LOCUS       NM_023737               3010 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A
            dehydrogenase (Ehhadh), mRNA.
ACCESSION   NM_023737
VERSION     NM_023737.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Ranea-Robles,P., Portman,K., Bender,A., Lee,K., He,J.C.,
            Mulholland,D.J., Argmann,C. and Houten,S.M.
  TITLE     Peroxisomal L-bifunctional protein (EHHADH) deficiency causes
            male-specific kidney hypertrophy and proximal tubular injury in
            mice
  JOURNAL   Kidney360 2 (9), 1441-1454 (2021)
   PUBMED   34651140
REFERENCE   4  (bases 1 to 3010)
  AUTHORS   Ranea-Robles,P., Violante,S., Argmann,C., Dodatko,T.,
            Bhattacharya,D., Chen,H., Yu,C., Friedman,S.L., Puchowicz,M. and
            Houten,S.M.
  TITLE     Murine deficiency of peroxisomal L-bifunctional protein (EHHADH)
            causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs
            hepatic cholesterol homeostasis
  JOURNAL   Cell Mol Life Sci 78 (14), 5631-5646 (2021)
   PUBMED   34110423
  REMARK    GeneRIF: Murine deficiency of peroxisomal L-bifunctional protein
            (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and
            perturbs hepatic cholesterol homeostasis.
REFERENCE   5  (bases 1 to 3010)
  AUTHORS   Wang,H., Lu,J., Chen,X., Schwalbe,M., Gorka,J.E., Mandel,J.A.,
            Wang,J., Goetzman,E.S., Ranganathan,S., Dobrowolski,S.F. and
            Prochownik,E.V.
  TITLE     Acquired deficiency of peroxisomal dicarboxylic acid catabolism is
            a metabolic vulnerability in hepatoblastoma
  JOURNAL   J Biol Chem 296, 100283 (2021)
   PUBMED   33450224
  REMARK    GeneRIF: Acquired deficiency of peroxisomal dicarboxylic acid
            catabolism is a metabolic vulnerability in hepatoblastoma.
REFERENCE   6  (bases 1 to 3010)
  AUTHORS   Jia,Y., Qi,C., Zhang,Z., Hashimoto,T., Rao,M.S., Huyghe,S.,
            Suzuki,Y., Van Veldhoven,P.P., Baes,M. and Reddy,J.K.
  TITLE     Overexpression of peroxisome proliferator-activated receptor-alpha
            (PPARalpha)-regulated genes in liver in the absence of peroxisome
            proliferation in mice deficient in both L- and D-forms of enoyl-CoA
            hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation
            system
  JOURNAL   J Biol Chem 278 (47), 47232-47239 (2003)
   PUBMED   14500732
REFERENCE   7  (bases 1 to 3010)
  AUTHORS   Baes,M., Gressens,P., Huyghe,S., De,N.K., Qi,C., Jia,Y.,
            Mannaerts,G.P., Evrard,P., Van,V.P., Declercq,P.E. and Reddy,J.K.
  TITLE     The neuronal migration defect in mice with Zellweger syndrome (Pex5
            knockout) is not caused by the inactivity of peroxisomal
            beta-oxidation
  JOURNAL   J Neuropathol Exp Neurol 61 (4), 368-374 (2002)
   PUBMED   11939592
REFERENCE   8  (bases 1 to 3010)
  AUTHORS   Cook,W.S., Jain,S., Jia,Y., Cao,W.Q., Yeldandi,A.V., Reddy,J.K. and
            Rao,M.S.
  TITLE     Peroxisome proliferator-activated receptor alpha-responsive genes
            induced in the newborn but not prenatal liver of peroxisomal fatty
            acyl-CoA oxidase null mice
  JOURNAL   Exp Cell Res 268 (1), 70-76 (2001)
   PUBMED   11461119
REFERENCE   9  (bases 1 to 3010)
  AUTHORS   Huyghe,S., Casteels,M., Janssen,A., Meulders,L., Mannaerts,G.P.,
            Declercq,P.E., Van Veldhoven,P.P. and Baes,M.
  TITLE     Prenatal and postnatal development of peroxisomal
            lipid-metabolizing pathways in the mouse
  JOURNAL   Biochem J 353 (Pt 3), 673-680 (2001)
   PUBMED   11171065
REFERENCE   10 (bases 1 to 3010)
  AUTHORS   Qi,C., Zhu,Y., Pan,J., Usuda,N., Maeda,N., Yeldandi,A.V., Rao,M.S.,
            Hashimoto,T. and Reddy,J.K.
  TITLE     Absence of spontaneous peroxisome proliferation in enoyl-CoA
            Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver.
            Further support for the role of fatty acyl CoA oxidase in PPARalpha
            ligand metabolism
  JOURNAL   J Biol Chem 274 (22), 15775-15780 (1999)
   PUBMED   10336479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB841865.1, AK004867.1 and AC130214.4.
