LOCUS       NM_010120               2879 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus eukaryotic translation initiation factor 1A (Eif1a),
            transcript variant 2, mRNA.
ACCESSION   NM_010120
VERSION     NM_010120.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Lamacova,L., Jansova,D., Jiang,Z., Dvoran,M., Aleshkina,D.,
            Iyyappan,R., Jindrova,A., Fan,H.Y., Jiao,Y. and Susor,A.
  TITLE     CPEB3 Maintains Developmental Competence of the Oocyte
  JOURNAL   Cells 13 (10), 850 (2024)
   PUBMED   38786074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Shi,F., Xu,Y., Zhang,S., Fu,Z., Yu,Q., Zhang,S., Sun,M., Zhao,X.
            and Feng,X.
  TITLE     Decabromodiphenyl ethane affects embryonic development by
            interfering with nuclear F-actin in zygotes and leads to cognitive
            and social disorders in offspring mice
  JOURNAL   FASEB J 36 (8), e22445 (2022)
   PUBMED   35816173
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Liu,Y., Sun,J., Su,Y., Lin,J., Lv,C., Mo,K., Xu,S. and Wang,S.
  TITLE     Nuclear-localized eukaryotic translation initiation factor 1A is
            involved in mouse preimplantation embryo development
  JOURNAL   J Mol Histol 52 (5), 965-973 (2021)
   PUBMED   34405343
  REMARK    GeneRIF: Nuclear-localized eukaryotic translation initiation factor
            1A is involved in mouse preimplantation embryo development.
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   De Iaco,A., Verp,S., Offner,S., Grun,D. and Trono,D.
  TITLE     DUX is a non-essential synchronizer of zygotic genome activation
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31806660
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Davis,W. Jr., De Sousa,P.A. and Schultz,R.M.
  TITLE     Transient expression of translation initiation factor eIF-4C during
            the 2-cell stage of the preimplantation mouse embryo:
            identification by mRNA differential display and the role of DNA
            replication in zygotic gene activation
  JOURNAL   Dev Biol 174 (2), 190-201 (1996)
   PUBMED   8631492
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Varmuza,S. and Tate,P.
  TITLE     Isolation of epiblast-specific cDNA clones by differential
            hybridization with polymerase chain reaction-amplified probes
            derived from single embryos
  JOURNAL   Mol Reprod Dev 32 (4), 339-348 (1992)
   PUBMED   1497882
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Hershey,J.W.
  TITLE     Translational control in mammalian cells
  JOURNAL   Annu Rev Biochem 60, 717-755 (1991)
   PUBMED   1883206
  REMARK    Review article
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   Lu,X.A. and Werner,D.
  TITLE     The complete cDNA sequence of mouse elongation factor 1 alpha (EF 1
            alpha) mRNA
  JOURNAL   Nucleic Acids Res 17 (1), 442 (1989)
   PUBMED   2911475
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Roth,W.W., Bragg,P.W., Corrias,M.V., Reddy,N.S., Dholakia,J.N. and
            Wahba,A.J.
  TITLE     Expression of a gene for mouse eucaryotic elongation factor Tu
            during murine erythroleukemic cell differentiation
  JOURNAL   Mol Cell Biol 7 (11), 3929-3936 (1987)
   PUBMED   3481036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019451.1, AK013268.1, AK150673.1 and CN722607.1.
            
            On Oct 24, 2007 this sequence version replaced NM_010120.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY743342.1, AK019451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               AK019451.1         2-670
            670-1902            AK013268.1         669-1901
            1903-2865           AK150673.1         1876-2838
            2866-2879           CN722607.1         292-305
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.68 cM"
     gene            1..2879
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="eukaryotic translation initiation factor 1A"
                     /db_xref="GeneID:13664"
                     /db_xref="MGI:MGI:95298"
     exon            1..97
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /inference="alignment:Splign:2.1.0"
     exon            98..157
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /inference="alignment:Splign:2.1.0"
     exon            158..2879
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..788
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="isoform 2 is encoded by transcript variant 2;
                     eukaryotic translation initiation factor 4C"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 1A
                     isoform 2"
