatt ttcacccaca atgggacgtc atcgttcaaa tcagctcttc aatggccatg
     1561 gggggcacat catgcctccc acgcaatcgc agtttggaga gatggggggc aagtttatga
     1621 aaagccaggg gctaagccag ctctaccata accagagtca gggactctta tcccagctac
     1681 aaggacagtc gaaggatatg ccacctcggt tttctaagaa aggacagctt aatgcagatg
     1741 agattagttt gaggcctgct cagtcgtttc taatgaataa aaatcaggtg ccaaagcttc
     1801 agccccagat aactatgatt cctcccagtg cacagccacc acgcactcaa acaccgcctc
     1861 tgggacagac acctcaactt ggtctcaaaa ctaatccacc acttatccag gaaaagcctg
     1921 ccaagactag caaaaagcca ccaccatcaa aggaagaact acttaaactg accgaagccg
     1981 ttgtgactga ctatctgaac agtggaaatg ccaacgacgc tgtcagtggt gtgagagaaa
     2041 tgagagctcc aaaacacttt cttcctgaga tgctaagcaa agtgatcatc ctgtcacttg
     2101 atagaagtga tgaagataaa gaaaaagcaa gctctttaat cagtttactc aaacaggaag
     2161 ggatagccac aagtgacaac ttcatgcagg ctttcctgaa tgtattggag cagtgcccca
     2221 aactggaggt tgacatcccc ttggtgaaat cttacttggc acagtttgca gctcgtgcta
     2281 taatttcaga gttggtgagc atttccgaac tagctcaacc actggagagt ggcacccact
     2341 tccctctctt cttactttgt cttcaacaat tagctaaatt gcaagaccga gagtggttaa
     2401 ccgaactttt tcaacaaagc aaggtcaata tgcagaaaat gctgccagaa attgatcaga
     2461 ataaggatcg aatgttggag attttggaag gaaagggact gagtttctta ttcccactcc
     2521 ttaaattgga gaaggaacta ttgaagcaaa ttaagctgga tccatcccct caaactatat
     2581 ataaatggat taaagataac atctctccca aacttcatgt agataaagga ttcgtgaaca
     2641 tcttaatgac cagcttctta cagtacattt ctagtgaagt aagcccaccc agcgatgaaa
     2701 cagattcttc ctctgctcct tccaaagagc agttagagca ggaaaaacag ctgctgctct
     2761 cttttaagcc agtgatgcag aaatttcttc atgatcatgt ggatctacag gtcagtgccc
     2821 tgtatgcttt gcaggtgcac tgttacaaca gcagcttccc aaaaggcatg ttacttcgat
     2881 tttttgttca cttctatgac atggaaatta ttgaagagga agctttctta gcttggaagg
     2941 aagacataac tcaagagttt ccaggaaaag gcaaggcttt gttccaggtg aatcagtggc
     3001 taacctggct agaaactgct gaagaagaag aatcagagga agaagctgac taaagaacca
     3061 gccaaagcct taaattgtgc aaaacatact gttgctatga tgtaactgca tttgacctaa
     3121 ccactgcgaa aattcattcc gctgtaacgt tttttcacaa tatttaaagc agaagcacgt
     3181 cagtaaggtt tccttctgca taaggttttt gtagtgtgat gtcttaatca tagtctacca
     3241 tcaaatactt taggagtatc cttaatgttt agatagaata ttagcagcat gcaataatta
     3301 catcctaagt tctcaagcag aggcagtcta ttgcaaggac cttctttgct gccagttacc
     3361 ataggctgtt ttaagttaga aaactgaata gcaacactga atactgtaga gatgcacttt
     3421 gctcagtaat acttgagttg ttgcaatatt tgattatcca tttggttgtt acagaaaaat
     3481 tcttaactgt aattgatggt tgttgccgta atagtatatt gcctgtattt ctacctctag
     3541 taatgggctt tatgtgctag attttaaaat ccttgagcct gggcaagtgc acaagtcttt
