LOCUS       NM_026030               2513 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 2 subunit 2
            beta (Eif2s2), mRNA.
ACCESSION   NM_026030
VERSION     NM_026030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Young-Baird,S.K., Lourenco,M.B., Elder,M.K., Klann,E., Liebau,S.
            and Dever,T.E.
  TITLE     Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule
            ISRIB
  JOURNAL   Mol Cell 77 (4), 875-886 (2020)
   PUBMED   31836389
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Fakruddin,M., Wei,F.Y., Suzuki,T., Asano,K., Kaieda,T., Omori,A.,
            Izumi,R., Fujimura,A., Kaitsuka,T., Miyata,K., Araki,K., Oike,Y.,
            Scorrano,L., Suzuki,T. and Tomizawa,K.
  TITLE     Defective Mitochondrial tRNA Taurine Modification Activates Global
            Proteostress and Leads to Mitochondrial Disease
  JOURNAL   Cell Rep 22 (2), 482-496 (2018)
   PUBMED   29320742
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Raini,G., Sharet,R., Herrero,M., Atzmon,A., Shenoy,A., Geiger,T.
            and Elroy-Stein,O.
  TITLE     Mutant eIF2B leads to impaired mitochondrial oxidative
            phosphorylation in vanishing white matter disease
  JOURNAL   J Neurochem 141 (5), 694-707 (2017)
   PUBMED   28306143
  REMARK    GeneRIF: This study provides evidence that even a mild mutation in
            eIF2B, leading merely to a ~ 20% decrease in its enzymatic
            activity, is associated with mitochondrial malfunction caused by
            defective oxphos and with increased mitochondrial biogenesis
            compensating for energetic needs.
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Silva,R.C., Sattlegger,E. and Castilho,B.A.
  TITLE     Perturbations in actin dynamics reconfigure protein complexes that
            modulate GCN2 activity and promote an eIF2 response
  JOURNAL   J Cell Sci 129 (24), 4521-4533 (2016)
   PUBMED   27852836
  REMARK    GeneRIF: GCN2 activation increased phosphorylation of its substrate
            eIF2alpha and the induction of the integrated stress response
            master regulator, ATF4.
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Cinelli,P., Casanova,E.A., Uhlig,S., Lochmatter,P., Matsuda,T.,
            Yokota,T., Rulicke,T., Ledermann,B. and Burki,K.
  TITLE     Expression profiling in transgenic FVB/N embryonic stem cells
            overexpressing STAT3
  JOURNAL   BMC Dev Biol 8, 57 (2008)
   PUBMED   18500982
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2513)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   9  (bases 1 to 2513)
  AUTHORS   Kebache,S., Zuo,D., Chevet,E. and Larose,L.
  TITLE     Modulation of protein translation by Nck-1
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5406-5411 (2002)
   PUBMED   11959995
REFERENCE   10 (bases 1 to 2513)
  AUTHORS   Charles,C.H., Abler,A.S. and Lau,L.F.
  TITLE     cDNA sequence of a growth factor-inducible immediate early gene and
            characterization of its encoded protein
  JOURNAL   Oncogene 7 (1), 187-190 (1992)
   PUBMED   1741163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ084276.1, AK166862.1 and AL929024.9.
            
            On Sep 23, 2006 this sequence version replaced NM_026030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145434.1, AK166862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                CJ084276.1         1-97
            98-1483             AK166862.1         2-1387
            1484-2513           AL929024.9         129455-130484       c
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.89 cM"
     gene            1..2513
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /note="eukaryotic translation initiation factor 2 subunit
                     2 beta"
                     /db_xref="GeneID:67204"
                     /db_xref="MGI:MGI:1914454"
     exon            1..217
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1198
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /note="eukaryotic translation initiation factor 2, subunit
                     2 (beta, 38kDa); eIF-2-beta; eukaryotic translation
                     initiation factor 2 subunit beta; eIF2-beta"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2
                     subunit 2"
                     /protein_id="NP_080306.1"
                     /db_xref="CCDS:CCDS38292.1"
                     /db_xref="GeneID:67204"
                     /db_xref="MGI:MGI:1914454"
                     /translation="MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDAQTEETQPSETKEV
                     EPEPTEEKDVDADEEDSRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEAIKDVK
                     IESDAQEPAEPEDDLDIMLGNKKKKKKNVKFPEEDEILEKDEALEDEDSKKDDGISFS
                     SQTAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFV
                     NFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEY
                     VTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN"
     exon            218..395
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            396..499
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            500..635
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            636..730
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            731..879
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            880..936
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1022
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..2513
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1467..1472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /note="hexamer: ATTAAA"
     polyA_site      1488
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /note="major polyA site"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
                     /note="hexamer: AATAAA"
     polyA_site      2507
                     /gene="Eif2s2"
                     /gene_synonym="2810026E11Rik; 38kDa; D2Ertd303e; EIF2;
                     EIF2B"
ORIGIN      
        1 ttactgtacg cctgcgcttt ggcgagctct gcgcaggcgc acttccaacg tttgagagga
       61 gggcggggtg tcgctccctt tcgctgatgc aagagcctag tgcggtgctg tgagaagtat
      121 cggtgggagc tacgctgact ccgggccgtg aagccgaccg gtttgacttt tcatccctgc
      181 cgaacccgct cgaactacag ccatgtccgg ggacgagatg atttttgatc ctactatgag
      241 caaaaagaaa aagaagaaga agaagccttt tatgttagat gaagaaggtg atgcccagac
      301 agaagaaacc cagccctcag agacaaaaga agtggagcca gaaccaactg aagaaaaaga
      361 cgtggacgct gatgaggaag acagtaggaa gaaagatgct tctgatgact tagatgattt
      421 gaacttcttt aatcaaaaga aaaagaagaa aaagacaaaa aagatatttg acattgatga
      481 agctgaagaa gctataaagg atgttaagat tgagagtgat gctcaagagc cagccgagcc
      541 agaggatgac cttgacatta tgcttggcaa caaaaaaaag aaaaagaaga atgttaaatt
      601 cccagaagaa gatgaaatac tagaaaaaga cgaagcttta gaagatgaag acagcaaaaa
      661 agatgatggc atttcattca gtagccaaac tgcttgggca ggctcagaaa gagactacac
      721 atatgaggag ttgctgaacc gagtgttcaa catcatgaga gaaaagaatc cagatatggt
      781 tgctggagag aagaggaaat ttgttatgaa acctccacag gtcgtccgag taggaaccaa
      841 gaaaacttct tttgtcaatt ttacagatat ctgtaaacta ttacatcgtc aacccaaaca
      901 tctccttgca tttttattgg cagaattggg tacaagtggt tctatagatg gtaataacca
      961 acttgtaatc aaaggaagat tccaacagaa acaaatagaa aatgtcttga gaagatatat
     1021 caaggaatat gtcacttgtc acacatgccg gtcaccggac acaatcctac agaaggacac
     1081 ccgactctat ttcttacaat gtgaaacttg tcattctcga tgctctgttg ccagtatcaa
     1141 aactggcttc caggctgtca caggcaagcg agcacagctc cgtgccaaag ctaactaatt
     1201 tgctaatcac cattgatttt tccaaaatgt gttggagatt tggctggaca ggttaccatc
     1261 agagtggatg taccattgag ttaaaaacaa gatagaaaaa ctgccaagtt gtttggcaag
     1321 tgattgttct gaaatacctt gcaagatacc gatattcaag ctgttgacat actcgttgcc
     1381 tactttaaca actgtcagag aaacgtgatg ggggtaagga ggtacttttt aaaatcgttc
     1441 atagacttct gtaaaatgca agataaatta aagttattat aacagtaatt ctttgaagtc
     1501 gatctgtcct tcagttttct tttctacaat aaagtgttcg ttaaatttgg ttaaaaacaa
     1561 aacaacaaac ttgattcctg ggctgtggca agttttcttt gtcctcaaaa ctggcagata
     1621 ctggagctgg gcagccattt ttccttttag tgtctcttga agctacatgg ctagaataga
     1681 taggtcttcc cttgaaagag tggttggaac ataaggaatg gggcagcgac ctgtttttaa
     1741 tgtctagaaa atgatttgga gggtttaatt tccttttgtg aggattactg ctacttcttc
     1801 ctagccaatt cctcattctc tcacgtgaca acagctgaaa gtgccaggtg ctagattcct
     1861 cctccttgga attgtgttag gctagttggt cctctttgag gaagcatata gtacagactt
     1921 cttagcactt aggaagcttc tccaacctgt gctctaggtc agtaaaactt cgtcctctga
     1981 aatgcttttc tgtactaaac taacttgaac gtgacctaga aaccaagaga tactgcttca
     2041 tgtgtggtct ttattgggcc acaggagggt caatcttgtg ggtctgtgct gtaatctgcc
     2101 ttacttgcac ccaccaggat aaggacataa acggtgctca acttttctgc caccagactg
     2161 ttaactttgc taaatggctc aagaacagtc agttagccct gctgtcttga ctatgttgtt
     2221 tttaatcact gtgacctctg aattttcaag tataggccaa atgagccaag taacttggct
     2281 gtgaaatggc agaaggaacc ttctctcaag caggtaggtc aagagatggg ccatatatat
     2341 actgatatac tggttgacct gccatcaccg ctcactgcca tgtgaataga actgtttatg
     2401 actgcaattt cttttttctt tttctttttt ttttgtacct ctgcccatga tccccaatgt
     2461 tggctataac tgcgtgaata aagcaaggat cagtgcctcc tgtgtaacta gtg
//
