LOCUS       NM_013557               2805 bp    mRNA    linear   ROD 20-DEC-2022
DEFINITION  Mus musculus eukaryotic translation initiation factor 2 alpha
            kinase 1 (Eif2ak1), mRNA.
ACCESSION   NM_013557 XM_282616
VERSION     NM_013557.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2805)
  AUTHORS   Ramos-Fernandez E, Arrazola MS, Oliva CA, Arredondo SB,
            Varela-Nallar L and Inestrosa NC.
  TITLE     Wnt5a promotes hippocampal postsynaptic development and
            GluN2B-induced expression via the eIF2alpha HRI kinase
  JOURNAL   Sci Rep 11 (1), 7395 (2021)
   PUBMED   33795747
  REMARK    GeneRIF: Wnt5a promotes hippocampal postsynaptic development and
            GluN2B-induced expression via the eIF2alpha HRI kinase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2805)
  AUTHORS   Mukherjee T, Ramaglia V, Abdel-Nour M, Bianchi AA, Tsalikis J, Chau
            HN, Kalia SK, Kalia LV, Chen JJ, Arnoult D, Gommerman JL, Philpott
            DJ and Girardin SE.
  TITLE     The eIF2alpha kinase HRI triggers the autophagic clearance of
            cytosolic protein aggregates
  JOURNAL   J Biol Chem 296, 100050 (2021)
   PUBMED   33168630
  REMARK    GeneRIF: The eIF2alpha kinase HRI triggers the autophagic clearance
            of cytosolic protein aggregates.
REFERENCE   3  (bases 1 to 2805)
  AUTHORS   Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller
            CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J and Blobel
            GA.
  TITLE     The HRI-regulated transcription factor ATF4 activates BCL11A
            transcription to silence fetal hemoglobin expression
  JOURNAL   Blood 135 (24), 2121-2132 (2020)
   PUBMED   32299090
REFERENCE   4  (bases 1 to 2805)
  AUTHORS   Alvarez-Castelao B, Tom Dieck S, Fusco CM, Donlin-Asp P, Perez JD
            and Schuman EM.
  TITLE     The switch-like expression of heme-regulated kinase 1 mediates
            neuronal proteostasis following proteasome inhibition
  JOURNAL   Elife 9, e52714 (2020)
   PUBMED   32329716
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2805)
  AUTHORS   Hamada Y, Furumoto Y, Izutani A, Taniuchi S, Miyake M, Oyadomari M,
            Teranishi K, Shimomura N and Oyadomari S.
  TITLE     Nanosecond pulsed electric fields induce the integrated stress
            response via reactive oxygen species-mediated heme-regulated
            inhibitor (HRI) activation
  JOURNAL   PLoS One 15 (3), e0229948 (2020)
   PUBMED   32155190
  REMARK    GeneRIF: Study in eIF2alpha kinase quadruple knockout (4KO) and
            single eIF2alpha kinase-rescued 4KO mouse embryonic fibroblast
            cells results indicate that the eIF2alpha kinase HRI is responsible
            for nanosecond pulsed electric fields (nsPEFs)-induced integrated
            stress response activation and is activated by nsPEF-generated
            reactive oxygen species.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2805)
  AUTHORS   Bauer BN, Rafie-Kolpin M, Lu L, Han A and Chen JJ.
  TITLE     Multiple autophosphorylation is essential for the formation of the
            active and stable homodimer of heme-regulated eIF2alpha kinase
  JOURNAL   Biochemistry 40 (38), 11543-11551 (2001)
   PUBMED   11560503
REFERENCE   7  (bases 1 to 2805)
  AUTHORS   Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D,
            Harding HP, Chen JJ, Han A, White BC, Krause GS and DeGracia DJ.
  TITLE     Brain ischemia and reperfusion activates the eukaryotic initiation
            factor 2alpha kinase, PERK
  JOURNAL   J Neurochem 77 (5), 1418-1421 (2001)
   PUBMED   11389192
REFERENCE   8  (bases 1 to 2805)
  AUTHORS   Crosby JS, Chefalo PJ, Yeh I, Ying S, London IM, Leboulch P and
            Chen JJ.