     3601 ttaaaagaaa catggtttac ttgcacaaaa ctgatcagtt tgagagatca ttaatgccct
     3661 tgaagtggtt tttgtgggtg tgaaacaaat ggtgagaatt tgaattggtc cctcttatta
     3721 tagtattgaa attaagtcta cttaatttat caagtcatgt tcatgccctg attttatata
     3781 cttgtatcta tcaataaaca ttgtgatact tgatgtagtt gtacatgact tcaaatagta
     3841 tctgcaaagt aatgaagaat tcatttggtt ttgaggtatg gatttatctc cgtttaagaa
     3901 cttgggaaat ttttaatttc atagtcttaa ttagtagtga ttgagcctat aacacccctt
     3961 aattcaagca ttaatttttt ttcacctcag aactattccc tatcaatcta atgcaaactg
     4021 tcaacttaat ctgaccttta ctattacaga ccttgtgtca actctttggc tctgctttct
     4081 aagcacctaa ggaataagct tgtctcatcc accaacctct gctgagatac ctgtttagcc
     4141 cttgatctcc atttgttctt tgcagcgaaa caaccagaac aagaaactga aaaacaaaac
     4201 tgctgcatgg tttagaaccc agcagacttt taagtcatcc taaaattggc tccctcttgc
     4261 tgcttttcat ttttcttgcc cttgcgtatt cagttacttt acctggaata atcagtggtc
     4321 ccctcaccct ttaaccttca ggtgtgatat aaatgtcaaa gaactggcct ttctctgctg
     4381 ggacagtgag aatgtttgtg tcaaagtctg ctgcaaaaga aaaaattgta ttttggcatg
     4441 gaatccagag aacagtagac cacagaaata gactgggtgg tcaagtcctg tgtccctgtc
     4501 aaatatctgt tctcagatgt ccccagctcc actggtgacc agagtaggaa cagataaact
     4561 cttgctgcct cccagcagaa ccgtagtctg ctttggcggc tcttgttttg aagatttgca
     4621 gtagagtaga agaaactggg aagagttgaa gtggatagct gaggaggccc atcccacatc
     4681 tcagcctagt tttagtccac tatccattta ccccacccct tggtgaaagc agatctccaa
     4741 ggagaataat gtagatgtgt cttcagccac tgctgagtag gatgataaat ttcagttttg
     4801 tgagcttcaa tcttaagaga attgcagtaa tagaaattaa gagcaattca aaattaggtt
     4861 taggatctaa aatgttctgg ataaaagatt gtctttgaat ctgaagcttg attgactgca
     4921 tgataactga gttagggcta acagaactaa ctgaaatgat ctgtgtatac cccactcact
     4981 agaaaaacta gtaatgaata aatgcttgga tagtgacctg ggttttttct tcatttgtta
     5041 caccacgtga tcctagcatt gcattgcaca atgcctccaa cccattattt ggccttcaca
     5101 gtgtggtggt tgtaatgttt tgtatgtaat atatatgata tactatcttc tatattaaat
     5161 aattactata taactttacg cacattgaaa actgagtacc ttgaaagcag tctctaagac
     5221 tgactgactg ctcatggcat gggtaaactc caaatccttg aggtgggtgt tgtggatcag
     5281 ctgtagctct caatgttaag gtaaaccagg atattacaaa gctcttaccc caccttgtct
     5341 tagagacagc ctgacaagag tcctggtcaa gaaatagcat aatagcactg aagtcatatg
     5401 tatggacttc acttttcacc cctacattac ttggaactgg gtcagaaaaa caggacaaaa
     5461 agccatccgc cctccaagag tgttcctaga actctgctag accccagcct cctgattgga
     5521 cattggtaga caagatataa ggatctttgt ccttcatcca aaaagacttg aaggagcgat
     5581 aagtgagaat tttgccccac ggactgaagg attcaatatg gctcagaagt agtgacacct
     5641 taagggccgc cgaacaaaca tctggaatac attctagtca acaggaacat ttacttacag
