LOCUS       NM_018799               1127 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit I
            (Eif3i), mRNA.
ACCESSION   NM_018799
VERSION     NM_018799.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1127)
  AUTHORS   Zhao,Z., Yang,W., Kong,R., Zhang,Y., Li,L., Song,Z., Chen,H.,
            Luo,Y., Zhang,T., Cheng,C., Li,G., Liu,D., Geng,X., Chen,H.,
            Wang,Y., Pan,S., Hu,J. and Sun,B.
  TITLE     circEIF3I facilitates the recruitment of SMAD3 to early endosomes
            to promote TGF-beta signalling pathway-mediated activation of MMPs
            in pancreatic cancer
  JOURNAL   Mol Cancer 22 (1), 152 (2023)
   PUBMED   37689715
  REMARK    GeneRIF: circEIF3I facilitates the recruitment of SMAD3 to early
            endosomes to promote TGF-beta signalling pathway-mediated
            activation of MMPs in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1127)
  AUTHORS   Huang,L., Wei,Z., Chang,X., Zheng,X., Yan,J., Huang,J., Zhang,J.
            and Sheng,L.
  TITLE     eIF3b regulates the cell proliferation and apoptosis processes in
            chronic myelogenous leukemia cell lines via regulating the
            expression of C3G
  JOURNAL   Biotechnol Lett 42 (7), 1275-1286 (2020)
   PUBMED   32236758
  REMARK    GeneRIF: eIF3b regulates the cell proliferation and apoptosis
            processes in chronic myelogenous leukemia cell lines via regulating
            the expression of C3G.
REFERENCE   3  (bases 1 to 1127)
  AUTHORS   Nyp,M.F., Mabry,S.M., Navarro,A., Menden,H., Perez,R.E., Sampath,V.
            and Ekekezie,I.I.
  TITLE     Lung epithelial-specific TRIP-1 overexpression maintains epithelial
            integrity during hyperoxia exposure
  JOURNAL   Physiol Rep 6 (5) (2018)
   PUBMED   29484847
  REMARK    GeneRIF: TRIP-1 overexpression protects alveolar epithelial cells
            against hyperoxic acute lung injury.
REFERENCE   4  (bases 1 to 1127)
  AUTHORS   Ramachandran,A., Ravindran,S., Huang,C.C. and George,A.
  TITLE     TGF beta receptor II interacting protein-1, an intracellular
            protein has an extracellular role as a modulator of matrix
            mineralization
  JOURNAL   Sci Rep 6, 37885 (2016)
   PUBMED   27883077
  REMARK    GeneRIF: TRIP-1 is a secreted protein and is present in the
            secretome of primary osteoblasts and in the extracellular
            matrix.TRIP-1 binds to type I collagen.TRIP-1 promotes calcium
            phosphate deposition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1127)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   6  (bases 1 to 1127)
  AUTHORS   Polesskaya,A., Cuvellier,S., Naguibneva,I., Duquet,A., Moss,E.G.
            and Harel-Bellan,A.
  TITLE     Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by
            increasing translation efficiency
  JOURNAL   Genes Dev 21 (9), 1125-1138 (2007)
   PUBMED   17473174
REFERENCE   7  (bases 1 to 1127)
  AUTHORS   Harris,T.E., Chi,A., Shabanowitz,J., Hunt,D.F., Rhoads,R.E. and
            Lawrence,J.C. Jr.
  TITLE     mTOR-dependent stimulation of the association of eIF4G and eIF3 by
            insulin
  JOURNAL   EMBO J 25 (8), 1659-1668 (2006)
   PUBMED   16541103
REFERENCE   8  (bases 1 to 1127)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 1127)
  AUTHORS   Joseph,P., Lei,Y.X. and Ong,T.M.
  TITLE     Up-regulation of expression of translation factors--a novel
            molecular mechanism for cadmium carcinogenesis
  JOURNAL   Mol Cell Biochem 255 (1-2), 93-101 (2004)
   PUBMED   14971650
  REMARK    GeneRIF: the up-regulation of expression of TIF3 is a novel
            molecular mechanism responsible, at least in part, for cadmium
            carcinogenesis
REFERENCE   10 (bases 1 to 1127)
  AUTHORS   Joseph,P., Lei,Y.X., Whong,W.Z. and Ong,T.M.
