LOCUS       NM_010123               5176 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 3, subunit A
            (Eif3a), mRNA.
ACCESSION   NM_010123
VERSION     NM_010123.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5176)
  AUTHORS   Gao,Y., Fu,Y., Chen,X., Li,Z., He,X. and Li,X.
  TITLE     [IL-33 up-regulates eIF3a expression by activating NF-kappaB
            signaling pathway to mediate the proliferation and differentiation
            of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 39 (8), 693-700 (2023)
   PUBMED   37515335
  REMARK    GeneRIF: [IL-33 up-regulates eIF3a expression by activating
            NF-kappaB signaling pathway to mediate the proliferation and
            differentiation of mouse pulmonary myofibroblasts and aggravate
            pulmonary fibrosis].
REFERENCE   2  (bases 1 to 5176)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   3  (bases 1 to 5176)
  AUTHORS   Kraushar,M.L., Thompson,K., Wijeratne,H.R., Viljetic,B., Sakers,K.,
            Marson,J.W., Kontoyiannis,D.L., Buyske,S., Hart,R.P. and Rasin,M.R.
  TITLE     Temporally defined neocortical translation and polysome assembly
            are determined by the RNA-binding protein Hu antigen R
  JOURNAL   Proc Natl Acad Sci U S A 111 (36), E3815-E3824 (2014)
   PUBMED   25157170
REFERENCE   4  (bases 1 to 5176)
  AUTHORS   Zeng,L., Wan,Y., Li,D., Wu,J., Shao,M., Chen,J., Hui,L., Ji,H. and
            Zhu,X.
  TITLE     The m subunit of murine translation initiation factor eIF3
            maintains the integrity of the eIF3 complex and is required for
            embryonic development, homeostasis, and organ size control
  JOURNAL   J Biol Chem 288 (42), 30087-30093 (2013)
   PUBMED   24003236
REFERENCE   5  (bases 1 to 5176)
  AUTHORS   Gildea,D.E., Luetkemeier,E.S., Bao,X., Loftus,S.K., Mackem,S.,
            Yang,Y., Pavan,W.J. and Biesecker,L.G.
  TITLE     The pleiotropic mouse phenotype extra-toes spotting is caused by
            translation initiation factor Eif3c mutations and is associated
            with disrupted sonic hedgehog signaling
  JOURNAL   FASEB J 25 (5), 1596-1605 (2011)
   PUBMED   21292980
  REMARK    GeneRIF: The pleiotropic mouse phenotype extra-toes spotting is
            caused by translation initiation factor Eif3c mutations.
REFERENCE   6  (bases 1 to 5176)
  AUTHORS   Mayeur,G.L. and Hershey,J.W.
  TITLE     Malignant transformation by the eukaryotic translation initiation
            factor 3 subunit p48 (eIF3e)
  JOURNAL   FEBS Lett 514 (1), 49-54 (2002)
   PUBMED   11904180
  REMARK    GeneRIF: Stable expression of a truncated eIF3e in NIH 3T3 cells
            causes malignant transformation
REFERENCE   7  (bases 1 to 5176)
  AUTHORS   Petzelt,C., Joswig,G., Mincheva,A., Lichter,P., Stammer,H. and
            Werner,D.
  TITLE     The centrosomal protein centrosomin A and the nuclear protein
            centrosomin B derive from one gene by post-transcriptional
            processes involving RNA editing
  JOURNAL   J Cell Sci 110 (Pt 20), 2573-2578 (1997)
   PUBMED   9372446
REFERENCE   8  (bases 1 to 5176)
  AUTHORS   Asano,K., Merrick,W.C. and Hershey,J.W.
  TITLE     The translation initiation factor eIF3-p48 subunit is encoded by
            int-6, a site of frequent integration by the mouse mammary tumor
            virus genome
  JOURNAL   J Biol Chem 272 (38), 23477-23480 (1997)
   PUBMED   9295280
REFERENCE   9  (bases 1 to 5176)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   10 (bases 1 to 5176)
  AUTHORS   Joswig,G., Petzelt,C. and Werner,D.
  TITLE     Murine cDNAs coding for the centrosomal antigen centrosomin A
  JOURNAL   J Cell Sci 98 (Pt 1), 37-43 (1991)
   PUBMED   1829085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145132.1, U14172.1, AK013070.1, AK162784.1 and AC163019.5.
