LOCUS       NM_145371               2012 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 2B, subunit
            alpha (Eif2b1), mRNA.
ACCESSION   NM_145371
VERSION     NM_145371.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Kashiwagi,K., Shigeta,T., Imataka,H., Ito,T. and Yokoyama,S.
  TITLE     Expression, purification, and crystallization of
            Schizosaccharomyces pombe eIF2B
  JOURNAL   J Struct Funct Genomics 17 (1), 33-38 (2016)
   PUBMED   27023709
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Wortham,N.C., Martinez,M., Gordiyenko,Y., Robinson,C.V. and
            Proud,C.G.
  TITLE     Analysis of the subunit organization of the eIF2B complex reveals
            new insights into its structure and regulation
  JOURNAL   FASEB J 28 (5), 2225-2237 (2014)
   PUBMED   24532666
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Jennings,M.D. and Pavitt,G.D.
  TITLE     A new function and complexity for protein translation initiation
            factor eIF2B
  JOURNAL   Cell Cycle 13 (17), 2660-2665 (2014)
   PUBMED   25486352
  REMARK    Review article
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Woo,C.W., Kutzler,L., Kimball,S.R. and Tabas,I.
  TITLE     Toll-like receptor activation suppresses ER stress factor CHOP and
            translation inhibition through activation of eIF2B
  JOURNAL   Nat Cell Biol 14 (2), 192-200 (2012)
   PUBMED   22231169
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Cabilly,Y., Barbi,M., Geva,M., Marom,L., Chetrit,D., Ehrlich,M. and
            Elroy-Stein,O.
  TITLE     Poor cerebral inflammatory response in eIF2B knock-in mice:
            implications for the aetiology of vanishing white matter disease
  JOURNAL   PLoS One 7 (10), e46715 (2012)
   PUBMED   23056417
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Kubica,N., Jefferson,L.S. and Kimball,S.R.
  TITLE     Eukaryotic initiation factor 2B and its role in alterations in mRNA
            translation that occur under a number of pathophysiological and
            physiological conditions
  JOURNAL   Prog Nucleic Acid Res Mol Biol 81, 271-296 (2006)
   PUBMED   16891174
  REMARK    Review article
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Yin,X., Warner,D.R., Roberts,E.A., Pisano,M.M. and Greene,R.M.
  TITLE     Identification of novel CBP interacting proteins in embryonic
            orofacial tissue
  JOURNAL   Biochem Biophys Res Commun 329 (3), 1010-1017 (2005)
   PUBMED   15752756
REFERENCE   9  (bases 1 to 2012)
  AUTHORS   Sans,M.D., DiMagno,M.J., D'Alecy,L.G. and Williams,J.A.
  TITLE     Caerulein-induced acute pancreatitis inhibits protein synthesis
            through effects on eIF2B and eIF4F
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (3), G517-G528 (2003)
   PUBMED   12773302
  REMARK    GeneRIF: Inhibition of pancreatic protein synthesis in this model
            of acute pancreatitis most likely results from inhibition of
            translation initiation from increased eIF2alpha phosphorylation,
            reduction of eIF2B activity, and inhibition of eIF4F complex
            formation.
REFERENCE   10 (bases 1 to 2012)
  AUTHORS   Klein,U., Ramirez,M.T., Kobilka,B.K. and von Zastrow,M.
  TITLE     A novel interaction between adrenergic receptors and the
            alpha-subunit of eukaryotic initiation factor 2B
  JOURNAL   J Biol Chem 272 (31), 19099-19102 (1997)
   PUBMED   9235896
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DV649595.1 and AK133695.1.
            
            On Aug 19, 2015 this sequence version replaced NM_145371.3.