  TITLE     Molecular cloning and functional analysis of a novel
            cadmium-responsive proto-oncogene
  JOURNAL   Cancer Res 62 (3), 703-707 (2002)
   PUBMED   11830523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ079467.1, AK010781.1 and BP769420.1.
            
            On Aug 14, 2009 this sequence version replaced NM_018799.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF271072.1, AK149955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CJ079467.1         2-27
            27-1108             AK010781.1         2-1083
            1109-1127           BP769420.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..1127
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /note="eukaryotic translation initiation factor 3, subunit
                     I"
                     /db_xref="GeneID:54709"
                     /db_xref="MGI:MGI:1860763"
     exon            1..55
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1030
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /note="eukaryotic translation initiation factor 3, subunit
                     2 (beta); TGF-beta receptor binding protein; eukaryotic
                     translation initiation factor 3, subunit 1; TRIP-1;
                     TGF-beta receptor-interacting protein 1; eukaryotic
                     translation initiation factor 3, subunit 2 (beta, 36kD)"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit I"
                     /protein_id="NP_061269.1"
                     /db_xref="CCDS:CCDS18698.1"
                     /db_xref="GeneID:54709"
                     /db_xref="MGI:MGI:1860763"
                     /translation="MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGER
                     LGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFD
                     FGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMKIPCNDSKITSAVWGPLGEC
                     VIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDST
                     TLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEE
                     EFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA"
     exon            56..148
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..236
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..302
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..452
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..580
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..691
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..781
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..855
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..948
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1109
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /note="hexamer: AATAAA"
     polyA_site      1109
                     /gene="Eif3i"
                     /gene_synonym="36kDa; D4Ertd632e; Eif3s2; Trip1"
                     /note="major polyA site"
ORIGIN      
        1 agtctttttc cggtcccact cacattgcct ctctcctcgc gtcaccgcca ggatgaaacc
       61 catcctgctg cagggccatg agcggtccat cacgcagatc aagtataacc gcgaaggaga
      121 ccttctcttc accgtggcca aagaccctat cgtcaacgtg tggtactctg tcaatgggga
      181 gaggctaggc acctacatgg gccacactgg agctgtgtgg tgcgtggatg ctgactggga
      241 caccaagcat gtccttactg gctcagctga caacagctgt cgtctctggg actgtgaaac
      301 agggaagcag ctggccctac tcaagaccaa ctcagctgtc cggacctgcg gctttgactt
      361 tgggggcaac atcatcatgt tctccacaga caagcagatg gggtatcagt gcttcgtgag
      421 cttctttgat ctgcgggatc caagccagat cgacagcaac gagccctaca tgaagatccc
      481 ctgtaatgat tccaagatca ccagtgccgt ctggggcccc ctcggggagt gcgtcatcgc
      541 aggccacgag agcggagagc tcaaccagta tagcgccaag tctggagagg tgttggtgaa
      601 cgtaaaggaa cactctcggc agatcaatga catccagttg tctagagaca tgaccatgtt
      661 tgtcactgca tctaaggaca acacagctaa gctcttcgac tccacgactc ttgaacatca
      721 gaagactttc cgaacagagc gtcctgtcaa ctcggctgct ctctctccca actatgacca
      781 tgtggtgctg ggaggaggtc aggaagccat ggatgtgacc acaacctcca ccaggattgg
      841 caagtttgag gccaggttct tccatttggc ttttgaggaa gagtttggaa gagtcaaggg
      901 ccactttgga ccgatcaaca gcgttgcctt ccatcctgat ggcaagagct acagcagcgg
      961 tggcgaagat ggttacgtcc gcatccacta cttcgaccca cagtactttg agttcgagtt
     1021 tgaggcctaa gttctgggtc tccatccaca acagagaagc tgctcacaga aggttttaga
     1081 ctgagaaata aattagtttg ttaaaaataa aaaaaaaaaa aaaaaaa
//
