LOCUS       NM_013719               5220 bp    mRNA    linear   ROD 24-MAR-2023
DEFINITION  Mus musculus eukaryotic translation initiation factor 2 alpha
            kinase 4 (Eif2ak4), transcript variant 1, mRNA.
ACCESSION   NM_013719
VERSION     NM_013719.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5220)
  AUTHORS   Chalvon-Demersay T, Gaudichon C, Moro J, Even PC, Khodorova N,
            Piedcoq J, Viollet B, Averous J, Maurin AC, Tome D, Foretz M,
            Fafournoux P and Azzout-Marniche D.
  TITLE     Role of liver AMPK and GCN2 kinases in the control of postprandial
            protein metabolism in response to mid-term high or low protein
            intake in mice
  JOURNAL   Eur J Nutr 62 (1), 407-417 (2023)
   PUBMED   36071290
  REMARK    GeneRIF: Role of liver AMPK and GCN2 kinases in the control of
            postprandial protein metabolism in response to mid-term high or low
            protein intake in mice.
REFERENCE   2  (bases 1 to 5220)
  AUTHORS   Farooq Z, Kusuma F, Burke P, Dufour CR, Lee D, Tabatabaei N, Toboz
            P, Radovani E, Greenblatt JF, Rehman J, Class J, Khoutorsky A,
            Fonseca BD, Richner JM, Mercier E, Bourque G, Giguere V,
            Subramaniam AR, Han J and Tahmasebi S.
  TITLE     The amino acid sensor GCN2 suppresses terminal oligopyrimidine
            (TOP) mRNA translation via La-related protein 1 (LARP1)
  JOURNAL   J Biol Chem 298 (9), 102277 (2022)
   PUBMED   35863436
  REMARK    GeneRIF: The amino acid sensor GCN2 suppresses terminal
            oligopyrimidine (TOP) mRNA translation via La-related protein 1
            (LARP1).
REFERENCE   3  (bases 1 to 5220)
  AUTHORS   Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C,
            Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW,
            Giguere V, Oliveira RL, Constante M, Santos MM, Morales CR,
            Pantopoulos K, Sonenberg N, Pinho S and Tahmasebi S.
  TITLE     The amino acid sensor GCN2 controls red blood cell clearance and
            iron metabolism through regulation of liver macrophages
  JOURNAL   Proc Natl Acad Sci U S A 119 (35), e2121251119 (2022)
   PUBMED   35994670
  REMARK    GeneRIF: The amino acid sensor GCN2 controls red blood cell
            clearance and iron metabolism through regulation of liver
            macrophages.
REFERENCE   4  (bases 1 to 5220)
  AUTHORS   Jonsson WO, Mirek ET, Wek RC and Anthony TG.
  TITLE     Activation and execution of the hepatic integrated stress response
            by dietary essential amino acid deprivation is amino acid specific
  JOURNAL   FASEB J 36 (7), e22396 (2022)
   PUBMED   35690926
REFERENCE   5  (bases 1 to 5220)
  AUTHORS   Raines LN, Zhao H, Wang Y, Chen HY, Gallart-Ayala H, Hsueh PC, Cao
            W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio CJ, Ho PC and
            Huang SC.
  TITLE     PERK is a critical metabolic hub for immunosuppressive function in
            macrophages
  JOURNAL   Nat Immunol 23 (3), 431-445 (2022)
   PUBMED   35228694
REFERENCE   6  (bases 1 to 5220)
  AUTHORS   Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D,
            Harding HP, Chen JJ, Han A, White BC, Krause GS and DeGracia DJ.
  TITLE     Brain ischemia and reperfusion activates the eukaryotic initiation
            factor 2alpha kinase, PERK
  JOURNAL   J Neurochem 77 (5), 1418-1421 (2001)
   PUBMED   11389192
REFERENCE   7  (bases 1 to 5220)
  AUTHORS   Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M and Ron D.
  TITLE     Regulated translation initiation controls stress-induced gene
            expression in mammalian cells
  JOURNAL   Mol Cell 6 (5), 1099-1108 (2000)
   PUBMED   11106749
  REMARK    GeneRIF: regulated translation initiation controls stress-induced
            gene expression in mammalian cells
REFERENCE   8  (bases 1 to 5220)
  AUTHORS   Sood R, Porter AC, Olsen DA, Cavener DR and Wek RC.
