LOCUS       NM_028659                757 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit K
            (Eif3k), transcript variant 1, mRNA.
ACCESSION   NM_028659
VERSION     NM_028659.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 757)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 757)
  AUTHORS   Fujii,K., Zhulyn,O., Byeon,G.W., Genuth,N.R., Kerr,C.H., Walsh,E.M.
            and Barna,M.
  TITLE     Controlling tissue patterning by translational regulation of
            signaling transcripts through the core translation factor eIF3c
  JOURNAL   Dev Cell 56 (21), 2928-2937 (2021)
   PUBMED   34752747
REFERENCE   3  (bases 1 to 757)
  AUTHORS   Zhao,Y., Zheng,D. and Cvekl,A.
  TITLE     A comprehensive spatial-temporal transcriptomic analysis of
            differentiating nascent mouse lens epithelial and fiber cells
  JOURNAL   Exp Eye Res 175, 56-72 (2018)
   PUBMED   29883638
REFERENCE   4  (bases 1 to 757)
  AUTHORS   Lin,Y.M., Chen,Y.R., Lin,J.R., Wang,W.J., Inoko,A., Inagaki,M.,
            Wu,Y.C. and Chen,R.H.
  TITLE     eIF3k regulates apoptosis in epithelial cells by releasing caspase
            3 from keratin-containing inclusions
  JOURNAL   J Cell Sci 121 (Pt 14), 2382-2393 (2008)
   PUBMED   18577580
REFERENCE   5  (bases 1 to 757)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   6  (bases 1 to 757)
  AUTHORS   Wei,Z., Zhang,P., Zhou,Z., Cheng,Z., Wan,M. and Gong,W.
  TITLE     Crystal structure of human eIF3k, the first structure of eIF3
            subunits
  JOURNAL   J Biol Chem 279 (33), 34983-34990 (2004)
   PUBMED   15180986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166357.3.
            
            On Dec 21, 2021 this sequence version replaced NM_028659.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004664.1, CB193280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC166357.3         2316-2440
            126-224             AC166357.3         3572-3670
            225-345             AC166357.3         6124-6244
            346-420             AC166357.3         6839-6913
            421-487             AC166357.3         9445-9511
            488-565             AC166357.3         9888-9965
            566-691             AC166357.3         11457-11582
            692-757             AC166357.3         12676-12741
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..757
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /note="eukaryotic translation initiation factor 3, subunit
                     K"
                     /db_xref="GeneID:73830"
                     /db_xref="MGI:MGI:1921080"
     exon            1..125
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..723
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 3, subunit 12;
                     eIF-3 p25"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit K isoform 1"
                     /protein_id="NP_082935.1"
                     /db_xref="CCDS:CCDS21062.1"
                     /db_xref="GeneID:73830"
                     /db_xref="MGI:MGI:1921080"
                     /translation="MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDL
                     EANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQI
                     LYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAE
                     MLGDLTDNQLKVWMSKYGWSADESGQVFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
                     "
     exon            126..224
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     exon            225..345
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     exon            346..420
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     exon            421..487
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     exon            488..565
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     exon            566..691
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      737..742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /note="hexamer: AATAAA"
     polyA_site      757
                     /gene="Eif3k"
                     /gene_synonym="1200009C21Rik; Eif3s12"
                     /note="major polyA site"
ORIGIN      
        1 cctctagtgc taagcaccgt gcctggtgtt cgactccagc tgaggctgcc gaaggcaaca
       61 gtgatcatgg cgatgtttga gcagatgaga gcgaacgtgg gcaagttgct caagggtatc
      121 gacaggtaca atcctgagaa cttggctacc ctggagcgat atgtggagac acaagccaaa
      181 gagaatgcct atgatctgga ggccaacctg gccgtcctga aactgtacca gttcaaccca
      241 gccttcttcc agaccacagt cactgcccag attctgctga aagccctcac caacctgccc
      301 cacaccgact tcactctgtg taaatgtatg atcgaccagg cacatcaaga agagcggccc
      361 atccggcaga tcttgtacct cggggacctg ctggagacct gccactttca agccttctgg
      421 caagccctgg atgagaacat ggaccttctg gaaggcataa ctggctttga agactctgtc
      481 cgaaaattta tctgccacgt ggtgggcatc acgtaccagc acatcgaccg ctggctgctg
      541 gccgagatgc tcggagacct gactgacaac cagctgaagg tgtggatgag caagtacggc
      601 tggagcgctg acgagtcagg gcaggtcttc atctgcagcc aggaagagag cattaagccc
      661 aagaacatcg tggagaagat tgactttgac agtgtgtcca gcatcatggc ctcctcccag
      721 taagccagtg tgcgttaata aagatttgtt cactccg
//
