LOCUS       NM_012010               3587 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 2, subunit 3,
            structural gene X-linked (Eif2s3x), mRNA.
ACCESSION   NM_012010 NM_133988 XM_980187
VERSION     NM_012010.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3587)
  AUTHORS   Young-Baird,S.K., Lourenco,M.B., Elder,M.K., Klann,E., Liebau,S.
            and Dever,T.E.
  TITLE     Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule
            ISRIB
  JOURNAL   Mol Cell 77 (4), 875-886 (2020)
   PUBMED   31836389
REFERENCE   2  (bases 1 to 3587)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   3  (bases 1 to 3587)
  AUTHORS   Wolstenholme,J.T., Rissman,E.F. and Bekiranov,S.
  TITLE     Sexual differentiation in the developing mouse brain: contributions
            of sex chromosome genes
  JOURNAL   Genes Brain Behav 12 (2), 166-180 (2013)
   PUBMED   23210685
REFERENCE   4  (bases 1 to 3587)
  AUTHORS   Raefski,A.S., Carone,B.R., Kaur,A., Krueger,W. and O'Neill,M.J.
  TITLE     Wnt pathway anomalies in developing amygdalae of Turner
            syndrome-like mice
  JOURNAL   J Mol Neurosci 32 (2), 111-119 (2007)
   PUBMED   17873295
REFERENCE   5  (bases 1 to 3587)
  AUTHORS   Xu,J., Watkins,R. and Arnold,A.P.
  TITLE     Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but
            not protein in mouse brain
  JOURNAL   Gene Expr Patterns 6 (2), 146-155 (2006)
   PUBMED   16325480
  REMARK    GeneRIF: Eif2s3x is expressed higher in females than in males in
            developing and adult brains as well as adult liver
REFERENCE   6  (bases 1 to 3587)
  AUTHORS   Filippova,G.N., Cheng,M.K., Moore,J.M., Truong,J.P., Hu,Y.J.,
            Nguyen,D.K., Tsuchiya,K.D. and Disteche,C.M.
  TITLE     Boundaries between chromosomal domains of X inactivation and escape
            bind CTCF and lack CpG methylation during early development
  JOURNAL   Dev Cell 8 (1), 31-42 (2005)
   PUBMED   15669143
REFERENCE   7  (bases 1 to 3587)
  AUTHORS   Sandstedt,S.A. and Tucker,P.K.
  TITLE     Evolutionary strata on the mouse X chromosome correspond to strata
            on the human X chromosome
  JOURNAL   Genome Res 14 (2), 267-272 (2004)
   PUBMED   14762062
REFERENCE   8  (bases 1 to 3587)
  AUTHORS   Xu,J., Burgoyne,P.S. and Arnold,A.P.
  TITLE     Sex differences in sex chromosome gene expression in mouse brain
  JOURNAL   Hum Mol Genet 11 (12), 1409-1419 (2002)
   PUBMED   12023983
REFERENCE   9  (bases 1 to 3587)
  AUTHORS   Ehrmann,I.E., Ellis,P.S., Mazeyrat,S., Duthie,S., Brockdorff,N.,
            Mattei,M.G., Gavin,M.A., Affara,N.A., Brown,G.M., Simpson,E.,
            Mitchell,M.J. and Scott,D.M.
  TITLE     Characterization of genes encoding translation initiation factor
            eIF-2gamma in mouse and human: sex chromosome localization, escape
            from X-inactivation and evolution
  JOURNAL   Hum Mol Genet 7 (11), 1725-1737 (1998)
   PUBMED   9736774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL646049.14 and AL646092.6.