  TITLE     A mammalian homologue of GCN2 protein kinase important for
            translational control by phosphorylation of eukaryotic initiation
            factor-2alpha
  JOURNAL   Genetics 154 (2), 787-801 (2000)
   PUBMED   10655230
REFERENCE   9  (bases 1 to 5220)
  AUTHORS   Berlanga JJ, Santoyo J and De Haro C.
  TITLE     Characterization of a mammalian homolog of the GCN2 eukaryotic
            initiation factor 2alpha kinase
  JOURNAL   Eur J Biochem 265 (2), 754-762 (1999)
   PUBMED   10504407
REFERENCE   10 (bases 1 to 5220)
  AUTHORS   Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF and Hinnebusch AG.
  TITLE     Phosphorylation of initiation factor 2 alpha by protein kinase GCN2
            mediates gene-specific translational control of GCN4 in yeast
  JOURNAL   Cell 68 (3), 585-596 (1992)
   PUBMED   1739968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929163.5, AK013758.1, CO430666.1, CN527645.1, BG086385.2,
            CB723221.1, CF748039.1, BF453236.1, BF462783.1, W75391.1,
            BM250244.2 and AI324072.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_013719.4.
            
            On Apr 28, 2010 this sequence version replaced NM_013719.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243533.1, AF193343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL929163.5         65114-65158
            46-654              AK013758.1         2-610
            655-1297            CO430666.1         10-652
            1298-1905           CN527645.1         93-700
            1906-2459           BG086385.2         10-563
            2460-3011           CB723221.1         80-631
            3012-3446           CF748039.1         178-612
            3447-3996           BF453236.1         61-610
            3997-4461           BF462783.1         168-632
            4462-4714           W75391.1           164-416
            4715-5211           BM250244.2         2-498               c
            5212-5220           AI324072.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..5220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..5220
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /note="eukaryotic translation initiation factor 2 alpha
                     kinase 4"
                     /db_xref="GeneID:27103"
                     /db_xref="MGI:MGI:1353427"
     exon            1..236
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..349
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..452
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..605
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..686
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            687..835
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..951
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1106
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1642
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1749
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1907
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2335
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2405
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2489
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2612
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2717
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2775
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2855
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2957
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3011
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3248
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3324
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3446
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3496
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3665
