LOCUS       NM_026114               3152 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus eukaryotic translation initiation factor 2, subunit 1
            alpha (Eif2s1), mRNA.
ACCESSION   NM_026114
VERSION     NM_026114.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3152)
  AUTHORS   Flury,A., Aljayousi,L., Park,H.J., Khakpour,M., Mechler,J.,
            Aziz,S., McGrath,J.D., Deme,P., Sandberg,C., Gonzalez Ibanez,F.,
            Braniff,O., Ngo,T., Smith,S., Velez,M., Ramirez,D.M.,
            Avnon-Klein,D., Murray,J.W., Liu,J., Parent,M., Mingote,S.,
            Haughey,N.J., Werneburg,S., Tremblay,M.E. and Ayata,P.
  TITLE     A neurodegenerative cellular stress response linked to dark
            microglia and toxic lipid secretion
  JOURNAL   Neuron 113 (4), 554-571 (2025)
   PUBMED   39719704
REFERENCE   2  (bases 1 to 3152)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3152)
  AUTHORS   Amiri,M., Kiniry,S.J., Possemato,A.P., Mahmood,N., Basiri,T.,
            Dufour,C.R., Tabatabaei,N., Deng,Q., Bellucci,M.A., Harwalkar,K.,
            Stokes,M.P., Giguere,V., Kaufman,R.J., Yamanaka,Y., Baranov,P.V.,
            Tahmasebi,S. and Sonenberg,N.
  TITLE     Impact of eIF2alpha phosphorylation on the translational landscape
            of mouse embryonic stem cells
  JOURNAL   Cell Rep 43 (1), 113615 (2024)
   PUBMED   38159280
REFERENCE   5  (bases 1 to 3152)
  AUTHORS   He,D., Tao,L., Cai,B., Chen,X., Wang,Y., Li,S., Liao,C., Chen,Y.,
            Chen,J., Liu,Z. and Wu,Y.
  TITLE     eIF2alpha incites photoreceptor cell and retina damage by
            all-trans-retinal
  JOURNAL   J Biol Chem 299 (5), 104686 (2023)
   PUBMED   37031820
  REMARK    GeneRIF: eIF2alpha incites photoreceptor cell and retina damage by
            all-trans-retinal.
REFERENCE   6  (bases 1 to 3152)
  AUTHORS   Harding,H.P., Zhang,Y., Bertolotti,A., Zeng,H. and Ron,D.
  TITLE     Perk is essential for translational regulation and cell survival
            during the unfolded protein response
  JOURNAL   Mol Cell 5 (5), 897-904 (2000)
   PUBMED   10882126
REFERENCE   7  (bases 1 to 3152)
  AUTHORS   Ito,M., Yuan,C.X., Okano,H.J., Darnell,R.B. and Roeder,R.G.
  TITLE     Involvement of the TRAP220 component of the TRAP/SMCC coactivator
            complex in embryonic development and thyroid hormone action
  JOURNAL   Mol Cell 5 (4), 683-693 (2000)
   PUBMED   10882104
REFERENCE   8  (bases 1 to 3152)
  AUTHORS   Harding,H.P., Zhang,Y. and Ron,D.
  TITLE     Protein translation and folding are coupled by an
            endoplasmic-reticulum-resident kinase
  JOURNAL   Nature 397 (6716), 271-274 (1999)
   PUBMED   9930704
  REMARK    Erratum:[Nature 1999 Mar 4;398(6722):90]
REFERENCE   9  (bases 1 to 3152)
  AUTHORS   De Sousa,P.A., Watson,A.J. and Schultz,R.M.
  TITLE     Transient expression of a translation initiation factor is
            conservatively associated with embryonic gene activation in murine
            and bovine embryos
  JOURNAL   Biol Reprod 59 (4), 969-977 (1998)
   PUBMED   9746750
REFERENCE   10 (bases 1 to 3152)
  AUTHORS   Disney,J.E., Johnson,K.R., Magnuson,N.S., Sylvester,S.R. and
            Reeves,R.
