LOCUS       NM_007914               4387 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ets homologous factor (Ehf), mRNA.
ACCESSION   NM_007914
VERSION     NM_007914.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4387)
  AUTHORS   Sun,M., Huang,X., Ruan,X., Shang,X., Zhang,M., Liu,L., Wang,P.,
            An,P., Lin,Y., Yang,J. and Xue,Y.
  TITLE     Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by
            chronic cerebral ischemia through phosphorylation of Ehf
  JOURNAL   J Cereb Blood Flow Metab 44 (9), 1655-1673 (2024)
   PUBMED   38513137
  REMARK    GeneRIF: Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced
            by chronic cerebral ischemia through phosphorylation of Ehf.
REFERENCE   2  (bases 1 to 4387)
  AUTHORS   Nightingale,R., Reehorst,C.M., Vukelic,N., Papadopoulos,N.,
            Liao,Y., Guleria,S., Bell,C., Vaillant,F., Paul,S., Luk,I.Y.,
            Dhillon,A.S., Jenkins,L.J., Morrow,R.J., Jackling,F.C., Chand,A.L.,
            Chisanga,D., Chen,Y., Williams,D.S., Anderson,R.L., Ellis,S.,
            Meikle,P.J., Shi,W., Visvader,J.E., Pal,B. and Mariadason,J.M.
  TITLE     Ehf controls mammary alveolar lineage differentiation and is a
            putative suppressor of breast tumorigenesis
  JOURNAL   Dev Cell 59 (15), 1988-2004 (2024)
   PUBMED   38781975
  REMARK    GeneRIF: Ehf controls mammary alveolar lineage differentiation and
            is a putative suppressor of breast tumorigenesis.
REFERENCE   3  (bases 1 to 4387)
  AUTHORS   Song,E.A.C., Smalley,K., Oyelakin,A., Horeth,E., Che,M., Wrynn,T.,
            Osinski,J., Romano,R.A. and Sinha,S.
  TITLE     Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland
  JOURNAL   J Dent Res 102 (3), 340-348 (2023)
   PUBMED   36348499
  REMARK    GeneRIF: Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
REFERENCE   4  (bases 1 to 4387)
  AUTHORS   Luk,I.Y., Jenkins,L.J., Schoffer,K.L., Ng,I., Tse,J.W.T.,
            Mouradov,D., Kaczmarczyk,S., Nightingale,R., Burrows,A.D.,
            Anderson,R.L., Arango,D., Dopeso,H., Croft,L., Richardson,M.F.,
            Sieber,O.M., Liao,Y., Mooi,J.K., Vukelic,N., Reehorst,C.M.,
            Afshar-Sterle,S., Whitehall,V.L.J., Fennell,L., Abud,H.E.,
            Tebbutt,N.C., Phillips,W.A., Williams,D.S., Shi,W., Mielke,L.A.,
            Ernst,M., Dhillon,A.S., Clemons,N.J. and Mariadason,J.M.
  TITLE     Epithelial de-differentiation triggered by co-ordinate epigenetic
            inactivation of the EHF and CDX1 transcription factors drives
            colorectal cancer progression
  JOURNAL   Cell Death Differ 29 (11), 2288-2302 (2022)
   PUBMED   35606410
  REMARK    GeneRIF: Epithelial de-differentiation triggered by co-ordinate
            epigenetic inactivation of the EHF and CDX1 transcription factors
            drives colorectal cancer progression.
REFERENCE   5  (bases 1 to 4387)
  AUTHORS   Reehorst,C.M., Nightingale,R., Luk,I.Y., Jenkins,L., Koentgen,F.,
            Williams,D.S., Darido,C., Tan,F., Anderton,H., Chopin,M.,
            Schoffer,K., Eissmann,M.F., Buchert,M., Mouradov,D., Sieber,O.M.,
            Ernst,M., Dhillon,A.S. and Mariadason,J.M.
