LOCUS       NM_172545               5086 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus euchromatic histone methyltransferase 1 (Ehmt1),
            transcript variant 2, mRNA.
ACCESSION   NM_172545
VERSION     NM_172545.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5086)
  AUTHORS   You,L., Deng,Y., Li,D., Lin,Y. and Wang,Y.
  TITLE     GLP-1 rescued gestational diabetes mellitus-induced suppression of
            fetal thalamus development
  JOURNAL   J Biochem Mol Toxicol 37 (2), e23258 (2023)
   PUBMED   36424357
  REMARK    GeneRIF: GLP-1 rescued gestational diabetes mellitus-induced
            suppression of fetal thalamus development.
REFERENCE   3  (bases 1 to 5086)
  AUTHORS   Demond,H., Hanna,C.W., Castillo-Fernandez,J., Santos,F.,
            Papachristou,E.K., Segonds-Pichon,A., Kishore,K., Andrews,S.,
            D'Santos,C.S. and Kelsey,G.
  TITLE     Multi-omics analyses demonstrate a critical role for EHMT1
            methyltransferase in transcriptional repression during oogenesis
  JOURNAL   Genome Res 33 (1), 18-31 (2023)
   PUBMED   36690445
  REMARK    GeneRIF: Multi-omics analyses demonstrate a critical role for EHMT1
            methyltransferase in transcriptional repression during oogenesis.
REFERENCE   4  (bases 1 to 5086)
  AUTHORS   Meziane,H., Birling,M.C., Wendling,O., Leblanc,S., Dubos,A.,
            Selloum,M., Pavlovic,G., Sorg,T., Kalscheuer,V.M., Billuart,P.,
            Laumonnier,F., Chelly,J., van Bokhoven,H. and Herault,Y.
  TITLE     Large-Scale Functional Assessment of Genes Involved in Rare
            Diseases with Intellectual Disabilities Unravels Unique
            Developmental and Behaviour Profiles in Mouse Models
  JOURNAL   Biomedicines 10 (12), 3148 (2022)
   PUBMED   36551904
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5086)
  AUTHORS   Alsaqati,M., Davis,B.A., Wood,J., Jones,M.M., Jones,L.,
            Westwood,A., Petter,O., Isles,A.R., Linden,D., Van den Bree,M.,
            Owen,M., Hall,J. and Harwood,A.J.
  TITLE     NRSF/REST lies at the intersection between epigenetic regulation,
            miRNA-mediated gene control and neurodevelopmental pathways
            associated with Intellectual disability (ID) and Schizophrenia
  JOURNAL   Transl Psychiatry 12 (1), 438 (2022)
   PUBMED   36216811
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5086)
  AUTHORS   Tachibana,M., Nozaki,M., Takeda,N. and Shinkai,Y.
  TITLE     Functional dynamics of H3K9 methylation during meiotic prophase
            progression
  JOURNAL   EMBO J 26 (14), 3346-3359 (2007)
   PUBMED   17599069
REFERENCE   7  (bases 1 to 5086)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   8  (bases 1 to 5086)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 5086)
  AUTHORS   Ueda,J., Tachibana,M., Ikura,T. and Shinkai,Y.
  TITLE     Zinc finger protein Wiz links G9a/GLP histone methyltransferases to
            the co-repressor molecule CtBP
  JOURNAL   J Biol Chem 281 (29), 20120-20128 (2006)
   PUBMED   16702210
  REMARK    GeneRIF: Wiz plays a major role in G9a/GLP heterodimer formation in
            cultured stem cells.
REFERENCE   10 (bases 1 to 5086)
  AUTHORS   Tachibana,M., Ueda,J., Fukuda,M., Takeda,N., Ohta,T., Iwanari,H.,
            Sakihama,T., Kodama,T., Hamakubo,T. and Shinkai,Y.
  TITLE     Histone methyltransferases G9a and GLP form heteromeric complexes
            and are both crucial for methylation of euchromatin at H3-K9
  JOURNAL   Genes Dev 19 (7), 815-826 (2005)
   PUBMED   15774718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732525.13, BB621957.1, AK086833.1, AK049454.1 and DV649682.1.