  TITLE     High-mobility group protein HMG-I localizes to G/Q- and C-bands of
            human and mouse chromosomes
  JOURNAL   J Cell Biol 109 (5), 1975-1982 (1989)
   PUBMED   2808516
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK143499.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026114.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143499.1, AK010592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3152              AK143499.1         2-3153
FEATURES             Location/Qualifiers
     source          1..3152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..3152
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="eukaryotic translation initiation factor 2, subunit
                     1 alpha"
                     /db_xref="GeneID:13665"
                     /db_xref="MGI:MGI:95299"
     exon            1..109
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            110..351
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1058
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="eIF-2A; eIF-2alpha; eIF-2-alpha; eukaryotic
                     translation initiation factor 2 subunit alpha; eukaryotic
                     translation initiation factor 2A; eIF2-alpha"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2
                     subunit 1"
                     /protein_id="NP_080390.1"
                     /db_xref="CCDS:CCDS26003.1"
                     /db_xref="GeneID:13665"
                     /db_xref="MGI:MGI:95299"
                     /translation="MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEG
                     MILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKF
                     TKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDP
                     SILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNC
                     STETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPK
                     VVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED"
     exon            352..431
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            432..583
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            584..690
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            691..788
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            789..932
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            933..3152
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="hexamer: AATAAA"
     polyA_site      1463
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="major polyA site"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="hexamer: ATTAAA"
     polyA_site      1675
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="hexamer: TATAAA"
     polyA_site      1953
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
     regulatory      2535..2540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
                     /note="hexamer: CATAAA"
     polyA_site      2561
                     /gene="Eif2s1"
                     /gene_synonym="0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a;
                     eIF2alpha"
ORIGIN      
        1 agcgcacgct gaggagcttc ggcgtccggg gttggtgttc cgagtctcct cgttgccact
       61 aagcagcacg gcgtgggacc ctacttcggg attcacacat ccacttcaga atgccggggc
      121 taagttgtag attttatcaa cacaaatttc ctgaggtgga agatgtagtg atggtgaatg
      181 taagatccat tgctgaaatg ggggcctatg tcagcttgtt ggaatataat aacattgaag
      241 gcatgattct tcttagtgaa ttatccagac gacgtatccg ttctataaac aaactgatcc
      301 gaattggcag aaatgaatgt gttgttgtca ttagagtgga taaagaaaaa ggatatatag