  TITLE     EHF is essential for epidermal and colonic epithelial homeostasis,
            and suppresses Apc-initiated colonic tumorigenesis
  JOURNAL   Development 148 (12) (2021)
   PUBMED   34180969
REFERENCE   6  (bases 1 to 4387)
  AUTHORS   Choi,Y.S. and Sinha,S.
  TITLE     Determination of the consensus DNA-binding sequence and a
            transcriptional activation domain for ESE-2
  JOURNAL   Biochem J 398 (3), 497-507 (2006)
   PUBMED   16704374
REFERENCE   7  (bases 1 to 4387)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   8  (bases 1 to 4387)
  AUTHORS   Kumar,R., Angelini,S., Czene,K., Sauroja,I., Hahka-Kemppinen,M.,
            Pyrhonen,S. and Hemminki,K.
  TITLE     BRAF mutations in metastatic melanoma: a possible association with
            clinical outcome
  JOURNAL   Clin Cancer Res 9 (9), 3362-3368 (2003)
   PUBMED   12960123
REFERENCE   9  (bases 1 to 4387)
  AUTHORS   Kleinbaum,L.A., Duggan,C., Ferreira,E., Coffey,G.P., Buttice,G. and
            Burton,F.H.
  TITLE     Human chromosomal localization, tissue/tumor expression, and
            regulatory function of the ets family gene EHF
  JOURNAL   Biochem Biophys Res Commun 264 (1), 119-126 (1999)
   PUBMED   10527851
REFERENCE   10 (bases 1 to 4387)
  AUTHORS   Bochert,M.A., Kleinbaum,L.A., Sun,L.Y. and Burton,F.H.
  TITLE     Molecular cloning and expression of Ehf, a new member of the ets
            transcription factor/oncoprotein gene family
  JOURNAL   Biochem Biophys Res Commun 246 (1), 176-181 (1998)
   PUBMED   9600089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE134913.1, AF035527.1, AK028651.1 and BX901906.3.
            
            On Sep 22, 2005 this sequence version replaced NM_007914.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               BE134913.1         1-291
            292-1309            AF035527.1         290-1307
            1310-2278           AK028651.1         1281-2249
            2279-4387           BX901906.3         114254-116362       c
FEATURES             Location/Qualifiers
     source          1..4387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.43 cM"
     gene            1..4387
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /note="ets homologous factor"
                     /db_xref="GeneID:13661"
                     /db_xref="MGI:MGI:1270840"
     exon            1..142
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            143..242
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1048
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /note="ETS domain-containing transcription factor"
                     /codon_start=1
                     /product="ETS homologous factor"
                     /protein_id="NP_031940.1"
                     /db_xref="CCDS:CCDS16475.1"
                     /db_xref="GeneID:13661"
                     /db_xref="MGI:MGI:1270840"
                     /translation="MILEGSGVMNLNPANNLLHQQPAWTDSYPTCNVSSGFFGSQWHE
                     IHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDISGEHLCSMSLQEFTRAAGSAGQ
                     LLYSNLQHLKWNGQCSSDLFQSAHNVIVKTEQTDPSIMNTWKEENYLYDPSYGSTVDL
