LOCUS       NM_007917               4999 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus eukaryotic translation initiation factor 4E (Eif4e),
            transcript variant 1, mRNA.
ACCESSION   NM_007917
VERSION     NM_007917.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4999)
  AUTHORS   Yang,H., Zingaro,V.A., Lincoff,J., Tom,H., Oikawa,S.,
            Oses-Prieto,J.A., Edmondson,Q., Seiple,I., Shah,H., Kajimura,S.,
            Burlingame,A.L., Grabe,M. and Ruggero,D.
  TITLE     Remodelling of the translatome controls diet and its impact on
            tumorigenesis
  JOURNAL   Nature 633 (8028), 189-197 (2024)
   PUBMED   39143206
REFERENCE   2  (bases 1 to 4999)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4999)
  AUTHORS   Yang,G., Smibert,C.A., Kaplan,D.R. and Miller,F.D.
  TITLE     An eIF4E1/4E-T complex determines the genesis of neurons from
            precursors by translationally repressing a proneurogenic
            transcription program
  JOURNAL   Neuron 84 (4), 723-739 (2014)
   PUBMED   25456498
REFERENCE   4  (bases 1 to 4999)
  AUTHORS   Santini,E., Huynh,T.N., MacAskill,A.F., Carter,A.G., Pierre,P.,
            Ruggero,D., Kaphzan,H. and Klann,E.
  TITLE     Exaggerated translation causes synaptic and behavioural aberrations
            associated with autism
  JOURNAL   Nature 493 (7432), 411-415 (2013)
   PUBMED   23263185
  REMARK    GeneRIF: increasing the levels eIF4E in mice results in exaggerated
            cap-dependent translation and aberrant behaviours reminiscent of
            autism, including repetitive and perseverative behaviours and
            social interaction deficits
REFERENCE   5  (bases 1 to 4999)
  AUTHORS   Gkogkas,C.G., Khoutorsky,A., Ran,I., Rampakakis,E., Nevarko,T.,
            Weatherill,D.B., Vasuta,C., Yee,S., Truitt,M., Dallaire,P.,
            Major,F., Lasko,P., Ruggero,D., Nader,K., Lacaille,J.C. and
            Sonenberg,N.
  TITLE     Autism-related deficits via dysregulated eIF4E-dependent
            translational control
  JOURNAL   Nature 493 (7432), 371-377 (2013)
   PUBMED   23172145
  REMARK    GeneRIF: translational control by eIF4E regulates the synthesis of
            neuroligins, maintaining the excitation-to-inhibition balance, and
            its dysregulation engenders autism spectrum disorder-like
            phenotypes
REFERENCE   6  (bases 1 to 4999)
  AUTHORS   Niedzwiecka,A., Darzynkiewicz,E. and Stolarski,R.
  TITLE     Thermodynamics of mRNA 5' cap binding by eukaryotic translation
            initiation factor eIF4E
  JOURNAL   Biochemistry 43 (42), 13305-13317 (2004)
   PUBMED   15491137
  REMARK    GeneRIF: Thermodynamic studies reveal the unique, large and
            positive heat capacity changes at constant pressure that accompany
            interactions between eIF4E and the mRNA 5' cap.
REFERENCE   7  (bases 1 to 4999)
  AUTHORS   Rousseau,D., Kaspar,R., Rosenwald,I., Gehrke,L. and Sonenberg,N.
  TITLE     Translation initiation of ornithine decarboxylase and
            nucleocytoplasmic transport of cyclin D1 mRNA are increased in
            cells overexpressing eukaryotic initiation factor 4E
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1065-1070 (1996)
   PUBMED   8577715
REFERENCE   8  (bases 1 to 4999)
  AUTHORS   Jaramillo,M., Pelletier,J., Edery,I., Nielsen,P.J. and Sonenberg,N.
  TITLE     Multiple mRNAs encode the murine translation initiation factor
            eIF-4E
  JOURNAL   J Biol Chem 266 (16), 10446-10451 (1991)
   PUBMED   2037592
REFERENCE   9  (bases 1 to 4999)
  AUTHORS   Dorfman,J., Lazaris-Karatzas,A., Malo,D., Sonenberg,N. and Gros,P.