     5701 gtagcaaaaa gtaaggataa gggaggagag ccatgtgagc gctacttaca acagggtgtt
     5761 gagaatccca tgtttggggg agatgaattt caggagggaa tcaagcctac atacaggaag
     5821 aaccttcaga caagggagct aaaaccacag gccctgaaat acagatggat gttaaacaag
     5881 gtcaggatgg tccagcagag aaaggtggtc tgaagcagga gagcgatgga atcgttggta
     5941 gaaccaatcc aactattcaa agtgaaacgg gctgtgctca gagagttatc agggatacta
     6001 ttcactaaat gcaaaatttg gttattctag tcaacatagc caacactgag catttagtat
     6061 gtcagatcag agtagacata ctatgattca tcccatctaa tctcaggtac tatgctctct
     6121 ttaatttact gatgaacctg agacttggat aagtcatata ccttgtacaa gatgtttaca
     6181 aagttcccaa accagaggct cttaaagtgg cacatgcaat gaaatcttgc attgtgattc
     6241 aagttactgc ttcctctatt cagtctgagt acttccccag ctcaaggatg atgccaccac
     6301 tttcaagtgg gtcttcagtt tacttattta caaatttaat caagttggca aggaaggtta
     6361 actatcacat ccagagaaac ttcatgcctg tggaatgaac ccccccccac tttttttttt
     6421 ttttttttaa tattttatgt gtatgagcac accattgctc tcttcagaca caccagaaga
     6481 aggcatcaga ccccattaca gatgattgtg agccaccatg tggttgctgg gaattgaact
     6541 caggacctct gggagagcag tcagtgctct taaaccactg agccatcctc cagcccaagc
     6601 cctttctaag attctgtaag gtgtatgtga aggggaggtg gggcaaggta tggagactgt
     6661 ttttttcaga agtccattct cttccatggt atttatgagg aaggagctct cttgttctac
     6721 agcacagcaa tatgagtttc tgtctgattc tcctgtctcc actttccatc tcattgtagg
     6781 agtgctggaa ttacagacat gagacaccac agctggcttt taaaactggt tcttggaatt
     6841 cagatcatct ggcttgagca gtgagtgcca tgctaccagc cccctttcta ttttcccttt
     6901 ttctgtacct ggtcctatca catgtgacta tatactggtt aagcactcct gtgtaacttt
     6961 tactagaatg gaaatgatgt gaacaaatgt ctattcaccc cagagagaac ctggatgact
     7021 gacaaaattt tatccaagtc tagtttattg ggatttcttt ttaatgactt acttatttga
     7081 tgtatatgag gatattgtca ctgtactcag acacaccaga agaggtatcc gatcccattg
     7141 ttaaggttgt gagtcaccat gtggttgctg ggaattgaac tccggacctc tggaagagta
     7201 gtcagtgctc ttaaaccact gagccatctc tccaagctta ttggggtttc ttaacagaag
     7261 aatggatgaa gaggtttcca gcacttgtct ctctctgctt cctgatcgtg agtactatgt
     7321 gacctcacac tgctgtcatc atggcttccc taccatcatg ggctacatgc tcttgaactg
     7381 tatcccaaaa taaatccttc cctccataaa tagcttatta gctattttgg tctccttaac
     7441 aaaagttact ggtggcttga atgggcagtg tcccctgtac acgtacatgt atctgcatac
     7501 ttggtctccc agttgattgt actatttgga gaggttagga gaggttagga aacctctaga
     7561 aagtggatcc ttgctggggg taattatatc actggggtag ggggcaggac ttgaaggctt
     7621 ataggctcac ccactgtttc ctatgtgcag cagaaattac atcagccagc tccctgctct
     7681 ggccactgac tgctgccatt tcttcctcac ccatatggac tcctctacaa ccataagcca
     7741 aaataaactc ttgaacattg
//
