LOCUS       NM_013506               2369 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4A2 (Eif4a2),
            transcript variant 1, mRNA.
ACCESSION   NM_013506
VERSION     NM_013506.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Kim,S.H., Choi,J.H., Marsal-Garcia,L., Amiri,M., Yanagiya,A. and
            Sonenberg,N.
  TITLE     The mRNA translation initiation factor eIF4G1 controls
            mitochondrial oxidative phosphorylation, axonal morphogenesis, and
            memory
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2300008120 (2023)
   PUBMED   37307456
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Percharde,M., Wong,P. and Ramalho-Santos,M.
  TITLE     Global Hypertranscription in the Mouse Embryonic Germline
  JOURNAL   Cell Rep 19 (10), 1987-1996 (2017)
   PUBMED   28591571
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Galicia-Vazquez,G., Di Marco,S., Lian,X.J., Ma,J.F., Gallouzi,I.E.
            and Pelletier,J.
  TITLE     Regulation of eukaryotic initiation factor 4AII by MyoD during
            murine myogenic cell differentiation
  JOURNAL   PLoS One 9 (1), e87237 (2014)
   PUBMED   24466343
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Williams-Hill,D.M., Duncan,R.F., Nielsen,P.J. and Tahara,S.M.
  TITLE     Differential expression of the murine eukaryotic translation
            initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon
            cellular growth status
  JOURNAL   Arch Biochem Biophys 338 (1), 111-120 (1997)
   PUBMED   9015395
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Balakin,A.G., Smith,L. and Fournier,M.J.
  TITLE     The RNA world of the nucleolus: two major families of small RNAs
            defined by different box elements with related functions
  JOURNAL   Cell 86 (5), 823-834 (1996)
   PUBMED   8797828
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Sudo,K., Takahashi,E. and Nakamura,Y.
  TITLE     Isolation and mapping of the human EIF4A2 gene homologous to the
            murine protein synthesis initiation factor 4A-II gene Eif4a2
  JOURNAL   Cytogenet Cell Genet 71 (4), 385-388 (1995)
   PUBMED   8521730
REFERENCE   9  (bases 1 to 2369)
  AUTHORS   Nielsen,P.J., Rochelle,J.M. and Seldin,M.F.
  TITLE     The functional genes for protein synthesis initiation factor 4AI
            and 4AII map to mouse chromosomes 11 and 16
  JOURNAL   Mamm Genome 4 (3), 185-186 (1993)
   PUBMED   8439732
REFERENCE   10 (bases 1 to 2369)
  AUTHORS   Nielsen,P.J. and Trachsel,H.
  TITLE     The mouse protein synthesis initiation factor 4A gene family
            includes two related functional genes which are differentially
            expressed
  JOURNAL   EMBO J 7 (7), 2097-2105 (1988)
   PUBMED   3046931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY286182.1, CF723811.1, AK076509.1, BC094422.1 and AC154540.2.
            
            On Jan 17, 2014 this sequence version replaced NM_013506.2.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094422.1, X12507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               BY286182.1         2-158
            158-290             CF723811.1         50-182
            291-1918            AK076509.1         2-1629
            1919-2184           BC094422.1         1615-1880
            2185-2369           AC154540.2         166164-166348
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.93 cM"
     gene            1..2369
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /note="eukaryotic translation initiation factor 4A2"
                     /db_xref="GeneID:13682"
                     /db_xref="MGI:MGI:106906"
     exon            1..353
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1548
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /EC_number="3.6.4.13"
                     /note="isoform a is encoded by transcript variant 1;
                     eukaryotic initiation factor 4A-II; ATP-dependent RNA
                     helicase eIF4A-2"
                     /codon_start=1
                     /product="eukaryotic initiation factor 4A-II isoform a"
                     /protein_id="NP_038534.2"
                     /db_xref="CCDS:CCDS28074.1"
                     /db_xref="GeneID:13682"
                     /db_xref="MGI:MGI:106906"
                     /translation="MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESL
