LOCUS       NM_001403869            4349 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus euchromatic histone lysine N-methyltransferase 2
            (Ehmt2), transcript variant 6, mRNA.
ACCESSION   NM_001403869 XM_011246249
VERSION     NM_001403869.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4349)
  AUTHORS   Wada,S., Ideno,H., Nakashima,K., Komatsu,K., Demura,N.,
            Tomonari,H., Kimura,H., Tachibana,M. and Nifuji,A.
  TITLE     The histone H3K9 methyltransferase G9a regulates tendon formation
            during development
  JOURNAL   Sci Rep 14 (1), 20771 (2024)
   PUBMED   39237663
  REMARK    GeneRIF: The histone H3K9 methyltransferase G9a regulates tendon
            formation during development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4349)
  AUTHORS   Komatsu,K., Ideno,H., Nakashima,K., Udagawa,N., Kobayashi,Y.,
            Kimura,H., Tachibana,M., Yamashita,T. and Nifuji,A.
  TITLE     The G9a histone methyltransferase represses osteoclastogenesis and
            bone resorption by regulating NFATc1 function
  JOURNAL   FASEB J 38 (13), e23779 (2024)
   PUBMED   38967255
  REMARK    GeneRIF: The G9a histone methyltransferase represses
            osteoclastogenesis and bone resorption by regulating NFATc1
            function.
REFERENCE   3  (bases 1 to 4349)
  AUTHORS   Pollin,G., Mathison,A.J., de Assuncao,T.M., Thomas,A., Zeighami,A.,
            Salmonson,A., Liu,H., Urrutia,G., Vankayala,P., Pandol,S.J.,
            Hong,J.C., Zimmermann,M.T., Iovanna,J., Jin,V.X., Urrutia,R. and
            Lomberk,G.
  TITLE     Ehmt2 inactivation in pancreatic epithelial cells shapes the
            transcriptional landscape and inflammation response of the whole
            pancreas
  JOURNAL   Front Genet 15, 1412767 (2024)
   PUBMED   38948355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4349)
  AUTHORS   Tsimpos,P., Desiderio,S., Cabochette,P., Poelvoorde,P., Kricha,S.,
            Vanhamme,L., Poulard,C. and Bellefroid,E.J.
  TITLE     Loss of G9a does not phenocopy the requirement for Prdm12 in the
            development of the nociceptive neuron lineage
  JOURNAL   Neural Dev 19 (1), 1 (2024)
   PUBMED   38167468
  REMARK    GeneRIF: Loss of G9a does not phenocopy the requirement for Prdm12
            in the development of the nociceptive neuron lineage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4349)
  AUTHORS   Tachibana,M., Sugimoto,K., Nozaki,M., Ueda,J., Ohta,T., Ohki,M.,
            Fukuda,M., Takeda,N., Niida,H., Kato,H. and Shinkai,Y.
  TITLE     G9a histone methyltransferase plays a dominant role in euchromatic
            histone H3 lysine 9 methylation and is essential for early
            embryogenesis
  JOURNAL   Genes Dev 16 (14), 1779-1791 (2002)
   PUBMED   12130538
  REMARK    GeneRIF: results indicate that euchromatic Histone H3 lysine 9
            (H3-K9) methylation regulated by G9a is essential for early
            embryogenesis and is involved in the transcriptional repression of
            developmental genes.
REFERENCE   7  (bases 1 to 4349)
  AUTHORS   Brown,S.E., Campbell,R.D. and Sanderson,C.M.
  TITLE     Novel NG36/G9a gene products encoded within the human and mouse MHC
            class III regions
  JOURNAL   Mamm Genome 12 (12), 916-924 (2001)
   PUBMED   11707778
REFERENCE   8  (bases 1 to 4349)
  AUTHORS   Tachibana,M., Sugimoto,K., Fukushima,T. and Shinkai,Y.
  TITLE     Set domain-containing protein, G9a, is a novel lysine-preferring
            mammalian histone methyltransferase with hyperactivity and specific
            selectivity to lysines 9 and 27 of histone H3
  JOURNAL   J Biol Chem 276 (27), 25309-25317 (2001)
   PUBMED   11316813
REFERENCE   9  (bases 1 to 4349)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   10 (bases 1 to 4349)
  AUTHORS   Gasser,D.L., Sternberg,N.L., Pierce,J.C., Goldner-Sauve,A.,
            Feng,H., Haq,A.K., Spies,T., Hunt,C., Buetow,K.H. and Chaplin,D.D.
