LOCUS       NM_144958               1897 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 4A1 (Eif4a1),
            transcript variant 1, mRNA.
ACCESSION   NM_144958 XM_907056
VERSION     NM_144958.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1897)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1897)
  AUTHORS   Screen,M., Matheson,L.S., Howden,A.J., Strathdee,D., Willis,A.E.,
            Bushell,M., Sansom,O. and Turner,M.
  TITLE     RNA helicase EIF4A1-mediated translation is essential for the GC
            response
  JOURNAL   Life Sci Alliance 7 (2), e202302301 (2023)
   PUBMED   38011999
  REMARK    GeneRIF: RNA helicase EIF4A1-mediated translation is essential for
            the GC response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1897)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1897)
  AUTHORS   Kim,S.H., Choi,J.H., Marsal-Garcia,L., Amiri,M., Yanagiya,A. and
            Sonenberg,N.
  TITLE     The mRNA translation initiation factor eIF4G1 controls
            mitochondrial oxidative phosphorylation, axonal morphogenesis, and
            memory
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2300008120 (2023)
   PUBMED   37307456
REFERENCE   5  (bases 1 to 1897)
  AUTHORS   Wang,J.J., Ge,W., Zhai,Q.Y., Liu,J.C., Sun,X.W., Liu,W.X., Li,L.,
            Lei,C.Z., Dyce,P.W., De Felici,M. and Shen,W.
  TITLE     Single-cell transcriptome landscape of ovarian cells during
            primordial follicle assembly in mice
  JOURNAL   PLoS Biol 18 (12), e3001025 (2020)
   PUBMED   33351795
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1897)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
REFERENCE   7  (bases 1 to 1897)
  AUTHORS   Pause,A. and Sonenberg,N.
  TITLE     Mutational analysis of a DEAD box RNA helicase: the mammalian
            translation initiation factor eIF-4A
  JOURNAL   EMBO J 11 (7), 2643-2654 (1992)
   PUBMED   1378397
REFERENCE   8  (bases 1 to 1897)
  AUTHORS   Reddy,N.S., Roth,W.W., Bragg,P.W. and Wahba,A.J.
  TITLE     Isolation and mapping of a gene for protein synthesis initiation
            factor 4A and its expression during differentiation of murine
            erythroleukemia cells
  JOURNAL   Gene 70 (2), 231-243 (1988)
   PUBMED   3215517
REFERENCE   9  (bases 1 to 1897)
  AUTHORS   Nielsen,P.J. and Trachsel,H.
  TITLE     The mouse protein synthesis initiation factor 4A gene family
            includes two related functional genes which are differentially
            expressed
  JOURNAL   EMBO J 7 (7), 2097-2105 (1988)
   PUBMED   3046931
REFERENCE   10 (bases 1 to 1897)
  AUTHORS   Nielsen,P.J., McMaster,G.K. and Trachsel,H.
  TITLE     Cloning of eukaryotic protein synthesis initiation factor genes:
            isolation and characterization of cDNA clones encoding factor
            eIF-4A
  JOURNAL   Nucleic Acids Res 13 (19), 6867-6880 (1985)
   PUBMED   3840589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5, AK169030.1 and AW493973.1.
            
            On Apr 15, 2009 this sequence version replaced NM_144958.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145375.1, AK152694.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL603707.5         51538-51652         c
            116-1877            AK169030.1         2-1763
            1878-1897           AW493973.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1897
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..1897
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /note="eukaryotic translation initiation factor 4A1"
                     /db_xref="GeneID:13681"
                     /db_xref="MGI:MGI:95303"
     exon            1..145
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            146..194
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            195..327
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            328..467
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            468..636
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..746
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            747..890
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1028
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1118
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1198
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1880
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /note="major polyA site"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
                     /note="hexamer: AATAAA"
     polyA_site      1880
                     /gene="Eif4a1"
                     /gene_synonym="BM-010; Ddx2a; Eif4"
ORIGIN      
        1 gtcgagttgc agagcgccgg caggcggggc agaggtggcc aagccaatgc gatggctggg
       61 gcggggtcgg acgctctata agttgtcgat aggcgggcac tccgccctag attctaagga
      121 tcatgtctgc gagtcaggat tctcgatcca gagacaatgg ccccgacggg atggagccgg
      181 aaggcgtcat cgagagtaac tggaacgaga ttgtggatag ctttgatgac atgaatctct
      241 cagagtccct cctccgtggt atttatgcct atggttttga gaagccctct gccatccagc
      301 agcgagctat tcttccttgt atcaagggtt atgatgtgat tgctcaagcc cagtctggga
      361 ctgggaaaac agctacattt gccatatcaa ttctgcagca gattgaatta gatctaaagg
      421 ccactcaggc tttggttctg gcacccacac gtgaattggc tcagcagata caaaaggtgg
      481 ttatggcatt aggagactac atgggtgcct cttgtcatgc ctgcattggg ggcaccaatg
      541 tgcgtgctga ggtgcagaag ctgcagatgg aagctcccca tatcatcgtg ggtacccctg
      601 gccgggtgtt tgacatgctt aaccggagat acctgtcccc caaatacatc aagatgttcg
      661 tactggatga agcagatgaa atgttaagcc gagggttcaa ggatcagatc tatgacatat
      721 tccagaagct caacagcaac acacaggtag ttttgttgtc tgctacaatg ccttctgatg
      781 tccttgaggt gaccaagaaa tttatgagag accctattcg gattcttgtc aagaaggaag
      841 aattgaccct ggagggtatc cgccaattct acatcaatgt ggaacgagag gagtggaagc
      901 ttgacacatt gtgtgacttg tatgagacgc tgaccatcac ccaggcagtc atctttatca
      961 acaccagaag gaaggtggac tggctcaccg agaagatgca tgcccgagat ttcactgttt
     1021 ctgccatgca cggagatatg gaccaaaagg aacgagatgt gatcatgagg gagttccggt
     1081 ctggctctag cagagtatta attaccactg acctgttggc cagaggcatt gatgtgcagc
     1141 aggtctcctt agtcatcaac tatgaccttc ccaccaacag ggaaaactac atccacagaa
     1201 tcggtcgagg tggtcggttt ggtcgtaagg gtgtggctat taacatggtg accgaagaag
     1261 acaagaggac tcttcgagac attgagactt tctacaacac ctccattgaa gagatgcccc
     1321 tcaacgttgc tgacctcatt tgaggggctg tcctgcgacc tggccctagc ccagggttca
     1381 gtcctggggt ggggctaagg aagagctgga ggggggaggg gagggagcca agggatggac
     1441 atcttgtttt tgttttggct tttttttttt ttgtttcagt tttttttctc tatgaataaa
     1501 tgtcactttt tgaggcaaaa agaaggaacc gtgaacattt tagacaccct tttctttggg
     1561 gtaggctctg ccccaggcgc cgtctccttc cccccccaaa cactaatgca tttccctaac
     1621 ctagtcacct cgttcctaaa ggctttccta ccccagccaa atctccaaaa gtgagtcaag
     1681 gggctaaaaa acaaggctgg cctcatttgc tggaccaaat ctacagggag aacccctgag
     1741 tgaggttgtc cagggaattg tcccctggtg aggggagcag gggagagaaa atggtagcca
     1801 tttttacatt gttttgtata gtatttattg attcaggaaa caaacacaaa attctgaata
     1861 aaattacttg gaaactgcct aaaaaaaaaa aaaaaaa
//
