LOCUS       NM_146200               2896 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit C
            (Eif3c), mRNA.
ACCESSION   NM_146200 NM_019646 XM_914725
VERSION     NM_146200.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2896)
  AUTHORS   Ding,X., Hou,L., Zhang,H., Chen,Z., Liu,Z., Gong,J., Tang,Z. and
            Hu,R.
  TITLE     EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the
            APP/HSPA1A/LMNB1 Axis
  JOURNAL   Dis Markers 2022, 9464094 (2022)
   PUBMED   36157221
  REMARK    GeneRIF: EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the
            APP/HSPA1A/LMNB1 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2896)
  AUTHORS   Fujii,K., Zhulyn,O., Byeon,G.W., Genuth,N.R., Kerr,C.H., Walsh,E.M.
            and Barna,M.
  TITLE     Controlling tissue patterning by translational regulation of
            signaling transcripts through the core translation factor eIF3c
  JOURNAL   Dev Cell 56 (21), 2928-2937 (2021)
   PUBMED   34752747
REFERENCE   3  (bases 1 to 2896)
  AUTHORS   Zeng,L., Wan,Y., Li,D., Wu,J., Shao,M., Chen,J., Hui,L., Ji,H. and
            Zhu,X.
  TITLE     The m subunit of murine translation initiation factor eIF3
            maintains the integrity of the eIF3 complex and is required for
            embryonic development, homeostasis, and organ size control
  JOURNAL   J Biol Chem 288 (42), 30087-30093 (2013)
   PUBMED   24003236
REFERENCE   4  (bases 1 to 2896)
  AUTHORS   Gildea,D.E., Luetkemeier,E.S., Bao,X., Loftus,S.K., Mackem,S.,
            Yang,Y., Pavan,W.J. and Biesecker,L.G.
  TITLE     The pleiotropic mouse phenotype extra-toes spotting is caused by
            translation initiation factor Eif3c mutations and is associated
            with disrupted sonic hedgehog signaling
  JOURNAL   FASEB J 25 (5), 1596-1605 (2011)
   PUBMED   21292980
REFERENCE   5  (bases 1 to 2896)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 2896)
  AUTHORS   Li,H., Bishop,K.M. and O'Leary,D.D.
  TITLE     Potential target genes of EMX2 include Odz/Ten-M and other gene
            families with implications for cortical patterning
  JOURNAL   Mol Cell Neurosci 33 (2), 136-149 (2006)
   PUBMED   16919471
REFERENCE   7  (bases 1 to 2896)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2896)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 2896)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2896)
  AUTHORS   Drake,T.A., Hannani,K., Kabo,J.M., Villa,V., Krass,K. and
            Lusis,A.J.
  TITLE     Genetic loci influencing natural variations in femoral bone
            morphometry in mice
  JOURNAL   J Orthop Res 19 (4), 511-517 (2001)
   PUBMED   11518254
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC024855.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_914725.1, NM_019646.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024855.1, BC025032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.14 cM"
     gene            1..2896
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /note="eukaryotic translation initiation factor 3, subunit
                     C"
                     /db_xref="GeneID:56347"
                     /db_xref="MGI:MGI:1926966"
     exon            1..19
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            20..160
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2795
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /note="NIPI-like protein; eIF3 p110; eukaryotic
                     translation initiation factor 3 subunit 8; eukaryotic
                     translation initiation factor 3, subunit 8 (110 kDa);
                     extra-toes spotting"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit C"
                     /protein_id="NP_666312.1"
                     /db_xref="CCDS:CCDS21832.1"
                     /db_xref="GeneID:56347"
                     /db_xref="MGI:MGI:1926966"
                     /translation="MSRFFTTGSDSESESSLSGEELVTKPVSGNYGKQPLLLSEDEED
                     TKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGV
                     PRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYK
                     QNPEQSADEDAEKNEEDSEGSSDEDEDEDGVGNTTFLKKKQESSGESRKFHKKMEDDD
                     EDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKA
                     KKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEI
                     LQVRGKKGTDRATQIELLQLLVQIAAENNLGVGVIVKIKFNIIASLYDYNPNLATYMK
                     PEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMD
                     EEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHT
                     YYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCA
                     ILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLT
                     KDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLEC
                     VYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
                     AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYD
                     SISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQ
                     LAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY"