            
            Summary: This gene encodes the alpha subunit of the eukaryotic
            translation initiation factor complex 2B (eIF2B). The eIF2B complex
            is a heterodecamer comprised of two molecules each of alpha, beta,
            gamma, delta and epsilon subunits. The eIF2B complex is a critical
            regulator of protein synthesis acting as the guanine nucleotide
            exchange factor for eIF2 to enable the formation of ternary complex
            that is required for the initiation of mRNA translation. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133695.1, BC003426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                DV649595.1         1-74
            75-2012             AK133695.1         2-1939
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.67 cM"
     gene            1..2012
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /note="eukaryotic translation initiation factor 2B,
                     subunit alpha"
                     /db_xref="GeneID:209354"
                     /db_xref="MGI:MGI:2384802"
     exon            1..131
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1036
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /note="eIF-2B GDP-GTP exchange factor subunit alpha;
                     eukaryotic translation initiation factor 2B, subunit 1
                     (alpha, 26kDa); eIF2B GDP-GTP exchange factor subunit
                     alpha; eukaryotic translation initiation factor 2B,
                     subunit 1 (alpha); translation initiation factor eIF-2B
                     subunit alpha"
                     /codon_start=1
                     /product="translation initiation factor eIF2B subunit
                     alpha"
                     /protein_id="NP_663346.1"
                     /db_xref="CCDS:CCDS39282.1"
                     /db_xref="GeneID:209354"
                     /db_xref="MGI:MGI:2384802"
                     /translation="MEDGELIEYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQG
                     LRANLTYAIKTLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLR
                     RISLSRNKIANLCHTFIKDGARILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLS
                     GKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVC
                     AKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSVQTGQDLKEEHPWVDYT
                     SPSLITLLFTDLGVLTPSAVSDELIKLYL"
     exon            132..233
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            234..370
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            371..487
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            488..600
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            601..669
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            670..745
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            746..871
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     exon            872..2012
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1552..1557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="Eif2b1"
                     /gene_synonym="D5Ertd406e; EIF2BA"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgacga gtgacgccac gcacgccgga gacgacggaa ctgacgcgcg agaagggcga
       61 cgcgctgtca ggccgtgctt tgctgctggc gccttgcggg aagtcgctcg aggaagccat
      121 ggaggacggt gagttaattg aatactttaa gtctcagatg aaaggagatc ctaaaatggc
      181 ctcagctgtg gctgccatcc agactttgtt ggaattcttg aagagagata aaggagaaac
      241 actccagggc ctgagagcaa atctcaccta tgccataaaa accctctgtg gtgtggactc
      301 ctcagtggcc gtgtcatctg gcggggagct cttccttcgc ttcatcagcc tcacctccct
      361 ggaatactct gactactcca aatgtaagaa gatcatgatt gagagaggag agctgttcct
      421 gagaagaata tccctgtcga gaaataagat tgccaatctg tgtcatacat tcatcaaaga
      481 cggggcgaga attttgactc acgcctactc cagagttgtc ttaagagtcc tggaagaagc
      541 cgtggcagcc aagaaacggt tcagtgtgta tatcacggag tcgcagcctg atttatctgg
      601 taagaaaatg gccaaagccc tctcccacct caacgtccct gtcactgtgg tgctggatgc
      661 tgctgtcggc tatatcatgg agaaagcaga tcttgtcata gttggtgctg aaggagtggt
      721 agagaacgga ggcattatta acaagattgg aaccaaccag atggccgtgt gtgccaaagc
      781 ccagaataag cccttctatg tggttgcaga aagcttcaag ttcgtacgcc tctttccact
      841 caaccaggag gacgtcccag ataagtttaa gtacaaggca gacactctga agtctgtgca
      901 gactgggcag gatctcaaag aggaacaccc atgggtggac tacacctccc catccctcat
      961 caccctgctg tttacggacc tgggtgtgtt gacgccatct gctgtaagcg atgagctcat
     1021 caagctgtac ctatgagccg agtcgctcct gccaacatgc aggaagcacg cgctgtgcag
     1081 gatgagcagc ctctccacgc cagccagcca ggggctgaaa ctgaatccaa catcagacgt
     1141 cctgaagaat ccgtggactt ctgctctgtc acatctgaag cctgtttcca gttctggaag
     1201 caagctgagg tgcccttatg gttttcggaa actcggtctc aggaaggaca actgagatta
     1261 catctgcagt cctgaggaaa gacggcacac gagcagagac ccccttctca taccacactc
     1321 agacggctga gtacaaacct tatggtgcct cacaagacag caaacactgg ctgactacgt
     1381 ctggcttcgg ggctccctcc cctcagcagc ccaagccaga caggagaaat accaatgcag
     1441 gagccattca tgtgccactg cgcacagaat gttgtctata gaaaatggga gtttacttta
     1501 aacatggtta gaacccaaac agctttttaa agttaaatgt ggaaacaaat caataaatta
     1561 tatgaacaat ttagatacgg tattgcctct ctaagttgac agatcagaaa cagtgcaagc
     1621 acaattaggc agaacccatt aacaagaaaa ggcctagcag cacttctcgg ggtagttctt
     1681 cctggtttta ataaaccacc gccagagcct gttctgaaat actctcaacc ccaatctgac
     1741 cccagcctgt ggccccagaa cacgggaggc taaggcagga ggatcagtct gaaatcatcc
     1801 tggactacat agttgtctta gttagggttt cattcctgtg tagagacacc aagactaagg
     1861 caactcttaa tttttgtttg ttttttcagt cagagtttct cttatagccc tgactgtcct
     1921 ggaacttact ctgtagacca ggctagcctc aaactcagag agatccacct gcctctgtct
     1981 cctgagtgct gggattaaag atgtgtacca tg
//