            
            On May 3, 2007 this sequence version replaced NM_010123.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14172.1, SRR1660817.248643.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AK145132.1         9-58
            51-322              U14172.1           1-272
            323-1930            AK145132.1         331-1938
            1931-2597           AK013070.1         246-912
            2598-3585           AK162784.1         511-1498
            3586-4463           U14172.1           3536-4413
            4464-5176           AC163019.5         69205-69917         c
FEATURES             Location/Qualifiers
     source          1..5176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..5176
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /note="eukaryotic translation initiation factor 3, subunit
                     A"
                     /db_xref="GeneID:13669"
                     /db_xref="MGI:MGI:95301"
     exon            1..225
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..4211
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /note="eukaryotic translation initiation factor 3, subunit
                     10 (theta); p162; eIF3 p167; eIF3 p180; eIF3 p185;
                     centrosomin; eIF-3-theta; EUKARYOTIC TRANSLATION
                     INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167)
                     (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN)"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit A"
                     /protein_id="NP_034253.3"
                     /db_xref="CCDS:CCDS38035.1"
                     /db_xref="GeneID:13669"
                     /db_xref="MGI:MGI:95301"
                     /translation="MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQ
                     KIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTE
                     AAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQC
                     LDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAI
                     NLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYY
                     NKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQEEMQRMSTRVLLATLSIPITPE
                     RTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFSVLQYVVPEVKDLYN
                     WLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQSI
                     EFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPVG
                     PHLQSMPSEQIRNQLTAMSSVLAKALEVIRPAHILQEKEEQHQLAVNAYLKNSRKEHQ
                     RILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERI
                     LQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKK
                     ELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRVKDMDLWEQQEEERITTMQLER
                     EKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHSRLEDRKRQR
                     KEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVER
                     KKRQRELEIEERERRREEERRLGDDPLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPP
                     EKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPRRGLDDDRGPRRGP
                     DEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDDERGSWR
                     TADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRGPRRGLDDDRG
                     PWRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKPGGWREKEKAR
                     EESWGPPRESRPSEEREWDRDKEKDRDNQDREENDKDLERDRDRERDGDREDRFRRPR
                     DEGGWRRGPAEESSSWRDSSRRDDRDREDRRRDRDDRRDLRDLRDRRDLRDDRDRRGP
                     PLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPALSRDREREREREGEKEKASWRA
                     EKDRESLRRTKNETDEDGWTTVRR"
     exon            226..416
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            417..553
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            554..717
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            718..917
