LOCUS       NM_023743               3709 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E nuclear
            import factor 1 (Eif4enif1), transcript variant 1, mRNA.
ACCESSION   NM_023743
VERSION     NM_023743.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3709)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3709)
  AUTHORS   Ding,Y., He,Z., Sha,Y., Kee,K. and Li,L.
  TITLE     Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics
            and leads to subfertility
  JOURNAL   Development 150 (23) (2023)
   PUBMED   38088064
  REMARK    GeneRIF: Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial
            dynamics and leads to subfertility.
REFERENCE   3  (bases 1 to 3709)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   4  (bases 1 to 3709)
  AUTHORS   Kolaj,A., Zahr,S.K., Wang,B.S., Krawec,T., Kazan,H., Yang,G.,
            Kaplan,D.R. and Miller,F.D.
  TITLE     The P-body protein 4E-T represses translation to regulate the
            balance between cell genesis and establishment of the postnatal NSC
            pool
  JOURNAL   Cell Rep 42 (3), 112242 (2023)
   PUBMED   36924490
REFERENCE   5  (bases 1 to 3709)
  AUTHORS   Kim,J., Muraoka,M., Okada,H., Toyoda,A., Ajima,R. and Saga,Y.
  TITLE     The RNA helicase DDX6 controls early mouse embryogenesis by
            repressing aberrant inhibition of BMP signaling through
            miRNA-mediated gene silencing
  JOURNAL   PLoS Genet 18 (10), e1009967 (2022)
   PUBMED   36197846
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3709)
  AUTHORS   Park,C.S., Rehrauer,H. and Mansuy,I.M.
  TITLE     Genome-wide analysis of H4K5 acetylation associated with fear
            memory in mice
  JOURNAL   BMC Genomics 14, 539 (2013)
   PUBMED   23927422
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3709)
  AUTHORS   Villaescusa,J.C., Allard,P., Carminati,E., Kontogiannea,M.,
            Talarico,D., Blasi,F., Farookhi,R. and Verrotti,A.C.
  TITLE     Clast4, the murine homologue of human eIF4E-Transporter, is highly
            expressed in developing oocytes and post-translationally modified
            at meiotic maturation
  JOURNAL   Gene 367, 101-109 (2006)
   PUBMED   16343815
REFERENCE   8  (bases 1 to 3709)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 3709)
  AUTHORS   Warner,D.R., Roberts,E.A., Greene,R.M. and Pisano,M.M.
  TITLE     Identification of novel Smad binding proteins
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1185-1190 (2003)
   PUBMED   14651998
REFERENCE   10 (bases 1 to 3709)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671968.17 and BC033410.1.
            
            On Oct 28, 2009 this sequence version replaced NM_023743.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 both encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033410.1, AB031388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AL671968.17        68791-68955
            166-3709            BC033410.1         1-3544
FEATURES             Location/Qualifiers
     source          1..3709
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.24 cM"
     gene            1..3709
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /note="eukaryotic translation initiation factor 4E nuclear
                     import factor 1"
                     /db_xref="GeneID:74203"
                     /db_xref="MGI:MGI:1921453"
     exon            1..215
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            216..336
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..3195
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /note="isoform a is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 4E transporter;
                     4E-T; eIF4E transporter; CD40 ligand-activated specific
                     transcript 4"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E
