LOCUS       NM_010124               1786 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E binding
            protein 2 (Eif4ebp2), mRNA.
ACCESSION   NM_010124
VERSION     NM_010124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Huang,Z., Wiebe,S., Nagpal,A., Choi,J., Walters,C., Mahmood,N.,
            Khoutorsky,A., Lacaille,J.C. and Sonenberg,N.
  TITLE     Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons
            impairs hippocampus-dependent learning and memory
  JOURNAL   Learn Mem 31 (10-11), a054018 (2024)
   PUBMED   39467641
  REMARK    GeneRIF: Dysregulating mTORC1-4E-BP2 signaling in GABAergic
            interneurons impairs hippocampus-dependent learning and memory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Han,X., Yang,F., Zhang,Z., Hou,Z., Sun,Q., Su,T., Lv,W., Wang,Z.,
            Yuan,C., Zhang,G., Pi,X., Long,J. and Liu,H.
  TITLE     4EBP2-regulated protein translation has a critical role in high-fat
            diet-induced insulin resistance in hepatocytes
  JOURNAL   J Biol Chem 299 (11), 105315 (2023)
   PUBMED   37797700
  REMARK    GeneRIF: 4EBP2-regulated protein translation has a critical role in
            high-fat diet-induced insulin resistance in hepatocytes.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Kincheloe,G.N., Roberson,P.A., Toro,A.L., Stanley,B.A.,
            Stanley,A.E., Jefferson,L.S., Dennis,M.D. and Kimball,S.R.
  TITLE     Loss of 4E-BPs prevents the hindlimb immobilization-induced
            decrease in protein synthesis in skeletal muscle
  JOURNAL   J Appl Physiol (1985) 134 (1), 72-83 (2023)
   PUBMED   36454675
  REMARK    GeneRIF: Loss of 4E-BPs prevents the hindlimb
            immobilization-induced decrease in protein synthesis in skeletal
            muscle.
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Miller,W.P., Sha,C.M., Sunilkumar,S., Toro,A.L., VanCleave,A.M.,
            Kimball,S.R., Dokholyan,N.V. and Dennis,M.D.
  TITLE     Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative
            Stress Under Hyperglycemic Conditions
  JOURNAL   Diabetes 71 (12), 2764-2776 (2022)
   PUBMED   36170669
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Saviuk,N., Chong,Y., Wang,P., Bermudez,S., Zhao,Z., Bhaskaran,A.A.,
            Bowie,D., Sonenberg,N., Cooper,E. and Haghighi,A.P.
  TITLE     Loss of 4E-BP converts cerebellar long-term depression to long-term
            potentiation
  JOURNAL   Cell Rep 39 (10), 110911 (2022)
   PUBMED   35675781
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Zhou,J. and Saba,J.D.
  TITLE     Identification of the first mammalian sphingosine phosphate lyase
            gene and its functional expression in yeast
  JOURNAL   Biochem Biophys Res Commun 242 (3), 502-507 (1998)
   PUBMED   9464245
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Tsukiyama-Kohara,K., Vidal,S.M., Gingras,A.C., Glover,T.W.,
            Hanash,S.M., Heng,H. and Sonenberg,N.
  TITLE     Tissue distribution, genomic structure, and chromosome mapping of
            mouse and human eukaryotic initiation factor 4E-binding proteins 1
            and 2
  JOURNAL   Genomics 38 (3), 353-363 (1996)
   PUBMED   8975712
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Lin,T.A. and Lawrence,J.C. Jr.
  TITLE     Control of the translational regulators PHAS-I and PHAS-II by
            insulin and cAMP in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 271 (47), 30199-30204 (1996)
   PUBMED   8939971
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Pause,A., Belsham,G.J., Gingras,A.C., Donze,O., Lin,T.A.,
            Lawrence,J.C. Jr. and Sonenberg,N.
  TITLE     Insulin-dependent stimulation of protein synthesis by
            phosphorylation of a regulator of 5'-cap function
  JOURNAL   Nature 371 (6500), 762-767 (1994)
   PUBMED   7935836
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122197.4.