            
            On Mar 9, 2013 this sequence version replaced NM_172545.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052174.1, SRR9219380.50548.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL732525.13        182620-182621       c
            3-114               BB621957.1         1-112
            115-729             AK086833.1         1-615
            730-4567            AK049454.1         1-3838
            4568-5072           DV649682.1         3-507
            5073-5086           AL732525.13        53781-53794         c
FEATURES             Location/Qualifiers
     source          1..5086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.73 cM"
     gene            1..5086
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /note="euchromatic histone methyltransferase 1"
                     /db_xref="GeneID:77683"
                     /db_xref="MGI:MGI:1924933"
     exon            1..56
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..3905
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /EC_number="2.1.1.367"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histone-lysine N-methyltransferase EHMT1; G9a-like protein
                     1; lysine N-methyltransferase 1D; euchromatic
                     histone-lysine N-methyltransferase 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EHMT1 isoform
                     2"
                     /protein_id="NP_766133.2"
                     /db_xref="CCDS:CCDS59635.1"
                     /db_xref="GeneID:77683"
                     /db_xref="MGI:MGI:1924933"
                     /translation="MAAADAEQAVLAKQETKQDCCMKTELLREDTPMAADEGSTEKQE
                     GETPMAADGETNGSCEKSGDPSHLNAPKHTQENTRASPQEGTNRVSRVAENGVSERDT
                     EVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNILTSSLPGHAAKTLPGGA
                     SKCRTLSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAA
                     SKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTAAAV
                     SRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKALDDSALHVNGES
                     LEMDSEDEDSDELEDDEDHGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQES
                     PDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSE
                     ACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLASGPDVLGTDGLQ
                     EVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLV
                     LCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCG
                     EEASKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDERSQSTAPQ
                     APECFDPAGPAGLVRPTSGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQG
                     ELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR
                     TPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMD
                     VNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE
                     ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL
                     SSQVWSALQMSKALRDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYK
                     YVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMA
                     EPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEY
                     VGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVF
                     MSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSSKCRHSSAALA
                     QRQASAAQEPQENGLPDTSSAAAADPL"
     exon            57..123
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            124..680
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            681..852
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            853..989
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1178
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1256
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1377
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1515