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1126
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1298
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1403
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1502
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1619
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1805
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2153
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2258
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2372
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2495
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2649
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2834
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2923
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3585
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3787
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3987
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..5176
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /note="hexamer: AATAAA"
     polyA_site      4508
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /note="hexamer: AATAAA"
     polyA_site      5176
                     /gene="Eif3a"
                     /gene_synonym="A830012B05Rik; Csma; Eif3; Eif3s10;
                     mKIAA0139"
                     /note="major polyA site"
ORIGIN      
        1 ggcgctgccg ccgcgaggga atcacgtggt tccttccttt ccgtctctgg ccggctgggc
       61 gcgggcatct gctggcgagg cgcgtggaag ctcgcgctag ttcccctccg ccttctctcc
      121 cggtccaggc cactagggag ttcgctgacg ccgggtgaac tgagcgtacc gtcaagatgc
      181 cggcctattt ccagaggccg gaaaatgccc tcaagcgcgc caacgaattt cttgaggttg
      241 gcaaaaagca gcctgccctg gatgttcttt atgatgtaat gaaaagtaag aagcacagaa
      301 catggcagaa gatacatgag ccaattatgc tgaaatactt ggaactgtgt gtggatcttc
      361 gtaagagcca cttggctaag gaagggttat atcaatataa gaacatatgc caacaggtaa
      421 acattaaatc tttagaagat gttgttaggg catatttgaa attagcagag gaaaaaacag
      481 aagctgctaa agaagagtcc caacaaatgg tgttagatat agaagatctg gataatattc
      541 agactcctga gagtgttctc ttaagtgcag taagtgggga agatactcag gatcgtactg
      601 acagattgct actgactccc tgggtcaagt tcctgtggga atcatacagg cagtgtttgg
      661 accttcttcg aaacaattct agagtagagc gcctttacca tgatatcgcc caacaagctt
      721 tcaaattctg cctccagtat actcggaagg ctgagttccg caagctatgt gacaacttgc
      781 gaatgcactt atcccagatt cagcgccacc ataaccaaag cacagcaatt aatcttaata
      841 atccagagag ccagtctatg catttggaaa ccagacttgt tcagttggac agtgctatca
      901 gcatggaatt atggcaggaa gccttcaaag ctgtggaaga tattcatgga ctattttcct
      961 tgtctaagaa accacctaag cctcagttga tggcaaatta ctataacaaa gtttcaacag
     1021 tgttttggaa atctggaaat gctttgttcc atgcatctac acttcatcgt ctttatcatc
     1081 tgtctagaga aatgagaaag aatcttacac aagaagagat gcaaagaatg tctactagag
     1141 tccttttggc gactctttcc attcctatta ctcctgagcg aactgatatt gctcgacttt
     1201 tggatatgga tggtattata gttgagaagc agcgacgcct tgccacattg ctaggtcttc
     1261 aagccccacc cacacgaatc ggcctaatta atgatatggt caggttcagt gtgctacagt
     1321 atgttgtccc agaagtgaaa gacctttaca actggttgga ggtggaattc aacccactaa
     1381 aactctgtga gagagttaca aaggtattaa attgggttag ggaacaacct gaaaaagaac
     1441 cagaattgca acaatatgta ccacaactcc agaacaatac catactccgc cttctgcaac
     1501 aggtggcaca gatttatcag agcattgagt tttctcgttt gacttctctg gttccttttg
     1561 ttgatgcttt ccaactggaa cgggccatag tagatgcagc caggcactgt gacctgcagg
     1621 tacgtattga ccatacttcc cggactctga gttttggatc agatttgaat tatgcaactc
     1681 gagaagatgc cccagttggc cctcatctgc agagcatgcc ttcagagcag ataagaaacc
     1741 agctcacggc catgtcctca gtgcttgcca aagcacttga agtcatcaga cctgctcaca
     1801 ttctgcaaga gaaagaagaa cagcatcaat tggcagttaa tgcatatctt aaaaattcaa
     1861 gaaaagagca ccagaggatc ctggctcgga gacagacaat tgaggaaaga aaagagcgtc
     1921 ttgagagtct gaatattcaa cgtgagaagg aagaactcga gcagagggaa gctgaactcc
     1981 agaaagtacg aaaggctgaa gaagaaaggc tgcgccaaga ggcaaaggag cgagagaagg