                     transporter isoform a"
                     /protein_id="NP_076232.2"
                     /db_xref="CCDS:CCDS24354.1"
                     /db_xref="GeneID:74203"
                     /db_xref="MGI:MGI:1921453"
                     /translation="MEKSVAETENGDAFLELKKLPTSKSPHRYTKEELLDIKERPYSK
                     QRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKESESDRPSLVRRIADPRE
                     RVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRII
                     SARAFEKDHRLSDKDLRDLRDRDRERDYKDKRFRREFGDSKRVFGERRRNDSYTEEEP
                     EWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEV
                     EVILAQEPSADQEVPRDVILPEQSPGEFDFNEFFNLDKVPCLASMIEDVLGEGSVSAS
                     RFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAVLSPGQNSGNYFAPIPSEDHAE
                     NKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQM
                     KNSTPFMAEHLEETLSAASSNRQLKKDGDMTAFNKLVNTMKASGTLPTQPKVSRNVES
                     HLLAPAEIPGQPVSKNILQELLGQPVQRPASSNLLSGLMGSLEATASLLSQRAPSPPM
                     SQVFRTQAASADYLHPRIPSPIGFPSGPQQLLGDPFQGMRKPMSPVSAQMSQLELQQA
                     ALEGLALPHDLAVQTAPFYQPGFSKPQVDRTRDGLRNRQQRMSKSPAPMHGGNSSSPA
                     PAASITSMLSPSFTPTSVIRKMYESREKTKEEMAPGMVVPGDGKEDTQKTSEENLLSS
                     NPIPNTDQDSSTTNPKLSTLQRSSCSTPLSQTSRYTKEQDYRPKTAGRKTPTLASPVP
                     GTPFLRPTHQVPLVPHVPIVRPAHQLHPGLVQRLIAQGVHPQHLPSLLQAGVLPPGID
                     MAPLQGLSGPLLGQPLYPLVSAASHPLLNPRPGTPLHLAVMQQQLQRSVLHPPGSSSQ
                     AAAISVQTPQNVPSRSGMPHMHSQLEHRTSQRSSSPVGLAKWFGSDVLQQPLPSMPTK
                     VISVDELEYRQ"
     exon            337..410
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            411..538
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            539..825
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1027
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1203
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1339
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1519
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1752
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1824
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2008
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2088
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2228
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2313
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2446
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2788
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2956
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3694
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /note="hexamer: ATTAAA"
     polyA_site      3692
                     /gene="Eif4enif1"
                     /gene_synonym="2610509L04Rik; A930019J01Rik; Clast4;
                     D11Ertd166e"
                     /note="major polyA site"
ORIGIN      
        1 tgggtccccc gcggtgcttg gcgggggggg ggggggagag ccgcgccgga gggccgggcc
       61 tcggttacgg cggctgagga gagccagccc gagcgggtgg gggggagggg ggcgcaagcg
      121 caggccgcgg ccagcgacgc cgggcctgga gcgggcgcgg ggggacgcgg cggccgaggc
      181 gcagggccgc ccggcggcgg gcgctcccag caagggtgca aaaatattgt acaccaagaa
      241 gccatggaga aaagtgtggc tgaaacagaa aatggagatg ctttccttga gctgaagaaa
      301 ctgcccacct ccaaatcccc ccatcgctat acgaaagagg agctcttgga tataaaagaa
      361 cgtccatact ccaagcagag gccatcatgc ctctctgaaa aatatgacag tgatggtgtc
      421 tgggaccctg agaagtggca tgcctctctc tacccagcct cggggcggag ctcaccagtg
      481 gaaagtctga agaaagagtc agaatccgat cgaccttctc tggtgcgcag aatagcagat
      541 ccacgagagc gagtgaaaga agatgactta gatgttgttc tcagcccaca gagacgaagc
      601 tttggaggtg gctgccatgt gacagctgct gttagctccc gacgatctgg cagtccattg