  TITLE     Chromosomal assignment of one of the mammalian translation
            initiation factor eIF-4E genes
  JOURNAL   Genomics 9 (4), 785-788 (1991)
   PUBMED   1674733
REFERENCE   10 (bases 1 to 4999)
  AUTHORS   Altmann,M., Muller,P.P., Pelletier,J., Sonenberg,N. and Trachsel,H.
  TITLE     A mammalian translation initiation factor can substitute for its
            yeast homologue in vivo
  JOURNAL   J Biol Chem 264 (21), 12145-12147 (1989)
   PUBMED   2663851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN714483.1, AK167097.1,
            AK082867.1, AC113988.8 and BP770650.1.
            
            On Sep 19, 2015 this sequence version replaced NM_007917.3.
            
            Summary: This gene encodes a component of the eukaryotic
            translation initiation factor 4F complex, which recognizes the
            7-methylguanosine cap structure at the 5' end of messenger RNAs.
            The encoded protein aids in translation initiation by recruiting
            ribosomes to the 5'-cap structure. Association of this protein with
            the 4F complex is the rate-limiting step in translation initiation.
            This gene acts as a proto-oncogene, and its expression and
            activation is associated with transformation and tumorigenesis. It
            has also been associated with autism spectrum disorders.
            Consistently, knockout of this gene results in increased
            translation of neuroligins, postsynaptic proteins linked to autism
            spectrum disorders. Pseudogenes of this gene are found on other
            chromosomes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA684264.1, ERR3363658.4369291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               CN714483.1         1-112
            113-1664            AK167097.1         2-1553
            1665-2882           AK082867.1         1546-2763
            2883-4440           AC113988.8         113972-115529
            4441-4999           BP770650.1         25-583              c
FEATURES             Location/Qualifiers
     source          1..4999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.3 cM"
     gene            1..4999
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="eukaryotic translation initiation factor 4E"
                     /db_xref="GeneID:13684"
                     /db_xref="MGI:MGI:95305"
     exon            1..104
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     exon            105..151
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..787
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eIF-4F 25 kDa subunit; mRNA cap-binding protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E
                     isoform 1"
                     /protein_id="NP_031943.3"
                     /db_xref="CCDS:CCDS38654.1"
                     /db_xref="GeneID:13684"
                     /db_xref="MGI:MGI:95305"
                     /translation="MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWA
                     LWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMW
                     EDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG
                     DKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV"
     exon            152..258
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     exon            259..354
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     exon            355..418
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     exon            419..532
