LOCUS       NM_008388               1541 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit E
            (Eif3e), mRNA.
ACCESSION   NM_008388 XM_354892
VERSION     NM_008388.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Fujii,K., Zhulyn,O., Byeon,G.W., Genuth,N.R., Kerr,C.H., Walsh,E.M.
            and Barna,M.
  TITLE     Controlling tissue patterning by translational regulation of
            signaling transcripts through the core translation factor eIF3c
  JOURNAL   Dev Cell 56 (21), 2928-2937 (2021)
   PUBMED   34752747
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Lin,Y., Li,F., Huang,L., Polte,C., Duan,H., Fang,J., Sun,L.,
            Xing,X., Tian,G., Cheng,Y., Ignatova,Z., Yang,X. and Wolf,D.A.
  TITLE     eIF3 Associates with 80S Ribosomes to Promote Translation
            Elongation, Mitochondrial Homeostasis, and Muscle Health
  JOURNAL   Mol Cell 79 (4), 575-587 (2020)
   PUBMED   32589965
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Sadato,D., Ono,T., Gotoh-Saito,S., Kajiwara,N., Nomura,N.,
            Ukaji,M., Yang,L., Sakimura,K., Tajima,Y., Oboki,K. and
            Shibasaki,F.
  TITLE     Eukaryotic translation initiation factor 3 (eIF3) subunit e is
            essential for embryonic development and cell proliferation
  JOURNAL   FEBS Open Bio 8 (8), 1188-1201 (2018)
   PUBMED   30087825
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Hashimoto,T., Chen,L., Kimura,H., Endler,A., Koyama,H., Miyata,T.,
            Shibasaki,F. and Watanabe,T.
  TITLE     Silencing of eIF3e promotes blood perfusion recovery after limb
            ischemia through stabilization of hypoxia-inducible factor 2alpha
            activity
  JOURNAL   J Vasc Surg 64 (1), 219-226 (2016)
   PUBMED   25758454
  REMARK    GeneRIF: eIF3e is an angiogenesis suppressor. Silencing of eIF3e
            promotes blood perfusion recovery after limb ischemia through
            stabilization of hypoxia-inducible factor 2alpha activity.
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Asano,K., Merrick,W.C. and Hershey,J.W.
  TITLE     The translation initiation factor eIF3-p48 subunit is encoded by
            int-6, a site of frequent integration by the mouse mammary tumor
            virus genome
  JOURNAL   J Biol Chem 272 (38), 23477-23480 (1997)
   PUBMED   9295280
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Diella,F., Levi,G. and Callahan,R.
  TITLE     Characterization of the INT6 mammary tumor gene product
  JOURNAL   DNA Cell Biol 16 (7), 839-847 (1997)
   PUBMED   9260927
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Miyazaki,S., Kozak,C.A., Marchetti,A., Buttitta,F., Gallahan,D. and
            Callahan,R.
  TITLE     The chromosomal location of the mouse mammary tumor gene Int6 and
            related pseudogenes in the mouse genome
  JOURNAL   Genomics 27 (3), 420-424 (1995)
   PUBMED   7558022
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Marchetti,A., Buttitta,F., Miyazaki,S., Gallahan,D., Smith,G.H. and
            Callahan,R.
  TITLE     Int-6, a highly conserved, widely expressed gene, is mutated by
            mouse mammary tumor virus in mammary preneoplasia
  JOURNAL   J Virol 69 (3), 1932-1938 (1995)
   PUBMED   7853537
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Rajan,L. and Dudley,J.P.
  TITLE     An MMTV integration site on the centromere proximal region of mouse
            chromosome 11
  JOURNAL   Mamm Genome 5 (11), 740-741 (1994)
   PUBMED   7873889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY114098.1, AK161650.1 and AA982184.1.