      661 gagaaagaca gtgatggact tcgcctgctt ggtggacgaa gaattggcag tggaaggata
      721 atttctgccc gggcctttga aaaggatcac cgtctcagtg ataaggacct gcgagacttg
      781 agagaccgag acagagagag ggactacaag gacaaacgtt tcaggaggga gtttggagat
      841 agtaaacgtg tctttggtga gcgtagaaga aacgattcat acactgagga agaaccagaa
      901 tggttttcag ctggacccac cagtcagtct gaaaccatag agctgactgg ctttgatgat
      961 aagattctag aggaggatca caaaggcaga aaaagaacaa ggcgacggac tgcctctgtg
     1021 aaggaaggca tagtggagtg caatggaggg gtggctgaag aggacgaggt ggaagtcatt
     1081 ctggcccagg agccctctgc tgatcaggaa gttccaaggg atgtcatcct acctgagcag
     1141 tccccaggag aatttgactt taatgaattc tttaaccttg ataaggtgcc atgcttggct
     1201 tcgatgatag aagatgttct gggggaagga tcggtctctg ccagccgctt cagtaggtgg
     1261 ttctctaacc caagccggtc agggagcaga tccagcagcc ttggatccac accccatgaa
     1321 gaacttgaga gactggcagg tttggagcaa gccgtcctct ctcctggaca gaactcgggg
     1381 aattattttg ctcctatacc atcggaagac catgctgaaa ataaagtgga cattttagaa
     1441 atgctacaga aagccaaagt agatttaaaa cctcttcttt ctagcctttc tgcaaataaa
     1501 gaaaaactta aggagagctc acattcaggg gttgtacttt cagtggaaga ggtagaagca
     1561 gggctgaagg gcttgaaagt ggaccagcaa atgaagaatt caactccctt catggcagaa
     1621 catttagagg agaccctgag tgctgcgagt agcaatagac agctcaagaa agatggagat
     1681 atgactgcat tcaacaagct agtgaacacc atgaaggcaa gtggaacttt gcctacccag
     1741 cccaaagtca gtcgaaacgt tgaaagtcac ttattggccc ctgctgagat tccaggccag
     1801 cctgtttcta aaaacatcct acaggaactt ctgggtcaac cggttcagag acccgcttct
     1861 tccaatcttc tcagtggcct tatggggagc ttggaggcta ctgcatcttt attgagccaa
     1921 agagcgccct ctcctccaat gtcacaggta tttcgaactc aagcagcctc agcagactac
     1981 cttcatccaa ggataccatc accaataggt ttcccttcag gaccccagca actacttgga
     2041 gatccattcc aaggcatgcg caagcccatg agtcctgtct cagcccagat gagccagcta
     2101 gaattgcagc aagctgcttt ggaggggctg gccctaccac atgaccttgc agtccagaca
     2161 gcacccttct accagcctgg ttttagcaaa ccacaagtgg acagaaccag agatgggctc
     2221 agaaacaggc aacagcgaat gtcaaagtca ccagcaccca tgcatggtgg aaattcctct
     2281 tccccagctc ctgctgcctc catcacaagc atgctttctc cttccttcac ccctacctca
     2341 gtgatccgga agatgtatga aagcagagag aaaaccaagg aggaaatggc acctggaatg
     2401 gtggttcctg gtgatggtaa agaggatact cagaagacca gcgaagagaa cctgctgtca
     2461 tccaatccca tacccaatac tgatcaagac tcttctacga caaatcctaa gctttcaaca
     2521 ttacagcggt cttcatgttc caccccactc tcccagacca gccgttatac caaagaacaa
     2581 gattatcgac ctaaaacagc aggaaggaaa acacctacct tggcatcccc agtcccagga
     2641 acaccttttc tccgccctac ccaccaagtt ccccttgtcc ctcatgttcc tattgttcga
     2701 cctgcacacc agcttcaccc aggattagtc caaaggttga tagcccaagg ggtacatcca
     2761 cagcatcttc caagtttgct ccaagctggt gtgcttcctc ctgggataga catggctcct
     2821 ttacaggggc tatctggccc actcctgggt caacccttgt accctttggt ctctgctgct
     2881 agtcaccctc tcctaaaccc tcgtcctggg acccctctgc atttggcggt gatgcagcag
     2941 cagctacagc gctcagttct gcatcctcca ggctctagtt cccaggcagc agctatcagc
     3001 gttcagactc ctcagaatgt acccagccgg tcgggcatgc cccacatgca ctcccagctg
     3061 gagcatcgta ccagccaaag gagcagctcc cctgtgggcc ttgccaaatg gtttggctca
     3121 gatgtgctac agcagcctct gccctccatg cccaccaaag tcatcagtgt agatgaactg
     3181 gaatatagac agtgaagagg gcaggctggc tcacccatac ctggacctgt ggtgacaccc
     3241 tggtcatgac tctcattccc tctttgtaat gggcttttac attggagcac actatgtgaa
     3301 gatgtttagg ggatccacat acctaccatg atctacatta tgacagaagg ctgttaaatc
     3361 gaatgaacct acatggttca aatacaaggg atacaagatt gtcagtcctg gaagtctttc
     3421 ttttataaaa tatgtgaatg aagtgttggt gtcttctaga ggtgacacct aagggttctg
     3481 aaaaaataaa atgtatagac ccttatgtac agacctgtgt ataaactttt gtacatacaa
     3541 atagggtagc tttttttgaa cttatacata cagctgtaca taaagtaact atcagttagg
     3601 cttgtgtcaa ctgtttggat ttttttcact tgaatatttg ggactttttc ttttggttta
     3661 ttaaaagtta catatgccac gtgtgtgaac gataaaaaaa aaaaaaaaa
//
