LOCUS       NM_001039169            2260 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E member 2
            (Eif4e2), transcript variant 2, mRNA.
ACCESSION   NM_001039169
VERSION     NM_001039169.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2260)
  AUTHORS   Kim,S.H., Choi,J.H., Marsal-Garcia,L., Amiri,M., Yanagiya,A. and
            Sonenberg,N.
  TITLE     The mRNA translation initiation factor eIF4G1 controls
            mitochondrial oxidative phosphorylation, axonal morphogenesis, and
            memory
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2300008120 (2023)
   PUBMED   37307456
REFERENCE   3  (bases 1 to 2260)
  AUTHORS   Wiebe,S., Huang,Z., Ladak,R.J., Skalecka,A., Cagnetta,R.,
            Lacaille,J.C., Aguilar-Valles,A. and Sonenberg,N.
  TITLE     Cell-type-specific translational control of spatial working memory
            by the cap-binding protein 4EHP
  JOURNAL   Mol Brain 16 (1), 9 (2023)
   PUBMED   36650535
  REMARK    GeneRIF: Cell-type-specific translational control of spatial
            working memory by the cap-binding protein 4EHP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2260)
  AUTHORS   Zhang,X., Chapat,C., Wang,P., Choi,J.H., Li,Q., Luo,J., Wiebe,S.,
            Kim,S.H., Robichaud,N., Karam,I.F., Dai,D., Hackett,A.P., Lin,R.,
            Alain,T., Yang,L., Jafarnejad,S.M. and Sonenberg,N.
  TITLE     microRNA-induced translational control of antiviral immunity by the
            cap-binding protein 4EHP
  JOURNAL   Mol Cell 81 (6), 1187-1199 (2021)
   PUBMED   33581076
  REMARK    GeneRIF: microRNA-induced translational control of antiviral
            immunity by the cap-binding protein 4EHP.
REFERENCE   5  (bases 1 to 2260)
  AUTHORS   Wiebe,S., Meng,X.Q., Kim,S.H., Zhang,X., Lacaille,J.C.,
            Aguilar-Valles,A. and Sonenberg,N.
  TITLE     The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term
            depression and impacts social behavior
  JOURNAL   Mol Autism 11 (1), 92 (2020)
   PUBMED   33225984
  REMARK    GeneRIF: The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal
            long-term depression and impacts social behavior.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2260)
  AUTHORS   Villaescusa,J.C., Buratti,C., Penkov,D., Mathiasen,L.,
            Planaguma,J., Ferretti,E. and Blasi,F.
  TITLE     Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation
  JOURNAL   PLoS One 4 (4), e5213 (2009)
   PUBMED   19365557
  REMARK    GeneRIF: Data show that Prep1 and 4EHP co-localize in the cytosol
            of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to
            inhibit its translation.[4EHP]
REFERENCE   7  (bases 1 to 2260)
  AUTHORS   Joshi,B., Cameron,A. and Jagus,R.
  TITLE     Characterization of mammalian eIF4E-family members
  JOURNAL   Eur J Biochem 271 (11), 2189-2203 (2004)
   PUBMED   15153109
REFERENCE   8  (bases 1 to 2260)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2260)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 2260)
  AUTHORS   Temeles,G.L., Ram,P.T., Rothstein,J.L. and Schultz,R.M.
  TITLE     Expression patterns of novel genes during mouse preimplantation
            embryogenesis
  JOURNAL   Mol Reprod Dev 37 (2), 121-129 (1994)
   PUBMED   7545925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017221.1 and AC102611.10.