            
            On Nov 17, 2006 this sequence version replaced NM_010124.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U75530.1, AK133912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               AC122197.4         30719-30986
            269-454             AC122197.4         48285-48470
            455-1786            AC122197.4         49560-50891
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.21 cM"
     gene            1..1786
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 2"
                     /db_xref="GeneID:13688"
                     /db_xref="MGI:MGI:109198"
     exon            1..268
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..486
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
                     /note="eIF4E-binding protein 2; phosphorylated heat- and
                     acid-stable protein regulated by insulin 2"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 2"
                     /protein_id="NP_034254.1"
                     /db_xref="CCDS:CCDS23879.1"
                     /db_xref="GeneID:13688"
                     /db_xref="MGI:MGI:109198"
                     /translation="MSASAGGSHQPSQSRAIPTRTVAISDAAQLPQDYCTTPGGTLFS
                     TTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGALIEDSKVEVNNLNNLN
                     NHDRKHAVGDEAQFEMDI"
     exon            269..454
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1786
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1423
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
                     /note="major polyA site"
     polyA_site      1502
                     /gene="Eif4ebp2"
                     /gene_synonym="2810011I19Rik; 4E-BP2; PHAS-II"
ORIGIN      
        1 cgaccgggcg agagcaggcg agttgagagc cgagcgtgag gagccagagc cgcccggccc
       61 cgccgccgcc gccgccgccg ccgccgccgc tgctgcacaa agcctcgagc ccgcgtcgga
      121 gccatgtccg cgtcggccgg tggtagccac cagcccagcc agagccgcgc catccccacg
      181 cgcaccgtgg ctatcagcga cgccgcgcag ctacctcagg actactgcac cacgcccggg
      241 gggacgctgt tctccacaac gccgggagga acacgaatca tttatgaccg aaagtttctg
      301 ttggaccgtc gcaattctcc catggcgcag accccacctt gccatctgcc caatatccct
      361 ggagtcacca gtcctggcgc cttaattgaa gactccaaag tagaagtgaa caacttaaac
      421 aacctgaaca atcatgacag gaagcatgca gttggggatg aggctcagtt tgagatggac
      481 atctgactac tgccatgtgg aaggaggcct cgtggagcag cctgtgtgca cctgactggc
      541 ccagtaggaa cacagtgtac agagaagctc ctgtccccct gtcccctctg ggtgccaaat
      601 aatgggagat gtgcactgtc tgatcacatc ttcccgtctc ctgccctctg cccagttaag
      661 gttaggttga tgaataagcc cttggattat tctgtggagc tgaccagtcc acagaagaaa
      721 gcagtccctg tagcttccct ggtcatttcc caagaatctt cctgccctgt tgagacttgc
      781 cccaagtcta gggcagtctc caagcagcac ctctgcttgt aggggttggg ggtgaaggag
      841 gtttagtgcc cattgtgttc ctgggctctc cctgtccttc cctacagccc actactggtg
      901 gagcgctgga tgtgggggac atttgtcctc agctctggag cacagtcctg tacctcctgc
      961 acctctgctg cattcctggg acatgtgaca gcagcctccc ctttctctgg gaggaaggct
     1021 tctgtcttgt cttgggtgtg atagctcatc atcccccccc cccccattcc tttacccatt
     1081 tcattggcac gggtattttt taagccctcc tgaagggacc ccttggtgac cagctggtct
     1141 ttgcctgtct gacattcttt ctacctgcat cccgtaggca gagtctgccc tggcacaccc
     1201 gtggctctgt ctgcttttag agcagaagtg ccaacacctt ggcctgcacc tggtgagtcc
     1261 agcctgctct cagcggtctg cctgagaata catcaggggc ctctgaagag gactgagccg
     1321 ccgtgcagcc agcctcgggg gtcatggttt taaaaccagg tgtaccttac gttgggtgtc
     1381 ctgcaggtta ctataccttg agtttaaagt cgacttcctc ttacatttct cccctgcttt
     1441 ggatctgctt tgtgcttggc tgctgagaga gcagcacagg ctaagacagt gtattcctcc
     1501 caggtctctc gcccttctca tcgtccgtct gtccgtcagt ccgtccgtcc ttccctccct
     1561 ctccccttaa attctttcct tctggttctt ccaccgggcc attttccaca tctgcatcag
     1621 aagagatgcc tcccatgtta gtatctgata atatcagtct ctccttatca gaggagagac
     1681 cttttatttt taagatgact acagacctat ttttagataa gttttcagta caattttgaa
     1741 ctacaacttt tttaacaaaa catcttccag tattgggaag gttatt
//
