LOCUS       NM_145445               1605 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 2B, subunit 2
            beta (Eif2b2), mRNA.
ACCESSION   NM_145445
VERSION     NM_145445.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Kashiwagi,K., Shigeta,T., Imataka,H., Ito,T. and Yokoyama,S.
  TITLE     Expression, purification, and crystallization of
            Schizosaccharomyces pombe eIF2B
  JOURNAL   J Struct Funct Genomics 17 (1), 33-38 (2016)
   PUBMED   27023709
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Dorval,V., Mandemakers,W., Jolivette,F., Coudert,L., Mazroui,R., De
            Strooper,B. and Hebert,S.S.
  TITLE     Gene and MicroRNA transcriptome analysis of Parkinson's related
            LRRK2 mouse models
  JOURNAL   PLoS One 9 (1), e85510 (2014)
   PUBMED   24427314
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159237.2 and AK049731.1.
            
            On Sep 17, 2015 this sequence version replaced NM_145445.3.
            
            Summary: This gene encodes the beta subunit of eukaryotic
            initiation factor-2B (EIF2B). EIF2B is involved in protein
            synthesis and exchanges GDP and GTP for its activation and
            deactivation. Mutations in the human gene are associated with
            ovarioleukodystrophy and leukoencephalopathy with vanishing white
            matter. [provided by RefSeq, Sep 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049731.1, BC003326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC159237.2         128020-128051
            33-1605             AK049731.1         2-1574
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.6 cM"
     gene            1..1605
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /note="eukaryotic translation initiation factor 2B,
                     subunit 2 beta"
                     /db_xref="GeneID:217715"
                     /db_xref="MGI:MGI:2145118"
     exon            1..244
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1137
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /note="translation initiation factor eIF-2B subunit beta;
                     eIF-2B GDP-GTP exchange factor subunit beta; eIF2B GDP-GTP
                     exchange factor subunit beta"
                     /codon_start=1
                     /product="translation initiation factor eIF2B subunit
                     beta"
                     /protein_id="NP_663420.1"
                     /db_xref="CCDS:CCDS26053.1"
                     /db_xref="GeneID:217715"
                     /db_xref="MGI:MGI:2145118"
                     /translation="MPGAAAKGSELSERIEGFVETLKRGGGQRSSEDMARETLGLLRR
                     LITDHHWNNAGDLMDLIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDE
                     SDQQESLHKLLTSGGLSEDFSFHFAPLKANIIEAINELLVELEGTMENIAAQALEHIH
                     SNEVIMTIGYSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKEGIETTVMT
                     DAAIFAVMSRVNKVIIGTKTILANGSLRAVAGTHTLALAAKHHSTPLIVCAPMFKLSP
                     QFPSEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPDLITLFISNIGGNAPS
                     YIYRLMSELYHPDDHVL"
     exon            245..365
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            366..514
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            515..678
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            679..774
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            775..912
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            913..979
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1605
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /note="hexamer: AATAAA"
     polyA_site      1470
                     /gene="Eif2b2"
                     /gene_synonym="EIF-2Bbeta; EIF2B"
                     /note="major polyA site"
ORIGIN      
        1 gttgacctct ctcggcccgg aagtgaaaca gtgctttggc aattgaggct tctgtaagtg
       61 agtcccggga cggtgttgga aatgccgggt gccgcggcga agggctcgga gttgtccgag
      121 aggatcgaag gcttcgtgga gactctgaag cgaggtggcg ggcagcgcag ctcggaggac
      181 atggctcggg agaccctggg gctgctgcgc cggcttatca cggaccacca ctggaacaac
      241 gcgggggacc ttatggattt gatccgcaga gagggcagga ggatgacggc tgcgcagccc
      301 tccgagacca ccgtgggaaa tatggtgcgg agagtcctca agatcatccg ggaggagtat
      361 ggcagactgc acgggcgcag tgacgagagc gatcagcagg agtccctgca caaactcttg
      421 acatccggag gcctgagcga ggatttcagc ttccattttg ccccacttaa ggccaacatc
      481 attgaggcga ttaatgagct gctggtggaa ctggaaggca caatggagaa cattgccgcc
      541 caggctctgg agcacatcca ctccaacgag gtgatcatga ccattggcta ctctaggaca
      601 gttgaggcct tccttaaaga ggcggcccgg aagaggaagt tccacgttat tgttgcagag
      661 tgcgctcctt tctgccaggg acatgaaatg gccgtcaatt tgtccaaaga aggtatcgag
      721 acaactgtca tgactgatgc cgccattttt gctgttatgt cgagagtcaa caaggtgatc
      781 attggcacga agactatcct ggccaacggt tccctgaggg cagtggcagg aacacacacc
      841 ctggccctgg cagcgaaaca ccactccacg cctctcatcg tctgcgcccc catgtttaag
      901 ctgtcccctc agttccccag tgaagaagat tcctttcaca agtttgtggc tcctgaagaa
      961 gtccttcctt tcacagaagg agacattctg gagaaggtca gcgtccactg tcctgtgttt
     1021 gactacgtgc cccccgacct cattaccctc tttatctcca acattggcgg gaacgcacca
     1081 tcctacatct accgcctgat gagcgagctc tatcatcctg atgaccacgt cctctgacac
     1141 ggcctgccct atgcggaccc agagtggagt ggagacacag cattgctgct acagtgggga
     1201 ggggaggcca gcctgagccc tcagtgtctc ctgccttcct gctcatctcc agtgatgagt
     1261 gcgtccagga ctgctcctgc cttccaggct tagctgagca gcagggctcg cttacctggg
     1321 gattttggag ccactcaggc tgtgtttgct tcaggaactt caaccttcta gctcagtagt
     1381 gtgctagaca tgccatgact actttgctgg gttggtgttt gctcagaaat gccttccaga
     1441 ccttttgcca ataaaagcta ctggaaactc ctcaagttcg tttattgttc tgagctctga
     1501 atggactgaa gcgtcagagt ggccccttct ctgtctgcat agaggctgtg gtcagagagg
     1561 gaagcctaaa acaagtacaa ataaaagcag tttctccgta caact
//