  TITLE     P1 and cosmid clones define the organization of 280 kb of the mouse
            H-2 complex containing the Cps-1 and Hsp70 loci
  JOURNAL   Immunogenetics 39 (1), 48-55 (1994)
   PUBMED   7993390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025759.14.
            
            On Apr 5, 2022 this sequence version replaced XM_011246249.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1250380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               CT025759.14        126626-127281
            657-863             CT025759.14        127388-127594
            864-1120            CT025759.14        127688-127944
            1121-1202           CT025759.14        131042-131123
            1203-1240           CT025759.14        131210-131247
            1241-1396           CT025759.14        131351-131506
            1397-1534           CT025759.14        133157-133294
            1535-1649           CT025759.14        133370-133484
            1650-1798           CT025759.14        133938-134086
            1799-1942           CT025759.14        134179-134322
            1943-2178           CT025759.14        134405-134640
            2179-2361           CT025759.14        134723-134905
            2362-2474           CT025759.14        134981-135093
            2475-2581           CT025759.14        135359-135465
            2582-2704           CT025759.14        135550-135672
            2705-2806           CT025759.14        135771-135872
            2807-2911           CT025759.14        136202-136306
            2912-3066           CT025759.14        136432-136586
            3067-3234           CT025759.14        136666-136833
            3235-3379           CT025759.14        138719-138863
            3380-3457           CT025759.14        139006-139083
            3458-3573           CT025759.14        139391-139506
            3574-3660           CT025759.14        139607-139693
            3661-3739           CT025759.14        140417-140495
            3740-3915           CT025759.14        140662-140837
            3916-4349           CT025759.14        141668-142101
FEATURES             Location/Qualifiers
     source          1..4349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.45 cM"
     gene            1..4349
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="euchromatic histone lysine N-methyltransferase 2"
                     /db_xref="GeneID:110147"
                     /db_xref="MGI:MGI:2148922"
     exon            1..656
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..4096
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /EC_number="2.1.1.367"
                     /note="isoform f is encoded by transcript variant 6; HLA-B
                     associated transcript 8; histone-lysine
                     N-methyltransferase, H3 lysine-9 specific 3;
                     histone-lysine N-methyltransferase EHMT2; protein G9a;
                     H3-K9-HMTase 3; histone H3-K9 methyltransferase 3"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EHMT2 isoform
                     f"
                     /protein_id="NP_001390798.1"
                     /db_xref="GeneID:110147"
                     /db_xref="MGI:MGI:2148922"
                     /translation="MLRGCNGAGGPEPNLQQTRGPTPGADEGTRGWEVGGVGAESHVP
                     PPAAPAWAVGTATPGARARGARGRPPGWGAAGVAGVGGRGPRGLGDKGGAARAAGRRG
                     RGRGAEAPPPPPPLLPAPEMRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRP
                     RSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSS
                     LGDTPQSEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEG
                     DGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGA
                     ATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMHLG
                     KVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAY
                     SVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRS
                     GSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVSNDTSSLETERGFEELPLC
                     SCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAH
