LOCUS       NM_025613               2559 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus EP300 interacting inhibitor of differentiation 1
            (Eid1), mRNA.
ACCESSION   NM_025613
VERSION     NM_025613.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Sato,T., Vargas,D., Miyazaki,K., Uchida,K., Ariyani,W.,
            Miyazaki,M., Okada,J., Lizcano,F., Koibuchi,N. and Shimokawa,N.
  TITLE     EID1 suppresses lipid accumulation by inhibiting the expression of
            GPDH in 3T3-L1 preadipocytes
  JOURNAL   J Cell Physiol 235 (10), 6725-6735 (2020)
   PUBMED   32056205
  REMARK    GeneRIF: EID1 suppresses lipid accumulation by inhibiting the
            expression of GPDH in 3T3-L1 preadipocytes.
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Fu,X., Luo,L., Yi,R., Ding,B., Wang,C., Zhang,W., Wang,X., Yang,Y.,
            Chen,C., Fei,X., Hu,D. and Xu,R.
  TITLE     Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links
            cell proliferation in the brain
  JOURNAL   Gene 717, 143998 (2019)
   PUBMED   31381951
  REMARK    GeneRIF: Regulation of cell proliferation is the main functions of
            Eid1 in mice brain.
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Fu,X., Ding,B., Wang,C., Chen,C., Wang,J., Fei,X. and Xu,R.
  TITLE     EID1 plays a crucial role in proliferation of neural stem cell
  JOURNAL   Biochem Biophys Res Commun 512 (4), 763-769 (2019)
   PUBMED   30926163
  REMARK    GeneRIF: Eid1 knockout impeded the proliferation of neural stem
            cells.
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Chen,X., Du,Z., Li,X., Wang,L., Wang,F., Shi,W. and Hao,A.
  TITLE     Protein Palmitoylation Regulates Neural Stem Cell Differentiation
            by Modulation of EID1 Activity
  JOURNAL   Mol Neurobiol 53 (8), 5722-5736 (2016)
   PUBMED   26497028
  REMARK    GeneRIF: palmitoylation modified E1A-like inhibitor of
            differentiation one (EID1) and this modification regulated EID1
            degradation and CREB-binding protein (CBP)/p300 histone
            acetyltransferase activity at the switch between self-renewal and
            differentiation of neural stem cells.
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Ye,B., Dai,Z., Liu,B., Wang,R., Li,C., Huang,G., Wang,S., Xia,P.,
            Yang,X., Kuwahara,K., Sakaguchi,N. and Fan,Z.
  TITLE     Pcid2 inactivates developmental genes in human and mouse embryonic
            stem cells to sustain their pluripotency by modulation of EID1
            stability
  JOURNAL   Stem Cells 32 (3), 623-635 (2014)
   PUBMED   24167073
  REMARK    GeneRIF: Pcid2 is present in the CBP/p300-EID1 complex to control
            the switch balance of mouse and human embryonic stem cells through
            modulation of EID1 degradation.
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Park,Y.Y., Park,K.C., Shong,M., Lee,S.J., Lee,Y.H. and Choi,H.S.
  TITLE     EID-1 interacts with orphan nuclear receptor SF-1 and represses its
            transactivation
  JOURNAL   Mol Cells 24 (3), 372-377 (2007)
   PUBMED   18182853
  REMARK    GeneRIF: EID-1 is expressed in the mouse testis, and its expression
            decreases during testis development. The results of the present
            study suggest that EID-1 can act as a repressor, regulating the
            function of SF-1.
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Ji,A., Dao,D., Chen,J. and MacLellan,W.R.
  TITLE     EID-2, a novel member of the EID family of p300-binding proteins
            inhibits transactivation by MyoD
  JOURNAL   Gene 318, 35-43 (2003)
   PUBMED   14585496
REFERENCE   8  (bases 1 to 2559)
  AUTHORS   Bavner,A., Johansson,L., Toresson,G., Gustafsson,J.A. and
            Treuter,E.
  TITLE     A transcriptional inhibitor targeted by the atypical orphan nuclear
            receptor SHP
  JOURNAL   EMBO Rep 3 (5), 478-484 (2002)
   PUBMED   11964378
  REMARK    GeneRIF: isolation of mouse E1A-like inhibitor of differentiation 1
            (EID1) as a candidate coinhibitor for SHP
REFERENCE   9  (bases 1 to 2559)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   10 (bases 1 to 2559)
  AUTHORS   Carim,L., Sumoy,L., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     Identification and expression analysis of C15orf3, a novel gene on
            chromosome 15q21.1-->q21.2
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 330-332 (2000)
   PUBMED   10828624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY703074.1, AK011293.1, AL357453.1, DV050753.1, AA016688.1,
            BU610167.1 and BU700648.1.