  TITLE     Regulation of hemoglobin synthesis and proliferation of
            differentiating erythroid cells by heme-regulated eIF-2alpha kinase
  JOURNAL   Blood 96 (9), 3241-3248 (2000)
   PUBMED   11050009
REFERENCE   9  (bases 1 to 2805)
  AUTHORS   Rafie-Kolpin M, Chefalo PJ, Hussain Z, Hahn J, Uma S, Matts RL and
            Chen JJ.
  TITLE     Two heme-binding domains of heme-regulated eukaryotic initiation
            factor-2alpha kinase. N terminus and kinase insertion
  JOURNAL   J Biol Chem 275 (7), 5171-5178 (2000)
   PUBMED   10671563
REFERENCE   10 (bases 1 to 2805)
  AUTHORS   Berlanga JJ, Herrero S and de Haro C.
  TITLE     Characterization of the hemin-sensitive eukaryotic initiation
            factor 2alpha kinase from mouse nonerythroid cells
  JOURNAL   J Biol Chem 273 (48), 32340-32346 (1998)
   PUBMED   9822714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB625879.1, AK173160.1 and DV644671.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_013557.3.
            
            On Jan 27, 2007 this sequence version replaced NM_013557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BB625879.1         2-51
            51-2786             AK173160.1         1-2736
            2787-2805           DV644671.1         262-280
FEATURES             Location/Qualifiers
     source          1..2805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..2805
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /note="eukaryotic translation initiation factor 2 alpha
                     kinase 1"
                     /db_xref="GeneID:15467"
                     /db_xref="MGI:MGI:1353448"
     exon            1..217
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1959
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /EC_number="2.7.11.1"
                     /note="heme-controlled repressor; hemin-sensitive
                     initiation factor 2-alpha kinase; heme-regulated
                     eukaryotic initiation factor eIF-2-alpha kinase;
                     heme-regulated inhibitor"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2-alpha
                     kinase 1"
                     /protein_id="NP_038585.2"
                     /db_xref="CCDS:CCDS84994.1"
                     /db_xref="GeneID:15467"
                     /db_xref="MGI:MGI:1353448"
                     /translation="MLGGSSVDGERDTDDDAAGAVAAPPAIDFPAEVSDPKYDESDVP
                     AELQVLKEPLQQPTFPFLVANQLLLVSLLEHLSHVHEPNPLHSKQVFKLLCQTFIKMG
                     LLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCQDNSYMQKIRSREIAFEAQT
                     SRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVL
                     AGLQHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSS
                     IVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVR
                     PVVRHQLPLGHSSELEGNFTSTDESSEGNLNLLGQTEVRYHLMLHIQMQLCELSLWDW
                     ITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHG
                     PDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGSQYDAKS
                     DMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVS
                     QRPSALQLLQSELFQTTGNVNLTLQMKIIEQEKEIEELKKQLSLLSQDRGLKR"
     exon            218..376
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            377..510
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            511..548
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            549..648
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            649..729
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            730..829
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            830..887
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1212
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1324
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1425