                     RARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASE
                     AQEVTIPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLA
                     DTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESESPPSPPPSPDRRKKLR
                     FHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQ
                     AGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNL
                     EMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICL
                     HWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELR
                     NKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCV
                     NGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWY
                     DKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRA
                     LQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFIN
                     HLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQC
                     GSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPINT"
     exon            657..863
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1120
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1202
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1240
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1396
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1534
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1649
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1798
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1942
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2178
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2361
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2474
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2581
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2704
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2806
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2911
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3066
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3234
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3379
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3457
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3573
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3660
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3739
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3915
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..4349
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4303..4308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="hexamer: AATAAA"
     regulatory      4322..4327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="hexamer: AATAAA"
     polyA_site      4327
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="major polyA site"
     polyA_site      4349
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
ORIGIN      
        1 gcgcgctcgt gcaatgctcc gggggtgcaa cggggccggg gggcccgagc cgaacttaca
       61 gcaaaccagg gggccaacac cgggggcgga tgaggggacc agggggtggg aggtgggggg
      121 agtgggcgcc gagtcgcacg tgccgccgcc cgctgcccct gcgtgggcgg tgggcaccgc
      181 gaccccggga gcccgcgcga ggggcgcgag gggccgtccg ccgggctggg gcgcagcggg
      241 cgttgcaggg gttggtggcc ggggtccccg cggcctgggg gacaaagggg gagcggcgcg
      301 tgcagccggg aggagggggc ggggccgggg cgcggaggcc ccgccccctc cccctcctct
      361 gctcccggcc ccagagatgc ggggtctgcc gagagggagg gggctgatgc gggcccgggg
      421 gcgggggcgt gcggccccca cgggcggccg cggccgcggt cgggggggcg cccaccgagg
      481 gcgaggtagg ccccgaagcc tgctctcgct gcccagggcc caggcgtctt gggcccccca
      541 gctgcctgcc gggctgaccg gccccccggt tccttgtctc ccctcccagg gggaggcccc
      601 cgctgagatg ggggcgctgc tgctggagaa ggagccccga ggagccgccg agagagttca
      661 tagctctttg ggggacaccc ctcagagtga ggagaccctt cccaaggcca accccgactc
      721 cttggagcct gccggcccct cctctccggc ctctgtcact gtcaccgtcg gcgatgaggg
      781 ggctgacacc cctgtcgggg ccgcatcact catcggggac gaacccgaga gcctggaggg
      841 agatgggggt cgcatcgtgc tgggccatgc cacaaagtcg ttcccctctt cccccagcaa
      901 ggggggtgcc tgtcccagtc gggccaaaat gtcaatgaca ggggcaggaa agtcgccccc
      961 ctcggtccag agtttggcca tgaggctgtt gagcatgccc ggggcccagg gagctgcaac
