LOCUS       NM_145139               1893 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit L
            (Eif3l), mRNA.
ACCESSION   NM_145139
VERSION     NM_145139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Seither,P., Iben,S., Thiry,M. and Grummt,I.
  TITLE     PAF67, a novel protein that is associated with the
            initiation-competent form of RNA polymerase I
  JOURNAL   Biol Chem 382 (8), 1163-1170 (2001)
   PUBMED   11592397
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Southard-Smith,E.M., Collins,J.E., Ellison,J.S., Smith,K.J.,
            Baxevanis,A.D., Touchman,J.W., Green,E.D., Dunham,I. and Pavan,W.J.
  TITLE     Comparative analyses of the Dominant megacolon-SOX10 genomic
            interval in mouse and human
  JOURNAL   Mamm Genome 10 (7), 744-749 (1999)
   PUBMED   10384052
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Southard-Smith,E.M., Kos,L. and Pavan,W.J.
  TITLE     Sox10 mutation disrupts neural crest development in Dom
            Hirschsprung mouse model
  JOURNAL   Nat Genet 18 (1), 60-64 (1998)
   PUBMED   9425902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075584.1.
            
            On Aug 10, 2004 this sequence version replaced NM_145139.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ310346.1, AK075584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1893              AK075584.1         7-1899
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..1893
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /note="eukaryotic translation initiation factor 3, subunit
                     L"
                     /db_xref="GeneID:223691"
                     /db_xref="MGI:MGI:2386251"
     exon            1..70
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1732
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /note="eukaryotic translation initiation factor 3 subunit
                     6-interacting protein; eukaryotic translation initiation
                     factor 3 subunit E-interacting protein; 67 kDa
                     polymerase-associated factor; 66 kDa tyrosine-rich heat
                     shock protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit L"
                     /protein_id="NP_660121.2"
                     /db_xref="CCDS:CCDS27632.1"
                     /db_xref="GeneID:223691"
                     /db_xref="MGI:MGI:2386251"
                     /translation="MSYPADDYESEAAYDPYAYPGDYDMHTGDPKQDLAYERQYEQQT
                     YQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKL
                     TERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNY
                     CNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEGEMDFLRSN
                     PKVWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVG
                     LLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIR
                     VFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLRE
                     KYGDKMLRMQKGDPQVYEELFSYACPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDE
                     VQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISA
                     LDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP"
     exon            71..119
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            120..330
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            331..410
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            411..472
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            473..542
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            543..616
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            617..788
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            789..943
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1114
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1612
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1693
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1893
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1874..1879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /note="hexamer: AGTAAA"
     polyA_site      1893
                     /gene="Eif3l"
                     /gene_synonym="0610011H21Rik; D15N1e; Eif3eip; Eif3ip;
                     Eif3s6ip; HSP-66Y; PAF67"
                     /note="major polyA site"
ORIGIN      
        1 tccgctctct cccacgggct tctggagcgc cgtagccatg tcttaccccg ctgatgacta
       61 cgagtctgag gctgcttatg atccctacgc ctacccgggc gactatgata tgcacacagg
      121 agatccgaag caggaccttg cctatgagcg gcagtatgag cagcagacat atcaggtgat
      181 accggaagtg atcaaaaact tcatccagta cttccacaag actgtctccg atttgattga
      241 ccagaaggtg tacgagcttc aggccagccg cgtctcgagt gatgtcattg accagaaggt
      301 gtacgagatc caggacattt acgagaacag ctggaccaag ctaactgaaa ggttcttcaa
      361 gaatacaccg tggcctgagg cagaagcaat tgcaccccaa gttggcaatg atgccgtatt
      421 cctaattttg tacaaagaat tgtactacag gcatatttac gccaaagtca gtgggggtcc
      481 ctccttagaa cagaggttcg aatcttatta caactactgc aatctcttca actacatcct
      541 caatgcggat ggacctgcgc cccttgaact ccccaaccag tggctctggg acatcatcga
      601 tgagttcatc taccagttcc agtcattcag tcagtaccgc tgcaagacgg ccaagaagtc
      661 agagggagag atggacttcc ttaggtccaa ccctaaagtc tggaacgtgc acagcgtcct
      721 caacgtgctg cactccctgg tggacaagtc caacatcaac cggcagctgg aggtctacac
      781 cagcggaggt gacccggaaa gtgtagctgg ggagtatgga cgacactccc tctacaagat
      841 gctcggctac ttcagcctgg tggggcttct gcgcctgcat tctctactgg gggattacta
      901 ccaggctatc aaggtgctgg agaatatcga gctgaacaag aaaagcatgt attcccgtgt
      961 gcctgagtgc caggtcacca cctactatta tgttggcttt gcgtatttaa tgatgcgtcg
     1021 atatcaggat gctatccgag tctttgccaa catcctcctg tacatccaga ggaccaagag
     1081 tatgttccag aggaccacat acaaatatga aatgattaac aagcagaacg agcagatgca
     1141 tgctctgctg gccattgctc tcaccatgta cccgatgcgg atcgacgaga gcatacacct
     1201 ccagctgcgg gagaaatacg gggacaagat gctgcgcatg cagaaggggg acccccaggt
     1261 ctatgaggaa cttttcagct atgcctgccc caagttcctg tcgcctgtgg tgccaaacta
     1321 cgacaatgtc catcctaact accacaaaga gcccttcctg cagcagctga aggtgttttc
     1381 cgatgaggtg cagcagcagg cccagctctc caccatccgc agcttcctca agctctacac
     1441 caccatgcct gtggccaagc tggccggctt cctggacctc accgagcagg agttccgcat
     1501 ccagctgctc gtcttcaagc acaagatgaa gaatctggtg tggaccagtg gcatttctgc
     1561 cctagatggc gaattccagt cggcctcgga ggtggacttc tatattgata aggacatgat
     1621 ccatattgca gacaccaaag ttgccagacg ctatggggat ttctttatcc gacagatcca
     1681 caagtttgaa gagcttaatc gaaccctgaa gaagatggga cagaggccct gaagatactc
     1741 atccacgagt caagaacctg ttttgatatt atagatggga agcattcttg tcaccaagaa
     1801 gccttaccta agtcagccgt cagctgaatt gaaacttgtt caaatcaagg actggatgtt
     1861 ttaaggcgct ctcagtaaag ggtctttgtt gga
//