                     LDSKTFCRAQISMTTSSHLPVAESPDMKKEQDHPVKSHTKKHNPRGTHLWEFIRDILL
                     SPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREIL
                     ERVDGRRLVYKFGKNARGWRENEN"
     exon            243..488
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..551
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            552..620
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..689
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..752
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..948
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            949..4387
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4382
                     /gene="Ehf"
                     /gene_synonym="9030625L19Rik"
                     /note="major polyA site"
ORIGIN      
        1 atttatcttc actctgatga gagctcagac gtgataaggc cgtggctccc catctcggta
       61 ggagctggtg tgatagcttc ctgccttctt cttcatcacc agagccatag gacttcccac
      121 ccagaatctt taggtaaatg agatcatgat tctggaagga agtggtgtaa tgaatctcaa
      181 cccagccaac aacctccttc accagcaacc agcctggacg gacagctacc ccacatgcaa
      241 tgtttccagc ggtttttttg gaagccagtg gcatgaaatc caccctcagt actggaccaa
      301 ataccaggtg tgggaatggc tgcagcacct cctggacacc aaccagctag acgctagctg
      361 catccctttc caggagttcg acattagcgg agaacacctg tgcagcatga gtctgcagga
      421 gttcacgagg gcagcaggct cagctgggca gctgctctac agcaacctac agcatctcaa
      481 gtggaacggc caatgcagca gtgacctttt ccagtccgca cacaatgtca ttgtcaagac
      541 tgaacaaacc gatccttcca tcatgaacac atggaaagaa gaaaactatc tctatgatcc
      601 cagctatggt agcacagtag atctgttgga cagtaagact ttctgccggg ctcagatctc
      661 catgacaacc tccagtcacc ttccagttgc agagtcacct gatatgaaaa aggagcaaga
      721 ccaccctgta aagtcccaca ccaaaaagca caacccaaga ggcactcact tatgggagtt
      781 catccgagac attctcttga gcccagacaa gaacccagga ctgatcaaat gggaagaccg
      841 ttcggaaggc atcttcaggt tcctgaagtc agaagctgtg gctcagctgt gggggaaaaa
      901 gaaaaataac agtagcatga catacgagaa gctcagccgg gctatgagat attactacaa
      961 acgagaaatc ctggaacgtg tggatggacg acggctggtc tataagtttg ggaagaatgc
     1021 tcgtggatgg agagaaaatg agaactgagg ctgccagccc ttgggacaca aaccaaaaca
     1081 cacagcaaat ggattctgat caatgaagaa ccggacgtaa atatctcaaa gactactttt
     1141 ctgtgatatt tatgtaccat gaagggacaa agaaaatcta cttctgacgg gaagaaggaa
     1201 cactacagtt gataaaaaaa aaattatttt gttactttga agtatgtcct tttgtgggga
     1261 acaaatgtac acagttttct gtgaactatg aagctgtatg tgattgtgat ttgctgttgc
     1321 ctcttcgtga agttcttttc tacccccaag aacaacaggg cctgtagcct tgtgcttctt
     1381 gctaagagga agggatagga aatgagggca ttaaatgttt tcaagtgtaa aatggtttag
     1441 aaaagaaagg caatgtgttc tctgcaccta agcatctgtg tgacctcaag agaaatggga
     1501 ttgggtaggg aggacaaagt ccagggtctc agattggtgg gatcaaccca aaagatgctg
     1561 ggaagtttga cttgaattgg gagatagtga gtggagagta ggaactttga cagtccagag
     1621 tggcctataa gcacagcatg atcacaggac tgggaacgtt taaatacggc aggtgaagag
     1681 tttatcctca gttatggaca attttcatgt agacccttca tccttgaatg gttggttaaa
     1741 aaagtcagtt accacatgca gtcacttcta gctattgaag agttcagtcc aaatattgaa
     1801 aattaagtgg gacaggaaaa tagtggcctg gaaatgatcg atgagcatgc tcttgtatct
