LOCUS       NM_001033269            1919 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E family
            member 1B (Eif4e1b), transcript variant 1, mRNA.
ACCESSION   NM_001033269 XM_138633 XM_906037
VERSION     NM_001033269.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1919)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1919)
  AUTHORS   Lorenzo-Orts,L., Strobl,M., Steinmetz,B., Leesch,F., Pribitzer,C.,
            Roehsner,J., Schutzbier,M., Durnberger,G. and Pauli,A.
  TITLE     eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs
  JOURNAL   EMBO Rep 25 (1), 404-427 (2024)
   PUBMED   38177902
  REMARK    GeneRIF: eIF4E1b is a non-canonical eIF4E protecting maternal
            dormant mRNAs.
REFERENCE   3  (bases 1 to 1919)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   4  (bases 1 to 1919)
  AUTHORS   Yang,G., Xin,Q., Feng,I., Wu,D. and Dean,J.
  TITLE     Germ cell-specific eIF4E1b regulates maternal mRNA translation to
            ensure zygotic genome activation
  JOURNAL   Genes Dev 37 (9-10), 418-431 (2023)
   PUBMED   37257918
  REMARK    GeneRIF: Germ cell-specific eIF4E1b regulates maternal mRNA
            translation to ensure zygotic genome activation.
REFERENCE   5  (bases 1 to 1919)
  AUTHORS   Guo,J., Zhao,H., Zhang,J., Lv,X., Zhang,S., Su,R., Zheng,W.,
            Dai,J., Meng,F., Gong,F., Lu,G., Xue,Y. and Lin,G.
  TITLE     Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte
            to Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (11), e2205500 (2023)
   PUBMED   36755190
  REMARK    GeneRIF: Selective Translation of Maternal mRNA by eIF4E1B Controls
            Oocyte to Embryo Transition.
REFERENCE   6  (bases 1 to 1919)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1919)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV659735.1 and DQ279473.1.
            
            On Oct 31, 2013 this sequence version replaced NM_001033269.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ279473.1, BC139143.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DV659735.1         1-5
            6-1919              DQ279473.1         1-1914
FEATURES             Location/Qualifiers
     source          1..1919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.39 cM"
     gene            1..1919
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /note="eukaryotic translation initiation factor 4E family
                     member 1B"
                     /db_xref="GeneID:218268"
                     /db_xref="MGI:MGI:2685119"
     exon            1..104
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..839
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 4E type 1B"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E type
                     1B isoform 1"
                     /protein_id="NP_001028441.1"
                     /db_xref="CCDS:CCDS49269.1"
                     /db_xref="GeneID:218268"
                     /db_xref="MGI:MGI:2685119"
                     /translation="MNKVEGGGHKEEVVVKEKEVVKEKPSEATAEGVQAGEAKDLPGS
                     LKTQRRKAHREHPPEVLSKLHPLQYRWVLWFFKNDRSRAWQDNLQLVTKFNTVEDFWA
                     VYSHIKLASKLSSGCDYALFKEGILPMWEDNRNKQGGRWLLSIDKQLRHFELDRLWLE
                     TLLCLVGNCFEEYSREVCGAVVNIRTKRDKIALWTSEAEDKAGVMQIGQIYKERLGIS
                     TKTIIGYQAHADTAAKSNNLANKFVV"
     exon            105..313
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     exon            314..409
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     exon            410..473
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     exon            474..587
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     exon            588..727
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1902
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="Eif4e1b"
                     /gene_synonym="Eif4eloo; Gm273"
                     /note="major polyA site"
ORIGIN      
        1 ggagccttga gccttgtcat ggccacttct gaggttgtga gtctacccca tccgcctttc
       61 ccagagcaac tgagtagctg gggtgaaaaa agcgggcatc agagatgaac aaagttgagg
      121 gtggagggca taaggaggag gtggtggtga aagaaaagga ggtagtgaaa gaaaagccat
      181 cagaagcaac tgcggaggga gtccaagcag gagaagccaa agaccttcct ggctccctta
      241 agactcagag gaggaaggcc cacagagaac atccaccaga ggtcctgagc aagctacacc
      301 ccttgcagta caggtgggtt ctgtggttct tcaagaatga ccgaagccgg gcctggcagg
      361 acaacctgca gctagtcacc aagtttaaca ctgtggagga cttctgggcg gtgtacagcc
      421 atatcaagct ggccagcaag ctctcttccg gctgtgacta tgccctgttc aaggaaggca
      481 tcctgcccat gtgggaagac aacagaaaca agcagggtgg ccgctggctg ctcagcattg
      541 acaaacaact gcgccacttc gaactggacc gtctgtggct ggagacgttg ctgtgtctgg
      601 ttgggaattg ttttgaggaa tacagcaggg aagtgtgcgg tgctgtcgtg aacatccgca
      661 cgaagaggga caagattgcc ctgtggacga gtgaagcaga ggacaaagcc ggagtgatgc
      721 agatcgggca aatatacaaa gagcgcctgg gcatctctac gaagaccatc attgggtacc
      781 aggcccatgc agacactgct gccaagagca acaacttagc aaacaagttt gtggtgtgag
      841 accggtttca gccactactc agtgggcacc ctcatcttgc tgcttgatgg acaaggaaga
      901 ctatactgca ctgtggattc tggggcaggg cttgggggag gcagacagcc tggttcttta
      961 cctctcttgg aacatgtata agcaccactc cttagataag gttttacctg ttgcccaggt
     1021 tggcctcgta tttgtgggct taagccactc tcctgcttca gcctacagac ctgggactgc
     1081 cacagctcat cactgtgcct gcatccataa taacttcttc agcatgtttt gggctcaggc
     1141 ctcatggcag ctggccaatg cttataaact actctcaatc gctagccctg tacgtggcca
     1201 tttgccaagg gcagggtaaa gcaaagtcct ggcacaaccc tgccaaacaa ggacaggaga
     1261 ctcctgaggc aggctcttct gtcttgggag gatggttcca ggccactgat attaagggtt
     1321 aggagttcag ttctctgtga gcttaaaggc tgattatggg gttaccctca tcagatctgt
     1381 agcttgggta cccatcctaa cacctgttcc ttccctggac cagttgtgat tgggttctcc
     1441 ctccctccct ctttccctcc ctccctcttt ccctccctcc ctctttcctt ccttctctcc
     1501 ctccctctct ccctccctct ctccctccct ccctccctgt ctccctgcct ccctccctcc
     1561 ctccctccct ctctccctcc ctccctctct ccctccctcc ctctctccct ccctccctct
     1621 ctcctccccc cccccttcaa gtatggacta ggttagagag gaatttgtgt aaagacaggt
     1681 aggactggga actgggaatg ccctgcacag ccttcccatc tgaagacagt cctatggatt
     1741 ctgtgtgtct cctcctgctg aaatgatgga tggataaacc ttcatgagtg aagagattac
     1801 agtggtagtt aggcttcacc gtggtcttgt taggagggat tcacttgatg ctgatgatgc
     1861 ttaaggccct ttctgtatct aaataaacac ttctggaaca aaaaaaaaaa aaaaaaaaa
//