                     /protein_id="NP_034250.3"
                     /db_xref="CCDS:CCDS29233.1"
                     /db_xref="GeneID:13664"
                     /db_xref="MGI:MGI:95298"
                     /translation="MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGN
                     GRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARS
                     LKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="hexamer: AATAAA"
     polyA_site      1832
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="major polyA site"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="hexamer: AATAAA"
     polyA_site      1903
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
     regulatory      2844..2849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="hexamer: ATTAAA"
     polyA_site      2865
                     /gene="Eif1a"
                     /gene_synonym="Ef1a; Eftu; eIF-1A; eIF-4C; Eif4c"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaggggc gtggccggcc gttgcctagg aagggcgcgt cgtctctctg ctcgtccggc
       61 tgtgacgggg aaggggtccc gctgcgtttt ggtcactact caggaggaga ccacaccttc
      121 cggagaacca ggccagaacc gaagtactat tttgtagctc tcagaagcca ggactctgca
      181 acactgtttg ctgcctgtgg atcttctata ttcacagtgt cccagttgct tctgatctac
      241 cactgttaga tacttctgcc acccatccta agagtatagt tgttcttgga aaggagtctc
      301 agctgctgtc agcaggagtc cctcattcga ctcctgtggt tgccctttcc atcatgccaa
      361 agaataaagg caaaggaggc aaaaacaggc gcagaggtaa aaatgaaaat gaatctgaga
      421 aaagagagtt ggtgtttaaa gaggatgggc aggagtatgc tcaggtgatc aaaatgctgg
      481 gaaatggacg gttggaagca atgtgctttg acggtgtgag gaggctgtgc catataagag
      541 ggaagctgag aaaaaaggtt tggataaata cctcggacat tatattgatt ggtctacgag
      601 actatcaaga taacaaagct gatgtaatct taaagtataa tgcagatgaa gcaagaagtc
      661 tgaaggccta tggagaactt ccagaacatg ccaaaatcaa tgaaacggac acatttggtc
      721 ctggggatga tgatgaaatc caatttgatg atattggaga tgatgatgaa gacattgatg
      781 acatctagcc tgacctaagc atgctacctt ccaagttctc tgaagatagc tccacacagt
      841 ggcatcttga ccttcatctg ttaagtaaaa cttcatggca tgtgtatgac ttgttaatgc
      901 aagctaatga attttatttt ttgaagtact atatttcttt gaaaaccaaa gatgttgagt
      961 tatcatctta agtgacatgt taacactttg tgcttttgaa tataattgaa cctagcgcac
     1021 agcagtgagc actgttaaga gactgccttt ccatttgtag cttcatttct ggcacgggag
     1081 tgttttgtgt cagcagttct gccaggtggc catcgtgagc tgaagtaagt cctagtccag
     1141 cacatctgct tcaggccttt gtactctagt catctggctg cgttcgagac ttctcagcag
     1201 acttatagat gtgtacggct gcacttggag tcagacaaga tatggctact tttgtactta
     1261 tggagccatg ccattttata ctttcacgtt gtatacattc gtttgatcct ttaagttgtt
     1321 gccacccata aaaaggcatc ttacagtgca gtttttaaat tacatgggta gcaattttga
     1381 gttttaaaaa ttagtcattg cagaaattaa atacttagag gagataatcc attatcttga
     1441 ctttaggaat ataatagttg acaatgttta tatataattt tacttctcta aggcataccc
     1501 aaaaatagaa aatgaaaaag agcagtgagt ctgttctgat gcttgcattg catagagaag
     1561 ttttccaaca aagcagctgt taataacaca taaaatatgt tttactttgc aaagtaggtt
     1621 gtgttaagtc attttcaaaa agttacctac tatatcgagg ctctggataa ttactatgtg
     1681 ttgattaaag ttagttacag aattgtacaa gctaagtttt ccttaaacta agcttaggtt
     1741 aaagggagag gagccacagc tcaatgaaaa cacggttcct gttttctaaa tggaggcgcc
     1801 cagaaacaca ataaaacatg ttggtacaaa aactttttct ttttaatatg ttcattgtat
     1861 ctctggtata taacaaaaat aaatgactgg gtgatttctg gtatatcatg agaggctttt
     1921 tttttttttt tttaaattag actctgggat ttaaatggga cttaactatt ttcccattta
     1981 aatgacgcca gtattggggt cctgcagcct aaccctgctg cttagggagt gagtataaac
     2041 cgcgactgtc agtcctcaga tgccttcctt tttaaagact agttctttct caggtcttct
     2101 tcttgacacc tacaaatggt gcctgaccac aagacgacag tattcatctt cacttttatt
     2161 ttttgattgc ttgttttcta gttaacccag aataatatag cttatgaaaa tctcccagtc
     2221 aggaagaaag aaagaaagag aaagaaaagc aaatatgatt ttcctgatca ttgattggtg
     2281 gatctcttct agatggagat atgtagatct ttgtaaaggt taattttata aagtgagagt
     2341 agacatggta cccacactta gaagcagatc ccacatcccc agaaggacag tgtgtgttta
     2401 gaaagaacac atcactggag ctttttattg ctctacacag tgtatctaaa taagctgtca
     2461 actacaattt atcctattgc tgctgtaaat ttttatgaca gaaagaaaac ctgaccatgg
     2521 accagctagc ttgatggcct tcagcagcaa acaagaaact gtccaagtta ggaggtgagg
     2581 actagtgcct gaagatgtcc tctcagtcca caacatgtac aggtgcccat acacacatca
     2641 gcactcgcac aaagatgctc tggaggctat agtagtgtgt cttggtcatt gcaaaccatc
     2701 agaggcaaac cctgaggtat tcccatttcc tgtttcctgc ttgcagtgtc tacatttctc
     2761 tcccattcta atgaaggaat gattctttta taacatgagt gattttatgc tgtttataaa
     2821 agtaaatgtt gacatgtgtt agaattaaaa tgacttagag aaatatctaa atgtttttt
//