     1861 ctgtagttca aggtttctcc atgggtagag ttgccatttg gggttgggtc attctttgtg
     1921 gtgagggtta tactgggcat tgtaaaatgt gtggcgatat ccatgacctc catcagcatt
     1981 ttgtaactgt gacaatctga agtgtttcta gatattgtca aatgtctcta ggaggacaat
     2041 agtacccttg agcgaggacc accaattgaa atggacagta tgaaggcagt cgttcagtct
     2101 cagaatagag agatctatag acacttctag tctctagagt aaagcaaaag caagaccttg
     2161 aagtcaatat atgtttattt tttaaaatag tagggacagc aggatgagaa taaatggagg
     2221 agattctttt cagagcttca catgaaaacc aaagtcaaat aaatgcaatg atgtatggaa
     2281 agtgcaagag aagttgtttg cacagagaat gcagatattg cagaagacag tgcctaaggc
     2341 agagtctatg gatgtctctg tgtgattctc tctctctctc tctctctctc tgtgtgtgtg
     2401 tgtgtgtgtg tgtttgtgaa gttactaggg gcctctgtca gttttctctc tgcttctcct
     2461 tccctgtctt tccctggctg tggtcgagga tggccagacc acatgtcttg ggttcattta
     2521 ttcctgggtt ctcttattcc tgtaactgga tttgaccctt cctacaccta cttcattata
     2581 gagctattgc tgtcagagag taggtgaatc tggagaggac cagtgggaac agttctgcag
     2641 ataaacagat tatgctgttg gctgagagtg gcagtttctt ggcacccagt tcccatttaa
     2701 atagacggga gtattaagtt ctctgcatat ctattgtctt ggcttgaatt tgcggtgttt
     2761 tctatgtgct attcatgact ttgagaattc caggtaatca agctatgcca atttggggtg
     2821 tagtggtgtg cttcccacca cagtttgaaa aaaaacaaaa caaaacaaga catgaaagtc
     2881 ctacagaaaa gcacctcttt ctttagggga tcgttaccta gttattaagt tcatctgaga
     2941 ttaattggcc acaggatcac taaatatagt ttcttgaata ttcctaagtg ttctattagt
     3001 ggtttccatg ggaactgaaa tcaagtaatg gaccattaat acttcacaag actcagatca
     3061 tctgagactc ctataggact tgatgaaatt aagcaaggtc ctggatccca gaaacaggtc
     3121 cacaggttct tcggtatgcc gagcaggaga gacaatgcct gagtttcatt cactgagcct
     3181 tccttcaagt tcccagctga ttagactgta agctcgccaa gggcagggag catgtctgat
     3241 cacctctgtt atcctcatac ctgggatgca acaggagaac ttctcatgaa tgaatgatga
     3301 ctgtcttctg ggagactcct ctggctggga acccatcagt catattcata actgggatgt
     3361 gaatcacttc ttcagaacag agcataataa ctaaaccttc caggatgaga acattttact
     3421 gtgacactct cctttgcctc ccacctatgc tgaaaagaaa ttcaaacagc ctgcttggtt
     3481 ccacatgtca gtgtctgctg gatgagaatt ctgttgcttt ttagaactgt gagacttaac
     3541 ctggttacaa gatgccagta acgaaccctt gatctattta atcaacgaag attataaatg
     3601 tgtttatatg atgtcaattg ctatttaagc aggaacccat tttcagtttt ggtatttagg
     3661 ggttggtttt tattttttgt tatttttttc ttcctttttg aaaaatgctg agggatattt
     3721 tgataaggtt agtcatgcat gttaggtttt cattttgcaa gtatgtcttt tttaatgtat
     3781 aaaaatataa gaaaagggag aacagtaaga aggggaagca cttacattac ttttcagtac
     3841 tttattaaag cacctactgg gtgccttgtg catagtgaaa caccatatat gtgaggagta
     3901 tatgtgagag aatagactat aaaagtcaca cgatctggac ctgcagagga atactgacta
     3961 agagaaggaa acaccagcat ggcaaactta gtgttaacag gtgagttacc ctcagctggg
     4021 gactcaggac tcagtttctg gaataaggga gaccattaag aaaaccaaac ttcttggaac
     4081 tgtatctcac aaacttttga aacatgtaga cttcagagtt cagctgaatt tggattaatc
     4141 attctgtagc tatctgtata aatctcactc ttcttgccac ctggcttctg ggttgataat
     4201 tggtgggcga caacccttct gccactgttt tatttttatt ttcattttta tttttattat
     4261 tttttaaatc atgactcttt ccccttaagc tgttaaattc aaacaattta tgtttaatga
     4321 aagaattctg ttttgtttgt ttgatgggtc ccagaaaaca ctaataaaaa gcacagaggc
     4381 catgctg
//
