LOCUS       NM_080635               1275 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit H
            (Eif3h), transcript variant 1, mRNA.
ACCESSION   NM_080635
VERSION     NM_080635.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Jin,H., Huang,X., Pan,Q., Ma,N., Xie,X., Wei,Y., Yu,F., Wen,W.,
            Zhang,B., Zhang,P., Chen,X., Wang,J., Liu,R.Y., Lin,J., Meng,X. and
            Lee,M.H.
  TITLE     The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to
            promote colorectal cancer progression
  JOURNAL   Nat Commun 15 (1), 2551 (2024)
   PUBMED   38514606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Wu,C., Liu,H., Zhan,Z., Zhang,X., Zhang,M., You,J. and Ma,J.
  TITLE     Unveiling dysregulated lncRNAs and networks in non-syndromic cleft
            lip with or without cleft palate pathogenesis
  JOURNAL   Sci Rep 14 (1), 1047 (2024)
   PUBMED   38200098
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Gehlen-Breitbach,S., Schmid,T., Frob,F., Rodrian,G., Weider,M.,
            Wegner,M. and Golz,L.
  TITLE     The Tip60/Ep400 chromatin remodeling complex impacts basic cellular
            functions in cranial neural crest-derived tissue during early
            orofacial development
  JOURNAL   Int J Oral Sci 15 (1), 16 (2023)
   PUBMED   37024457
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Fujii,K., Zhulyn,O., Byeon,G.W., Genuth,N.R., Kerr,C.H., Walsh,E.M.
            and Barna,M.
  TITLE     Controlling tissue patterning by translational regulation of
            signaling transcripts through the core translation factor eIF3c
  JOURNAL   Dev Cell 56 (21), 2928-2937 (2021)
   PUBMED   34752747
REFERENCE   6  (bases 1 to 1275)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   7  (bases 1 to 1275)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 1275)
  AUTHORS   Hui,D.J., Terenzi,F., Merrick,W.C. and Sen,G.C.
  TITLE     Mouse p56 blocks a distinct function of eukaryotic initiation
            factor 3 in translation initiation
  JOURNAL   J Biol Chem 280 (5), 3433-3440 (2005)
   PUBMED   15561726
REFERENCE   9  (bases 1 to 1275)
  AUTHORS   Ficker,M., Powles,N., Warr,N., Pirvola,U. and Maconochie,M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
REFERENCE   10 (bases 1 to 1275)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102229.7.
            
            On Mar 21, 2023 this sequence version replaced NM_080635.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088436.1, BC086915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC102229.7         199830-200009       c
            181-337             AC102229.7         176972-177128       c
            338-505             AC102229.7         133696-133863       c
            506-605             AC102229.7         132117-132216       c
            606-755             AC102229.7         130892-131041       c
            756-876             AC102229.7         124497-124617       c
            877-1009            AC102229.7         122410-122542       c
            1010-1275           AC102229.7         121064-121329       c
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 19.42 cM"
     gene            1..1275
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /note="eukaryotic translation initiation factor 3, subunit
                     H"
                     /db_xref="GeneID:68135"
                     /db_xref="MGI:MGI:1915385"
     exon            1..180
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1107
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 3, subunit 3
                     (gamma); eukaryotic translation initiation factor 3,
                     subunit 3 (gamma, 40kD); eIF3 p40 subunit; eukaryotic
                     translation initiation factor 3 subunit 3"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit H isoform 1"
                     /protein_id="NP_542366.1"
                     /db_xref="CCDS:CCDS27461.1"
                     /db_xref="GeneID:68135"
                     /db_xref="MGI:MGI:1915385"
                     /translation="MASRKEGTGSTATSSGSAGGAVGKGKGKGGSGDSAVKQVQIDGL
                     VVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQME
                     MMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQG
                     SLSLKAYRLTPKLMEVCKEKDFSPEALKKASITFEHMFEEVPIVIKNSHLINVLMWEL
                     EKKSAVADKHELLSLASSNHLGKSLQLLMDRVDEMSQDIIKYNTYMRNTSKQQQQKHQ
                     YQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQAPARMDSLLIAGQINTYCQNIKEFT
                     AQNLGKLFMAQALQEYNN"
     exon            181..337
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     exon            338..505
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..605
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..755
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..876
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1009
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1275
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1249..1254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /note="hexamer: AATAAA"
     polyA_site      1275
                     /gene="Eif3h"
                     /gene_synonym="1110008A16Rik; 40kD; 9430017H16Rik;
                     EIF3-gamma; EIF3-P40; Eif3s3"
                     /note="major polyA site"
ORIGIN      
        1 ccgcttccgg cgcctcacgc ttctctttct tcctgtctgg ctggaaacat ggcgtcgcgc
       61 aaggaaggca ccggctctac cgccacctcc tccggttctg ctggcggcgc ggtggggaag
      121 ggcaaaggca aaggcggctc cggagattcg gccgtgaagc aggtgcagat cgacggcctg
      181 gtagtattaa agataatcaa acattatcaa gaagaaggac aaggcactga ggttgttcag
      241 ggcgtgctcc tgggtctggt tgtggaagac cggctagaga ttaccaactg cttcccgttc
      301 ccccagcaca cggaggatga tgctgacttt gatgaggtac agtatcagat ggagatgatg
      361 cgcagccttc gccatgtcaa cattgatcac ctccacgtgg gctggtatca gtccacatat
      421 tacggctcct tcgttacccg ggcgcttctg gattctcagt tcagctacca gcacgccatt
      481 gaagagtctg tcgtcctcat ttatgatccc ataaaaactg cccaaggatc tctctcgctg
      541 aaggcgtaca gactgactcc taaactgatg gaagtttgta aagagaagga cttttcccct
      601 gaagcattga aaaaggcaag catcaccttt gagcacatgt ttgaagaagt gccgattgta
      661 attaaaaact cacatctgat caatgtcctt atgtgggaac ttgagaagaa gtcagctgtg
      721 gcggataagc acgaattgct cagtcttgct agcagcaatc atctggggaa gagcctccag
      781 ctgctgatgg accgggtgga cgaaatgagc caggacataa tcaaatacaa cacgtacatg
      841 cgcaacacca gtaagcagca gcagcagaaa catcagtatc agcagcgtcg ccaacaggag
      901 aatatgcagc gacagagtcg aggcgagccc ccactccctg aggaggacct ctctaaactc
      961 ttcaagcccc accaggcccc tgccaggatg gattcactgc tcattgcagg ccagattaac
     1021 acttactgcc agaacatcaa ggagttcact gcccaaaact taggcaaact cttcatggcc
     1081 caggctcttc aagaatacaa taattaagaa aaggagcctc ctgagaaggc gttgagtaga
     1141 cagactgttg agaggccaca gagtgcactt ggaaaaactc atttctgtgc tgcaaagcaa
     1201 tggtggggag gcgcagtgcc gcgactgctg tagtggtttc tagccaataa taaaacttta
     1261 attggttgtt cagtt
//
