LOCUS       NM_138669               1489 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4A3 (Eif4a3),
            mRNA.
ACCESSION   NM_138669
VERSION     NM_138669.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Yang,Y., Yang,H. and Yang,C.
  TITLE     Circ-AMOTL1 enhances cardiac fibrosis through binding with EIF4A3
            and stabilizing MARCKS expression in diabetic cardiomyopathy
  JOURNAL   Cell Signal 111, 110853 (2023)
   PUBMED   37586467
  REMARK    GeneRIF: Circ-AMOTL1 enhances cardiac fibrosis through binding with
            EIF4A3 and stabilizing MARCKS expression in diabetic
            cardiomyopathy.
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Luo,P., Gong,Y., Weng,J., Wen,F., Luo,J., Hu,C., Xiao,J. and Shu,J.
  TITLE     CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate
            c-src/FAK and promotes TNBC progression
  JOURNAL   Cell Signal 108, 110690 (2023)
   PUBMED   37121557
  REMARK    GeneRIF: CircKIF4A combines EIF4A3 to stabilize SDC1 expression to
            activate c-src/FAK and promotes TNBC progression.
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Lupan,B.M., Solecki,R.A., Musso,C.M., Alsina,F.C. and Silver,D.L.
  TITLE     The exon junction complex component EIF4A3 is essential for mouse
            and human cortical progenitor mitosis and neurogenesis
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37139782
  REMARK    GeneRIF: The exon junction complex component EIF4A3 is essential
            for mouse and human cortical progenitor mitosis and neurogenesis.
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Miller,E.E., Kobayashi,G.S., Musso,C.M., Allen,M., Ishiy,F.A.A., de
            Caires,L.C. Jr., Goulart,E., Griesi-Oliveira,K., Zechi-Ceide,R.M.,
            Richieri-Costa,A., Bertola,D.R., Passos-Bueno,M.R. and Silver,D.L.
  TITLE     EIF4A3 deficient human iPSCs and mouse models demonstrate neural
            crest defects that underlie Richieri-Costa-Pereira syndrome
  JOURNAL   Hum Mol Genet 26 (12), 2177-2191 (2017)
   PUBMED   28334780
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Koroleva,O.A., Calder,G., Pendle,A.F., Kim,S.H., Lewandowska,D.,
            Simpson,C.G., Jones,I.M., Brown,J.W. and Shaw,P.J.
  TITLE     Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of
            exon junction complex: fast relocation to nucleolus and splicing
            speckles under hypoxia
  JOURNAL   Plant Cell 21 (5), 1592-1606 (2009)
   PUBMED   19435936
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   Feng,J., Lawson,M.A. and Melamed,P.
  TITLE     A proteomic comparison of immature and mature mouse gonadotrophs
            reveals novel differentially expressed nuclear proteins that
            regulate gonadotropin gene transcription and RNA splicing
  JOURNAL   Biol Reprod 79 (3), 546-561 (2008)
   PUBMED   18480465
  REMARK    GeneRIF: The knockdown of PRPF19 or EIF4A3 decreased splicing of
            Lhb, or of both beta subunit transcripts, respectively.
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC008132.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008132.1, AK167107.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.35 cM"
     gene            1..1489
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /note="eukaryotic translation initiation factor 4A3"
                     /db_xref="GeneID:192170"
                     /db_xref="MGI:MGI:1923731"
     exon            1..216
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            217..289
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            290..356
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            357..419
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            420..552
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            553..633
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            634..775
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            776..914
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1030
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1138
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1266
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1463
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1439..1444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /note="hexamer: ATTAAA"
     polyA_site      1463
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /note="major polyA site"
ORIGIN      
        1 ccggttcccg ccgcggcttg cagttgtctt tctgcggaat ccggatcatg gcggctaacg
       61 ccacgatggc gacgtctggc tcggcgcgga agcggctgct caaagaggag gacatgacca
      121 aagtggagtt cgagacgagc gaggaggtgg acgtgacccc cacgttcgac accatgggcc
      181 tgcgagagga cctgctgcgc ggcatctacg cctacggttt tgaaaaacct tcagcgattc
      241 agcagcgtgc tatcaagcag ataattaaag ggagagatgt cattgcacag tctcagtctg
      301 gcacaggcaa gacggccacc ttcagtgtct cagtgctgca gtgcttggat atccaggttc
      361 gagaaaccca agctttgatc ctggctccaa ccagggagtt agcggtgcag attcagaagg
      421 gtctgctcgc gctgggggat tacatgaacg tgcagtgcca tgcctgcatt gggggcacca
      481 acgtcggcga ggacatccgg aagctggact acggacagca cgtggtggca ggcacgccgg
      541 gacgcgtctt tgatatgatc cgccggagaa gtttacggac acgggctatc aagatgctgg
      601 ttttggatga ggctgatgaa atgttgaaca aaggtttcaa ggagcagatc tatgatgtgt
      661 acaggtactt gccaccagcc acacaggtcg tcctcatcag cgccacactg cctcatgaga
      721 tcctggagat gaccaacaag ttcatgaccg accccatccg catcttggtg aagcgtgatg
      781 agttgactct ggaaggcatc aaacagttct ttgtggctgt ggaaagagag gaatggaaat
      841 ttgatactct atgtgatctc tatgacacgc tgaccatcac ccaggccgtc atcttctgca
      901 acaccaagcg gaaggttgac tggctgacag agaaaatgag agaagccaat ttcactgtgt
      961 cgtccatgca tggagacatg ccccagaaag aacgagagtc tatcatgaag gagttccggt
     1021 caggtgccag ccgggtgctc atctccacag acgtctgggc ccggggcctg gatgtccctc
     1081 aggtgtccct catcattaac tacgacctgc ccaacaacag agaactgtac attcacagaa
     1141 ttgggagatc gggtcggtat ggacgaaaag gtgtggccat caattttgtg aagaatgatg
     1201 acatccggat tctcagggac attgagcagt actactccac ccagatagac gagatgccca
     1261 tgaatgtggc tgacctcatc tgaagctggt gctggtgcac cgaggccctg tttggaaacg
     1321 gaagcttcta tttaatgggg ttgatatgga ctgtcttctc ggagcccctc gggaagaccc
     1381 tcagcctccg ccatcttttc taatgcacat gtacataatc cgatgcttaa ccttttacat
     1441 taaacgtgga cattttcctg tgaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