     1021 tgctgggcct gaaccctctc cggcaacaac tgccgcccag gaggggcagc ccaaagtgca
     1081 ccgagcccgg aaaaccatgt ccaaacctag caacggacag cctccaatcc ctgagaagcg
     1141 gccccctgaa gtccagcatt tccgcatgag tgatgacatg catctgggga aggtgacttc
     1201 agatgtggcc aaaaggagga agctgaactc tggtagcctg tccgaggact tgggctctgc
     1261 cgggggctca ggagatataa tcctggagaa gggagagccc aggcccctgg aggagtggga
     1321 gacggtggtg ggcgatgact tcagcctgta ctatgatgcg tactctgtgg atgagcgggt
     1381 ggactctgac agcaagtctg aagtcgaagc tctagctgaa cagttgagtg aggaggagga
     1441 ggaggaagag gaggaagaag aagaagagga ggaggaggag gaagaggagg aggaggaaga
     1501 agaggacgag gagtcgggca atcagtcaga caggagcggt tctagtggcc ggcgcaaggc
     1561 caagaagaaa tggcggaaag acagcccgtg ggtgaagcca tctagaaaac ggcggaaacg
     1621 agagcctccg agggccaagg agccaagagg ggtctccaat gacacgtctt cactggagac
     1681 agaacgcggg tttgaggagc tgcccctctg cagctgccgc atggaggctc ccaagattga
     1741 ccgcatcagc gagagagcag ggcacaagtg catggccaca gagagtgtgg atggagagct
     1801 cctgggctgc aatgctgcca tccttaagcg ggagaccatg cggccgtcta gccgcgtggc
     1861 gctgatggtg ctctgtgagg cccatcgagc ccgcatggtc aagcaccatt gctgcccggg
     1921 ctgcggctac ttctgcacag cgggcacctt cctggaatgc caccccgact ttcgtgtagc
     1981 tcaccgcttc cataaggcct gcgtatccca gctcaatggg atggtcttct gtccccactg
     2041 tggagaggat gcctcagagg cccaggaggt gaccattcct cggggcgatg ggggaacacc
     2101 cccaattggc accgcagctc ctgctctgcc acccctggca catgatgccc cagggcgagc
     2161 ggatacctcc cagcctagcg cccgaatgcg agggcatgga gagccgcggc gcccgccctg
     2221 tgatcccctg gctgacacca tcgacagctc agggccttca ctgactctgc ctaatggggg
     2281 ctgcctctcc gctgtgggtc tgcccccagg gccgggcagg gaagccctgg aaaaagcctt
     2341 ggtcatccag gagtctgaga gcccaccttc tccccctcca tcccctgaca ggcggaagaa
     2401 gctgcgattc cacccacggc agctgtacct gtcggtgaag cagggggagc tgcagaaggt
     2461 gatccttatg ctgttagaca acctggaccc caacttccag agcgaccagc agagcaagcg
     2521 cacgcccctg cacgcggccg cccagaaggg gtcggtagag atctgtcatg tgctgctgca
     2581 ggcaggagcc aacatcaatg ccgtagataa gcaacaacgc acgccactaa tggaggccgt
     2641 ggtgaacaac cacctggagg tggcacgcta catggtgcag ttaggtggct gtgtctacag
     2701 caaggaagag gatggctcca cctgtctaca tcatgcagcc aaaattggga acttggaaat
     2761 ggtcagcctg ctactgagca caggacaggt ggacgtcaat gcccaggaca gtgggggctg
     2821 gacgcccatc atctgggcag ccgagcacaa gcacatcgat gtgattcgta tgctgctgac
     2881 ccggggtgcc gatgtcaccc tgactgacaa tgaggaaaac atctgcctgc actgggcctc
     2941 cttcacgggt agtgccgcca tcgctgaggt ccttctgaat gcccagtgtg atctccatgc
     3001 tgtcaactac catggggaca cgcccctgca catagccgcc agggagagct accatgactg
     3061 tgttctgttg ttcctgtctc gtggagccaa ccctgagctt cggaacaaag aaggagacac
     3121 ggcatgggat ctgaccccag agcgctctga tgtgtggttt gcactgcagc tcaatcgaaa
     3181 gcttaggctt ggggtaggga accgggctgt ccgcaccgag aagatcatct gccgggacgt
     3241 agcccgaggc tatgagaatg tacccatccc ctgtgtcaat ggtgtggatg gggagccgtg
     3301 cccggaggac tacaagtaca tctctgagaa ctgcgagaca tcgaccatga acatcgaccg
     3361 caacatcacc catctgcagc actgcacgtg tgtggatgac tgctccagct ccaattgcct
     3421 atgtggtcag ctcagtatcc gatgctggta tgacaaggac gggcggctgc tccaggagtt
     3481 taacaagatc gagccccccc tgatctttga gtgtaaccag gcatgctcct gctggagaag
     3541 ctgcaagaac cgcgtggtgc agagcggcat caaggtacgg ctgcagctct accggactgc
     3601 caagatgggc tggggggtcc gagccttgca gaccatcccc cagggcacgt tcatctgcga
     3661 gtatgtagga gagctgatct ctgatgccga ggctgatgtg agagaggatg attcttacct
     3721 cttcgattta gataacaagg atggcgaggt ttactgcatt gatgcccgtt actatggcaa
     3781 catcagccga ttcattaacc acctgtgtga ccccaacatc atccctgtcc gggttttcat
     3841 gctgcaccaa gatctacggt tcccacgcat tgccttcttc agctccaggg acatccggac
     3901 tggggaggag ctgggctttg actacggtga ccgattctgg gacatcaaga gcaagtattt
     3961 cacctgccag tgtggctctg agaagtgcaa gcattcagcg gaggccatcg ccctggagca
     4021 gagccgcctg gcccggctgg acccccaccc ggagctgctc cctgacctca gctccctgcc
     4081 ccccatcaac acctgaggac tcttaaaatc caggccgggc actgcccttc agacatttct
     4141 ccatcagaga ccccagtaag gcctggaagg tcgatggccc ctctcccaga gctggtttct
     4201 cactgggagt gcaagtgact tcagggctgg ccttccccac tgagcctggc ctcagttagc
     4261 tgattgaagt tgggcctctg ccagctgatt ttctgtgttc tcaataaatg ttgggtttgg
     4321 taataaactg tctggtgatt gtttcagga
//
