LOCUS       NP_001005509             581 aa            linear   ROD 04-FEB-2025
DEFINITION  eukaryotic translation initiation factor 2A isoform 1 [Mus
            musculus].
ACCESSION   NP_001005509
VERSION     NP_001005509.1
DBSOURCE    REFSEQ: accession NM_001005509.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 581)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 581)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (residues 1 to 581)
  AUTHORS   Ding,S.M., Shi,L.G., Xing,F., Cui,S.S., Cheng,H.R., Liu,Y.,
            Ji,D.M., Liang,D., Cao,Y.X. and Liu,Y.J.
  TITLE     Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian
            Damage Caused by Chronic Unpredictable Mild Stress Through the
            eIF2alpha-AFT4 Signaling Pathway in Mice
  JOURNAL   Reprod Sci 31 (10), 3191-3201 (2024)
   PUBMED   39060751
  REMARK    GeneRIF: Melatonin Protects Against Mitochondrial Dyshomeostasis
            and Ovarian Damage Caused by Chronic Unpredictable Mild Stress
            Through the eIF2alpha-AFT4 Signaling Pathway in Mice.
REFERENCE   4  (residues 1 to 581)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 581)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 581)
  AUTHORS   Scheuner,D., Patel,R., Wang,F., Lee,K., Kumar,K., Wu,J.,
            Nilsson,A., Karin,M. and Kaufman,R.J.
  TITLE     Double-stranded RNA-dependent protein kinase phosphorylation of the
            alpha-subunit of eukaryotic translation initiation factor 2
            mediates apoptosis
  JOURNAL   J Biol Chem 281 (30), 21458-21468 (2006)
   PUBMED   16717090
  REMARK    GeneRIF: Double-stranded RNA-dependent protein kinase
            phosphorylation of the alpha-subunit of eukaryotic translation
            initiation factor 2 mediates apoptosis
REFERENCE   7  (residues 1 to 581)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   8  (residues 1 to 581)
  AUTHORS   Datta,B., Majumdar,A., Datta,R. and Balusu,R.
  TITLE     Treatment of cells with the angiogenic inhibitor fumagillin results
            in increased stability of eukaryotic initiation factor 2-associated
            glycoprotein, p67, and reduced phosphorylation of extracellular
            signal-regulated kinases
  JOURNAL   Biochemistry 43 (46), 14821-14831 (2004)
   PUBMED   15544353
REFERENCE   9  (residues 1 to 581)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 581)
  AUTHORS   Ito,T., Jagus,R. and May,W.S.
  TITLE     Interleukin 3 stimulates protein synthesis by regulating
            double-stranded RNA-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7455-7459 (1994)
   PUBMED   7519779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121794.3 and AC119873.38.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078519.1, BC082557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.58 cM"
     Protein         1..581
                     /product="eukaryotic translation initiation factor 2A
                     isoform 1"
                     /note="eIF-2A"
                     /calculated_mol_wt=64272
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine, in Eukaryotic translation
                     initiation factor 2A, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          10..567
                     /region_name="COG5354"
                     /note="Uncharacterized protein, contains Trp-Asp (WD)
                     repeat [General function prediction only]"
                     /db_xref="CDD:227657"
     Region          23..63
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          125..163
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          216..411
                     /region_name="eIF2A"
                     /note="Eukaryotic translation initiation factor eIF2A;
                     pfam08662"
                     /db_xref="CDD:462552"
     Region          356..401
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          432..533
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            503
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            513
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     CDS             1..581
                     /gene="Eif2a"
                     /gene_synonym="D030048D22; D3Ertd194e"
                     /coded_by="NM_001005509.3:17..1762"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17367.1"
                     /db_xref="GeneID:229317"
                     /db_xref="MGI:MGI:1098684"
ORIGIN      
        1 mapstplltv rgseglymvn gpphftestv lpresgrnck vytfskdgtl fawsngekvn
       61 iinvankgll hsfdlpkavc lefspnntvl atwqpyttsk dgtagtpnlq lydmktgacl
      121 ksfiqkkmqn wcpswsddei icarnvnnev hffennnfnt ianklhlqkv ndfnlspgtq
      181 pykvavyvpg skgapsfvrl yqypnfagpq aalanksffk adkvtmlwnk katavlvias
      241 tevdktgasy ygeqtlhyia tngesavvql pkngpiydvv wnssstefca vygfmpakat
      301 vfnlkcdpvf dfgtgprnaa fysphghilv lagfgnlrgq mevwdvknyk liskpvasds
      361 tyfawcpdge hiltatcapr lrvnngykiw hytgsllhky dvpsngelwq vswqpfldgi
      421 fpaktikyqa vpsevpseep kvatayrppa lrnkpvtnsk lheeeppqnm kphpgsdkpl
      481 sktalknqrk heakkaakqe arsdaaptpv pqsaprntvt qsasgdpevd kkiknlkkkl
      541 kaieqlkeqa aagkqleknq lekiqketal lqeledlelg v
//