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1661
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1805
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2032
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2200
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2283
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2390
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2513
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2615
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2720
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2875
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3043
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3188
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3266
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3382
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3469
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3548
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3724
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..5086
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5061..5066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /note="hexamer: AATAAA"
     polyA_site      5082
                     /gene="Ehmt1"
                     /gene_synonym="9230102N17Rik; D330003E03; Eu-HMTase1; GLP;
                     GLP1; KMT1D; mKIAA1876"
                     /note="major polyA site"
ORIGIN      
        1 gcgggagggg cggggccacg ctgcgggccc gggccatggc cgccgctgat gctgagcagg
       61 cagttctggc caagcaagag accaagcagg attgctgcat gaaaactgag ctgctaaggg
      121 aagatacacc tatggctgct gatgaaggtt ccacagagaa acaagaagga gagactccca
      181 tggctgcaga tggagaaaca aatgggtctt gtgaaaagag tggggatccc agccatctaa
      241 atgcacccaa acacactcag gagaacacaa gagctagccc acaggaaggc accaacagag
      301 tgtctcgggt ggcagaaaat ggggtttcag aaagagacac agaagtgggg aagcaaaacc
      361 atgtcacagc tgacgacttc atgcagacat ctgtcattgg cagcaatgga tatttcttaa
      421 ataaaccagc cctgcagggg cagccgttga ggactcccaa cattctaacc tcctcgcttc
      481 ctggtcatgc tgcaaaaact cttcctggag gagccagtaa atgcaggact ctgagtgcac
      541 ttcctcagac accaaccaca gcacccactg tgcctgggga agggagtgca gacacagagg
      601 acagaaagcc tacagcctcg ggcactgatg tcagggttca cagggcacgc aagaccatgc
      661 cgaagtccat cttgggcctg catgcagcca gcaaagacca tagagaagtt caagaccata
      721 aggaaccaaa agaggatatc aacagaaaca tttctgaatg tggacgacag cagcttttac
      781 caaccttccc agccctccac cagtcgctac ctcagaatca gtgctacatg gccaccacaa
      841 agtcccagac agcagctgca gtatctcgga agaaaaaacg aagaatggga acctatagtt
      901 tagttcccaa gaaaaagacc aaagtattaa aacagaggac ggtgattgag atgtttaaaa
      961 gcataaccca ttccactgtg ggcgccaagg gcgagaaagc cttagatgat agtgccctgc
     1021 atgtaaatgg cgagagcttg gagatggact cagaagatga agactccgat gagctggagg
     1081 atgacgagga ccatggagct gagcaagcgg ctgcatttcc caccgaggat agtaggactt
     1141 ctaaagagag catgtctgag actgaccggg ctgcaaagat ggatggagat tcagaggagg
     1201 aacaggagtc tcccgacaca ggggaggatg aagatggtgg agacgagtct gacctgagtt
     1261 ctgaatccag tatcaagaag aaatttctca agaggagagg gaagactgac agcccctgga
     1321 tcaaacctgc tcggaaaagg aggcggagaa gtagaaagaa gccgagcagc atgcttggtt
     1381 ccgaggcttg taagtcatct ccaggaagca tggagcaggc agctctggga gacagcgctg
     1441 gctatatgga agtttccctg gattccctgg atctccgtgt cagaggaatt ctgtcttccc
     1501 agacagaaaa tgaagggctg gccagtggtc cggatgtgct ggggacggat ggcctccagg
     1561 aagtgcctct ctgcagctgc cgaatggaaa cccccaagag ccgcgagatc agcaccctgg
     1621 ccaacaacca gtgcatggcc actgagagcg tggatcacga attgggccgg tgtacaaaca
     1681 gcgtggtcaa gtatgagctg atgcgcccat ccaacaaagc accgctcttg gtgttatgtg
     1741 aagaccatcg gggtcgcatg gtgaagcacc agtgctgtcc tggctgcggc tacttctgca
     1801 cggcgggtaa cttcatggaa tgccagcctg agagcagcat ctctcatcgt ttccataagg
     1861 actgtgcctc tcgagtcaac aatgccagct actgtcccca ttgtggggaa gaagcttcca
     1921 aggccaaaga ggtgaccata gcaaaagcag acacaacttc cacagtgacc ctagcccctg
