LOCUS       NM_145625               3871 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4B (Eif4b),
            mRNA.
ACCESSION   NM_145625 XM_001005455
VERSION     NM_145625.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3871)
  AUTHORS   Screen,M., Matheson,L.S., Howden,A.J., Strathdee,D., Willis,A.E.,
            Bushell,M., Sansom,O. and Turner,M.
  TITLE     RNA helicase EIF4A1-mediated translation is essential for the GC
            response
  JOURNAL   Life Sci Alliance 7 (2), e202302301 (2023)
   PUBMED   38011999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3871)
  AUTHORS   Liang,R., Shen,X., Wang,F., Wang,X., DesJarlais,A., Syed,A.,
            Saba,R., Tan,Z., Yu,F., Ji,X., Shrestha,S., Ren,Y., Yang,J.,
            Park,Y., Schwartz,R.J., Soibam,B., McConnell,B.K., Stewart,M.D.,
            Kumar,A. and Liu,Y.
  TITLE     H19X-encoded miR-322(424)/miR-503 regulates muscle mass by
            targeting translation initiation factors
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (6), 2174-2186 (2021)
   PUBMED   34704401
REFERENCE   5  (bases 1 to 3871)
  AUTHORS   Chen,B., Chen,Y., Rai,K.R., Wang,X., Liu,S., Li,Y., Xiao,M., Ma,Y.,
            Wang,G., Guo,G., Huang,S. and Chen,J.L.
  TITLE     Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral
            Immunity
  JOURNAL   Front Immunol 12, 723885 (2021)
   PUBMED   34566982
  REMARK    GeneRIF: Deficiency of eIF4B Increases Mouse Mortality and Impairs
            Antiviral Immunity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3871)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3871)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 3871)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3871)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3871)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD563487.1, AK045250.1 and CO043713.1.
            
            On Feb 7, 2008 this sequence version replaced NM_145625.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036293.1, AK148012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               CD563487.1         1-157
            158-3852            AK045250.1         2-3696
            3853-3871           CO043713.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.26 cM"
     gene            1..3871
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /note="eukaryotic translation initiation factor 4B"
                     /db_xref="GeneID:75705"
                     /db_xref="MGI:MGI:95304"
     exon            1..191
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2014
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /note="eIF-4B"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4B"
                     /protein_id="NP_663600.2"
                     /db_xref="CCDS:CCDS49737.1"
                     /db_xref="GeneID:75705"
                     /db_xref="MGI:MGI:95304"
                     /translation="MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVPKPVSWADET
                     DDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGN
                     LPYDVTEDSIKDFFRGLNISAVRLPREPSNPDRLKGFGYAEFEDLDSLLSALSLNEES
                     LGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPTTDSFDDYPPRRGDD
                     SFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGS
                     GRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPRL
                     NLKPRSAPKEDDASASTSQSSRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLD
                     EPKLDRRPRERHPSWRSEETQERERSRTGSESSQTGASATSGRNTRRRESEKSLENET
                     LNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQPSPTSG
                     GGKVAAVQPPEEGPSRKDGNKVDVVGATQGQAGSCSRGPGDGGSRDHWKDLDRKDGKK
                     DQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDEDEGDDCTE"
     exon            192..329
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..538
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..655
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..710
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..845
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..983
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1157
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1386
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1484
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1698
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1754
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1860
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1933
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..3854
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /note="hexamer: AATAAA"
     polyA_site      3854
                     /gene="Eif4b"
                     /gene_synonym="2310046H11Rik; Eif4a2"
                     /note="major polyA site"
ORIGIN      
