LOCUS       NM_025829               2513 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E member 3
            (Eif4e3), mRNA.
ACCESSION   NM_025829
VERSION     NM_025829.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Osborne,M.J., Volpon,L., Kornblatt,J.A., Culjkovic-Kraljacic,B.,
            Baguet,A. and Borden,K.L.
  TITLE     eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of
            methyl-7-guanosine cap recognition
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 3877-3882 (2013)
   PUBMED   23431134
  REMARK    GeneRIF: eIF4E3 specifically binds the m(7)G cap in the absence of
            an aromatic sandwich, using instead a different spatial arrangement
            of residues to provide the necessary electrostatic and van der
            Waals contacts.
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Joshi,B., Cameron,A. and Jagus,R.
  TITLE     Characterization of mammalian eIF4E-family members
  JOURNAL   Eur J Biochem 271 (11), 2189-2203 (2004)
   PUBMED   15153109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122929.4 and
            AC152987.1.
            
            On Apr 29, 2007 this sequence version replaced NM_025829.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005054.2, SRR13422591.12761.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC122929.4         186439-186582
            145-217             AC122929.4         201419-201491
            218-312             AC152987.1         188902-188996       c
            313-373             AC152987.1         187449-187509       c
            374-440             AC152987.1         184395-184461       c
            441-596             AC152987.1         180543-180698       c
            597-2513            AC152987.1         173423-175339       c
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 45.98 cM"
     gene            1..2513
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /note="eukaryotic translation initiation factor 4E member
                     3"
                     /db_xref="GeneID:66892"
                     /db_xref="MGI:MGI:1914142"
     exon            1..144
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..643
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /note="eukaryotic translation initiation factor-3;
                     eIF-4E3; eIF4E type 3; eIF-4E type 3"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E type
                     3"
                     /protein_id="NP_080105.1"
                     /db_xref="CCDS:CCDS20386.1"
                     /db_xref="GeneID:66892"
                     /db_xref="MGI:MGI:1914142"
                     /translation="MALPPAAAPPGANEPLDKALSALPPEPGGVPLHSPWTFWLDRSL
                     PGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEES
                     NAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEIIGVSVSVRDREDVVQV
                     WNVNASLVGEATVLEKIHQLLPHIAFKAVFYKPHEEHHAFEGGRGKH"
     exon            145..217
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     exon            218..312
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..373
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     exon            374..440
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..596
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..2513
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      880
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /note="major polyA site"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
                     /note="hexamer: AATAAA"
     polyA_site      2512
                     /gene="Eif4e3"
                     /gene_synonym="1300018P11Rik; eIF4E-3"
ORIGIN      
        1 ggcctggccg gcggagaaca tggcgctgcc cccggctgcc gcaccccccg gggctaacga
       61 gcctctcgac aaggctctgt ccgcgttgcc gccggagccg ggcggtgtcc cgctgcactc
      121 gccctggacc ttctggctgg acagatcact ccctggtgcc acagcagccg agtgtgcctc
      181 gaatctgaag aaaatctaca cggtacaaac agtgcagata ttctggagtg tatacaataa
      241 catccctcct gtgaccagcc tgcctttgag atgtagttat cacttaatga gaggagagag
      301 gcgaccactt tgggaggagg agagtaatgc gaagggtggc gtgtggaaga tgaaagttcc
      361 caaggacagc acgtccacag tttggaaaga attgttgtta gcgaccattg gagagcagtt
      421 cacagactgt gctgcagcag atgacgagat catcggagtc agcgtgagtg tgcgggaccg
      481 agaggatgtc gtccaggtgt ggaatgtcaa cgcctcacta gtgggcgaag cgactgtgct
      541 agagaagatc caccagctcc tgccccacat agcttttaaa gcagtgtttt ataaacccca
      601 tgaagagcat catgcttttg aaggtggacg tggaaaacac taattgcact ctgtaaagaa
      661 ttctttgtcc tttgctgatt ggttttggaa acggtcttaa caggagggag agtgaagaga
      721 agacttgccg aagcccgatg ctggtccatt tagagtgggt ttctgtcctt gcaaaccggg
      781 ccattaggac tcaaagtggc aggtggggtt ggggaagaag gtgcgggttt ctgccatcgt
      841 atcacttgct ttaaagagaa agagtgagag aagaaagaaa gaaagaaaga aagaaagaaa
      901 gaaagaaaga aagaaagaaa gaaagaaaga aagaaaagaa agaaagactt tcttaaagct
      961 ttccaaattc tctgggtttt tttgcactct tcccctcccc ataagattcc ttattcaggg
     1021 taattattgt tttctgccca ccctttcatt gaggcataag agttgggttt ccccttcagt
     1081 gactctactg taccttgtta aggaacatag ccgccacagg actgcctgtg aagccacagg
     1141 gcaccaggag gaggcctagc ctagcaaaac cctttttctg ataaattgtt gtgacacttc
     1201 cctgcatatt gtgagctggg cattgtttct tttgtgtgtg tgttccgtag aaagcacact
     1261 caattgatag cacacacatc ttaaaacccc tttaaaaagc agtataagga aaataaattg
     1321 ttggtttgcc taaaatgaaa actttaatca caattgggtg tcaggctcca aatcaaactc
     1381 taggttttgg gggcctacag tgtaagtatt tctaaccaga attccccctc cccaccatat
     1441 ctgacccttt caacaaaaga cccaatgatt tgtcctgaga ggaaaccttc tatttctgat
     1501 ttatagagga ggcgatgtgt attaattgtg gggagtagag cttcttccat gttgcagcat
     1561 gtttacccaa accaattctc acatcttttg ttaagtgagc cggctttcct gcccctgtca
     1621 cgtgtccttt ctgaaaaccg atggccttcc tgcagaggcg tctttcccct catctgtgca
     1681 cttacaggaa gcacctagcc actcacacag ctgcccttga gtgcatctca ttcctgtgga
     1741 ctgtgttatt cgatattgga ttatagtacc aaagaaatac tgccttcagt agaagaaaac
     1801 ctttcagagc ctcccagctc ctcccagatg ttccccggtt ccctctcatc tttgccccac
     1861 ccctggtcat tttccttcag aaagggcttc tcccctgcgg gcttgggtca gatccatggg
     1921 ccagtgtgca gcttctgttc ttctcaaaag ggcgaatttt taattcccct tgcactgtgg
     1981 gaaggagagg tggggttaca ctaagccttc cacatgcatt tgtaaataaa attcccattc
     2041 agatatttca gatggctctc ggtagcatct gtttataaaa agtcaggggc ctccacttgc
     2101 attgctaaac aggaagccaa attaattagt ggtcagagcg taagaggcgc ttctttccca
     2161 accttaagtc cctccacggt ttcactcatg aggggctcgg atccttcttg tctcaatgac
     2221 gtgcatttct ctgaacagtt tctaaacttg ttttaaaact ataactcaag gactttaaaa
     2281 cttactgtag acacaattcc tttttataat ataagtattt ttttctgaca gattagcaca
     2341 aaggatataa ttgacttcaa tattataatt gtcatatgca tatatatatt tccataagta
     2401 aataaatttt gagaaaattt tatttttgaa ctttatttaa agcatttgtg ataacatgtt
     2461 caaattttgc gtgtatgtag cttttgaagt aaaaataaaa taaaataaat agg
//
