LOCUS       NM_145380               1230 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit M
            (Eif3m), mRNA.
ACCESSION   NM_145380
VERSION     NM_145380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Liang,R., Shen,X., Wang,F., Wang,X., DesJarlais,A., Syed,A.,
            Saba,R., Tan,Z., Yu,F., Ji,X., Shrestha,S., Ren,Y., Yang,J.,
            Park,Y., Schwartz,R.J., Soibam,B., McConnell,B.K., Stewart,M.D.,
            Kumar,A. and Liu,Y.
  TITLE     H19X-encoded miR-322(424)/miR-503 regulates muscle mass by
            targeting translation initiation factors
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (6), 2174-2186 (2021)
   PUBMED   34704401
REFERENCE   2  (bases 1 to 1230)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1230)
  AUTHORS   Zeng,L., Wan,Y., Li,D., Wu,J., Shao,M., Chen,J., Hui,L., Ji,H. and
            Zhu,X.
  TITLE     The m subunit of murine translation initiation factor eIF3
            maintains the integrity of the eIF3 complex and is required for
            embryonic development, homeostasis, and organ size control
  JOURNAL   J Biol Chem 288 (42), 30087-30093 (2013)
   PUBMED   24003236
  REMARK    GeneRIF: not only is eIF3m an essential gene, but its expression
            level is also important for mouse embryonic development and the
            control of organ size.
REFERENCE   4  (bases 1 to 1230)
  AUTHORS   Kleinjan,D.A., Seawright,A., Elgar,G. and van Heyningen,V.
  TITLE     Characterization of a novel gene adjacent to PAX6, revealing
            synteny conservation with functional significance
  JOURNAL   Mamm Genome 13 (2), 102-107 (2002)
   PUBMED   11889558
REFERENCE   5  (bases 1 to 1230)
  AUTHORS   Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
            and Gessler,M.
  TITLE     A 7.5 Mb sequence-ready PAC contig and gene expression map of human
            chromosome 11p13-p14.1
  JOURNAL   Genome Res 9 (11), 1074-1086 (1999)
   PUBMED   10568747
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL606494.4.
            
            On Nov 17, 2006 this sequence version replaced NM_145380.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103795.1, AK077480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL606494.4         170969-171050       c
            83-215              AL606494.4         168793-168925       c
            216-354             AL606494.4         167768-167906       c
            355-478             AL606494.4         167221-167344       c
            479-573             AL606494.4         166874-166968       c
            574-657             AL606494.4         160779-160862       c
            658-757             AL606494.4         159804-159903       c
            758-839             AL606494.4         158948-159029       c
            840-983             AL606494.4         155294-155437       c
            984-1044            AL606494.4         154265-154325       c
            1045-1230           AL606494.4         153679-153864       c
FEATURES             Location/Qualifiers
     source          1..1230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.06 cM"
     gene            1..1230
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /note="eukaryotic translation initiation factor 3, subunit
                     M"
                     /db_xref="GeneID:98221"
                     /db_xref="MGI:MGI:1351744"
     exon            1..82
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1165
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /EC_number="3.6.5.3"
                     /note="PCI domain-containing protein 1; PCI domain
                     containing 1 (herpesvirus entry mediator); dendritic cell
                     protein GA17"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit M"
                     /protein_id="NP_663355.1"
                     /db_xref="CCDS:CCDS16495.1"
                     /db_xref="GeneID:98221"
                     /db_xref="MGI:MGI:1351744"
                     /translation="MSVPAFIDISEEDQAAELRAYLKSKGAELSEENSEGGLHVDLAQ
                     IIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLR
                     LQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWKLTTEK
                     KHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAF
                     LFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAK
                     MRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVV
                     SHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT"
     exon            83..215
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            216..354
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            355..478
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            574..657
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            658..757
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            758..839
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            840..983
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1044
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1230
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1209..1214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /note="hexamer: AGTAAA"
     polyA_site      1230
                     /gene="Eif3m"
                     /gene_synonym="Ga17; Pcid1; Tango7"
                     /note="major polyA site"
ORIGIN      
        1 gtttctggat cggagcgtct tccgcagccc ggccttcacc atgagcgtcc cggccttcat
       61 cgatatcagc gaggaagacc aggctgctga acttcgagct tatctgaaat caaaaggagc
      121 tgagctctca gaagaaaact cggaaggtgg acttcatgta gatttagctc agattattga
      181 agcctgtgat gtgtgtctga aggaagatga taaagatgtt gaaagtgtga tgaacagtgt
      241 ggtgtccctc ctgttgatcc tggaaccaga caagcaagaa gcattgattg aaagtctgtg
      301 tgaaaagctg gtcaagtttc gggaaggcga acgcccatct ctgagactac agttgctcag
      361 caaccttttc catgggatgg acaagaatac tcctgtgagg tacacagtgt actgcagcct
      421 catcaaagtg gcggcatcat gtggggccat ccagtacatc ccaacggagc tggatcaagt
      481 gagaaagtgg atctctgact ggaagctcac cactgaaaag aagcacaccc tcctcagact
      541 gctctacgag gcgctcgtgg attgtaagaa aagtgatgct gcatcaaagg tcatggtgga
      601 attgctcggg agttacacag aggacaatgc ttcccaggct cgagttgatg cccacaggtg
      661 tattgtgcgg gcactaaagg atccaaatgc ctttcttttt gaccatcttc ttactctaaa
      721 gccagtcaaa tttttggaag gcgagcttat ccatgattta ttaaccattt ttgtgagtgc
      781 taaattggca tcgtatgtca agttctatca gaataacaaa gacttcatag attcacttgg
      841 cttgttacat gagcaaaata tggcgaaaat gagactcctc acctttatgg gaatggcagt
      901 ggaaaacaaa gagatttctt ttgacacaat gcagcaagag ctacagattg gagctgatga
      961 tgttgaagca tttgttattg atgctgtaag aactaaaatg gtctactgca aaattgatca
     1021 gacccaaaga aaagtagttg tcagtcacag cacacatcgg acatttggaa aacagcagtg
     1081 gcaacaactg tatgacactc ttaatgcctg gaaacagaac ttgaacaaag tgaaaaatag
     1141 ccttttgagt ctttcagata cctgaatttt tatgaaaatg attttgttcg ttgagaaaaa
     1201 aagttctaag taaaacatta tcaactgaaa
//