      361 atttgtcaaa aagaagagtt tctccagagg aagcaatcaa atgtgaggac aaattcacaa
      421 aatccaaaac tgtttatagc attcttcgcc atgttgctga ggtattagaa tataccaagg
      481 atgagcagct ggagagcctg ttccagagga ctgcctgggt cttcgatgac aagtacaaga
      541 gacctggata cggtgcctac gatgctttta agcatgcagt ctcagaccca tctatcttgg
      601 atagtttaga tttgaatgaa gatgaaagag aagtactcat taataatatc aataggcgtt
      661 tgaccccaca agcggtcaaa attcgagcag atattgaagt agcttgctat ggttatgaag
      721 gcattgatgc tgtaaaagaa gccctgaggg caggtttgaa ttgttctaca gaaaccatgc
      781 ccatcaagat taatctaata gctccaccca ggtatgtgat gacaacaacg accctggaga
      841 ggacagaagg cctgtctgtc ctcaatcagg ctatggcagt tatcaaagag aagatcgagg
      901 agaagagggg cgtcttcaat gttcagatgg agcccaaagt ggtcacagat acagatgaga
      961 ctgaacttgc aaggcagctg gaacggctgg agagagaaaa tgcagaagtg gatggagatg
     1021 atgatgcaga agaaatggaa gccaaagctg aagattaacg ttttggcaaa cagtccaatt
     1081 taaggagtac gaagcagccc ttcctggctg tcaaccctag acttgagagt tttccagtat
     1141 tgaaaacttc aaagctgaat atttttattt ccaagtattt aagtattcaa caagccagaa
     1201 tctaaatgcc ctccttcatg tcagctgttt ccacatagtg gctctaacac ctcaagcatt
     1261 tttcaaggga gtggcttgat ttgaccagag acaaatctta aacagcagtc ctaatattgg
     1321 gcctacagtt tccatttctc atgtctctgg aatggcaccc ttatggttca gagatttacc
     1381 agggactcca aacacaaaca atcccaatct ttctatataa aatgtattca agcaaacatc
     1441 aaataaattt ctgggatatt taattgtagg cttcttcctt cttgtcacaa gttaaagcca
     1501 atctgaatgc tcagatccta attatcttca tatggtagaa ctcaatgggc aagtaactaa
     1561 atgacttatg caggaacaga ctctccaaag gaatgttaga gaagaaatta ggaatttgac
     1621 ccctggtaga gaaaaacctt gaaatcaatt aaagatttat gtgcctgtta acttacttga
     1681 aagcagtgat aacttgtgtg agaagtcatc acactcagtc cctttggttt attctaagct
     1741 acttaccttg aattcataat tcaaggggta ttttaatgtg ctgctgcttt gatggagtta
     1801 ttttgagcag catcacccat ctgaagggga cagtttcctc tatctggtag gtgctaccta
     1861 attcttgagt tgtgtgtatg tgtgtgtgtg tgtgtatata tacatacatg gttttatata
     1921 tatataaacc acacatgatg tgatttaaca aaatttttaa tcccattttt accttctcaa
     1981 actagctact ttaaaggtta atgtgcaaaa taattttttc aaataacaca aagttacagc
     2041 tacaatatca catgtagaaa gtcttcattt agtttggcat gcttatctta ggatatgtat
     2101 actatttatt atctgtaagc aaacttgaaa ctaagtcagt ccaggactag acatcatggg
     2161 aagagttcta gagttgggta cagaagcaca tgctgatggc tccagtactt ggaaagttga
     2221 ggagggaaaa ttccttgagc caagagttgc tgatcagcct ggacaaccac tgcaagactc
     2281 tgtatcaaaa ggattggaaa ttagaatgtt gagagatgtt ttatgccatt tatgaaagtt
     2341 cttttgttta atctactggt ctaaccttgt gtgacccatt tccgaggagc catgcttgct
     2401 agtctgcata ccatgttgct agtatttagg gactctgaat gtactccaga ttggctgact
     2461 acagcagtgg ttctcaacct tcctaatgct gggacctgtc gatacaggtc ttcacattga
     2521 ggtgaccccc caaccataaa gttatttttg ttaccacttc ataactttaa ttttgctact
     2581 attatgaatc ataatataaa tatctggttt ttgatggtct agaacaacca ctggtcatgc
     2641 atcaagaagc aagtttaggg ccaggtatgg tagtgcatgc ctttagtccc atcatagaca
     2701 gtggcagttg gatctctgag ttcaaggcat agctggtcta tatataccaa gttacaggtc
     2761 acctaagact gcatagtgag actgtctcaa tttttttttc aagtttataa aagaacatga
     2821 aggtgttacc aaagctgcaa tagtaactgt aatctcagat aattcagaga cagaatacac
     2881 atattttaag gatttagaaa tatagctaag ttggcctggt gcatagctag caagtcaagg
     2941 ccctgggatc aatccccatt accacagaag aaaaaatgta ttatcaagta tagcaagcgc
     3001 ccttttccta gggattgttt actgaaaagt tttatattta agagaacaat ttagtcaggt
     3061 tggtggcata tatctttaat tccagtactt gggaggctag cctagttttc aaagcaagtt
     3121 ccagcgctgt tacacagaga aaccctgtct cc
//
