LOCUS       NM_007918                981 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E binding
            protein 1 (Eif4ebp1), mRNA.
ACCESSION   NM_007918
VERSION     NM_007918.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 981)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   3  (bases 1 to 981)
  AUTHORS   Iyyappan,R., Aleshkina,D., Ming,H., Dvoran,M., Kakavand,K.,
            Jansova,D., Del Llano,E., Gahurova,L., Bruce,A.W., Masek,T.,
            Pospisek,M., Horvat,F., Kubelka,M., Jiang,Z. and Susor,A.
  TITLE     The translational oscillation in oocyte and early embryo
            development
  JOURNAL   Nucleic Acids Res 51 (22), 12076-12091 (2023)
   PUBMED   37950888
REFERENCE   4  (bases 1 to 981)
  AUTHORS   Radzishevsky,I., Odeh,M., Bodner,O., Zubedat,S., Shaulov,L.,
            Litvak,M., Esaki,K., Yoshikawa,T., Agranovich,B., Li,W.H.,
            Radzishevsky,A., Gottlieb,E., Avital,A. and Wolosker,H.
  TITLE     Impairment of serine transport across the blood-brain barrier by
            deletion of Slc38a5 causes developmental delay and motor
            dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2302780120 (2023)
   PUBMED   37812701
REFERENCE   5  (bases 1 to 981)
  AUTHORS   So,H.K., Kim,H., Lee,J., You,C.L., Yun,C.E., Jeong,H.J., Jin,E.J.,
            Jo,Y., Ryu,D., Bae,G.U. and Kang,J.S.
  TITLE     Protein Arginine Methyltransferase 1 Ablation in Motor Neurons
            Causes Mitochondrial Dysfunction Leading to Age-related Motor
            Neuron Degeneration with Muscle Loss
  JOURNAL   Research (Wash D C) 6, 0158 (2023)
   PUBMED   37342629
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 981)
  AUTHORS   Blackshear,P.J., Stumpo,D.J., Carballo,E. and Lawrence,J.C. Jr.
  TITLE     Disruption of the gene encoding the mitogen-regulated translational
            modulator PHAS-I in mice
  JOURNAL   J Biol Chem 272 (50), 31510-31514 (1997)
   PUBMED   9395487
REFERENCE   7  (bases 1 to 981)
  AUTHORS   Lawrence,J.C. Jr. and Abraham,R.T.
  TITLE     PHAS/4E-BPs as regulators of mRNA translation and cell
            proliferation
  JOURNAL   Trends Biochem Sci 22 (9), 345-349 (1997)
   PUBMED   9301335
  REMARK    Review article
REFERENCE   8  (bases 1 to 981)
  AUTHORS   Tsukiyama-Kohara,K., Vidal,S.M., Gingras,A.C., Glover,T.W.,
            Hanash,S.M., Heng,H. and Sonenberg,N.
  TITLE     Tissue distribution, genomic structure, and chromosome mapping of
            mouse and human eukaryotic initiation factor 4E-binding proteins 1
            and 2
  JOURNAL   Genomics 38 (3), 353-363 (1996)
   PUBMED   8975712
REFERENCE   9  (bases 1 to 981)
  AUTHORS   Lin,T.A. and Lawrence,J.C. Jr.
  TITLE     Control of the translational regulators PHAS-I and PHAS-II by
            insulin and cAMP in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 271 (47), 30199-30204 (1996)
   PUBMED   8939971
REFERENCE   10 (bases 1 to 981)
  AUTHORS   Lin,T.A., Kong,X., Saltiel,A.R., Blackshear,P.J. and Lawrence,J.C.
            Jr.
  TITLE     Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis,
            degradation, and phosphorylation by a rapamycin-sensitive and
            mitogen-activated protein kinase-independent pathway
  JOURNAL   J Biol Chem 270 (31), 18531-18538 (1995)
   PUBMED   7629182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY318447.1, BE651550.1 and AK013033.1.
            
            On Jan 18, 2007 this sequence version replaced NM_007918.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013033.1, AK167836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               BY318447.1         2-352
            352-697             BE651550.1         243-588
            698-981             AK013033.1         624-907
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.95 cM"
     gene            1..981
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 1"
                     /db_xref="GeneID:13685"
                     /db_xref="MGI:MGI:103267"
     exon            1..224
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..436
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
                     /note="eIF4E-binding protein 1; phosphorylated heat- and
                     acid-stable protein regulated by insulin 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 1"
                     /protein_id="NP_031944.3"
                     /db_xref="CCDS:CCDS22214.1"
                     /db_xref="GeneID:13685"
                     /db_xref="MGI:MGI:103267"
                     /translation="MSAGSSCSQTPSRAIPTRRVALGDGVQLPPGDYSTTPGGTLFST
                     TPGGTRIIYDRKFLMECRNSPVAKTPPKDLPAIPGVTSPTSDEPPMQASQSQLPSSPE
                     DKRAGGEESQFEMDI"
     exon            225..404
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            405..981
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      886
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
                     /note="major polyA site"
     polyA_site      970
                     /gene="Eif4ebp1"
                     /gene_synonym="4e-bp1; PHAS-I"
ORIGIN      
        1 ggaaggggcg ggccgggcac gagaagggct gggccgaggt gccgcggggt tgctggaggg
       61 tcgtgggcgg cgtgcaggag acatgtcggc gggcagcagc tgcagccaga ctcccagccg
      121 ggccatcccc actcgccgcg tagccctcgg cgatggcgtg cagctcccgc ccggggacta
      181 cagcaccact ccgggcggca cgctcttcag caccaccccg ggaggaacca ggattatcta
      241 tgaccggaaa tttctgatgg agtgtcggaa ctcacctgtg gccaaaacac ccccaaagga
      301 cctgccagcc attcctgggg tcactagccc taccagcgat gagcctccca tgcaagccag
      361 ccagagccaa ctgcccagca gcccggaaga taagcgggca ggcggtgaag agtcacaatt
      421 tgagatggac atttaaggga ccagccgtag gacgcaatga tgcttctatg tcccccaagg
      481 cccttgggag gagagctgca cagcattcag gcctcatacc aggcagacac tgggtgtggg
      541 tcggccaccc agtcctgctc ctcactcagg gtgccagctc tgccttgaat tttgtgaaca
      601 ccagcacata cctccttgtg cctctgtcta taccgagctg ctactgcagg ggaatgactc
      661 tcactcacac cctccctgca tggagctcca gcgagtggac tcagaggagt ctatcagaat
      721 gatctggcaa tcctagcccc agcctccgga gcacacccat ctttccttag gctgggttac
      781 ctgggaaagc cacactttta cttctttccc tgacaggaaa taaaagccac atttacccta
      841 ggcccgccca cagctgggcc ctgtctgaac tgttttccac tcgaaatgac gacatgatta
      901 ctattctctg tccagtgttt atggtgtgat ttccctgtac aatatttttt aaaaagattt
      961 attttatgta tatgagtaat c
//