     2041 aacgaatcct tcaagaacac gagcaaatca agaagaaaac tgttcgggag cggttagagc
     2101 agatcaagaa gacagagctg ggcgccaaag catttaaaga tattgacatt gaagaccttg
     2161 aagaactgga tccagatttt attatggcca aacaggttga acaactggag aaagaaaaga
     2221 aggaacttca ggaacgcctg aagaatcaag aaaagaagat tgactatttt gagagagcta
     2281 agcgtttgga agaaattcct ttaataaaga gtgcttatga ggaacaaagg gttaaagaca
     2341 tggacctgtg ggaacagcaa gaagaagaaa gaatcactac aatgcagcta gaacgagaaa
     2401 aagctctgga gcataagaat aggatgtcac gaatgttgga agacagagat ctatttgtga
     2461 tgcgcctcaa agctgcccgg cagtctgtct acgaggaaaa actgaaacag tttgaagagc
     2521 gcttagcaga agaaaggcat agtcgcctag aagatcggaa aaggcagcgg aaagaagaac
     2581 gcaaaataac ttattacaga gaaaaggaag aagaagagca gaggagggca gaggagcaga
     2641 tgctcaaaga gcgagaagaa agagaacgtg ctgagagagc aaaacgggag gaagaactta
     2701 gagagtatca ggagcgagtc aagaaactag aagaagtaga aaggaaaaag cggcaaagag
     2761 agctggaaat tgaagaaagg gaaaggcgca gagaggaaga aaggagactt ggtgatgatc
     2821 cactttctag gaaggactct cggtggggag atagagattc agaaggcacc tggaggaaag
     2881 gaccagaagc tgactctgag tggagaagag gcccaccaga aaaggagtgg agacgagaaa
     2941 ctcgggatga tgagaggcct cacaggagag atgaggatcg gctgaggcgc ttggggggtg
     3001 acgatgaaga gagagagtct tctcttagac cggatgatga tcgtatcccc aggcgtggcc
     3061 tggatgatga cagagggcct agacgtggtc ccgatgaaga tagattttct cgtagaggaa
     3121 cagatgatga ccgtccttcc tggcgtaatg cagatgatga taggcctccc aggcgaattg
     3181 gtgatgatga caggggaagc tggcgtcaca cagatgacga cagaccaccc agacggggac
     3241 tggatgatga gagaggaagc tggcgtacag cagatgagga cagaggacct agacgaggga
     3301 tggatgatga ccgggggcca agacgaggag gtgctgatga tgaacggtca tcctggcgga
     3361 atgctgatga tgataggggt cccaggagag gcatggatga tgataggggt cccaggcgag
     3421 ggctggatga tgaccgagga ccttggagga atgctgctga agataggatt tccaggagag
     3481 gtgcagatga tgaccgaggg ccttggagaa atatggatga tgatagggtt cctagaaggg
     3541 gtgatgatgc aagacctggt ccttggagac catttgtcaa gccaggtgga tggagagaga
     3601 aagaaaaggc tagagaagag agttggggtc cacctcgaga atcaagacca tcagaagaac
     3661 gtgaatggga tagagacaaa gagaaggaca gagataatca agatcgagag gagaatgaca
     3721 aagaccttga acgagatagg gacagagaga gagatgggga ccgggaggat cgattcagaa
     3781 gacccaggga tgaaggtggc tggagaagag gaccagcaga agaatcttca agctggagag
     3841 attcaagtcg ccgtgatgat agggacaggg aagaccgtcg acgggataga gatgatcgtc
     3901 gtgatctgag agacctgaga gacagaaggg atttaagaga tgatagagat cggagaggac
     3961 ctcccctcag atcagagcga gaagaagcaa gctcttggag acgcactgat gacaggaaag
     4021 atgaccggac tgaagagagg gatccacctc gtcgtgttcc tcccccagct ctttcaagag
     4081 atcgagaaag agagcgagaa cgagaaggtg agaaagagaa agcatcctgg agagctgaga
     4141 aagataggga gtcccttcgt cgtactaaga atgaaactga tgaagatgga tggaccacag
     4201 tacgacgtta agtcccaaga tgatggagtc aaacttgtgg cttacatagg tttgatcaca
     4261 ttcaaggatt attatacttg tgcttcaacc agtctaaatt gaattcttta atgttgtctc
     4321 accataacac aaaaagcatg aacttgtatt aatcatatat aatagattga tcatgcactg
     4381 tattcacagg aggttggaaa accatgccat tttctggaac ttaaggtgtt gcattatttc
     4441 atcaatcatt tgttaaaaaa aaaaaactaa aaaataaaaa tgtgaaccct tcaggtgtaa
     4501 acaccttatc ttggtataca attgatcttt ttgttttgtt ttgaagtatc agatattaat
     4561 ttggaataag gtaaggttct cttgaaacat ttgaaaaccc tttaagccaa ctgatctgac
     4621 agctttccca tcagtagaag tgggaacata ccttcttagg tatttactat taactacatg
     4681 taggcagttt atagcttctg atcagtgtag tagacattac aaacactggt tgtaatgggg
     4741 ttttctgtag actttacttg agaggtgagt ataaagcatt ttttagtcat catcatgacg
     4801 atgctgctca agtgcagatc cagaacagta cagcgttggg ttcctagagc atttggtaaa
     4861 ctgttgtggg ttttttcttt ctgttgccaa aactgctttt ccactaattc atgcctttca
     4921 agcattttaa atatgacaat atttataaat gtgtggtttg gaggaattgt ttaaattctt
     4981 tttcctaatt ttcttttttc aggatagatt atttcaacaa gtaatttgta gtgatgactg
     5041 tgttgacttc aattttggag tgtagtagct gtgtttaaaa aaaagagtaa taaccatttg
     5101 gtcttattga agccaacacg gaatttgctg ctgtgttttt ttctttggtg ataaataaaa
     5161 tacttacata attggt
//
