LOCUS       NM_010122               1752 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus eukaryotic translation initiation factor 2B, subunit 4
            delta (Eif2b4), transcript variant 2, mRNA.
ACCESSION   NM_010122
VERSION     NM_010122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1752)
  AUTHORS   Witkamp,D., Oudejans,E., Hoogterp,L., Hu-A-Ng,G.V., Glaittli,K.A.,
            Stevenson,T.J., Huijsmans,M., Abbink,T.E.M., van der Knaap,M.S. and
            Bonkowsky,J.L.
  TITLE     Lithium: effects in animal models of vanishing white matter are not
            promising
  JOURNAL   Front Neurosci 18, 1275744 (2024)
   PUBMED   38352041
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1752)
  AUTHORS   Oudejans,E., Witkamp,D., Hu-A-Ng,G.V., Hoogterp,L., van Rooijen-van
            Leeuwen,G., Kruijff,I., Schonewille,P., Lalaoui El Mouttalibi,Z.,
            Bartelink,I., van der Knaap,M.S. and Abbink,T.E.
  TITLE     Pridopidine subtly ameliorates motor skills in a mouse model for
            vanishing white matter
  JOURNAL   Life Sci Alliance 7 (3), e202302199 (2024)
   PUBMED   38171595
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1752)
  AUTHORS   Abbink,T.E.M., Wisse,L.E., Jaku,E., Thiecke,M.J.,
            Voltolini-Gonzalez,D., Fritsen,H., Bobeldijk,S., Ter Braak,T.J.,
            Polder,E., Postma,N.L., Bugiani,M., Struijs,E.A., Verheijen,M.,
            Straat,N., van der Sluis,S., Thomas,A.A.M., Molenaar,D. and van der
            Knaap,M.S.
  TITLE     Vanishing white matter: deregulated integrated stress response as
            therapy target
  JOURNAL   Ann Clin Transl Neurol 6 (8), 1407-1422 (2019)
   PUBMED   31402619
REFERENCE   4  (bases 1 to 1752)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1752)
  AUTHORS   Dooves,S., Bugiani,M., Postma,N.L., Polder,E., Land,N., Horan,S.T.,
            van Deijk,A.L., van de Kreeke,A., Jacobs,G., Vuong,C., Klooster,J.,
            Kamermans,M., Wortel,J., Loos,M., Wisse,L.E., Scheper,G.C.,
            Abbink,T.E., Heine,V.M. and van der Knaap,M.S.
  TITLE     Astrocytes are central in the pathomechanisms of vanishing white
            matter
  JOURNAL   J Clin Invest 126 (4), 1512-1524 (2016)
   PUBMED   26974157
REFERENCE   6  (bases 1 to 1752)
  AUTHORS   Kashiwagi,K., Shigeta,T., Imataka,H., Ito,T. and Yokoyama,S.
  TITLE     Expression, purification, and crystallization of
            Schizosaccharomyces pombe eIF2B
  JOURNAL   J Struct Funct Genomics 17 (1), 33-38 (2016)
   PUBMED   27023709
REFERENCE   7  (bases 1 to 1752)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1752)
  AUTHORS   Klein,U., Ramirez,M.T., Kobilka,B.K. and von Zastrow,M.
  TITLE     A novel interaction between adrenergic receptors and the
            alpha-subunit of eukaryotic initiation factor 2B
  JOURNAL   J Biol Chem 272 (31), 19099-19102 (1997)
   PUBMED   9235896
REFERENCE   9  (bases 1 to 1752)
  AUTHORS   Henderson,R.A., Krissansen,G.W., Yong,R.Y., Leung,E., Watson,J.D.
            and Dholakia,J.N.
  TITLE     The delta-subunit of murine guanine nucleotide exchange factor
            eIF-2B. Characterization of cDNAs predicts isoforms differing at
            the amino-terminal end
  JOURNAL   J Biol Chem 269 (48), 30517-30523 (1994)
   PUBMED   7982969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665023.1, AK158282.1 and CD768292.1.
            
            On May 15, 2008 this sequence version replaced NM_010122.1.