            
            Transcript Variant: This variant (2) uses an alternate splice
            junction at the 3' end of the first exon compared to variant 1. The
            resulting isoform (2) has a shorter and distinct N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028903.1, BI411117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1202              AK017221.1         2-1203
            1203-2260           AC102611.10        186068-187125
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.08 cM"
     gene            1..2260
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /note="eukaryotic translation initiation factor 4E member
                     2"
                     /db_xref="GeneID:26987"
                     /db_xref="MGI:MGI:1914440"
     exon            1..557
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..1275
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     eukaryotic translation initiation factor 4E like 3;
                     eukaryotic translation initiation factor 4E type 2;
                     eIF4E-2; eIF4E type 2; eIF-4E type 2; eIF4E-like protein
                     4E-LP; mRNA cap-binding protein type 2"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E type
                     2 isoform 2"
                     /protein_id="NP_001034258.1"
                     /db_xref="CCDS:CCDS15131.1"
                     /db_xref="GeneID:26987"
                     /db_xref="MGI:MGI:1914440"
                     /translation="MSLKDDDSGDHDQNEENSTQKDGEKEKTDRDKSQSSGKRKAVVP
                     GPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWKFYSHMVRPGDL
                     TGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEE
                     ICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKM
                     PGRLGPQRLLFQNLWKPRLNVP"
     exon            558..672
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     exon            673..807
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..912
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1065
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1202
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..2260
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /note="hexamer: AATAAA"
     polyA_site      1465
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /note="major polyA site"
     regulatory      1653..1658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /note="hexamer: AATAAT"
     polyA_site      1677
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
                     /note="hexamer: ATTAAA"
     polyA_site      2260
                     /gene="Eif4e2"
                     /gene_synonym="2700069E09Rik; D0H0S6743E; Eif4el3"
ORIGIN      
        1 gatgggaccc ggtagagcgg aagtcactcc gtgaggcagt ggcgacagcg gcggcaagag
       61 gatgaacaac aagttcgacg cgtgagtggc gcgtggccga ccccggggcc ccttccccca
      121 accgtccccc gggaccgctc ccgccggggc cgggcgcgcc ctcagccgag ccgctcgctc
      181 ccgggccgcc gcagcccgag ccttcctgcg cccgcgggcc cgacggggcc gggagagcgc
      241 ggccgaggtc gccgggaccc ctgagccgct ggaccccggc gcggcacggg ccgggggagg
      301 ggaggccgcg ccgcccggaa ggagattttc ggacgccccg ccctggtggg tgcgggctgc
      361 cggcggcgtg gaggggcggg acctcagcgc ttcgggtgtt tccgcagcct tgctgccttc
      421 tctctgaacg cggcttccct cccgcactcg ctcggcgtcc tgggaaggtc acctctccct
      481 tccgagcctc gattttgtct tctgcaagcg gggacggtaa cagagcccgt gtcgtagagt
      541 tgggcagctg cgatgagctt aaaagatgat gacagtggag accatgatca gaatgaagaa
      601 aacagcacac agaaagatgg tgagaaggaa aaaacagacc gagacaagag ccagagcagt
      661 ggcaagagga aggctgttgt ccctggacca gcagagcatc ccctgcagta caactacacc
      721 ttttggtact cgaggagaac ccctggccgt cccaccagct cgcagagcta tgagcagaac
      781 atcaagcaga ttggcacctt tgcctctgtg gagcagttct ggaagtttta cagccacatg
      841 gtacgtcctg gggacctgac aggccacagt gactttcatc tcttcaaaga agggattaaa
      901 cctatgtggg aggatgatgc aaataaaaat gggggcaagt ggatcattcg actccggaag
      961 ggcttagctt cccgctgctg ggagaatctc atcctggcta tgctcgggga gcaattcatg
     1021 gttggggagg agatctgcgg ggctgtggtc tctgtccgct ttcaggagga cattatttct
     1081 atatggaata agactgccag cgaccaagca actacagccc gaatccggga tactcttcgg
     1141 cgcgtgctta acctacctcc caacaccatt atggaataca aaactcacac cgacagcatc
     1201 aaaatgccag gcaggctggg cccccaaagg ctcctttttc aaaacctctg gaagccgcga
     1261 ttgaatgtgc catgaccctc tccctctctg gatggcacca tcattgaagc tggcatcatc
     1321 ggagtctctt gttctgttgg cgtgccacct ggaagaccct tctgtcctgg acaagaggaa
     1381 cggaagagca tgttatcctt tgagaacagg ctgacagcag caactactac aacagctgag
     1441 atcacaaata aatggtgcta aaccagcttg tctcatgctc ttgctcttta tggtgcatca
     1501 agatgtggcc tctggattga ctgtcaccat tttcaaggga tggcacacag acttctccat
     1561 gcagggccat tcagggaaca caacttcata gccacaagcc cattgtgtag tcacatggta
     1621 ctttattccg ggactgttgt ggtctgacat taaataatga ggtgacgtct aactcaagac
     1681 ccaactgcct ggtgctcaag tgtactagtt tccatccagt tagaccaatg gctggcccag
     1741 agtggcggct gagttcaggt ccagcttgaa agtctcttaa ggttggaaag gggtatcctt
     1801 ggcttttctt tgctaacttc catttgcctt tagttcatag aagtctcttg cttggaacta
     1861 agccctgctt ctgtctgtct gtggccgcac atacatactt ttttgctttg tgctaatggg
     1921 gtattctctc tggtgccaaa gctgcttggc aacctcctcc gtttccttgc agagtagatt
     1981 gtcttcctct ttggtagtct tgcttggtga gagcccttca ttctttctag cccagggtta
     2041 ctgtgccagg ctctagggtg agaggtgcct tcatcttggg gtgggggtgt gcagtcgcct
     2101 gtgaggtaat ctgaatgtac atgtgctacc cttgtgagta ctatggcttt ggcttatatg
     2161 tgcgggcagc ttggctttta gaccattaac ctgcatggag agtttcaaca agctttgtta
     2221 gccatcccca aaactaaaaa ttaaaaagca tttttgtgaa
//