            
            On Nov 17, 2006 this sequence version replaced NM_012010.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063755.1, AK146900.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL646049.14        4848-4934           c
            88-151              AL646049.14        4002-4065           c
            152-279             AL646092.6         31916-32043         c
            280-401             AL646092.6         31709-31830         c
            402-496             AL646092.6         27429-27523         c
            497-655             AL646092.6         26330-26488         c
            656-790             AL646092.6         25194-25328         c
            791-885             AL646092.6         23270-23364         c
            886-1030            AL646092.6         22094-22238         c
            1031-1200           AL646092.6         19668-19837         c
            1201-1373           AL646092.6         18652-18824         c
            1374-3587           AL646092.6         11089-13302         c
FEATURES             Location/Qualifiers
     source          1..3587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 41.52 cM"
     gene            1..3587
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /note="eukaryotic translation initiation factor 2, subunit
                     3, structural gene X-linked"
                     /db_xref="GeneID:26905"
                     /db_xref="MGI:MGI:1349431"
     exon            1..87
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1437
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /EC_number="3.6.5.3"
                     /note="eukaryotic translation initiation factor 2 subunit
                     gamma, X-linked; eIF2-gamma X"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2
                     subunit 3, X-linked"
                     /protein_id="NP_036140.1"
                     /db_xref="CCDS:CCDS30277.1"
                     /db_xref="GeneID:26905"
                     /db_xref="MGI:MGI:1349431"
                     /translation="MAGGEGGVTLGQPHLSRQDLATLDVTKLTPLSHEVISRQATINI
                     GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY
                     RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIA
                     GNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG
                     APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKG
                     GVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPG
                     GLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKA
                     AKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKH
                     WRLIGWGQIRRGVTIKPTVDDD"
     exon            88..151
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            152..279
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            280..401
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            402..496
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            497..655
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            656..790
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            791..885
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1030
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1200
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1373
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..3587
                     /gene="Eif2s3x"
                     /gene_synonym="eIF-2-gamma X; Eif-2gx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttctctc cgagcaagat ggctgggggt gagggtggag tgactctcgg tcagccccat
       61 ctttcccgac aggatctcgc cacattggat gttaccaagt tgacaccact ttcacatgaa
      121 gttatcagca gacaagctac aattaatatt ggtacaattg gtcacgtagc tcatgggaag
      181 tccactgtgg tgaaggctat ttctggagtt cacactgtca gattcaaaaa tgaactcgaa
      241 aggaacatta ccatcaagct tggatatgct aatgctaaga tttataaact tgatgaccca
      301 agttgtccta gaccagaatg ttacagatcg tgtggaagca gcacaccaga tgagtttcct
      361 acagacattc cggggaccaa agggaacttc aagttagtca ggcatgtttc ctttgttgac