     exon            161..226
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            227..416
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            417..542
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            543..597
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            598..704
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            705..829
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            830..989
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1093
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1235
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1361
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1455
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1646
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1871
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2235
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2395
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2461
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2549
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2712
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2882
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /note="hexamer: ATTAAA"
     polyA_site      2882
                     /gene="Eif3c"
                     /gene_synonym="110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3);
                     NipilA3; Xs; Xsl"
                     /note="major polyA site"
ORIGIN      
        1 ggactcggca gcttagctgg ttccggccgc gagcgcctca gcccttcagc gccgtcgcca
       61 tgtcgcgatt cttcaccacc ggctcggaca gtgagtcgga gtcgtccctg tccggggagg
      121 agctcgtcac caaaccggtc tccgggaact acggcaaaca gcctttgtta ctgagcgagg
      181 atgaggagga tacaaagaga gttgtccgaa gcgccaagga caagaggttt gaggagctga
      241 ccaacctcat acgaaccatc cgtaatgcca tgaagattcg agatgtcacc aagtgtctag
      301 aagagtttga gctcctggga aaggcctatg ggaaagccaa gagtattgtg gataaggaag
      361 gtgtcccccg attctacatc cgaatactgg ctgacctgga ggactatctt aatgagcttt
      421 gggaagataa agaaggaaag aagaagatga ataaaaacaa cgccaaggct ctgagtacct
      481 tgcgccagaa gatccggaaa tacaaccgag atttcgagtc acacatcacc aactacaagc
      541 agaaccctga gcagtctgca gatgaagatg cagaaaagaa tgaggaagac tccgaaggct
      601 cttcagatga ggatgaggac gaggacggag tcggtaatac gactttcttg aagaagaagc
      661 aagaatcttc tggagagagt cggaagttcc acaaaaagat ggaagatgat gatgaggact
      721 ctgaagattc tgaagatgaa gaatgggaca ccagctccac atcttctgat tcagactctg
      781 aggaagaaga aggaaaacaa actgttctgg cctcaaagtt ccttaaaaag gcacccacta
      841 cagaggagga caaaaaagca gctgaaaaga aacgggaaga caaagccaag aagaagcacg
      901 ataggaagtc taagcgcctg gatgaggaag aggaggacaa tgagggcggg gagtgggaac
      961 gggtccgagg tggcgtacca cttgttaagg aaaagccaaa aatgtttgcc aagggaactg
     1021 agatcactca tgctgttgtc atcaagaaac tgaatgagat tctacaggtc agaggcaaga
     1081 agggaacaga ccgtgccact cagattgaat tgctccagct gctggttcag attgctgctg
     1141 aaaacaacct gggggtgggc gtcattgtca agatcaagtt caatatcatt gcctctctct
     1201 acgattacaa ccctaacctg gccacgtaca tgaagccaga gatgtggcag atgtgcctag
     1261 actgcatcaa tgaactgatg gatacgttgg ttgcacattc caacatcttt gttggagaga
     1321 acattttgga agagagtgag aacttacaca actttgatca gccactgcgt gtacgaggct
     1381 gcatcctaac tttggtggag cgaatggatg aagaatttac caaaataatg caaaatactg
     1441 atcctcactc ccaagagtat gtggagcacc tgaaggatga ggcacaagtg tgtgccatca
     1501 ttgagcgagt gcagcgctac ctggaggaga aaggtaccac tgaggagatc tgccagatct
     1561 acttaaggcg catcctgcac acgtactaca agtttgacta caaggcccat cagcggcagc
     1621 ttactcctcc tgaaggatcc tcaaagtctg agcaagacca ggcagaaaat gagggtgagg
     1681 actcagctgt gctaatggaa agactgtgca agtacatcta tgccaaggac cgtacagacc
     1741 ggatccgtac ctgtgccatc ctctgccata tctaccatca tgcgctccac tcccgctggt
     1801 atcaggcccg tgacctcatg ctcatgagcc acctacagga caacattcag cacgcagacc
     1861 cgccggtgca gatcctgtat aaccgtacta tggtgcaact gggcatctgt gctttccgcc
     1921 aaggcctgac aaaggatgca cacaatgcac ttctggatat tcagtcaagt ggtcgtgcca
     1981 aggagcttct aggtcagggt ctgctgctgc gcagcctgca ggagcgaaat caggaacagg
     2041 aaaaggtaga gcgacgccgg caggtgccct ttcacctgca catcaacctg gagctgctgg
     2101 agtgtgtcta tctggtgtca gctatgctcc tggagatccc ctacatggct gcccatgaga
     2161 gcgatgcccg ccgacgcatg atcagcaagc agttccacca ccaactgcgg gtgggcgagc
     2221 ggcagcccct gctaggtcct cccgagtcaa tgagggagca tgtggtcgct gcctccaagg
     2281 ccatgaagat gggcgactgg aagacctgcc acagtttcat cattaatgaa aagatgaatg
     2341 ggaaagtgtg ggaccttttc cctgaggctg acaaagttcg caccatgcta gttcggaaga
     2401 tccaggaaga gtctctgagg acctaccttt ttacctacag cagtgtctat gactcaatca
     2461 gtatggagac actatcagat atgtttgagc tggatctacc cactgttcac tccatcatca
     2521 gcaagatgat cattaacgaa gaattgatgg cttccctgga ccagccgaca cagactgtgg
     2581 tgatgcaccg tactgagccc actgcccagc agaacttggc tctgcagctg gctgagaagc
     2641 ttggcagcct agtggagaat aatgaacggg tgtttgacca taagcaggga acctatggtg
     2701 gctatttccg agaccaaaag gatggctacc gaaaaaatga aggctatatg cgccgtggtg
     2761 gctaccgcca gcagcagtct cagacagcct actgagttct ccacttcagt caccctgtga
     2821 acagaccatc tagccttttg ctcctaactc accccagtca ttaaagatct gttgagaatt
     2881 taaaaaaaaa aaaaaa
//