        1 cgccgcgcca ccccctcgcg ctgctttacg aacccagcgc ggcggcggcg ccccgccttc
       61 tgcctccgtc ctcggctccc cgccccctcc tggtttcacg tctccaagcc cgtcgcgccc
      121 gctataatca cgtgactgcc tcatccgggt cctttgcgtt ctctctccct ctcccaacat
      181 ggcggcctca gcaaaaaaga agaataagaa ggggaagacc atctccctaa cggactttct
      241 agctgaggat ggaggaactg gtggaggaag cacctatgtc cccaaaccag tcagctgggc
      301 tgatgaaaca gacgatctgg aaggagatgt gtcaacaact tggcatagta acgatgatga
      361 cgtgtacagg gcgcctccaa ttgaccgttc catccttccc actgctccac gggctgctcg
      421 ggaacccaat attgaccgga gccgtcttcc caagtcgcca ccctacactg ctttcctagg
      481 gaatctgccc tatgatgtga cagaagactc cattaaggat ttctttagag gattaaatat
      541 cagcgctgta cgcttaccac gggaacccag caatccagac aggttgaaag gtttcggcta
      601 cgcagaattt gaggacctgg attctctgct cagtgctctg agtctcaatg aagagtctct
      661 aggtaacagg agaattcgtg tggatgttgc tgatcaagca caggataaag acagggatga
      721 ccgttctttt ggtcgagata gaaatcggga ttctgacaaa acagacacag actggagggc
      781 ccgtcccacc acagacagtt ttgatgacta cccacctaga agaggcgatg atagctttgg
      841 agacaagtat cgagatcgtt acgattcaga ccggtatcgg gatgggtata gggacggata
      901 tcgggacggc ccacgcagag acatggaccg ctatgggggc cgggatcgct atgatgaccg
      961 aggcagcaga gactatgacc gaggctatga ctccaggata ggcagtggca gaagggcatt
     1021 tggaagtggg taccggagag atgatgacta cagaggaggt ggggaccgct atgaagaccg
     1081 ctatgacaga cgggatgatc ggtcgtggag ctccagggat gactactctc gggatgatta
     1141 taggcgtgat gacagaggtc ccccccagag acccagactg aacctcaagc ctcgaagcgc
     1201 tcctaaggag gatgacgcct ccgccagcac ctcccagtcc agccgggcag cctccatctt
     1261 tggaggggcg aagcctgttg acacagctgc tagggaaaga gaagtagagg agcggctaca
     1321 gaaggagcag gagaagctgc agcgtcagct ggatgagcca aaactagacc gccggccccg
     1381 ggagagacac ccaagctggc gaagtgaaga aactcaggaa agagaacggt caaggacagg
     1441 aagtgagtca tcgcagactg gggcctcagc cacatctggc agaaatacac gaaggagaga
     1501 gagtgagaag tctctagaaa atgaaaccct caataaagaa gaagactgtc actctccaac
     1561 ctctaagcct cctaaacctg accagcctct aaaggtaatg ccagcccctc caccaaagga
     1621 gaatgcgtgg gtgaagcgaa gctctaaccc tcctgcccga tctcagagct cagacacaga
     1681 gcagccgtcc cctacaagtg gtggagggaa agtagctgca gtccagcccc ctgaggaagg
     1741 accatcaaga aaagatggaa ataaagtgga tgtggtgggt gccacacaag gccaagctgg
     1801 aagctgcagc cgtggtcccg gggatggagg gagcagagac cactggaagg acttggatag
     1861 gaaggatggc aaaaaagatc aagactccag atctgcgcct gagccaaaga aacctgagga
     1921 gaacccagcc tctaagttca gctctgcaag caagtacgct gctctgtctg tggatggcga
     1981 ggatgaggat gagggcgacg actgcactga gtaggacctc cgcaccctgt gctttctcct
     2041 agtctccacc ccggaacatt caagagcaaa tcaaacctct atccagacaa gacaaaataa
     2101 actcaccatc tcctgaagac ctttctaaac ttttttttta atgaaatgaa attcttttgc
     2161 atgctgctgc agccttttaa agtattgaag taactggaga atcaccattg tagccagaga
     2221 cgtggctacc gcttttgaat ggggaagttg tgtctgacaa taccaagcag ttactgtgtg
     2281 actagtgcct ggggctccat tcagcagaat tgcagtgaca gagaggcagt cacatcagtt
     2341 aggcagtaga aaaaggtgca aagcagaagt gagatttcta ctttctaatt cttatcctga
     2401 gatggcacct gtgaataccc aaacattacc tgaatttacc tgaataaatt tcccatcctt
     2461 agaaaggtag ctctagtctc aagctgtttt agtctccagg aggctgccag cccctctact
     2521 ttagttctga cttcaatggg gccagcctaa gggggaattg ttttattttt ttacccccca
     2581 agggggtagt tgggagtgag tctacggggc actaacaagt agttcccgct tggggaccaa
     2641 gatgaacgga aactcaatcg tggtttggaa agctttgggg aggtgactaa ttatatttta
     2701 tacccggtag tgagggaaac agtgtgacct ccagtaaaca catacataga atggtcattt
     2761 ctggatgagg aagcacttaa caggtagtga gaaggcctgg ctttgcccct tctaaactct
     2821 cctttctaga ggttgaaata tacccatatt attttgaaaa ccttgtcact ctggtcatct
     2881 catggtctcc atgacactta gcctcccaga gctgtctgtg agtcacacac ctcccacaga
     2941 cactgtatct tagccacaaa aagccatggc ctgaggactc gctgcttttc tcaagcaagc
     3001 cagtgagttt tctctgtgct atctttgatt tctgcctgct cctgcagctt tcagcctcaa
     3061 ctgatgggct tgggtggtga ataggggtgt gtaaatgggg tgagttggag gtcttcagcc
     3121 ttgaatggga tgtaaggttt ctataaatct ccctcactgg agccccacgc tggtgcttgt
     3181 ttataatgta tgtgaccctg actggttttc tgcttaggag ggttggcttc tttactcccc
     3241 tcaagaataa aggataatgc aaagaacgat tgagcaaggt cctggtttct cttgcaacac
     3301 tgtagcttga cctgtctgct ttgatgtgca cctttgtagg ggtcagctcc aaagatggcg
     3361 agcctccctg ttgtgggtag tcaggtacct gcagacagag gataccttgg tcctaggcct
     3421 gctgtgcagg agcactgatg tcccgtgctg cagcagtagg cacagcaaat cgcttctccg
     3481 gtggatttga ttggctagta gctaggaagt gggcttttgc agatacccac agttgaatgg
     3541 gtttttttaa accattgttg tagacaatga gaaggtagtt tgccctcttc atgtctattt
     3601 cccttccaga tagttgcatc cgaagacagc tgttttgtcc cactctccta ctttgctcct
     3661 ctgttaaaat aaaaacaggg gttgacttat gtcccgctcc tgaatacatg taaaatttgt
     3721 acaaaaatat cttctatgaa aatgatttgt aatctgtaga cattacttgg gagatgtctt
     3781 gagatgtaaa atcccatcct ttgggttgag ggtttttttg tttttctcca aataaatcca
     3841 gtctttaaag ttgaaaaaaa aaaaaaaaaa a
//
