LOCUS       NM_001403867            4451 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus euchromatic histone lysine N-methyltransferase 2
            (Ehmt2), transcript variant 5, mRNA.
ACCESSION   NM_001403867 XM_011246248
VERSION     NM_001403867.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Wada,S., Ideno,H., Nakashima,K., Komatsu,K., Demura,N.,
            Tomonari,H., Kimura,H., Tachibana,M. and Nifuji,A.
  TITLE     The histone H3K9 methyltransferase G9a regulates tendon formation
            during development
  JOURNAL   Sci Rep 14 (1), 20771 (2024)
   PUBMED   39237663
  REMARK    GeneRIF: The histone H3K9 methyltransferase G9a regulates tendon
            formation during development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Komatsu,K., Ideno,H., Nakashima,K., Udagawa,N., Kobayashi,Y.,
            Kimura,H., Tachibana,M., Yamashita,T. and Nifuji,A.
  TITLE     The G9a histone methyltransferase represses osteoclastogenesis and
            bone resorption by regulating NFATc1 function
  JOURNAL   FASEB J 38 (13), e23779 (2024)
   PUBMED   38967255
  REMARK    GeneRIF: The G9a histone methyltransferase represses
            osteoclastogenesis and bone resorption by regulating NFATc1
            function.
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Pollin,G., Mathison,A.J., de Assuncao,T.M., Thomas,A., Zeighami,A.,
            Salmonson,A., Liu,H., Urrutia,G., Vankayala,P., Pandol,S.J.,
            Hong,J.C., Zimmermann,M.T., Iovanna,J., Jin,V.X., Urrutia,R. and
            Lomberk,G.
  TITLE     Ehmt2 inactivation in pancreatic epithelial cells shapes the
            transcriptional landscape and inflammation response of the whole
            pancreas
  JOURNAL   Front Genet 15, 1412767 (2024)
   PUBMED   38948355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Tsimpos,P., Desiderio,S., Cabochette,P., Poelvoorde,P., Kricha,S.,
            Vanhamme,L., Poulard,C. and Bellefroid,E.J.
  TITLE     Loss of G9a does not phenocopy the requirement for Prdm12 in the
            development of the nociceptive neuron lineage
  JOURNAL   Neural Dev 19 (1), 1 (2024)
   PUBMED   38167468
  REMARK    GeneRIF: Loss of G9a does not phenocopy the requirement for Prdm12
            in the development of the nociceptive neuron lineage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Tachibana,M., Sugimoto,K., Nozaki,M., Ueda,J., Ohta,T., Ohki,M.,
            Fukuda,M., Takeda,N., Niida,H., Kato,H. and Shinkai,Y.
  TITLE     G9a histone methyltransferase plays a dominant role in euchromatic
            histone H3 lysine 9 methylation and is essential for early
            embryogenesis
  JOURNAL   Genes Dev 16 (14), 1779-1791 (2002)
   PUBMED   12130538
  REMARK    GeneRIF: results indicate that euchromatic Histone H3 lysine 9
            (H3-K9) methylation regulated by G9a is essential for early
            embryogenesis and is involved in the transcriptional repression of
            developmental genes.
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Brown,S.E., Campbell,R.D. and Sanderson,C.M.
  TITLE     Novel NG36/G9a gene products encoded within the human and mouse MHC
            class III regions
  JOURNAL   Mamm Genome 12 (12), 916-924 (2001)
   PUBMED   11707778
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Tachibana,M., Sugimoto,K., Fukushima,T. and Shinkai,Y.
  TITLE     Set domain-containing protein, G9a, is a novel lysine-preferring
            mammalian histone methyltransferase with hyperactivity and specific
            selectivity to lysines 9 and 27 of histone H3
  JOURNAL   J Biol Chem 276 (27), 25309-25317 (2001)
   PUBMED   11316813
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Gasser,D.L., Sternberg,N.L., Pierce,J.C., Goldner-Sauve,A.,
            Feng,H., Haq,A.K., Spies,T., Hunt,C., Buetow,K.H. and Chaplin,D.D.