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3782
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3848
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4019
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4154
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..4262
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4263..4391
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4392..4478
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4591
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4650
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4748
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..4817
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..4862
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..4981
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5213
                     /gene="Eif2ak4"
                     /gene_synonym="2610011M03; GCN2; MGCN2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcagttcg gtcacggcgc gggctggagc tcccctaccc accccagaat caccgctacc
       61 tcgcctaggc cgctgcgcct gccccggccg ccatggctgg gggccgcggg gcctctggac
      121 gcggccgggc tgagccacag gagagctatt cgcagcgaca ggaccacgag ctgcaggccc
      181 tggaggccat ttacggctcg gacttccagg atctgcggcc ggatgcgcgc ggacgggtga
      241 gagagcctcc tgaaatcaac ttagttcttt accctcaggg cctagctggt gaagaagtat
      301 acgtgcaagt ggaactgagg gttaaatgcc cacctacata cccagatgta gttcccgaaa
      361 tagacttaaa aaatgctaaa ggcctgtcga atgaaagtgt taatttgtta aaatcacacc
      421 tggaagaact ggccaaaaag cagtgtggag aggtgatgat atttgaactg gcacaccatg
      481 tgcagtcgtt tctcagcgag cataacaagc ccccaccaaa gtctttccat gaagaaatgc
      541 tggaaaggca ggctcaggag aagcagcaga ggttgctgga ggccaggcgg aaggaggagc
      601 aggagcaacg tgaaatcctc cacgagattc agagaaggaa agaggagatc aaggaagaga
      661 agaaaaggaa ggaaatggct aagcaggaac gtttggaaat cactagcttg acaaaccagg
      721 actatgcctc taagagagac ccagcagggc acagggcagc tgccatcctc catggaggct
      781 ctcctgactt tgtaggaaat ggtaaagccc ggacatactc ctcaggaagg tccaggcgag
      841 aacgtcagta ttctgtgtgt agtggtgaac cctctcctgg ctcgtgtgac atcctccatt
      901 tctctgtggg tagccctgat cagctcatgg tgcacaaagg gagatgtgtt ggcagtgatg
      961 agcagctggg aaaggtggta tacaatgctt tggaaacagc cacgggcagc tttgtcttgc
     1021 tgcatgagtg ggtccttcaa tggcagaaga tgggcccttg ccttaccagt caagagaaag
     1081 agaagattga caagtgcaaa aggcagattc aaggagcaga aacagaattc agctccctag
     1141 tgaaactgag ccatccaaat atcgtccgct actttgcgat gaactccaga gaggaggagg
     1201 actccattgt gatcgacatt ctggcagagc acgtcagtgg catctctctg gctacacacc
     1261 tgagccactc gggcccagtc cccgcccacc agctgcgcaa gtacacagcc cagctcctgg
     1321 caggcctgga ttacctacac agcaactccg tggtgcacaa ggttctgagc gcgtccagtg
     1381 tcttggtaga tgccgagggc actgtcaaga taacagacta cagcatctct aagcgtctgg
     1441 cagacatttg caaggaggat gtatttgagc aagctcgagt tcgttttagt gacagtgccc
     1501 tgccttataa aacaggaaag aaaggggatg tgtggcggct cggcctcctg ctgttgtctc
     1561 tcagccaagg acaggagtgt ggggagtatc cggtgaccat ccccagtgac ctgccagctg
     1621 acttccaaga cttcctgaag aagtgtgtct gcctggacga caaggaaaga tggagccctc
     1681 agcagctgct gaaacacagc tttataaacc ctcaaccaaa gctgcctttg gtggagcaga
     1741 gtcctgaaga ctctggggga caagactaca ttgagaccgt cattcccagc aaccagctgc
     1801 ccagcgctgc gttcttcagt gagacacaga aacagttctc ccggtacttc attgagtttg
     1861 aagaactaca actcctaggg aaaggagctt ttggagctgt catcaaggtg caaaacaagc
     1921 ttgatggctg ctgctatgct gtgaagcgca tccctatcaa ccctgcaagc agacacttcc
     1981 gccggatcaa gggcgaggtg acactgctat cgcgcctgca ccatgagaac attgtgcgct
     2041 actacaacgc ctggatcgag cggcatgagc gcccagcggt gccagggaca ccgcccccag
     2101 actgcacacc ccaggcccag gacagcccag ccacctgcgg gaaaacatca ggcgacactg
     2161 aagaactggg cagcgtggag gctgcagcac cgccacccat cctcagcagc tcggtggagt
