LOCUS       NP_081168                113 aa            linear   ROD 30-APR-2024
DEFINITION  eukaryotic translation initiation factor 1b [Mus musculus].
ACCESSION   NP_081168
VERSION     NP_081168.1
DBSOURCE    REFSEQ: accession NM_026892.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 113)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 113)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 113)
  AUTHORS   Zhu,F., Yan,P., Zhang,J., Cui,Y., Zheng,M., Cheng,Y., Guo,Y.,
            Yang,X., Guo,X. and Zhu,H.
  TITLE     Deficiency of TPPP2, a factor linked to oligoasthenozoospermia,
            causes subfertility in male mice
  JOURNAL   J Cell Mol Med 23 (4), 2583-2594 (2019)
   PUBMED   30680919
  REMARK    GeneRIF: Deficiency of TPPP2 might affect the translation of
            specific proteins, such as eEf1b, altering the structure and
            function of sperm mitochondria, and resulting in decreased sperm
            count, motility and fertility.
REFERENCE   5  (residues 1 to 113)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (residues 1 to 113)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI154212.1, AK013965.1 and AK005192.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005192.1, BY712983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..113
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.67 cM"
     Protein         1..113
                     /product="eukaryotic translation initiation factor 1b"
                     /note="translation factor sui1 homolog"
                     /calculated_mol_wt=12693
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:O60739; propagated from
                     UniProtKB/Swiss-Prot (Q9CXU9.2)"
     Region          4..113
                     /region_name="eIF1_SUI1_like"
                     /note="Eukaryotic initiation factor 1 and related
                     proteins; cl00229"
                     /db_xref="CDD:469673"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60739; propagated from
                     UniProtKB/Swiss-Prot (Q9CXU9.2)"
     Site            order(38,41..42,44,61,64..66,68..70,72,86,89)
                     /site_type="other"
                     /note="rRNA binding site [nucleotide binding]"
                     /db_xref="CDD:211318"
     Site            88..89
                     /site_type="other"
                     /note="Mutations affecting start-site selection"
                     /db_xref="CDD:211318"
     CDS             1..113
                     /gene="Eif1b"
                     /gene_synonym="1500010M16Rik; 3110001N14Rik; Gc20"
                     /coded_by="NM_026892.3:206..547"
                     /db_xref="CCDS:CCDS23628.1"
                     /db_xref="GeneID:68969"
                     /db_xref="MGI:MGI:1916219"
ORIGIN      
        1 mstiqnlqsf dpfadatkgd dllpagtedy ihiriqqrng rktlttvqgi addydkkklv
       61 kafkkkfacn gtviehpeyg eviqlqgdqr knicqfllev givkeeqlkv hgf
//