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1537
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1620
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1854
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2787
                     /gene="Eif2ak1"
                     /gene_synonym="HCR; Hri"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggctctt gtgttacttc cggcttgggg ggaggctcta gtggccggca gcgtctgggg
       61 accggcagag cgaggttact atccacgctc cgaacggcaa tgctgggggg cagctccgtg
      121 gacggcgagc gcgacacgga cgacgacgcg gcgggggcgg tggccgcgcc tcctgccatc
      181 gacttccccg cagaggtgtc ggaccccaag tatgatgagt ccgatgtccc cgcagagctc
      241 caagtgttaa aagagcccct acagcagccc acgttccctt tcctggtggc aaaccagctg
      301 ctgctcgtct ccttactgga acacttgagc catgtgcacg agccaaaccc gctccactcc
      361 aaacaggtgt ttaaattact gtgccagact tttatcaaga tggggctgct ctcttccttt
      421 acctgcagtg atgagtttag ctctctgaga ctccaccaca acagagccat cactcattta
      481 atgaggtctg ccaaagagag agtccgtcag gatccttgtc aagataattc ttacatgcag
      541 aaaatcagat ccagagagat agccttcgaa gcacaaacgt cacgctactt aaatgaattt
      601 gaagagcttg ccatcttagg gaaaggagga tatggaagag tttacaaggt ccggaacaaa
      661 ttagatggtc agcattatgc aattaagaaa atcctgatta agagcgcaac taaaacagat
      721 tgtatgaagg tgctacggga agtgaaggtt ctggcaggtc tccagcatcc caatattgtt
      781 ggctaccaca ctgcgtggat agaacatgtt catgtggttc agccacaaga cagagttccg
      841 attcaactgc cctctctcga agtgctgtcg gagcaggaag gggacagaga ccaaggtggt
      901 gttaaagata atgaaagcag ttcgtccatt gtctttgctg aactcacccc agaaaaagaa
      961 aaaccttttg gggagtctga ggttaaaaat gagaataaca acctggtgag ctacacggcc
     1021 aacttagtgg tcaggaacag cagtgaaagt gaatcgtcca ttgagctcca agaagacggc
     1081 ttgactgatt tgtccgtcag accagttgtc aggcatcagc tgccgctggg gcatagctcg
     1141 gaattggaag ggaattttac atccacggat gagtcttctg aaggcaactt gaacctgctg
     1201 gggcagacgg aggttcggta ccacctgatg ttgcacatcc agatgcagct gtgtgagctc
     1261 tccctgtggg actggataac tgagaggaac aagcggagcc gggagtatgt ggacgaagct
     1321 gcttgtccct atgttatggc cagtgttgca acaaaaattt ttcaagaatt ggtggaaggt
     1381 gtcttttaca tacataacat gggcattgtc cacagagatc tgaagcctag aaatattttt
     1441 cttcatggcc ctgatcagca agtaaaaata ggagactttg gtctggcctg tgcagacatc
     1501 atccagaatg cagactggac caacagaaat gggaaaggaa cacggacaca cacatccaga
     1561 gtggggactt gtctctacgc atcaccggaa cagctggagg gatcccagta cgatgccaag
     1621 tcagatatgt atagcttggg tgtgatcctg ctcgagctct ttcagccatt cgggacagaa
     1681 atggagaggg caacagtctt aacaggcgta aggactggtc ggatacccga atccctcagt
     1741 aaaaggtgtc cggtgcaagc caagtatatc cagctcctaa ccgggaggaa tgtgtcacag
     1801 agaccatctg cccttcagct gctgcagagt gagctttttc aaacaactgg aaatgttaat
     1861 ctcacattgc agatgaagat aatagaacaa gagaaggaaa ttgaagaact aaagaagcaa
     1921 ctaagcctcc tttctcagga cagagggctg aagagatgag agggaaaatg gggcctaccc
     1981 tgtggcctga gttatgccgc caagcatgtg aaagtggact tgcattatag tcaataggaa
     2041 tgtacatttc caacccttag tgaggacagg tgtgactccc agttgtactg agaaaaccta
     2101 tgtaaagact taaaaggacc ccagcttcct ttccctcaac ccttccatga cccaagactg
     2161 gactaaatga agcctcttcc tcccacctcc tccaagtttt gattcctcaa tttcctactc
     2221 aaatgttact ccccacccct gaacctattt ttttaagctc tgcctattga ccaggaatcc
     2281 tgccttcctt cccgagggct gtactacaga atcagtgctc cctccccaca cccgcttgcc
     2341 tgccccagga tgactgccag cctggctgct gttgctgtgg cagctgcaag tcttccctgg
     2401 tccttctgta ctgctgccat ggccagttac caggacactt gatcactcct tggctcaaaa
     2461 tgtctgtggg ctctgtactg cctggaaggt cagagttctg cttcgaagca ctgtgcactc
     2521 ttccagccct ctgttctttc cacttggcat catcctgcag cttgccctaa agtgatctca
     2581 gcagctaaaa tgtcttctac ctttattctg tatagtctcc catgatccgt tgcctcctta
     2641 aagccccaac tccccaaacc acctgaagtc ctcagatagc aatctctgac gccataaagt
     2701 gcctgcctct ggctggcagc catctcagtg cactgcactt ggttttactc actttaaaat
     2761 aaaataaact ccatagatga tatggtaaaa aaaaaaaaaa aaaaa
//