            
            On Aug 26, 2009 this sequence version replaced NM_023737.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016899.1, AK004867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BB841865.1         1-111
            112-1549            AK004867.1         83-1520
            1550-3010           AC130214.4         158591-160051       c
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.86 cM"
     gene            1..3010
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /note="enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme
                     A dehydrogenase"
                     /db_xref="GeneID:74147"
                     /db_xref="MGI:MGI:1277964"
     exon            1..128
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     exon            129..232
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     exon            233..399
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     exon            400..511
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     exon            512..616
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     exon            617..958
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     exon            959..3010
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /note="hexamer: AATAAA"
     polyA_site      3008
                     /gene="Ehhadh"
                     /gene_synonym="1300002P22Rik; HD; L-PBE; LBFP; LBP; MFE1;
                     MFP; MFP-1; MFP1; PBFE"
                     /note="major polyA site"
ORIGIN      
        1 gaaaaggagc cccgggctgc cccagacatc agaggcgcag gataccttga gaaaatggct
       61 gagtatctga ggctgcccca ctccctggct atgatccgcc tctgcaatcc accggtcaat
      121 gccatcagtc caactgtaat cacagaagta aggaatggac tccagaaagc tagtttggac
      181 catacggtta gagccatagt gatctgtgga gcaaatgaca acttctgtgc aggtgctgat
      241 atccatggct ttaaatctcc cactggcctt acattaggaa gcttggtaga tgaaatacag
      301 cgataccaga agccagtggt ggccgccatc caaggcgtgg ctcttggagg aggactagag
      361 ctggccttgg gctgtcacta tcggattgcc aatgcaaagg ctcgtgttgg cttcccggaa
      421 gtgatgctgg gaattcttcc tggtgcaaga ggaacgcagc ttctacccag ggtcgttgga
      481 gttcctgttg ctcttgactt aattacctca ggaagacata tttcaacaga tgaagcactc
      541 aagcttggaa ttctggatgt agttgtaaag tcagacccag ttgaagaagc catcaaattt
      601 gctcagacgg ttataggtaa acccatagaa ccccgcagga tcctaaacaa gccagtccca
      661 agcttgccca acatggacag tgtttttgca gaagccattg ccaaggtacg gaagcagtac
      721 cctggccgcc tggctccgga gacttgtgtc cgttcagtcc aggcctccgt gaagcatcca
      781 tatgaagtgg ccatcaagga agaagcaaag ctgtttatgt accttcgggg gtcggggcag
      841 gctagagccc tgcagtacgc cttttttgct gaaaagtctg caaataagtg gtcaactccc
      901 tcaggagcat cttggaaaac agcatctgct caacccgtct cctcggttgg tgttcttggc
      961 ttgggaacga tgggccgagg catcgccatc tcttttgcaa gggtggggat ccctgtggtt
     1021 gctgtagagt cagacccaaa gcagctagat actgcaaaga agataataac ttccaccttg
     1081 gaaaaggaag catcgaagag tggccaagct tcagcaaaac caaacctcag gttctcctca
     1141 tccacaaagg agctttcgag tgtggattta gtgattgaag cagtgttcga agatatgaac
     1201 ctgaagaaga aggtcttcgc tgaactgtca gccctgtgca agccgggagc ctttctgtgc
     1261 accaatacct cagcactgga tgtggatgac attgcttctt ccacagatcg cccccagctg
     1321 gtgattggca cccacttctt ctccccagcc cacatcatga ggttactaga ggtcattcct
     1381 agccgatact cttcccccac taccatcgcc acagtcatga gcttatccaa aaggattgga
     1441 aagattggag tcgttgttgg taactgctat ggatttgttg ggaatcgaat gttggctccc
     1501 tattacaacc agggctattt cttgatagag gaaggtagta agccagagga tgtagatggg
     1561 gtcttagaag agtttggttt tagaatggga cccttcaggg tgtctgacct cgcagggcta
     1621 gatgtgggtt ggaaagttcg caaagggcaa ggccttactg gaccgtcctt acctccagga
     1681 acccccaccc gaaagagggg caataccagg tactccccaa ttgctgatat gctctgtgaa
     1741 gctgggcgat ttggtcagaa gacaggtaag ggctggtatc agtatgacaa gccactgggt
     1801 cgcatccaca aacctgatcc ctggctttct gagtttctgt cacagtatag agaaacccat
     1861 cacatcaagc agcgctccat cagcaaggag gaaatcctgg agcgttgctt atattccctt
     1921 atcaacgagg cattccgcat cttggaggag gggatggccg ctagcccaga gcacattgat
     1981 gtcatctact tgcatgggta tgggtggcca aggcacgtgg gtgggcccat gtactatgct
     2041 gcctcagttg ggctgcccac agttctagag aaattgcaga aatattacag acagaatcct
     2101 gacatccccc agctggagcc cagtgactac ctgaggaggc tggttgccca gggaagccct
     2161 cctctgaaag aatggcaaag cttggcagga ccccatagca gcaaactgtg attcagcctt
     2221 ctgcattttg ccatgtatgg tggcatctaa tttcagtgtg attcattcct aaaatccaaa
     2281 cagatttctc tgaagtacaa atgatgattg ctgctgttgc tgctgctgct ggtggtggtg
     2341 gtgctaaatg gtcagcaaaa gcccctctct gtatcttcct acctcataat tctaatggcc
     2401 agatttcagg aatgtgtttt ctatacctct gacggtactt ctatcagaaa aattcagcaa
     2461 atatgtattt actactgcaa gcgttcttct cttttgactg tttgcttggt atagccataa
     2521 cttatacaaa atgttgctaa gagaataatt cataactcca gttgacaacc cagatatacc
     2581 ttttagcaaa tcaacaaaag tggcatggac atacaagtca cacatttcag ctgtgtgacg
     2641 gaacatgatg caccatggtg ctgtgttgca gcattgctct gactaagagg aggcagccaa
     2701 agaaggccac atgtcatatg gatgtggata taaaattcca gaatatacag atctgagaac
     2761 aatgtagatg agtagcccaa ggctataatt gttttaagtt aaaattactg ctgattaata
     2821 cagagtatct ttggagtttg ataaactttt ctaaaattac tttagtggtg tatctgtaac
     2881 acattgagtt caatggttca aagtgaacta tgtagtgtgt gtgtatatac acacaacata
     2941 tatatatata catatatata tatatattct atctcaatga agttaataaa attaatgatg
     3001 gtaaagcctt
//
