LOCUS       NM_201256               1151 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E binding
            protein 3 (Eif4ebp3), mRNA.
ACCESSION   NM_201256
VERSION     NM_201256.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1151)
  AUTHORS   Sharma,V., Sood,R., Lou,D., Hung,T.Y., Levesque,M., Han,Y.,
            Levett,J.Y., Wang,P., Murthy,S., Tansley,S., Wang,S., Siddiqui,N.,
            Tahmasebi,S., Rosenblum,K., Avoli,M., Lacaille,J.C., Sonenberg,N.
            and Khoutorsky,A.
  TITLE     4E-BP2-dependent translation in parvalbumin neurons controls
            epileptic seizure threshold
  JOURNAL   Proc Natl Acad Sci U S A 118 (15) (2021)
   PUBMED   33876772
REFERENCE   3  (bases 1 to 1151)
  AUTHORS   Pearl,D., Katsumura,S., Amiri,M., Tabatabaei,N., Zhang,X.,
            Vinette,V., Pang,X., Beug,S.T., Kim,S.H., Jones,L.M., Robichaud,N.,
            Ong,S.G., Jia,J.J., Ali,H., Tremblay,M.L., Jaramillo,M., Alain,T.,
            Morita,M., Sonenberg,N. and Tahmasebi,S.
  TITLE     4E-BP-Dependent Translational Control of Irf8 Mediates Adipose
            Tissue Macrophage Inflammatory Response
  JOURNAL   J Immunol 204 (9), 2392-2400 (2020)
   PUBMED   32213561
REFERENCE   4  (bases 1 to 1151)
  AUTHORS   Muendlein,H.I., Sarhan,J., Liu,B.C., Connolly,W.M., Schworer,S.A.,
            Smirnova,I., Tang,A.Y., Ilyukha,V., Pietruska,J., Tahmasebi,S.,
            Sonenberg,N., Degterev,A. and Poltorak,A.
  TITLE     Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine
            Translation
  JOURNAL   Cell Rep 30 (3), 699-713 (2020)
   PUBMED   31968247
REFERENCE   5  (bases 1 to 1151)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1151)
  AUTHORS   Wang,F., Alain,T., Szretter,K.J., Stephenson,K., Pol,J.G.,
            Atherton,M.J., Hoang,H.D., Fonseca,B.D., Zakaria,C., Chen,L.,
            Rangwala,Z., Hesch,A., Chan,E.S.Y., Tuinman,C., Suthar,M.S.,
            Jiang,Z., Ashkar,A.A., Thomas,G., Kozma,S.C., Gale,M. Jr.,
            Fitzgerald,K.A., Diamond,M.S., Mossman,K., Sonenberg,N., Wan,Y. and
            Lichty,B.D.
  TITLE     S6K-STING interaction regulates cytosolic DNA-mediated activation
            of the transcription factor IRF3
  JOURNAL   Nat Immunol 17 (5), 514-522 (2016)
   PUBMED   27043414
REFERENCE   7  (bases 1 to 1151)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1151)
  AUTHORS   Poulin,F., Brueschke,A. and Sonenberg,N.
  TITLE     Gene fusion and overlapping reading frames in the mammalian genes
            for 4E-BP3 and MASK
  JOURNAL   J Biol Chem 278 (52), 52290-52297 (2003)
   PUBMED   14557257
  REMARK    GeneRIF: there are overlapping reading frames in the mouse and
            human genes for 4E-BP3 and MASK
REFERENCE   9  (bases 1 to 1151)
  AUTHORS   Poulin,F., Gingras,A.C., Olsen,H., Chevalier,S. and Sonenberg,N.
  TITLE     4E-BP3, a new member of the eukaryotic initiation factor 4E-binding
            protein family
  JOURNAL   J Biol Chem 273 (22), 14002-14007 (1998)
   PUBMED   9593750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115631.4, AY226182.1 and CX565744.1.
            
            On Oct 2, 2010 this sequence version replaced NM_201256.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061242.1, BU962951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC115631.4         131245-131366
            123-542             AY226182.1         1-420
            543-1151            CX565744.1         173-781
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..1151
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 3"
                     /db_xref="GeneID:108112"
                     /db_xref="MGI:MGI:1270847"
     exon            1..243
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..446
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /note="eIF4E-binding protein 3"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 3"
                     /protein_id="NP_957708.1"
                     /db_xref="CCDS:CCDS29155.1"
                     /db_xref="GeneID:108112"
                     /db_xref="MGI:MGI:1270847"
                     /translation="MSSSTSCPIPGCRDQLPDGYSTTPGGTLYATTPGGTRIIYDRKF
                     LLECKNSPIARTPPCCLPQIPGVTTLPAVPPSKLELLKEQKQTEVEITDDEQFEMDM"
     exon            244..417
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1151
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /note="hexamer: AGTAAA"
     polyA_site      742
                     /gene="Eif4ebp3"
                     /gene_synonym="4e-bp3"
                     /note="major polyA site"
ORIGIN      
        1 aggtgggtgg agccctcaag ttgactggcc agtggcctgc cccgggtgta acatattcta
       61 gttgttgcct gctgcgactg cctacacctc agagctgttt tccacgcttt caaggcacca
      121 gctcttgcct tcctgctgct atgtcctcgt ccacgagttg cccaattcca gggtgccggg
      181 accagctgcc agacggctac agcaccacgc ctggcggcac actatacgcc actaccccgg
      241 gaggcaccag gatcatctac gacagaaagt tcctgctgga gtgcaagaac tcacccattg
      301 cccggacacc tccctgctgc ctccctcaga ttcccggggt cacaactctc ccagcagtac
      361 caccctccaa gttggagttg ctgaaggaac agaagcagac agaggtagaa ataaccgatg
      421 acgaacagtt tgaaatggac atgtaatcta gtgcaaaatg acctgtatgg agtaatggaa
      481 ggagctctca tcctactatt gccatcacct cttcctgggt atccaagggc cagctggcct
      541 catctaatcc agaaaagaat gacttgttgg ttctgggctt cctttagttg aggcagctag
      601 accagggata gcagcgggca acctgccaag cctttagctt tctctggtct atacatattc
      661 ctcccaaacc tcttcccctc agggctggca ctggggaaca gagtatgtca ccttctggct
      721 gcttagtaaa ctttcaaaaa actgtcttgg ctccattgtt gtcctcagtg ctaaattcac
      781 agctgcacat ctgagggacc cagcagcctt ggttaagagg ctggaagtgt ttccagctcc
      841 cactggccca tttccagcag caatcaaggc ttgagggaag gctactggaa ttgccaggca
      901 ccagcaataa cagcctgagc cttgccaagg tctagcagtt cctgtctttc caggcagcag
      961 ccttcctgga attggactgt tccagcagct cctccctagc catttgtaaa ctggactcct
     1021 ggaagagatg ctgtttcacc taatagttat ccccaatttc ttgccctgcc tttcctgctt
     1081 actacttcta agtaccaatc ccagttctat gctggaaact ttatatcctc ttctcaacat
     1141 aaccaccagt a
//