                     LRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKET
                     QALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTP
                     GRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMP
                     TDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQA
                     VIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLA
                     RGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFY
                     NTTVEEMPMNVADLI"
     exon            354..399
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            400..532
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            533..672
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            673..841
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            842..951
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1095
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1233
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1323
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1403
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..2369
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="Eif4a2"
                     /gene_synonym="4833432N07Rik; BM-010; Ddx2b; eIF-4A-II;
                     Eif4; eIF4A-II"
                     /note="major polyA site"
ORIGIN      
        1 aggagcaggg cggccgagga gcgcggcgcg cggtcgcgct gctgcaatat tcttccgccg
       61 aaagcaaaga gtcccagacc cgttcccgat tcgtggatct ccgggaacgc tgtaatacca
      121 agtaatagtg aaatgtggat tttgtcatcg actcctgtag ggcttcacct ccggtaacaa
      181 actccaggag tacaattttg tggcttccga aaggggaata aggaaattcc tccgcgagaa
      241 acgggttccg gccgcgagcc tataaaaaac gggcggcgcc gtccgcctgt cttttcagtc
      301 gggcgctgag tgggttttcg gatcatgtct ggtggctccg cggattacaa cagagaacat
      361 ggcggcccag agggaatgga ccccgatggt gtcatcgaga gcaactggaa tgaaattgtt
      421 gataactttg atgatatgaa tttaaaggag tcccttcttc gaggcatcta tgcatatggt
      481 tttgagaagc cttcagctat tcagcaaaga gctattatcc cttgtattaa agggtatgat
      541 gtgattgctc aagctcagtc aggtactggc aagacagcca catttgctat ttccatcctg
      601 caacagttgg agattgagtt caaggagacc caagcactag tattggcccc caccagagaa
      661 ctggctcaac agatccaaaa ggtaattttg gctcttggag attatatggg agcaacttgt
      721 catgcttgca ttggaggaac aaatgttcga aatgaaatgc agaagttgca ggctgaagcc
      781 cctcacattg ttgttggtac tccagggaga gtgtttgata tgctaaacag aagatacctt
      841 tctccaaaat ggatcaaaat gttcgttttg gacgaagcag atgaaatgtt gagccgaggg
      901 tttaaggatc agatctatga gattttccag aaattaaata caagcattca ggttgtgttg
      961 ctttctgcca caatgccaac tgatgtgcta gaagtgacca agaaattcat gagagatcca
     1021 attcgaattc tggtgaagaa ggaagaattg acccttgaag gaattaaaca attttatatt
     1081 aatgttgagc gagaggagtg gaagctggac actctttgtg acttgtatga gactttgact
     1141 atcacacaag cagttatttt tctcaataca aggcgcaagg tggactggct cacggagaaa
     1201 atgcatgcca gggacttcac agtttctgct ctgcatggtg acatggacca gaaggaaaga
     1261 gatgtcatca tgagggaatt ccgatcaggg tcaagccgtg ttctgatcac tactgacttg
     1321 ttggcccgtg ggattgacgt gcaacaagtg tccttggtta taaactacga tctacctacc
     1381 aatcgtgaaa actatattca cagaattggc agagggggtc gatttgggag gaaaggtgtg
     1441 gctataaact ttgttactga agaagacaag aggattcttc gtgacattga gactttctac
     1501 aatactacag tggaggaaat gcccatgaat gtggctgacc taatttaatc cctgggatga
     1561 gatagttttg aatgcagtgc tcgctgttgc tgaataggcg atcacaacgt gcattgtgct
     1621 tccttgagaa tatttgaatc ttgtctcaat gctcataacg gatcacaaat acagattctg
     1681 atagcaaagc gactttagtc ctgagctctt gtgaggaaag gcattggctt tatcctcttt
     1741 agagttagac tgttgggggt gggtataaaa gatggggtct gtaaaatctt tttttcttag
     1801 aaattcattt actagttatg tagaaatggt tgtattagat gttctctatc atttaataat
     1861 atacttgtgg actaaaagat ataagtgctg tataaaatca gccaattatg ttaaactggc
     1921 atatctgcct ttattgtgtt tgtcattagc ctgactagag aggcctttaa agtgatttct
     1981 tttttttaga gaaaatttga atgcattttg ttggtattgt atttattcaa taaagtattt
     2041 aattagtgct aagtgtgaac tggaccctgt tgctaagcct cagcaagcaa tcatcctagg
     2101 tagggttaaa cccccagtaa aattgccata ttgcacatgt cttaatgaag tttgaatgtt
     2161 aaataaaatt gtatattcac tttatatagg tggtctggcc atttatttat agtaactggt
     2221 ttcatacaaa aggggagaga tgaagcctct aacagttctg agttagctgc tgcatcacag
     2281 ttgcacaaag gctcatcaac tgcaggtgtt catctgcacc atctgccaag cacttgtcta
     2341 cttcctacaa aaggaaataa aaaaattac
//