  TITLE     P1 and cosmid clones define the organization of 280 kb of the mouse
            H-2 complex containing the Cps-1 and Hsp70 loci
  JOURNAL   Immunogenetics 39 (1), 48-55 (1994)
   PUBMED   7993390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025759.14.
            
            On Apr 5, 2022 this sequence version replaced XM_011246248.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2041932.1,
                                           SRR13948564.980958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               CT025759.14        126626-127281
            657-863             CT025759.14        127388-127594
            864-1120            CT025759.14        127688-127944
            1121-1202           CT025759.14        131042-131123
            1203-1240           CT025759.14        131210-131247
            1241-1396           CT025759.14        131351-131506
            1397-1534           CT025759.14        133157-133294
            1535-1649           CT025759.14        133370-133484
            1650-1751           CT025759.14        133638-133739
            1752-1900           CT025759.14        133938-134086
            1901-2044           CT025759.14        134179-134322
            2045-2280           CT025759.14        134405-134640
            2281-2463           CT025759.14        134723-134905
            2464-2576           CT025759.14        134981-135093
            2577-2683           CT025759.14        135359-135465
            2684-2806           CT025759.14        135550-135672
            2807-2908           CT025759.14        135771-135872
            2909-3013           CT025759.14        136202-136306
            3014-3168           CT025759.14        136432-136586
            3169-3336           CT025759.14        136666-136833
            3337-3481           CT025759.14        138719-138863
            3482-3559           CT025759.14        139006-139083
            3560-3675           CT025759.14        139391-139506
            3676-3762           CT025759.14        139607-139693
            3763-3841           CT025759.14        140417-140495
            3842-4017           CT025759.14        140662-140837
            4018-4451           CT025759.14        141668-142101
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.45 cM"
     gene            1..4451
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="euchromatic histone lysine N-methyltransferase 2"
                     /db_xref="GeneID:110147"
                     /db_xref="MGI:MGI:2148922"
     exon            1..656
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..4198
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /EC_number="2.1.1.367"
                     /note="isoform e is encoded by transcript variant 5; HLA-B
                     associated transcript 8; histone-lysine
                     N-methyltransferase, H3 lysine-9 specific 3;
                     histone-lysine N-methyltransferase EHMT2; protein G9a;
                     H3-K9-HMTase 3; histone H3-K9 methyltransferase 3"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EHMT2 isoform
                     e"
                     /protein_id="NP_001390796.1"
                     /db_xref="GeneID:110147"
                     /db_xref="MGI:MGI:2148922"
                     /translation="MLRGCNGAGGPEPNLQQTRGPTPGADEGTRGWEVGGVGAESHVP
                     PPAAPAWAVGTATPGARARGARGRPPGWGAAGVAGVGGRGPRGLGDKGGAARAAGRRG
                     RGRGAEAPPPPPPLLPAPEMRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRP
                     RSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSS
                     LGDTPQSEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEG
                     DGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGA
                     ATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMHLG
                     KVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAY
                     SVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRS
                     GSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSL
                     ELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATE
                     SVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLE
                     CHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPIGTAAPALP
                     PLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLP
                     PGPGREALEKALVIQESESPPSPPPSPDRRKKLRFHPRQLYLSVKQGELQKVILMLLD
                     NLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNH
                     LEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP
                     IIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHA
                     VNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLN
                     RKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTM
                     NIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
                     CSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD
                     VREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRI
                     AFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDP
                     HPELLPDLSSLPPINT"
     exon            657..863
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1120
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1202
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1240
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1396
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1534
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1649
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1751
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1900
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2044
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2280
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2463
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2576
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2683
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2806
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2908
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3013
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3168
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3336
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3481
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3559
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3675
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3762
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3841
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..4017
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4451
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4405..4410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="hexamer: AATAAA"
     regulatory      4424..4429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="hexamer: AATAAA"
     polyA_site      4429
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
                     /note="major polyA site"
     polyA_site      4451
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; D17Ertd710e; G9a; KMT1C; NG36"
ORIGIN      
        1 gcgcgctcgt gcaatgctcc gggggtgcaa cggggccggg gggcccgagc cgaacttaca
       61 gcaaaccagg gggccaacac cgggggcgga tgaggggacc agggggtggg aggtgggggg
      121 agtgggcgcc gagtcgcacg tgccgccgcc cgctgcccct gcgtgggcgg tgggcaccgc
      181 gaccccggga gcccgcgcga ggggcgcgag gggccgtccg ccgggctggg gcgcagcggg
      241 cgttgcaggg gttggtggcc ggggtccccg cggcctgggg gacaaagggg gagcggcgcg
      301 tgcagccggg aggagggggc ggggccgggg cgcggaggcc ccgccccctc cccctcctct
      361 gctcccggcc ccagagatgc ggggtctgcc gagagggagg gggctgatgc gggcccgggg
      421 gcgggggcgt gcggccccca cgggcggccg cggccgcggt cgggggggcg cccaccgagg
      481 gcgaggtagg ccccgaagcc tgctctcgct gcccagggcc caggcgtctt gggcccccca
      541 gctgcctgcc gggctgaccg gccccccggt tccttgtctc ccctcccagg gggaggcccc
      601 cgctgagatg ggggcgctgc tgctggagaa ggagccccga ggagccgccg agagagttca
      661 tagctctttg ggggacaccc ctcagagtga ggagaccctt cccaaggcca accccgactc
      721 cttggagcct gccggcccct cctctccggc ctctgtcact gtcaccgtcg gcgatgaggg
      781 ggctgacacc cctgtcgggg ccgcatcact catcggggac gaacccgaga gcctggaggg
      841 agatgggggt cgcatcgtgc tgggccatgc cacaaagtcg ttcccctctt cccccagcaa
      901 ggggggtgcc tgtcccagtc gggccaaaat gtcaatgaca ggggcaggaa agtcgccccc
      961 ctcggtccag agtttggcca tgaggctgtt gagcatgccc ggggcccagg gagctgcaac
     1021 tgctgggcct gaaccctctc cggcaacaac tgccgcccag gaggggcagc ccaaagtgca