            
            On Jun 2, 2007 this sequence version replaced NM_025613.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY703074.1         1-11
            12-15               AK011293.1         5-8
            16-16               BY703074.1         15-15
            17-1002             AK011293.1         9-994
            1003-1686           AL357453.1         969-1652
            1687-1984           DV050753.1         448-745
            1985-1989           AA016688.1         211-215
            1990-2540           BU610167.1         1-551
            2541-2559           BU700648.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2559
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
                     /note="EP300 interacting inhibitor of differentiation 1"
                     /db_xref="GeneID:58521"
                     /db_xref="MGI:MGI:1889651"
     exon            1..2544
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..572
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
                     /note="CREBBP/EP300 inhibitory protein 1; E1A-like
                     inhibitor of differentiation 1"
                     /codon_start=1
                     /product="EP300-interacting inhibitor of differentiation
                     1"
                     /protein_id="NP_079889.2"
                     /db_xref="CCDS:CCDS50696.1"
                     /db_xref="GeneID:58521"
                     /db_xref="MGI:MGI:1889651"
                     /translation="MAEMAELCELYEESNELQMDVLPGEGYMEVGRGARGPAPEEGPM
                     EEEAGPAAARAQRGLFPEAGADLEGDEFDDWEDDYEFPEEERWSGAMHRVSAALEEAN
                     KVFLRTARAGDALDGGFQARCEKSPFDQLAFIEELFSLMVVNRLTEELGCDEIIDRE"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
                     /note="major polyA site"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
                     /note="hexamer: AATACA"
     polyA_site      2544
                     /gene="Eid1"
                     /gene_synonym="2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22;
                     PTD014"
ORIGIN      
        1 tcttgcctgc gcacgcgcac cacgcccgtt cgcgcgcccg tctctgcaaa aggttccttt
       61 tttttttcca ccttggtcga gtcgcttcca ccatggcgga gatggcagag ctttgcgagc
      121 tgtacgaaga aagcaacgag ttgcagatgg acgtgctgcc cggcgagggc tatatggagg
      181 taggccgcgg ggcccgcggg ccggccccgg aggagggccc catggaggag gaggccgggc
      241 cggccgccgc ccgcgcccag cgcggtctgt tccccgaggc tggcgcggac ctggaaggcg
      301 acgagtttga tgactgggag gacgactacg agttccctga agaggagcgc tggagcggcg
      361 cgatgcacag ggtgtccgcc gccctggagg aagccaacaa ggtgttcctg cgaaccgcgc
      421 gagccggaga tgccctggat ggcggctttc aggcgcggtg tgagaagagc cctttcgacc
      481 agctagcttt tatcgaagag ctgttttcgc tgatggttgt caatcgactg accgaagagc
      541 tcggttgtga tgagatcatt gatcgagagt aaatgctgac gagagaggag gaaactacct
      601 gagagggaga gattcaacat tctgctattt tggggttcat tccaaatagt tctgtgcaaa
      661 aaataaaaac agttggtttt tgtttctcgg aatagaagac gggacagtga atgaccatgc
      721 attgtggaaa aggagaatcg aggaaggagg agtgttaaac ctgagaatcg cgaggagaaa
      781 aagaccaaat cgttcctctt tggtctcaca ggggctcagc aaaaacctct ggttcagact
      841 gttgatcgag atgattttcc ttacattgga gaagagcttt ctctgttaag cttttaaaga
      901 tggtttggaa gagtaaattg tgactaccaa tacaagaatc taattaaaga atggggggaa
      961 atacattcca agatgtcttt aattcgaact gaaaggctat tgaaaaaaaa aaaaactttc
     1021 caaattcttt ttggtgattt atacacatca gttatcaaaa gctaaacttg aggtttaaga
     1081 ttgagtattc atctacccca cagagtagtc caagtaaatg tgggtataaa tgtagacgtg
     1141 ttatcatgtg tgctgtcatc ttaaaatgtg ttacaaacgc ttctggaatt ttgactgcac
     1201 atgtatcttc atgatttata aagctactgt gacctctaat ttggaaaaac ccattgtaat
     1261 gattttcaaa gtaaagaaag aaacaggatg tctttttaag gttttaagtt catgcattaa
     1321 ataaaatgta tgggaaagcc caaagacaaa ctttctaata cccttttata ctagggaaat
     1381 ttcacttgct gttttgtacc ttgacagatg gtaagactat aactgaagtt catattgtaa
     1441 gaactgtttg ctaaaattgt caagtaaaaa gaaatcctgc ctgtatctat aaaaagatgt
     1501 atgagctatt atgttgtcaa actttgaagg ttttaaacct acccagaagt ccacctgggt
     1561 gtctgatatt catattctct ctctccctct ctgcctcttt cttcccctcc ccctcccttc
     1621 ttctaattat gcttgttaat ctttatgcac cagcattggc gataataaat tttcttgttc
     1681 tgtgtatttt gctttgtcta atagctttgc atacatgctt tatacaggat tctcttgctg
     1741 tgtgtgccac gcctccatct tgatatttaa acatccaatg cttacaatgt aaaccagtat
     1801 caaatatcca aaaaatgggt tctgggatgt taaagcaaat ttcagagttt tctggaagac
     1861 ccgctctgtg aatgtgatgc tatggcttaa ttgatgctga agttccttga gaagaaaatg
     1921 atgtattagc acgatgtccc tgctgatgcc accatggcaa ccaatacaga acagagctga
     1981 gacagtagga taactcctgg gtttctgtgg ggttggttgg ttggttttac agtcatcttg
     2041 tttgagaggc tgccgaggtg gttcagtggg taaaggtacc ttctgccata tagccaagcc
     2101 tgatggcctg agtttgatct ctggggtcca tgtggtggag ggagggagag agacctcccc
     2161 caagattggg caggcctgtt agtaatttta gaccctcacc tgggatttta gttgctcctg
     2221 tacctccaaa gcacctgtac ataattttgc cccggttaca tgtggtttca gaaggtgcta
     2281 aaacacaaaa ggtgggaggt tggctgatgt taggtgggga ctcgtgtttg ggaagctgtc
     2341 acccatgtta gggtaggaca tttagataga gccgctacaa acacttccat gggtaacccc
     2401 tcagccctct tttttactca cccaataaat tgcctcacta gttggacttg agggaatcat
     2461 ttattgatct gttattggta tttacctgct gtaaatagac ttttgttcac atctccacag
     2521 aaatataata caaatatcca taaaaaaaaa aaaaaaaaa
//