            
            Transcript Variant: This variant (2) lacks a segment spanning the
            5' UTR and 5' coding region, compared to variant 1, resulting in
            translation initiation from an alternate start codon and a shorter
            protein (isoform 2) with a distinct N-terminus, compared to isoform
            1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M98036.1, SRR1660817.284349.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               BB665023.1         1-191
            192-1723            AK158282.1         101-1632
            1724-1752           CD768292.1         618-646
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.24 cM"
     gene            1..1752
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /note="eukaryotic translation initiation factor 2B,
                     subunit 4 delta"
                     /db_xref="GeneID:13667"
                     /db_xref="MGI:MGI:95300"
     exon            1..147
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1691
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     translation initiation factor eIF-2B subunit delta; eIF-2B
                     GDP-GTP exchange factor subunit delta; eIF2B GDP-GTP
                     exchange factor subunit delta; translation initiation
                     factor eIF2B subunit delta"
                     /codon_start=1
                     /product="translation initiation factor eIF2B subunit
                     delta isoform 2"
                     /protein_id="NP_034252.2"
                     /db_xref="CCDS:CCDS19176.1"
                     /db_xref="GeneID:13667"
                     /db_xref="MGI:MGI:95300"
                     /translation="MAAVAVAVREESRSEMKTELSPRPGAAGRELTQEEKLQLRKEKK
                     QQKKKRKEEKGADQEIGSAVSAAQRQDPIRELPGPGSQLGGTAGEKLPAGRSKAELRA
                     ERRAKQEAERALKQARKGEQGGVPPQACPSTAGETTSGVKRVPEHTPADDPTLLRRLL
                     RKPDRQQVPTRKDYGSKVSLFSHLPQYSRQSSLTQYMSIPSSVIHPAMVRLGLQYSQG
                     LISGSNARCIALLHALQQVIQDYTTPPSEELSRDLVNKLKPYISFLTQCRPMSASMCN
                     AIKFLTKEVTGMSSSKREEEAKSELREALDRYVQEKIVLAAQAISRFASTKISDGDVI
                     LVYGCSSLVSRILQEARVEGRRFRVVVVDSRPRLEGRHMLHSLVRAGVPTSYLLIPAA
                     SYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQT
                     DAFVSNELDDPDDLQCKRGDQVALANWQSHPSLRLLNLVYDVTPPELVDLVITELGMI
                     PCSSVPVVLRVKSSDQ"
     exon            148..191
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            192..327
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            328..534
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            535..617
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            618..709
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            710..824
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            825..901
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1004
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1132
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1310
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1491
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1734
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /note="hexamer: AATAAA"
     polyA_site      1725
                     /gene="Eif2b4"
                     /gene_synonym="Eif2b"
                     /note="major polyA site"
ORIGIN      
        1 gccggaagtt gtagtccgct ggggactgac tccgcgggag gcatcagggg agccagcagc
       61 ccaggtggcg ctgtagtgtg agtgacctcg gcgggaggag cctaggaccc acagtcatgg
      121 ctgcggtggc ggtggctgtt cgcgaagaat cgagatccga gatgaagact gaactttctc
      181 ctcggcccgg ggcagcaggg cgggagttga cccaagaaga gaagcttcag cttcgaaaag
      241 aaaagaaaca gcagaagaag aaacggaagg aggaaaaggg ggcagaccaa gaaattggct
      301 ctgctgtgtc tgcagctcaa cggcaagacc caatcagaga actcccagga cctggtagtc
      361 agctgggagg tactgctggg gagaaacttc cagctggccg gagtaaggca gaacttcgcg
      421 ccgaaaggag agccaagcag gaggcagagc gggccctgaa acaggcaaga aaaggggaac
      481 aaggaggcgt ccctcctcag gcctgcccca gcactgctgg agaaaccacc tcaggagtga
      541 agcgtgtccc cgagcacacc ccagctgatg accccacact tctgaggagg ctccttagaa
      601 agccagatcg acaacaggtt cctacacgaa aggattacgg atccaaagtc agtctcttct
      661 cccacctgcc tcagtacagc agacaaagct ccttgaccca gtacatgagc atcccatcct
      721 ctgtgatcca cccagccatg gtgagactcg gtctgcagta ctcccagggc ctcatcagtg
      781 gctccaatgc ccggtgcatc gcactgcttc acgccctgca gcaggtgatt caggattaca
      841 caacacctcc cagtgaggaa ctctccaggg atcttgtaaa taaactaaaa ccctacatca
      901 gcttcctgac gcagtgccgc cccatgtcgg caagtatgtg caacgccatc aagttcctaa
      961 ccaaggaagt cactggcatg agcagctcca agcgggaaga ggaggccaag tcagaactta
     1021 gagaagccct cgaccggtac gtgcaagaga agatcgtgct tgcagctcag gcaatttcac
     1081 gatttgcttc tacaaagatc agtgatgggg acgtgatcct ggtatatgga tgctcatctt
     1141 tggtgtcgag aattctccag gaggccaggg tcgagggcag gcggtttcgg gtggtggtgg
     1201 tggacagccg gccccggctg gaaggaaggc acatgctcca ctctcttgtc cgtgctgggg
     1261 tccctacctc ctatctgctg attcctgcag cctcctatgt gcttccagag gtttctaagg
     1321 tgctattggg agctcatgca ctcctggcca atggatctgt gatgtctcgg gtagggacag
     1381 cacagttggc cctggtggct cgagctcata acgttccagt actggtctgc tgtgaaacgt
     1441 acaagttctg tgaacgtgtg cagactgatg cctttgtctc caacgagcta gatgatcccg
     1501 atgatctgca gtgtaagcgg ggagaccagg tggccctggc taactggcag agccacccgt
     1561 ccctccggtt gttgaatctg gtctatgacg tgactccacc tgagctcgtg gatctggtga
     1621 tcacagagtt gggcatgatc ccttgcagtt ctgtgcctgt tgttcttcga gtcaagagca
     1681 gtgaccagtg aagggaacaa gggtcaataa aaagcttact ccctactccc atgaaaaaaa
     1741 aaaaaaaaaa aa
//