     1081 ccgagcccgg aaaaccatgt ccaaacctag caacggacag cctccaatcc ctgagaagcg
     1141 gccccctgaa gtccagcatt tccgcatgag tgatgacatg catctgggga aggtgacttc
     1201 agatgtggcc aaaaggagga agctgaactc tggtagcctg tccgaggact tgggctctgc
     1261 cgggggctca ggagatataa tcctggagaa gggagagccc aggcccctgg aggagtggga
     1321 gacggtggtg ggcgatgact tcagcctgta ctatgatgcg tactctgtgg atgagcgggt
     1381 ggactctgac agcaagtctg aagtcgaagc tctagctgaa cagttgagtg aggaggagga
     1441 ggaggaagag gaggaagaag aagaagagga ggaggaggag gaagaggagg aggaggaaga
     1501 agaggacgag gagtcgggca atcagtcaga caggagcggt tctagtggcc ggcgcaaggc
     1561 caagaagaaa tggcggaaag acagcccgtg ggtgaagcca tctagaaaac ggcggaaacg
     1621 agagcctccg agggccaagg agccaagagg agtgaatggt gtgggttcct cagggcccag
     1681 tgagtacatg gaggttcctc tggggtccct ggagctgccc agcgagggga ccctctcccc
     1741 caaccacgct ggggtctcca atgacacgtc ttcactggag acagaacgcg ggtttgagga
     1801 gctgcccctc tgcagctgcc gcatggaggc tcccaagatt gaccgcatca gcgagagagc
     1861 agggcacaag tgcatggcca cagagagtgt ggatggagag ctcctgggct gcaatgctgc
     1921 catccttaag cgggagacca tgcggccgtc tagccgcgtg gcgctgatgg tgctctgtga
     1981 ggcccatcga gcccgcatgg tcaagcacca ttgctgcccg ggctgcggct acttctgcac
     2041 agcgggcacc ttcctggaat gccaccccga ctttcgtgta gctcaccgct tccataaggc
     2101 ctgcgtatcc cagctcaatg ggatggtctt ctgtccccac tgtggagagg atgcctcaga
     2161 ggcccaggag gtgaccattc ctcggggcga tgggggaaca cccccaattg gcaccgcagc
     2221 tcctgctctg ccacccctgg cacatgatgc cccagggcga gcggatacct cccagcctag
     2281 cgcccgaatg cgagggcatg gagagccgcg gcgcccgccc tgtgatcccc tggctgacac
     2341 catcgacagc tcagggcctt cactgactct gcctaatggg ggctgcctct ccgctgtggg
     2401 tctgccccca gggccgggca gggaagccct ggaaaaagcc ttggtcatcc aggagtctga
     2461 gagcccacct tctccccctc catcccctga caggcggaag aagctgcgat tccacccacg
     2521 gcagctgtac ctgtcggtga agcaggggga gctgcagaag gtgatcctta tgctgttaga
     2581 caacctggac cccaacttcc agagcgacca gcagagcaag cgcacgcccc tgcacgcggc
     2641 cgcccagaag gggtcggtag agatctgtca tgtgctgctg caggcaggag ccaacatcaa
     2701 tgccgtagat aagcaacaac gcacgccact aatggaggcc gtggtgaaca accacctgga
     2761 ggtggcacgc tacatggtgc agttaggtgg ctgtgtctac agcaaggaag aggatggctc
     2821 cacctgtcta catcatgcag ccaaaattgg gaacttggaa atggtcagcc tgctactgag
     2881 cacaggacag gtggacgtca atgcccagga cagtgggggc tggacgccca tcatctgggc
     2941 agccgagcac aagcacatcg atgtgattcg tatgctgctg acccggggtg ccgatgtcac
     3001 cctgactgac aatgaggaaa acatctgcct gcactgggcc tccttcacgg gtagtgccgc
     3061 catcgctgag gtccttctga atgcccagtg tgatctccat gctgtcaact accatgggga
     3121 cacgcccctg cacatagccg ccagggagag ctaccatgac tgtgttctgt tgttcctgtc
     3181 tcgtggagcc aaccctgagc ttcggaacaa agaaggagac acggcatggg atctgacccc
     3241 agagcgctct gatgtgtggt ttgcactgca gctcaatcga aagcttaggc ttggggtagg
     3301 gaaccgggct gtccgcaccg agaagatcat ctgccgggac gtagcccgag gctatgagaa
     3361 tgtacccatc ccctgtgtca atggtgtgga tggggagccg tgcccggagg actacaagta
     3421 catctctgag aactgcgaga catcgaccat gaacatcgac cgcaacatca cccatctgca
     3481 gcactgcacg tgtgtggatg actgctccag ctccaattgc ctatgtggtc agctcagtat
     3541 ccgatgctgg tatgacaagg acgggcggct gctccaggag tttaacaaga tcgagccccc
     3601 cctgatcttt gagtgtaacc aggcatgctc ctgctggaga agctgcaaga accgcgtggt
     3661 gcagagcggc atcaaggtac ggctgcagct ctaccggact gccaagatgg gctggggggt
     3721 ccgagccttg cagaccatcc cccagggcac gttcatctgc gagtatgtag gagagctgat
     3781 ctctgatgcc gaggctgatg tgagagagga tgattcttac ctcttcgatt tagataacaa
     3841 ggatggcgag gtttactgca ttgatgcccg ttactatggc aacatcagcc gattcattaa
     3901 ccacctgtgt gaccccaaca tcatccctgt ccgggttttc atgctgcacc aagatctacg
     3961 gttcccacgc attgccttct tcagctccag ggacatccgg actggggagg agctgggctt
     4021 tgactacggt gaccgattct gggacatcaa gagcaagtat ttcacctgcc agtgtggctc
     4081 tgagaagtgc aagcattcag cggaggccat cgccctggag cagagccgcc tggcccggct
     4141 ggacccccac ccggagctgc tccctgacct cagctccctg ccccccatca acacctgagg
     4201 actcttaaaa tccaggccgg gcactgccct tcagacattt ctccatcaga gaccccagta
     4261 aggcctggaa ggtcgatggc ccctctccca gagctggttt ctcactggga gtgcaagtga
     4321 cttcagggct ggccttcccc actgagcctg gcctcagtta gctgattgaa gttgggcctc
     4381 tgccagctga ttttctgtgt tctcaataaa tgttgggttt ggtaataaac tgtctggtga
     4441 ttgtttcagg a
//