     1981 gacaggagaa gagcctggct gctgaaggca gggctgacac gaccacgggc agcattgctg
     2041 gagccccaga ggatgaaaga tcgcagagca cagcccccca ggcaccagag tgcttcgacc
     2101 ctgccggacc ggctgggctc gtgaggccga catctggcct ttcccagggc ccaggaaagg
     2161 aaaccttgga aagtgctcta atcgctctag actctgaaaa acccaagaaa cttcgcttcc
     2221 acccaaagca gctgtacttc tctgccaggc agggtgagct gcagaaggtg cttctcatgc
     2281 tggttgatgg aattgatccc aacttcaaaa tggagcacca aagtaagcgt tccccattac
     2341 atgctgctgc ggaggctggc cacgtggaca tctgccacat gctggttcag gcgggtgcca
     2401 atattgacac ttgctcagag gaccagcgga ccccactgat ggaggctgca gagaacaacc
     2461 acttggatgc agtgaagtac ctcatcaagg ctggagcaca ggtggatccg aaggacgcag
     2521 agggctccac atgtttgcat ttggctgcca agaaaggcca ctatgatgtg gttcagtatc
     2581 tgctttcaaa tggacagatg gatgtcaact gccaggatga cggtggatgg acacctatga
     2641 tctgggccac tgagtacaag cacgtggagc tggtgaagct gctgctgtct aagggctctg
     2701 acatcaacat ccgggacaac gaggagaaca tttgtctgca ctgggcagca ttttcaggct
     2761 gtgtggacat agctgaaata cttctggctg ccaagtgtga cctgcatgct gtgaatatcc
     2821 atggagactc acccctgcac atcgcagcca gggagaatcg ctacgactgt gttgtcctct
     2881 ttctttctcg ggattcagat gttactctga aaaacaagga aggagagact cccttgcagt
     2941 gtgcaagtct cagttcgcag gtgtggagtg cattgcagat gagcaaagca cttcgggact
     3001 cagcccctga caagcccgtt gctgttgaga agacggtgag cagggatatc gctcgagggt
     3061 atgagcgcat tcccattccc tgtgtcaatg ctgtggacag tgagctgtgt cctaccaact
     3121 ataagtatgt ctcccagaac tgtgtgacat cccccatgaa cattgacagg aacatcactc
     3181 atttgcagta ctgcgtgtgt gtagatgact gctcctctag cacctgcatg tgtggccagc
     3241 tgagcatgcg ctgctggtat gataaggatg gccgacttct gcctgagttt aacatggcag
     3301 aaccaccctt gatcttcgag tgcaatcatg cctgctcatg ctggaggaac tgccgcaatc
     3361 gtgtggtgca aaatggtctc agggcaaggc tgcagcttta tcggacacag gacatgggct
     3421 ggggtgtgcg gtccctccag gatatcccac tgggcacctt tgtctgcgaa tacgtagggg
     3481 agctgatttc ggactctgaa gctgatgttc gggaagagga ctcttacctc tttgatcttg
     3541 acaataagga tggagaggta tactgcattg acgctcggtt ctatgggaat gtcagccggt
     3601 tcataaacca ccactgcgaa cccaaccttg tgcctgtgcg agtgttcatg tcacaccagg
     3661 acctgcggtt tcccaggatt gccttcttca gtacccgcct gattcaggct ggggagcagc
     3721 tcgggttcga ctacggggag cgcttttggg acgtcaaggg caagctcttc agttgccggt
     3781 gtgggtcttc caagtgtcgg cactcaagcg cagccctggc ccagaggcaa gccagtgcag
     3841 cccaggagcc tcaggagaat ggccttccag ataccagctc tgcagccgct gctgaccccc
     3901 tatgaattgc cagtgtggcc agtgggaccc tcaaaatcag attctggtga ctgcaattta
     3961 gagaggaaga aactctacat atgtccaaga ggagctggag gtatggacac ctctcaggaa
     4021 tgttctgggc ccgaggtgtt catttagctg gcccagtgct caggccagag catgcctctg
     4081 ggcctgcacc tcagagacct gggactccat gttgcataac ttgtgagtta ctggtggtga
     4141 ctccgtgctg cagcactttc cacgtctccc tctggtctcc gaagcccttg ctccactgcc
     4201 agttttgttt gtataatgtc tggtcacgct cctgtatggc actcaccaag gccaccatca
     4261 cctacaagct gctccgttag acctgctgcc cacagcctgt gttgctggca ccagctccca
     4321 tgtgccactg gaggacacta gctcccttac agccttggag agtttggctg acccaccact
     4381 cattttgatg aaatgtgggt ttgcttttta aagaaaccct atatctagcc ctatatatca
     4441 agcctcttac tggtgtttct ttgctaggaa gcaggttggt gtgtgcaggc agaccctgta
     4501 ctggccccag ccagttccgt tgacgcaggc acctttggtt gatttctaag ccacacgcta
     4561 tgatgatgat gaataaactc gtttgttttt taccattact gaacattagg acatcaaaga
     4621 ataaaaacac aaaacacaga caacggtgct gaatctggtg tggtctctac tcaccacatg
     4681 aaaataaact atcaactgta aaaaaaaaaa aagaaaaaga acaaaatgat tttagaataa
     4741 agtgcaggaa aaactttttt aaaatgttag tcttgtagct gaataaattt gccatcacct
     4801 tttgtgtggt ggccgggcag gtcatgtact tttttttggc atataccttt ctaaatactg
     4861 taattagtgc agcgacagtg ggtggttttt ttgttttttg tttttctttt gtgtgtgtgt
     4921 gtgtgtgtgt gagtgtgtgt gactcttcta aaacattcat aatgcagtca tgtttatttt
     4981 tttctgttaa aatgtttttt gacagtttta tgagcagtct tttggctcag accatttctt
     5041 gttctgtttt caatgaaatc aataaaaaaa aagtacttta aatgga
//