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     exon            533..672
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     exon            673..4979
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="major polyA site"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="hexamer: AATAAA"
     polyA_site      2192
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="hexamer: GATAAA"
     polyA_site      2466
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="hexamer: AATACA"
     polyA_site      2887
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
     regulatory      4959..4964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
                     /note="hexamer: ATTAAA"
     polyA_site      4979
                     /gene="Eif4e"
                     /gene_synonym="EG668879; eIF-4E; Eif4e-ps; If4e"
ORIGIN      
        1 ggaggcggag ggagctggtc cttaaggaag gcacgcgctt gcttctagat tccgaagcgt
       61 tttcaaagct ggttacagtc cttaccacag cacacccttg tgaggagcgg ttgtgcgatc
      121 agatcgatct aagatggcga ctgtggaacc ggaaaccacc cctaccacta atcccccacc
      181 tgcagaagag gaaaaaacag agtctaatca ggaggttgct aacccagagc actatattaa
      241 acaccctcta cagaacaggt gggcactctg gttttttaaa aatgataaaa gcaaaacttg
      301 gcaagcaaac cttcgattga tctctaagtt tgatactgtt gaagactttt gggctctata
      361 caaccatatc cagttgtcta gtaatttaat gcctggctgt gactactcac tttttaagga
      421 cgggattgag cctatgtggg aagatgagaa aaacaaacga ggaggacggt ggctgatcac
      481 actgaacaag cagcagagac ggagtgacct cgatcgcttc tggctagaga cactgctgtg
      541 ccttattgga gaatctttcg atgactacag tgatgatgtg tgtggagctg ttgttaatgt
      601 tagagctaaa ggtgataaga tagcaatatg gactactgag tgtgaaaaca gagatgcagt
      661 cacacacata gggagggtat acaaggaaag gttaggactt cctccgaaga tagtgattgg
      721 ttatcagtcc cacgcagaca cagctacaaa gagcggctcc accactaaaa ataggtttgt
      781 tgtttaagaa gacaccttct gagtattctc acaggagact gcgtcacgca atcgagattg
      841 ggagctgaac caaagcctca tcaaagcaga gtggactgca ctgaagttga ttccatccaa
      901 gtgttgctaa gatataagag aagtctcatt cgcctttgtc ttgtacttct gtgttcattc
      961 tcctccccca cccccaattt ttgctagtgt gtccactatc ccaatcaaag aattacagta
     1021 tacgtcaccc cagaacccgc agatgtgttc ctggcccgct ctgtaacagc cggttagaat
     1081 taccatgaca cacacatttg cctttccaca gtattcgaaa aagaacttgc atttctatta
     1141 ccttagcagg aaagatctgg ttttgctcca ctccatgcag gagcggactt tgctggtgtg
     1201 agagtctgag tacagctttc tagcaacctt ctgtttcctt tcacagcatt gtccttgctg
     1261 tcctcttgct gatggctgct agatttaatt tatttgcttc cctccttgat aacattagtg
     1321 attctgattt cagtttttca tttgttttgc ttttgttttt ttcctcgtgt aacattggtg
     1381 aaggatccag gaatatgaca gaaaggtgga ataaacatta aatttgtgca ttctttggta
     1441 atttttttgt tttttgtaac tacaaagctt tgctacaaat ttatgcattt cattcaaatc
     1501 agtgatctat gtctgtgtga tccctaaaca taattgtgga ctataaaaat gtaacaccat
     1561 aattacattc ctaactagaa ttagtatgtc tgcctttgta tctctatgct gtactttaac
     1621 actttgtatt cttaggttat tttgctttgg ttacaatggc tcaagtagaa aagcggtccc
     1681 atccatatta agacagtgta caaaactgta aataaaatgt gtacagtgaa ttgtctttta
     1741 gacaactaga tttgtccttt atttctccat ctctagaagg aatctgtact tcgtattgca
     1801 aggcagtctc ttgtgtcttc ttagagtgtc ttccccatgc acagcctcag tttggagcac
     1861 tagtttatta tgtttattac aatttttaat aaattgacta ggtagtatca catgtaatta
     1921 cactgatgtg gctatctttt taataaagtt aaggcacagt tgctcagtcc taggttgagt
     1981 gatggacttt gactatgtta cagttgatga ggattggggt tttggtgcat caccattcgg
     2041 taggaacagc ggctagaaac tgattgttgg gtttaagatg tttttactta atggccagaa
     2101 aattagcgta aggaaagtat atagagaaac atgcgttagg gacattagtg ttactatctg