            
            On Jun 27, 2006 this sequence version replaced NM_008388.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146936.1, BC029177.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY114098.1         2-31
            31-1399             AK161650.1         1-1369
            1400-1541           AA982184.1         1-142               c
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.73 cM"
     gene            1..1541
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /note="eukaryotic translation initiation factor 3, subunit
                     E"
                     /db_xref="GeneID:16341"
                     /db_xref="MGI:MGI:99257"
     exon            1..134
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1382
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /note="eukaryotic translation initiation factor 3, subunit
                     6 48kDa; MMTV integration site 6; viral integration site
                     protein INT-6; mammary tumor-associated protein INT-6;
                     mammary tumor integration site 6"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit E"
                     /protein_id="NP_032414.1"
                     /db_xref="CCDS:CCDS27452.1"
                     /db_xref="GeneID:16341"
                     /db_xref="MGI:MGI:99257"
                     /translation="MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDL
                     LSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTR
                     QMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPA
                     TDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWS
                     LFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKD
                     LVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIE
                     NARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVV
                     MGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY"
     exon            135..249
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            250..367
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            368..410
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..515
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            516..641
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            642..766
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            767..893
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            894..995
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1105
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1208
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1343
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1541
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /note="hexamer: AATAAA"
     polyA_site      1528
                     /gene="Eif3e"
                     /gene_synonym="48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6"
                     /note="major polyA site"
ORIGIN      
        1 gtcaataaag ttttagcgaa caagcgctcc tttcccccgg caagatggcg gagtacgacc
       61 tgactactcg catcgcgcat tttctggatc ggcacctggt ctttccgctt cttgagtttc
      121 tctctgtgaa agagatttat aatgaaaaag aattattaca aggaaaatta gatcttctta
      181 gtgataccaa tatggtggat tttgctatgg atgtttacaa aaacctttat tctgatgata
      241 tccctcatgc tttgagagaa aaaagaacca cagttgttgc gcagctgaaa cagctccagg
      301 cagaaacaga accaatcgtg aagatgtttg aagatccaga aactacaagg cagatgcagt
      361 caaccaggga tggcaggatg ttatttgact acctggcaga caaacatggg tttaggcaag
      421 agtacttaga tacactctac agatacgcaa aattccagta tgagtgtgga aattactctg
      481 gagctgcaga gtatctttac ttctttagag ttttggtccc agcaacagat agaaatgctt
      541 taagttcgct ctggggaaaa ctggcctctg aaatcttaat gcagaattgg gatgcagcca
      601 tggaagacct tactcgatta aaagaaacca tagacaataa ttctgtgagt tctccactcc
      661 agtctcttca gcagcgaaca tggctcattc attggtctct atttgttttt ttcaaccatc
      721 caaagggccg tgataacatt attgatctct tcctttacca accacagtat cttaatgcaa
      781 ttcagacaat gtgtccacat attctacgct atttgactac tgccgtcata accaacaaag
      841 atgtgcggaa acgccggcag gtgctgaaag atctggtgaa agtgattcaa caggagtctt
      901 acacatataa agacccaatt acagaatttg ttgaatgcct atatgttaac tttgattttg
      961 acggggctca gaaaaagctg agagaatgtg aatcagtgct cgtgaatgac ttcttcctgg
     1021 tagcgtgtct ggaggacttc attgagaatg cccgtctctt catatttgag acgttttgtc
     1081 gtatccacca gtgtatcagc attaatatgt tagcagacaa actgaatatg actccagaag
     1141 aagctgaaag atggattgtg aatttgatta gaaatgcgag gttggatgcc aagattgatt
     1201 ctaaactagg tcatgtggta atgggcaaca atgcagtctc gccctaccag caagtgattg
     1261 aaaagaccaa aagcctttct tttagaagcc aaatgttggc catgaatatc gaaaagaaac
     1321 ttaatcagaa cagtagatca gaggctccca actgggcaac ccaagactct ggcttctatt
     1381 aaaggattat aaagaaaaga agaaaaagga ataagtgaaa gacacagtag ccattgtgta
     1441 taaaggatga catacatttt tagaagcaat taacatgttt gctacaaatt ttggagaatt
     1501 tgaataaaat tggctatgat taatttttta ttttgcttga a
//