     2221 ggagcacatc tgcagagcgt tctaccagca cccgcttccc agtcacgggc caggattcca
     2281 gcagcgatga ggaggacgag gacgagcgcg atggcgtctt ctcccagtcc tttctacctg
     2341 cttcagattc tgacagtgac atcatctttg acaatgaaga tgaaaacagt aaaagtcaaa
     2401 atcaggatga agactgcaat caaaaggacg gtagccatga gattgagcct tcagtgacag
     2461 ctgaggctgt gcactacctt tatatccaga tggagtactg cgagaagagc acgctgcggg
     2521 acaccattga ccaggggctg ttccgagaca ccagccggct ctggaggctt ttccgagaga
     2581 ttctggatgg attagcttat atccatgaga aaggaatgat tcatcgcgac ttgaagcctg
     2641 tcaatatttt tttggattct gatgaccatg tgaaaatagg tgactttggc ctggcaacag
     2701 accatctggc cttcactgct gaaggtaaac aggacgacca ggcaggtgac ggagtgatta
     2761 agtcagaccc ttcaggccat ttgactggca tggttggtac tgctctgtat gtaagccctg
     2821 aggtccaagg aagcaccaag tctgcataca accagaaagt ggatctcttc agcctgggaa
     2881 ttatcttctt tgagatgtct tatcacccga tggtgactgc ctcagaaaga attttcgttc
     2941 tcaaccaact tcgagatccc acatcgccca agtttccaga cgacttcgat gatggagaac
     3001 atacaaagca gaaatctgtc atctcctggc tgttgaacca tgatccagct aaacggccca
     3061 cggccatgga actgctcaag agtgagctgc tccccccgcc gcagatggag gagtccgagc
     3121 tgcatgaagt gctgcaccac acgctggcca acatagatgg gaaggcctac cgcaccatga
     3181 tgagtcagat cttctgccag cacatctccc ccgctataga ctacacctac gacagtgaca
     3241 tcctgaaggg caacttcttg attcgtacag ccaagatcca gcagcttgta tgtgaaacca
     3301 tcgtccgcgt ctttaaaagg catggcgctg tccagctgtg caccccactg ctgcttcccc
     3361 gaaacaggca aatatatgag cacaacgaag cggctttgtt catggatcac agcggcatgc
     3421 tggtgatgct tccgttcgac ctgcgggtcc cttttgcaag atatgtggca agaaataaca
     3481 tactgaattt aaaacgatac tgcatagagc gggtgttcag acctcggaag ttagaccgat
     3541 ttcatcccaa agaactcctg gaatgtgcat ttgatatcgt cacttctacc accaacagct
     3601 ctctgcccac tgccgaaacc atctacacca tctatgaaat aatccaggag tttcctgcac
     3661 ttcaggaaag gaattacagc atttacttga accatacgat gcttctgaag gcaatactcc
     3721 tacactgtgg gatcccagag gacaagctca gccaagtcta cgtcattctg tatgatgctg
     3781 tgacagagaa gctgactagg agagaagtgg aagctaaatt ctgtaacctg tccttgtctt
     3841 ctaatagcct gtgtagactc tacaagttca ttgagcagaa gggggatttg caagacttaa
     3901 cgccaaccat caactcacta ataaaacaga aaacaggcgt tgctcagttg gtgaagtata
     3961 gcttaaaaga cctcgaggac gtcgtcgggc tgctgaagaa acttggcgtg aagttacagg
     4021 tctccatcaa cctgggcttg gtctacaagg tgcagcagca cactggcatc atcttccagt
     4081 tcctggcatt cagcaaacgc aggcaaaggg ttgtgcctga gatccttgcc gccggtggca
     4141 gatacgacct gctgattccc aagttcagag gcccacagac tgtggggcca gtccccactg
     4201 ctgtcggtgt cagcatagcc atagacaaga tatttgctgc tgtcctcaac atggaagagc
     4261 ctgttacagt gagctcctgt gacctcctgg ttgtcagtgt tggccagatg tccatgtcca
     4321 gggccatcaa cctaacccag aaactgtgga cagcgggcat cactgcagaa atcatgtatg
     4381 actggtccca gtcccaggaa gagttacaag agtactgcag acaccatgaa atcacctatg
     4441 tggctctggt ctccgataaa gaaggaagcc atgtcaaggt caagtccttt gagaaggaga
     4501 ggcaaacaga aaagcgtgta ttggaatcgg atcttgtgga tcacgttatg cagaaactaa
     4561 gaaccaaagt tggtgacgaa agaaatttca gagacgcttc tgataatctt gccgtacaaa
     4621 ctctgaaggg gtcgttttct aatgcttcag gtttgtttga aatccatgga actacagtag
     4681 tccccaacgt gattgttcta gcaccagaaa agctgtcagc cagcaccagg aggcgacatg
     4741 agattcaggt gcaaacccga cttcagacta cacttgccaa cttacatcag aaaagcagtg
     4801 aaattgaaat tttggctgtg gacctaccca aggaaacaat cttacagttt ctatcattag
     4861 agtgggatgc tgatgaacag gcatttaaca caactgtgaa gcagctgctg tcacgcctgc
     4921 caaagcaaag atacctcaaa ctcgtctgcg atgaaattta taacatcaaa gttgaaaaga
     4981 aggtgtcagt gctgttcctg tacagctaca gagatgacta ctacagaatc ctattttgac
     5041 cctaaagaac tgctgctgta ttgttcaaat ggacagggac ttatactgaa ataatggaat
     5101 gttgtgcatt cattttaact ttaaattcta ataagctgtc ctacaaagct gagctttgtc
     5161 gggttttcat gtataaattt acctttttga tataataaat gttttcatag ataaaaaaaa
//