     2161 aataaaacac aataaacaag tattaagaac tacttatatt ggtcaattgt tgcagtatgg
     2221 ttttctgtaa acttgaaacc ttgatctatt ctttgtatca tttaaagcaa acatgaagac
     2281 attttgtctg cagtacgtaa ttgtatagtt cagatcctgt gagatgaggt gtggctgtta
     2341 acgccgaagg gtaagctgaa ctgtgggtag cagagtggaa accattggct gagagaaaaa
     2401 tgctctttaa gtggtggttg ttatgaattc acactgataa cttgataaag atccttataa
     2461 aatacatacg gaattaatag cattgctctt attatgtacg tcaagaatgt ataaccgcct
     2521 gctcttgttg tcacagataa ctccctgttc agtgctttgg aaatagcgat gctcacgatc
     2581 tcagcattct gtaccctaca tctactgtgt ggatcattga gagatctttt gacattgcaa
     2641 catgatatgg tctatgttgg gctgcattcc tggctgtctt gtatgagacc ccggttggct
     2701 ccctgaagct gattgataca gtgtacaggc atgaaggtgg ctgatgaggc tttcttacca
     2761 acatgtggga ttctagtagt tgtatctatt agagattaat tctcatattc cttttcattc
     2821 atttgtaaga agtatcaact ttagaagtga aaaaagaatc ataaaataca gtttttaaag
     2881 ttaaaaactt tgagtaggat gtatctttgt tatagaaagt tgaaataatt tgtaatggat
     2941 gaataattat aatggaaaaa tgaaaaaact ggacagaaag atttagcata tactatatag
     3001 gaattaataa ctacagcact tacataataa gttaggcagt gttttattct tgtcacgtgt
     3061 tcataatata tgtaggtatt tctccctttt ataaatgaat gagaattggg atttggtgta
     3121 tcaccatttg atacattaag atttaaataa tttcatagct tctgtcagat acagagtatg
     3181 aacttgtgaa taattcttaa tcacataaat cacacactcc ctgaagatgt aataaatagg
     3241 ttgtagtaca ttagattcta aattccagtt agactcagct acaagctagg catataaaca
     3301 gccagcaaag ctagtcacaa ataaccatgg agactaaggt acagggttaa agtatgaatg
     3361 tttttattgg tgctctaaat caccatctaa gatagatggt agtgttcaac ttgacagaaa
     3421 tagacgttct tgaatgctgc tggagttgca tttaaaaggt taaatttagt aaatggcctg
     3481 tatggtgggt acatatctgt aatcacagtg ctgagatgga atgaccataa ggccaacctg
     3541 ggttacgtaa accctttatc aaaaagacaa ggaccaggaa tgtgcttcat tgagagtgct
     3601 tgccaagcat gtactatgtt ctgtgtgtga ttgccagcac tgtcaggaag atgaggtgta
     3661 gtgttgggtc tctgtgtatc acgtttctca tgacacccag ctttgtattc tcagtgtgga
     3721 gtattatggg gcaagtggat agatattctc atttggcacc agccctctaa atacacatca
     3781 aattgatgag tataccttga ggccagcctg gtccataatg ctagttctag gacaactaag
     3841 gctacacaaa ccctgtctcg aaacattgaa tccaaatgaa tcccactgtg ggaggatgcc
     3901 tgaaagccag tgcatacaaa tgccactttg taacatcccc tcccctccag ctgtggtcat
     3961 gccagtcgtg ggtttggttt ggtttggttt tttaatgtgt atgcatgcat gttttgtatc
     4021 gtgtggtgcc tgaggtggtc agcagagggc atgaaatccc tgcaactgaa gttaattact
     4081 tagcacagtt gtgagccacc atgtgagtgc tgggagtcaa ctggatctta cacaaaacca
     4141 acgactctgc ttactgcaga gccattactc cagccccatg gctcttgttt atgtgatggt
     4201 atgttcattt gtttttcatg acaggctttc tataagccca ggctgtcctg gaactcactg
     4261 tagactaggc tgggcaccag aataagtgct gggattaaag gttgtgcccc caacactgcc
     4321 cggtagtact ttgattttct ttctttgggg gagaggggag cttggtgtag tggtgcctgc
     4381 ctttaatccc agcactcagg aggtagaaac aggcacagcc tgatctacag aggctagcct
     4441 gatctacaga gctatatcta ggacagccag ggctatacac agattatata aattttgtta
     4501 ttttgagaca ggttttctct gtagccttgg ctgttctgga actcattctg tagaccaggc
     4561 tgagcaactg cctctgcctc cagagtgctg ggattaaagg tgttcaccac cactacccct
     4621 acccagtttt gtattctcag attaagactc catggtctaa atgtctagat ggcaataaat
     4681 atttaaatca atgtaaaaat cacttgtaga aaaaacgaaa aacaccgtct taaaactcaa
     4741 atgggagaac ttgcttatta cctgtatttt ttgtgggttt ttctttttct tttgagctta
     4801 ggttctacac agcccagaat ggctttaaac ctgcctcagc ctcccaaatg ttgggattac
     4861 agctgtgtgc ctgcttgttt gttccttttg agacctggtg tcgtttcata tctccggctg
     4921 taatggaagt cagatccatc ttattgcaga ggattggaat taaatgcgtt cactaccgaa
     4981 aaaaaaaaaa aaaaaaaaa
//