      421 tgtcctggcc atgatatttt gatggctacg atgctgaacg gtgcagcagt gatggatgcg
      481 gcccttctgt tgatagctgg taacgaatca tgccctcagc cccagacttc cgaacacctg
      541 gctgccatag aaatcatgaa actcaagcat attttgatct tacagaataa aattgatctg
      601 gtaaaagaaa gtcaggctaa ggaacaatat gagcaaatcc tcgcatttgt gcaaggaacc
      661 gtagcagaag gggcaccaat tattccaatt tctgctcaac tgaagtacaa tattgaagtt
      721 gtctgtgagt atatagtgaa gaaaatacca gtgcccccaa gagactttac ttcagagccc
      781 cgtctcattg tcatcaggtc atttgatgtc aacaaacctg gctgtgaagt cgatgacctt
      841 aagggaggtg tagctggtgg tagtatccta aaaggagtgt taaaggtagg ccaggagata
      901 gaagtgagac ccggtattgt ctccaaagac agtgaaggaa aactcatgtg taaaccaatc
      961 ttttccaaaa ttgtgtcact ttttgcggaa cataatgatc ttcaatatgc tgccccgggt
     1021 ggtctcattg gagttggaac aaagatcgac cccaccttgt gccgagctga cagaatggtg
     1081 ggacaagtgc tcggtgcagt tggagcttta cctgaaatat tcaccgaact ggagatttcc
     1141 tatttcctgc ttagacgtct tctgggtgta cgtactgaag gagacaagaa agcagcaaag
     1201 gtccaaaagc tgtctaagaa tgaagtgctt atggtcaaca taggctccct gtcgacagga
     1261 ggaagagtta gtgcagtcaa ggctgatttg ggcaaaattg ttttgaccaa tcccgtgtgc
     1321 acagaagtag gagaaaaaat tgcccttagc agaagagttg agaaacactg gcgtttaatt
     1381 ggttggggtc agataagaag aggagtgacc attaagccaa ctgtagatga tgactgaaga
     1441 cttcaagtta aacaatgcct tgggaaggag ttggaatttc ttttactagc ctaggggtat
     1501 attttcaaag caatactaga aagaattaat ttcctagctc attaccttac tagtagcagc
     1561 tataaattta ttcttatatt ttggcgatga aaatgtgacc tctacttttt tttttctttt
     1621 tattgattcc ttgtttgaca tcatgtagcc caatcccatt catcccctca tatccaacct
     1681 ttgcccatgc gacctccccc aaagtagcac accaacaaca gaacaaagcc tagaaaacat
     1741 gccatcgtgg aagctgtagc ttctgtgaca acaacaatgt tggctcctca tcaggactcc
     1801 ctccagttat cctgttgctg cgctgtgtca tagagatcct gcagctttgg aacagcaggg
     1861 tggccctttc acgatcccca ccattcgaac atgacataga ttttaggtgg gtcaattcag
     1921 agccccggat aagggccagg atggtagctg agctggtcag ctggggccca ttcttccaag
     1981 tgctgcggct tgtgagagcc tgggccaatt ctccctacag aaggtggcaa cgggggaggg
     2041 tgtcccatcc acaccacctc ataacagaca agtggcaggg ccagctgtcc agagtgctat
     2101 atccaatgag ggatggtggc agacctgcac agcctcagac acccagtgtt ccctagtggt
     2161 aataatgagc catggacact gacccaccac tgtggatcca cagactcaaa caaggccctg
     2221 atggcaggga tgcccactta taacaggcta cttctctcca cccttgaatt cctttttctc
     2281 tcccgtctgt catggtgaca agcaggtatc tatgcttatg cactggaggg caggactgtg
     2341 ggtggcatgg aggtctacaa gaccttgtgt tcctcttctc atgccgtgct gccttgcttt
     2401 aatttgattt ttatgagtcc taggcataag acaaggtttg gccatcaagc taggatgaac
     2461 aaaggactgc catctgctct gcccctgata aagaacaata ccaccaataa ggggtctctg
     2521 ctggttgctg gggttgtaac ctacttctaa tatggggctt aaaattaaat gtgaaaagtg
     2581 gtatactata tacattggat caagtctata tagtagctaa aattaagcat tccaaagtaa
     2641 tgtctaattt atcaatcaat gaaagtttga agtgaaactt ggctgcaacc agtctttggc
     2701 gtagcacttg tatcatgaac ctgtctaaga tgaaaatgat ctcttctcat gattcatctg
     2761 tgagtagctc catagtgaag ggcaattagt aaaggctaaa gacttacccc tttatttgtc
     2821 cttctatttg gggttctgtt gtctgaaatt tgaaggaata cgaccagtgg gctcaaatga
     2881 gcaccactct tagaagttgt gtgcccattc ccttaacaca ggtagatctg tcttacccgt
     2941 ttcctgggtg ggaccttagg aatccagtgc cctgagacta tgtctttatt atttatgcct
     3001 agtatctcag tcttcccaca ctggcaaaga gtatagcaac tggtggttag tgataattga
     3061 caaggttctg tccaggctgc ttttttgagg tctttgtttt agtaagctat gaatggagct
     3121 gtctcttgca tgatgaataa acactctacc attgtctcca ctgcccctag ctgtagtact
     3181 ggctgatagg attatggtgg aaattgtgtt attggtaatc tttgagcctt gagagaggta
     3241 gaaattgttc agaaactgtg tcctctggtt tctaaatcta ttccccacgt gcctccaatt
     3301 ttcttgtgct gtgcatttta aattaatcat gttttttctt aattaaatac tctttcacag
     3361 caatgatttc caactctggc tgacgtaaga attgctgggg aagtttgaag gggggaaaaa
     3421 gaaagctctg gggtggagtc caggctttga tagttttttt tgtttgtttg tttgtttgtt
     3481 tttttttttt gaggaaacct attgatatat gtatttgatt gactctaaaa agttgttgta
     3541 ttggaacatg aagaaaacat ttaaataaaa caagattctg aaacaag
//
